ISMARA results: sox6

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for sox6

Z-value: 1.22

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Transcription factors associated with sox6

Gene Symbol	Gene ID	Gene Info
sox6 NCBI UniProt	ENSDARG00000015536	SRY-box transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sox6	dr11_v1_chr7_+_27250186_27250186	-0.98	3.5e-12	Click!

Activity profile of sox6 motif

Sorted Z-values of sox6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_2578026 Show fit	6.46	ENSDART00000065821	zp3.2 NCBI UniProt Show fit	zona pellucida glycoprotein 3, tandem duplicate 2
chr12_+_48340133 Show fit	4.90	ENSDART00000152899 ENSDART00000153335 ENSDART00000054788	ddit4 NCBI UniProt Show fit	DNA-damage-inducible transcript 4
chr17_-_2590222 Show fit	4.56	ENSDART00000185711	CR759892.1 NCBI UniProt Show fit
chr1_-_33645967 Show fit	3.94	ENSDART00000192758	cldng NCBI UniProt Show fit	claudin g
chr22_-_10541372 Show fit	3.83	ENSDART00000179708	si:dkey-42i9.4 NCBI UniProt Show fit	si:dkey-42i9.4
chr12_-_33354409 Show fit	3.79	ENSDART00000178515	slc16a3 NCBI UniProt Show fit	solute carrier family 16 (monocarboxylate transporter), member 3
chr19_-_27588842 Show fit	3.56	ENSDART00000121643	si:dkeyp-46h3.2 NCBI UniProt Show fit	si:dkeyp-46h3.2
chr17_-_2573021 Show fit	3.45	ENSDART00000074181	zp3.2 NCBI UniProt Show fit	zona pellucida glycoprotein 3, tandem duplicate 2
chr24_-_24724233 Show fit	3.38	ENSDART00000127044 ENSDART00000012399	armc1 NCBI UniProt Show fit	armadillo repeat containing 1
chr10_+_15608326 Show fit	3.08	ENSDART00000188770	zfand5b NCBI UniProt Show fit	zinc finger, AN1-type domain 5b

Showing 1 to 10 of 196 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sox6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	9.9	GO:0035803	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.0	5.9	GO:0008285	negative regulation of cell proliferation(GO:0008285)
0.1	4.9	GO:0032007	negative regulation of TOR signaling(GO:0032007)
0.8	3.9	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	3.8	GO:0015718	monocarboxylic acid transport(GO:0015718)
0.7	2.9	GO:0070987	error-free translesion synthesis(GO:0070987)
0.1	2.8	GO:0030901	midbrain development(GO:0030901)
0.5	2.5	GO:0010482	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.1	2.2	GO:0070897	DNA-templated transcriptional preinitiation complex assembly(GO:0070897)
0.0	2.2	GO:0031101	fin regeneration(GO:0031101)

Showing 1 to 10 of 61 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.9	GO:0031012	extracellular matrix(GO:0031012)
0.0	3.9	GO:0070160	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0	2.4	GO:0031901	early endosome membrane(GO:0031901)
0.3	2.2	GO:0000126	transcription factor TFIIIB complex(GO:0000126)
0.2	2.1	GO:0045095	keratin filament(GO:0045095)
0.3	1.9	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	1.7	GO:0016607	nuclear speck(GO:0016607)
0.0	1.6	GO:0005814	centriole(GO:0005814)
0.4	1.5	GO:0044326	dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.0	1.2	GO:0032587	ruffle membrane(GO:0032587)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	9.9	GO:0035804	structural constituent of egg coat(GO:0035804)
1.2	4.9	GO:0071889	14-3-3 protein binding(GO:0071889)
0.3	3.8	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	3.5	GO:0042802	identical protein binding(GO:0042802)
0.1	2.9	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.3	2.2	GO:0000995	transcription factor activity, core RNA polymerase III binding(GO:0000995)
0.0	2.1	GO:0005044	scavenger receptor activity(GO:0005044)
0.2	1.9	GO:0005158	insulin receptor binding(GO:0005158)
0.1	1.8	GO:0008301	DNA binding, bending(GO:0008301)
0.0	1.7	GO:0003755	peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Showing 1 to 10 of 44 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.7	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	2.0	PID PLK1 PATHWAY	PLK1 signaling events
0.1	1.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.3	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.1	1.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	1.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	0.9	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.8	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.6	PID FGF PATHWAY	FGF signaling pathway
0.0	0.5	ST G ALPHA I PATHWAY	G alpha i Pathway

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.8	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	2.9	REACTOME DNA REPAIR	Genes involved in DNA Repair
0.1	2.0	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.5	1.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	1.9	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	1.4	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	1.2	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.4	1.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	1.1	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.9	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex

Showing 1 to 10 of 21 entries

Results for sox6

Z-value: 1.22

Motif logo

Transcription factors associated with sox6

Activity-expression correlation:

Activity profile of sox6 motif

Sorted Z-values of sox6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sox6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: