ISMARA results: sox12

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for sox12

Z-value: 1.17

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Transcription factors associated with sox12

Gene Symbol	Gene ID	Gene Info
sox12 NCBI UniProt	ENSDARG00000025847	SRY-box transcription factor 12

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sox12	dr11_v1_chr11_-_24191928_24191928	-0.83	1.8e-05	Click!

Activity profile of sox12 motif

Sorted Z-values of sox12 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_32660716 Show fit	4.19	ENSDART00000063544 ENSDART00000141013	atg101 NCBI UniProt Show fit	autophagy related 101
chr10_+_3153973 Show fit	2.80	ENSDART00000183223	hic2 NCBI UniProt Show fit	hypermethylated in cancer 2
chr5_-_28149767 Show fit	2.45	ENSDART00000051515	zgc:110329 NCBI UniProt Show fit	zgc:110329
chr20_-_23876291 Show fit	2.43	ENSDART00000043316	katna1 NCBI UniProt Show fit	katanin p60 (ATPase containing) subunit A 1
chr12_-_17863467 Show fit	2.34	ENSDART00000042006	baiap2l1a NCBI UniProt Show fit	BAI1-associated protein 2-like 1a
chr20_+_1385674 Show fit	2.31	ENSDART00000145981	mmachc NCBI UniProt Show fit	methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
chr17_-_23709347 Show fit	2.28	ENSDART00000124661	papss2a NCBI UniProt Show fit	3'-phosphoadenosine 5'-phosphosulfate synthase 2a
chr5_+_3891485 Show fit	2.20	ENSDART00000129329 ENSDART00000091711	rpain NCBI UniProt Show fit	RPA interacting protein
chr10_+_5268054 Show fit	2.19	ENSDART00000114491	ror2 NCBI UniProt Show fit	receptor tyrosine kinase-like orphan receptor 2
chr22_+_21618121 Show fit	2.16	ENSDART00000133939	tle2a NCBI UniProt Show fit	transducin like enhancer of split 2a

Showing 1 to 10 of 168 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sox12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.4	GO:1905037	autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.4	2.4	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3	2.4	GO:0051013	microtubule severing(GO:0051013)
0.8	2.3	GO:0050428	sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.3	2.3	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1	2.3	GO:0006767	water-soluble vitamin metabolic process(GO:0006767)
0.1	2.2	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0	2.2	GO:0044744	protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0	2.2	GO:0090090	negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1	2.1	GO:0008286	insulin receptor signaling pathway(GO:0008286)

Showing 1 to 10 of 59 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.2	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.1	4.1	GO:0016605	PML body(GO:0016605)
0.3	2.4	GO:0071005	U2-type precatalytic spliceosome(GO:0071005)
0.2	2.4	GO:0097431	mitotic spindle pole(GO:0097431)
0.2	2.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	1.9	GO:0031941	filamentous actin(GO:0031941)
0.1	1.8	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3	1.6	GO:0031415	NatA complex(GO:0031415)
0.1	1.6	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	1.6	GO:0000786	nucleosome(GO:0000786)

Showing 1 to 10 of 25 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.3	GO:0005343	organic acid:sodium symporter activity(GO:0005343)
0.0	2.8	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2	2.4	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.1	2.4	GO:0017069	snRNA binding(GO:0017069)
0.8	2.3	GO:0004781	adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.3	2.3	GO:0031419	cobalamin binding(GO:0031419)
0.1	2.3	GO:0042805	actinin binding(GO:0042805)
0.1	2.2	GO:0017147	Wnt-protein binding(GO:0017147)
0.1	2.2	GO:0070491	repressing transcription factor binding(GO:0070491)
0.1	1.8	GO:0016018	cyclosporin A binding(GO:0016018)

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.9	PID ARF6 PATHWAY	Arf6 signaling events
0.1	2.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	2.2	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	1.8	PID REELIN PATHWAY	Reelin signaling pathway
0.1	1.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.5	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	1.2	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	1.1	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	1.0	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.8	PID CDC42 PATHWAY	CDC42 signaling events

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	1.7	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.1	1.5	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	1.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	1.2	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	1.1	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	0.8	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.7	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.1	0.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis

Showing 1 to 10 of 17 entries

Results for sox12

Z-value: 1.17

Motif logo

Transcription factors associated with sox12

Activity-expression correlation:

Activity profile of sox12 motif

Sorted Z-values of sox12 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sox12

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: