ISMARA results: sox11a+sox11b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for sox11a+sox11b

Z-value: 0.80

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Transcription factors associated with sox11a+sox11b

Gene Symbol	Gene ID	Gene Info
sox11a NCBI UniProt	ENSDARG00000077811	SRY-box transcription factor 11a
sox11b NCBI UniProt	ENSDARG00000095743	SRY-box transcription factor 11b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
sox11b	dr11_v1_chr20_-_30035326_30035326	-0.79	1.1e-04	Click!
sox11a	dr11_v1_chr17_-_35881841_35881841	0.71	9.4e-04	Click!

Activity profile of sox11a+sox11b motif

Sorted Z-values of sox11a+sox11b motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_3118346 Show fit	1.51	ENSDART00000167554	hsf5 NCBI UniProt Show fit	heat shock transcription factor family member 5
chrM_+_6425 Show fit	1.44	ENSDART00000093606	mt-co1 NCBI UniProt Show fit	cytochrome c oxidase I, mitochondrial
chr10_+_2587234 Show fit	1.25	ENSDART00000126937	wu:fb59d01 NCBI UniProt Show fit	wu:fb59d01
chr8_+_34434345 Show fit	1.09	ENSDART00000190246 ENSDART00000189447 ENSDART00000185557 ENSDART00000189230	zgc:174461 NCBI UniProt Show fit	zgc:174461
chr5_+_66353750 Show fit	1.06	ENSDART00000143410	si:ch211-261c8.5 NCBI UniProt Show fit	si:ch211-261c8.5
chr23_+_12198242 Show fit	1.03	ENSDART00000144104	sycp2 NCBI UniProt Show fit	synaptonemal complex protein 2
chr12_-_19279103 Show fit	0.92	ENSDART00000186669	si:ch211-141o9.10 NCBI UniProt Show fit	si:ch211-141o9.10
chr20_+_33519435 Show fit	0.92	ENSDART00000061829	drc1 NCBI UniProt Show fit	dynein regulatory complex subunit 1 homolog (Chlamydomonas)
chrM_+_12897 Show fit	0.91	ENSDART00000093622	mt-nd5 NCBI UniProt Show fit	NADH dehydrogenase 5, mitochondrial
chr16_-_23346095 Show fit	0.89	ENSDART00000160546	si:dkey-247k7.2 NCBI UniProt Show fit	si:dkey-247k7.2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of sox11a+sox11b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.3	GO:0015990	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) electron transport coupled proton transport(GO:0015990)
0.1	1.5	GO:0044154	histone H3-K14 acetylation(GO:0044154)
0.0	1.5	GO:0007283	spermatogenesis(GO:0007283)
0.1	1.3	GO:0051445	regulation of meiotic cell cycle(GO:0051445)
0.1	0.9	GO:0003352	regulation of cilium movement(GO:0003352)
0.0	0.9	GO:0006284	base-excision repair(GO:0006284)
0.1	0.8	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0	0.8	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.0	0.8	GO:0042073	intraciliary transport(GO:0042073)
0.2	0.7	GO:0006740	NADPH regeneration(GO:0006740)

Showing 1 to 10 of 58 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	1.3	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	1.3	GO:0043186	P granule(GO:0043186)
0.0	1.0	GO:0000795	synaptonemal complex(GO:0000795)
0.0	0.9	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.9	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0	0.8	GO:0098978	glutamatergic synapse(GO:0098978)
0.1	0.6	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.6	GO:0014704	intercalated disc(GO:0014704)
0.0	0.6	GO:0005868	cytoplasmic dynein complex(GO:0005868)

Showing 1 to 10 of 22 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.5	GO:0010484	H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0	1.3	GO:0015002	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	1.3	GO:0003724	RNA helicase activity(GO:0003724)
0.1	0.9	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.9	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1	0.8	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.8	GO:0051018	protein kinase A binding(GO:0051018)
0.2	0.7	GO:0016652	NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.0	0.7	GO:0032051	clathrin light chain binding(GO:0032051)

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.5	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
1.1	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.6	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.6	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.5	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.3	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP

Showing 1 to 10 of 11 entries

Results for sox11a+sox11b

Z-value: 0.80

Motif logo

Transcription factors associated with sox11a+sox11b

Activity-expression correlation:

Activity profile of sox11a+sox11b motif

Sorted Z-values of sox11a+sox11b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of sox11a+sox11b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: