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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for sox5

Z-value: 0.96

Motif logo

Transcription factors associated with sox5

Gene Symbol Gene ID Gene Info
ENSDARG00000011582 SRY-box transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
sox5dr11_v1_chr4_-_17055782_17055782-0.542.0e-02Click!

Activity profile of sox5 motif

Sorted Z-values of sox5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_868187 2.77 ENSDART00000186626
eomesodermin homolog a
chr18_+_36066389 2.22 ENSDART00000059347
branched chain keto acid dehydrogenase E1, alpha polypeptide
chr19_+_10661520 1.98 ENSDART00000091813
ENSDART00000165653
argonaute RISC catalytic component 3b
chr2_+_32846602 1.90 ENSDART00000056649
transmembrane protein 53
chr13_-_36844945 1.69 ENSDART00000129562
ENSDART00000150899
ninein (GSK3B interacting protein)
chr18_+_45571378 1.68 ENSDART00000077251
kinesin family member C3
chr19_+_41479990 1.60 ENSDART00000087187
argonaute RISC catalytic component 2
chr17_+_28005763 1.59 ENSDART00000155838
leucine zipper protein 1
chr9_-_14273652 1.57 ENSDART00000135458
ATP-binding cassette, sub-family B (MDR/TAP), member 6b
chr23_+_30730121 1.55 ENSDART00000134141
additional sex combs like transcriptional regulator 1
chr22_-_10541372 1.55 ENSDART00000179708
si:dkey-42i9.4
chr17_-_14966384 1.48 ENSDART00000105064
thioredoxin domain containing 16
chr5_+_40835601 1.46 ENSDART00000147767
si:dkey-3h3.3
chr21_+_13233377 1.46 ENSDART00000142569
sperm antigen with calponin homology and coiled-coil domains 1-like b
chr12_+_48340133 1.45 ENSDART00000152899
ENSDART00000153335
ENSDART00000054788
DNA-damage-inducible transcript 4
chr21_+_7605803 1.42 ENSDART00000121813
WD repeat domain 41
chr21_+_13327527 1.38 ENSDART00000114294
small nuclear ribonucleoprotein D3 polypeptide, like
chr12_-_33357655 1.37 ENSDART00000066233
ENSDART00000148165
solute carrier family 16 (monocarboxylate transporter), member 3
chr15_-_41689981 1.37 ENSDART00000059327
splA/ryanodine receptor domain and SOCS box containing 4b
chr6_-_42336987 1.31 ENSDART00000128777
ENSDART00000075601
Fanconi anemia, complementation group D2
chr19_+_7549854 1.29 ENSDART00000138866
ENSDART00000151758
pre-B-cell leukemia homeobox interacting protein 1a
chr3_-_25369557 1.28 ENSDART00000055491
SMAD specific E3 ubiquitin protein ligase 2
chr11_-_25257045 1.27 ENSDART00000130477
snail family zinc finger 1a
chr24_-_19719240 1.26 ENSDART00000135405
cysteine-serine-rich nuclear protein 1b
chr14_-_2588216 1.25 ENSDART00000188082
ENSDART00000167293
F-box and WD repeat domain containing 11a
chr1_+_45958904 1.24 ENSDART00000108528
Rho guanine nucleotide exchange factor (GEF) 7b
chr12_-_17592215 1.24 ENSDART00000134597
ubiquitin specific peptidase 42
chr11_-_34572202 1.24 ENSDART00000077883
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr11_-_25257595 1.23 ENSDART00000123567
snail family zinc finger 1a
chr16_-_39267185 1.21 ENSDART00000058550
ENSDART00000133642
glycerol-3-phosphate dehydrogenase 1 like
chr12_+_11650146 1.19 ENSDART00000150191
WAPL cohesin release factor b
chr5_+_24543862 1.19 ENSDART00000029699
ATPase H+ transporting V0 subunit a2b
chr2_+_16696052 1.19 ENSDART00000022356
ENSDART00000164329
protein phosphatase 1, regulatory (inhibitor) subunit 7
chr17_+_19626479 1.13 ENSDART00000044993
ENSDART00000131863
regulator of G protein signaling 7a
chr3_+_51684963 1.12 ENSDART00000091180
ENSDART00000183711
ENSDART00000159493
BAI1-associated protein 2a
chr18_-_12327426 1.12 ENSDART00000136992
ENSDART00000114024
family with sequence similarity 107, member B
chr13_-_22961605 1.12 ENSDART00000143112
ENSDART00000057641
tetraspanin 15
chr15_-_41689684 1.12 ENSDART00000143447
splA/ryanodine receptor domain and SOCS box containing 4b
chr15_+_24737599 1.12 ENSDART00000078024
v-crk avian sarcoma virus CT10 oncogene homolog
chr2_+_44512324 1.11 ENSDART00000155017
ENSDART00000156310
ENSDART00000156686
PAS domain containing serine/threonine kinase
chr11_+_26375979 1.10 ENSDART00000087652
ENSDART00000171748
ENSDART00000103513
ENSDART00000165931
ENSDART00000170043
copine I
RNA binding motif protein 12
chr7_-_60351537 1.09 ENSDART00000159875
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr23_+_24501918 1.08 ENSDART00000078824
SUZ RNA binding domain containing 1
chr15_-_35930070 1.07 ENSDART00000076229
insulin receptor substrate 1
chr2_-_29923403 1.07 ENSDART00000144672
PAX interacting (with transcription-activation domain) protein 1
chr25_+_16895294 1.06 ENSDART00000159773
zgc:77158
chr14_+_49683767 1.06 ENSDART00000192515
tetraspanin 17
chr16_+_30117798 1.06 ENSDART00000135723
ENSDART00000000198
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E
chr9_-_41040098 1.06 ENSDART00000008275
adenosine deaminase, tRNA-specific 3
chr17_-_39185336 1.05 ENSDART00000050534
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr9_+_29520696 1.02 ENSDART00000144430
ferredoxin 1
chr9_+_42607138 1.01 ENSDART00000138133
ENSDART00000002027
GULP, engulfment adaptor PTB domain containing 1a
chr25_-_29074064 1.00 ENSDART00000165603
AT rich interactive domain 3B (BRIGHT-like)
chr15_+_29025090 1.00 ENSDART00000131755
si:ch211-137a8.2
chr23_+_19590006 1.00 ENSDART00000021231
sarcolemma associated protein b
chr7_+_25003851 0.99 ENSDART00000144526
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr6_-_12900154 0.99 ENSDART00000080408
ENSDART00000150887
islet cell autoantigen 1-like
chr9_-_41040492 0.96 ENSDART00000163164
adenosine deaminase, tRNA-specific 3
chr3_-_42086577 0.95 ENSDART00000083111
ENSDART00000187312
tweety family member 3a
chr23_-_32157865 0.95 ENSDART00000000876
nuclear receptor subfamily 4, group A, member 1
chr2_-_29923630 0.95 ENSDART00000158844
ENSDART00000031130
PAX interacting (with transcription-activation domain) protein 1
chr20_+_26943072 0.94 ENSDART00000153215
cell division cycle associated 4
chr15_-_5799170 0.94 ENSDART00000142334
ENSDART00000171528
heterogeneous nuclear ribonucleoprotein L2
chr4_-_14624481 0.94 ENSDART00000137847
plexin b2a
chr11_-_25461336 0.93 ENSDART00000014945
host cell factor C1a
chr2_+_36620011 0.93 ENSDART00000177428
p21 protein (Cdc42/Rac)-activated kinase 2a
chr14_-_38889311 0.92 ENSDART00000186978
zgc:101583
chr8_+_13106760 0.92 ENSDART00000029308
integrin, beta 4
chr2_-_21170517 0.92 ENSDART00000135417
bmi1 polycomb ring finger oncogene 1b
chr14_-_41478265 0.91 ENSDART00000149886
ENSDART00000016002
tetraspanin 7
chr10_-_15879569 0.91 ENSDART00000136789
tight junction protein 2a (zona occludens 2)
chr19_-_46566430 0.90 ENSDART00000166668
exostosin glycosyltransferase 1b
chr15_-_1036878 0.90 ENSDART00000123844
si:dkey-77f5.3
chr6_+_32382743 0.89 ENSDART00000190009
dedicator of cytokinesis 7
chr10_+_5954787 0.88 ENSDART00000161887
ENSDART00000160345
ENSDART00000190046
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr8_+_20488322 0.88 ENSDART00000036630
zgc:101100
chr23_-_36446307 0.87 ENSDART00000136623
zgc:174906
chr13_+_25364324 0.86 ENSDART00000187471
conserved helix-loop-helix ubiquitous kinase
chr2_+_4303125 0.86 ENSDART00000161211
ENSDART00000162269
Cdk5 and Abl enzyme substrate 1
chr16_-_10223741 0.86 ENSDART00000188099
si:rp71-15i12.1
chr18_+_19131773 0.84 ENSDART00000060766
RAB11a, member RAS oncogene family
chr8_+_42941555 0.84 ENSDART00000183206
solute carrier family 23 (ascorbic acid transporter), member 2
chr1_+_53321878 0.82 ENSDART00000143909
TBC1 domain family, member 9 (with GRAM domain)
chr10_+_15255012 0.82 ENSDART00000023766
very low density lipoprotein receptor
chr13_+_11440389 0.82 ENSDART00000186463
zinc finger and BTB domain containing 18
chr10_+_15255198 0.79 ENSDART00000139047
ENSDART00000172107
ENSDART00000183413
ENSDART00000185314
very low density lipoprotein receptor
chr23_-_3759692 0.79 ENSDART00000028885
high mobility group AT-hook 1a
chr21_+_19547806 0.78 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
retinoic acid induced 14
chr1_-_21714025 0.78 ENSDART00000129066
zinc finger, CCHC domain containing 7
chr20_+_54383838 0.77 ENSDART00000157737
leucine rich repeat and fibronectin type III domain containing 5b
chr3_+_26244353 0.77 ENSDART00000103733
ATPase family, AAA domain containing 5a
chr11_+_2649891 0.76 ENSDART00000093052
si:ch211-160o17.4
chr19_+_29808699 0.76 ENSDART00000051799
ENSDART00000164205
histone deacetylase 1
chr12_+_33403694 0.76 ENSDART00000124083
fatty acid synthase
chr13_+_25364753 0.76 ENSDART00000027428
conserved helix-loop-helix ubiquitous kinase
chr15_+_29662401 0.75 ENSDART00000135540
nuclear receptor interacting protein 1a
chr23_-_36003282 0.75 ENSDART00000103150
calcium binding and coiled-coil domain 1a
chr7_+_24528866 0.75 ENSDART00000180552
si:dkeyp-75h12.2
chr14_-_38889840 0.75 ENSDART00000035779
zgc:101583
chr13_-_32898962 0.74 ENSDART00000163757
rho-associated, coiled-coil containing protein kinase 2a
chr10_-_14929630 0.74 ENSDART00000121892
ENSDART00000044756
ENSDART00000128579
ENSDART00000147653
SMAD family member 2
chr23_-_3759345 0.74 ENSDART00000132205
ENSDART00000137707
ENSDART00000189382
high mobility group AT-hook 1a
chr2_+_22363824 0.74 ENSDART00000163172
heparan sulfate 2-O-sulfotransferase 1a
chr13_-_25196758 0.73 ENSDART00000184722
adenosine kinase a
chr20_-_31238313 0.73 ENSDART00000028471
hippocalcin-like 1
chr25_+_26441054 0.72 ENSDART00000158607
death-associated protein kinase 2b
chr19_+_20793388 0.72 ENSDART00000142463
thioredoxin-like 4A
chr6_+_18520859 0.72 ENSDART00000158263
si:dkey-10p5.10
chr19_+_29808471 0.71 ENSDART00000186428
histone deacetylase 1
chr16_+_27614989 0.71 ENSDART00000005625
GLI pathogenesis-related 2, like
chr3_+_54047342 0.71 ENSDART00000178486
olfactomedin 2a
chr17_+_16192486 0.71 ENSDART00000156832
kinesin family member 13Ba
chr5_+_25762271 0.71 ENSDART00000181323
transmembrane protein 2
chr2_+_2967255 0.70 ENSDART00000167649
ENSDART00000166449
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)
chr16_-_21047483 0.70 ENSDART00000136235
chromobox homolog 3b
chr12_-_23365737 0.69 ENSDART00000170376
membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7)
chr14_-_6402769 0.69 ENSDART00000121552
solute carrier family 44 (choline transporter), member 1b
chr10_-_36625752 0.68 ENSDART00000138344
remodeling and spacing factor 1b, tandem duplicate 1
chr6_-_46742455 0.67 ENSDART00000011970
zgc:66479
chr17_+_28706946 0.66 ENSDART00000126967
striatin, calmodulin binding protein 3
chr24_+_32411753 0.66 ENSDART00000058530
neuronal differentiation 6a
chr25_+_28253844 0.66 ENSDART00000151891
Ca++-dependent secretion activator 2
chr2_+_35880600 0.65 ENSDART00000004277
laminin, gamma 1
chr8_-_49766205 0.65 ENSDART00000137941
ENSDART00000097919
ENSDART00000147309
heterogeneous nuclear ribonucleoprotein K
chr19_+_13410903 0.65 ENSDART00000165033
ENSDART00000168672
serine/arginine-rich splicing factor 4
chr19_-_5058515 0.65 ENSDART00000150980
chromodomain helicase DNA binding protein 4a
chr3_-_32873641 0.64 ENSDART00000075277
zgc:113090
chr17_+_21486047 0.62 ENSDART00000104608
phospholipase A2, group IVF, tandem duplicate 2
chr15_-_21669618 0.62 ENSDART00000156995
sortilin-related receptor, L(DLR class) A repeats containing
chr8_-_14604606 0.62 ENSDART00000090254
ENSDART00000188953
centrosomal protein 350
chr25_+_388258 0.62 ENSDART00000166834
regulatory factor X7b
chr21_+_19368720 0.62 ENSDART00000187759
ENSDART00000185829
ENSDART00000158471
ENSDART00000168728
betacellulin, epidermal growth factor family member
chr3_-_37148594 0.60 ENSDART00000140855
MLX, MAX dimerization protein
chr16_-_21047872 0.60 ENSDART00000131582
chromobox homolog 3b
chr3_+_40407352 0.59 ENSDART00000155112
trinucleotide repeat containing 18
chr18_-_20466061 0.59 ENSDART00000060311
progestin and adipoQ receptor family member Va
chr2_+_31308587 0.58 ENSDART00000027090
clusterin-like 1 (retinal)
chr10_+_8847033 0.58 ENSDART00000140894
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 1
chr5_-_20893993 0.58 ENSDART00000137603
si:ch211-225b11.4
chr5_-_38342992 0.58 ENSDART00000140337
misshapen-like kinase 1
chr3_+_31058464 0.57 ENSDART00000153381
si:dkey-66i24.7
chr12_+_27704015 0.57 ENSDART00000153256
calcium channel, voltage-dependent, T type, alpha 1G subunit
chr10_+_31244619 0.57 ENSDART00000145562
ENSDART00000184412
roundabout, axon guidance receptor, homolog 4 (Drosophila)
chr6_-_6258451 0.56 ENSDART00000081966
ENSDART00000125918
reticulon 4a
chr20_+_21391181 0.56 ENSDART00000185158
ENSDART00000049586
ENSDART00000024922
jagged 2b
chr17_+_24597001 0.56 ENSDART00000191834
rearranged L-myc fusion
chr3_-_30186296 0.54 ENSDART00000134395
ENSDART00000077057
ENSDART00000017422
TBC1 domain family, member 17
chr15_+_29728377 0.54 ENSDART00000099958
zgc:153372
chr21_-_42876565 0.54 ENSDART00000126480
zmp:0000001268
chr3_-_26244256 0.52 ENSDART00000103741
protein phosphatase 4, catalytic subunit a
chr17_-_24889837 0.52 ENSDART00000187980
UDP-galactose-4-epimerase
chr6_-_51771634 0.50 ENSDART00000073847
bladder cancer associated protein
chr23_-_31428763 0.50 ENSDART00000053545
zgc:153284
chr3_+_19685873 0.50 ENSDART00000006490
tousled-like kinase 2
chr23_+_43770149 0.49 ENSDART00000024313
ring finger protein 150b
chr5_-_24543526 0.48 ENSDART00000046384
tRNA methyltransferase 2 homolog A
chr22_-_29906764 0.47 ENSDART00000019786
structural maintenance of chromosomes 3
chr7_+_67749251 0.47 ENSDART00000167562
DEAH (Asp-Glu-Ala-His) box polypeptide 38
chr6_-_45869127 0.47 ENSDART00000062459
ENSDART00000180563
RNA binding motif protein 19
chr8_+_17869225 0.47 ENSDART00000080079
solute carrier family 44, member 5b
chr16_+_35535375 0.47 ENSDART00000171675
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b
chr22_+_10232527 0.46 ENSDART00000139297
si:dkeyp-87e7.4
chr23_+_20640875 0.45 ENSDART00000147382
ubiquitin-like modifier activating enzyme 1
chr18_+_30421528 0.45 ENSDART00000140908
Gse1 coiled-coil protein
chr9_-_43213229 0.45 ENSDART00000139775
SEC14 and spectrin domains 1
chr6_-_10728057 0.44 ENSDART00000002247
Sp3b transcription factor
chr10_-_8672820 0.44 ENSDART00000080763
si:dkey-27b3.2
chr10_+_9222476 0.44 ENSDART00000064973
ENSDART00000145879
progestin and adipoQ receptor family member IIIb
chr4_-_2059233 0.44 ENSDART00000188177
ENSDART00000129521
ENSDART00000082289
cleavage and polyadenylation specific factor 6
chr22_-_20342260 0.44 ENSDART00000161610
ENSDART00000165667
transcription factor 3b
chr23_+_22819971 0.44 ENSDART00000111345
arginine-glutamic acid dipeptide (RE) repeats a
chr16_+_40954481 0.44 ENSDART00000058587
glycogen synthase kinase binding protein
chr17_+_31621788 0.43 ENSDART00000111629
ENSDART00000157148
cyclin-dependent kinase 2 interacting protein
chr21_+_13244450 0.43 ENSDART00000146062
sperm antigen with calponin homology and coiled-coil domains 1-like b
chr17_-_35278763 0.43 ENSDART00000063437
ADAM metallopeptidase domain 17a
chr23_-_5685023 0.42 ENSDART00000148680
ENSDART00000149365
troponin T type 2a (cardiac)
chr19_+_37848830 0.41 ENSDART00000042276
ENSDART00000180872
neurexophilin 1
chr23_-_17003533 0.41 ENSDART00000080545
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr17_+_49281597 0.41 ENSDART00000155599
zgc:113176
chr16_-_36196700 0.40 ENSDART00000172324
calpain 7
chr18_-_12451772 0.40 ENSDART00000175083
si:ch211-1e14.1
chr8_-_43677762 0.39 ENSDART00000167762
E1A binding protein p400
chr5_+_64397454 0.39 ENSDART00000015940
endothelial differentiation-related factor 1
chr23_-_15916316 0.39 ENSDART00000134096
ENSDART00000042469
ENSDART00000146605
MRG/MORF4L binding protein
chr2_+_24867534 0.37 ENSDART00000158050
RAB3A, member RAS oncogene family, a
chr7_-_32020858 0.37 ENSDART00000023568
kinesin family member 18A
chr2_+_35806672 0.37 ENSDART00000137384
RAS protein activator like 2
chr25_+_7321675 0.36 ENSDART00000104712
ENSDART00000142934
high mobility group 20A
chr7_-_33351485 0.36 ENSDART00000146420
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr23_+_17102960 0.36 ENSDART00000053414
COMM domain containing 7
chr14_-_44773864 0.36 ENSDART00000158386
si:dkey-109l4.3
chr6_+_46406565 0.35 ENSDART00000168440
ENSDART00000131203
ENSDART00000138567
ENSDART00000132845
polybromo 1, like
chr8_-_39978767 0.35 ENSDART00000083066
aspartate beta-hydroxylase domain containing 2
chr7_+_38090515 0.34 ENSDART00000131387
CCAAT/enhancer binding protein (C/EBP), gamma
chr19_-_38872650 0.34 ENSDART00000146641
adhesion G protein-coupled receptor B2
chr19_-_6988837 0.34 ENSDART00000145741
ENSDART00000167640
zinc finger protein 384 like
chr13_+_15933168 0.34 ENSDART00000131390
fidgetin-like 1
chr4_+_23134366 0.33 ENSDART00000185788
MDM2 oncogene, E3 ubiquitin protein ligase
chr5_-_18962794 0.33 ENSDART00000145210
ankyrin repeat and LEM domain containing 2
chr23_+_25201077 0.33 ENSDART00000136675
si:dkey-151g10.3

Network of associatons between targets according to the STRING database.

First level regulatory network of sox5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.6 1.9 GO:0097095 frontonasal suture morphogenesis(GO:0097095)
0.4 1.2 GO:0071896 protein localization to adherens junction(GO:0071896)
0.4 1.2 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.3 1.7 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.3 1.6 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.3 1.6 GO:0098795 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.3 1.2 GO:0046168 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.3 0.8 GO:0018872 arsonoacetate metabolic process(GO:0018872)
0.3 0.8 GO:0015882 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.3 1.3 GO:1990918 double-strand break repair involved in meiotic recombination(GO:1990918)
0.2 0.7 GO:0060031 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) mediolateral intercalation(GO:0060031)
0.2 1.1 GO:0001961 positive regulation of cytokine-mediated signaling pathway(GO:0001961) positive regulation of response to cytokine stimulus(GO:0060760)
0.2 1.3 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.2 1.5 GO:0033687 osteoblast proliferation(GO:0033687)
0.2 2.0 GO:0072091 regulation of stem cell proliferation(GO:0072091)
0.2 0.6 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.2 1.3 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 1.6 GO:1901678 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 2.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 0.4 GO:0046831 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 1.1 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 1.0 GO:1904086 regulation of epiboly involved in gastrulation with mouth forming second(GO:1904086)
0.1 0.7 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.7 GO:0044209 AMP salvage(GO:0044209)
0.1 1.0 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 2.5 GO:0008078 mesodermal cell migration(GO:0008078)
0.1 0.6 GO:0060231 mesenchymal to epithelial transition(GO:0060231)
0.1 1.0 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.4 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.1 0.5 GO:0019388 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 1.7 GO:0015693 magnesium ion transport(GO:0015693)
0.1 0.6 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 1.2 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.7 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.1 1.0 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.6 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)
0.1 0.4 GO:0051570 regulation of histone H3-K9 methylation(GO:0051570)
0.1 1.1 GO:0090279 regulation of calcium ion import(GO:0090279)
0.1 0.2 GO:0033210 leptin-mediated signaling pathway(GO:0033210) cellular response to leptin stimulus(GO:0044320) response to leptin(GO:0044321)
0.1 0.3 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.1 0.8 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887) endosome to plasma membrane protein transport(GO:0099638) neurotransmitter receptor transport, endosome to plasma membrane(GO:0099639)
0.1 0.9 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.5 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 1.7 GO:0048570 notochord morphogenesis(GO:0048570)
0.1 0.9 GO:0034453 microtubule anchoring(GO:0034453)
0.1 0.4 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 0.5 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.1 0.7 GO:0043551 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 0.8 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.1 0.2 GO:1904871 positive regulation of protein localization to nucleus(GO:1900182) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.0 0.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.9 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.1 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.6 GO:1990504 dense core granule exocytosis(GO:1990504)
0.0 0.2 GO:0021516 dorsal spinal cord development(GO:0021516) anterior lateral line nerve development(GO:0048909)
0.0 1.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.2 GO:0071387 cellular response to cortisol stimulus(GO:0071387) response to dexamethasone(GO:0071548)
0.0 1.1 GO:0071456 cellular response to hypoxia(GO:0071456)
0.0 1.0 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.5 GO:0002031 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) G-protein coupled receptor internalization(GO:0002031) negative adaptation of signaling pathway(GO:0022401) adaptation of signaling pathway(GO:0023058)
0.0 0.1 GO:0051099 positive regulation of DNA binding(GO:0043388) positive regulation of binding(GO:0051099)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.9 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 0.6 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.3 GO:0003315 heart rudiment formation(GO:0003315)
0.0 1.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.4 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0061056 sclerotome development(GO:0061056)
0.0 0.3 GO:0051928 positive regulation of calcium ion transport(GO:0051928)
0.0 0.5 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.6 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.1 GO:0010269 response to selenium ion(GO:0010269)
0.0 1.7 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.0 GO:0030901 midbrain development(GO:0030901)
0.0 0.5 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.6 GO:0030488 tRNA methylation(GO:0030488)
0.0 1.5 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.4 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 2.1 GO:1990778 protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778)
0.0 0.4 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.5 GO:0048546 digestive tract morphogenesis(GO:0048546)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 1.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.3 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.3 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 0.3 GO:0051289 protein homotetramerization(GO:0051289)
0.0 1.2 GO:0006909 phagocytosis(GO:0006909)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0030062 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.4 3.6 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.3 1.6 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 0.7 GO:0031213 RSF complex(GO:0031213)
0.2 1.6 GO:0035517 PR-DUB complex(GO:0035517)
0.2 1.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 1.4 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.1 0.4 GO:0042382 paraspeckles(GO:0042382)
0.1 1.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 0.8 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.1 1.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.6 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 0.4 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.1 1.8 GO:0005921 gap junction(GO:0005921)
0.1 0.7 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.0 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 0.9 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.5 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.7 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.6 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.8 GO:0005771 multivesicular body(GO:0005771)
0.0 0.3 GO:0070449 elongin complex(GO:0070449)
0.0 0.3 GO:0019908 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 2.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.9 GO:0032040 small-subunit processome(GO:0032040)
0.0 0.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.4 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.9 GO:0008305 integrin complex(GO:0008305)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.4 GO:0001726 ruffle(GO:0001726)
0.0 0.7 GO:0098978 glutamatergic synapse(GO:0098978)
0.0 1.7 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0051059 NF-kappaB binding(GO:0051059)
0.7 2.0 GO:0052717 tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.4 1.6 GO:0008384 IkappaB kinase activity(GO:0008384)
0.4 1.6 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.4 1.6 GO:0070883 pre-miRNA binding(GO:0070883)
0.4 1.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 1.3 GO:0070182 DNA polymerase binding(GO:0070182)
0.3 1.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.3 1.2 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.3 0.8 GO:0030792 arsenite methyltransferase activity(GO:0030791) methylarsonite methyltransferase activity(GO:0030792)
0.2 2.0 GO:0035198 miRNA binding(GO:0035198)
0.2 1.0 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.2 0.7 GO:0004394 heparan sulfate 2-O-sulfotransferase activity(GO:0004394)
0.2 0.9 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.2 1.6 GO:0015232 heme transporter activity(GO:0015232)
0.2 0.5 GO:0003978 UDP-glucose 4-epimerase activity(GO:0003978)
0.2 2.2 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 0.7 GO:0004001 adenosine kinase activity(GO:0004001)
0.1 1.1 GO:0008506 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1 1.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.7 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 1.0 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 1.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.7 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.1 1.1 GO:0005158 insulin receptor binding(GO:0005158)
0.1 1.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.1 1.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.7 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.6 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.1 1.2 GO:0051117 ATPase binding(GO:0051117)
0.1 1.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.5 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 0.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.3 GO:0030504 inorganic diphosphate transmembrane transporter activity(GO:0030504)
0.0 1.0 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.5 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.0 0.2 GO:0005536 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.7 GO:0070411 I-SMAD binding(GO:0070411)
0.0 1.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 1.1 GO:0004629 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.5 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.3 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.6 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.7 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.3 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.0 0.3 GO:0019870 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0 0.3 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.1 GO:0033781 cholesterol 24-hydroxylase activity(GO:0033781)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.5 GO:0098631 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.3 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.3 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 1.6 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 0.8 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 1.6 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 1.6 PID REELIN PATHWAY Reelin signaling pathway
0.1 1.1 PID S1P S1P2 PATHWAY S1P2 pathway
0.1 1.8 PID ATM PATHWAY ATM pathway
0.1 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 0.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.3 PID BMP PATHWAY BMP receptor signaling
0.0 0.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 1.3 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 1.0 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.2 1.6 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 3.6 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 2.2 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 1.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.8 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 1.2 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.9 REACTOME TRAF6 MEDIATED NFKB ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 1.3 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.1 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.2 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.6 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.1 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.3 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing