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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for smarcc1a+smarcc1b

Z-value: 0.42

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Transcription factors associated with smarcc1a+smarcc1b

Gene Symbol Gene ID Gene Info
ENSDARG00000017397 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a
ENSDARG00000098919 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
smarcc1adr11_v1_chr16_-_42461263_424612630.551.7e-02Click!
smarcc1bdr11_v1_chr19_-_19379084_193790840.391.1e-01Click!

Activity profile of smarcc1a+smarcc1b motif

Sorted Z-values of smarcc1a+smarcc1b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_551963 0.55 ENSDART00000110495
A kinase (PRKA) anchor protein 9
chr18_+_3243292 0.45 ENSDART00000166580
p21 protein (Cdc42/Rac)-activated kinase 1
chr16_-_24832038 0.44 ENSDART00000153731
si:dkey-79d12.5
chr16_+_23403602 0.43 ENSDART00000159848
S100 calcium binding protein W
chr22_+_11756040 0.41 ENSDART00000105808
keratin 97
chr21_+_20901505 0.40 ENSDART00000132741
complement component 7b
chr2_-_985417 0.40 ENSDART00000140540
si:ch211-241e1.3
chr20_+_28364742 0.38 ENSDART00000103355
ras homolog family member V
chr1_-_59252973 0.34 ENSDART00000167061
si:ch1073-286c18.5
chr1_+_46598764 0.31 ENSDART00000053240
calcium binding protein 39-like
chr25_+_18583877 0.31 ENSDART00000148741
MET proto-oncogene, receptor tyrosine kinase
chr21_+_20903244 0.30 ENSDART00000186193
complement component 7b
chr5_-_49951106 0.29 ENSDART00000135954
family with sequence similarity 172, member A
chr10_-_32877348 0.27 ENSDART00000018977
ENSDART00000133421
RAB guanine nucleotide exchange factor (GEF) 1
chr16_+_13818500 0.27 ENSDART00000135245
folliculin
chr5_-_42180205 0.25 ENSDART00000145247
family with sequence similarity 222, member Ba
chr22_+_8979955 0.25 ENSDART00000144005
si:ch211-213a13.1
chr23_-_270847 0.24 ENSDART00000191867
ankyrin repeat and sterile alpha motif domain containing 1Aa
chr14_+_24845941 0.24 ENSDART00000187513
Rho guanine nucleotide exchange factor (GEF) 37
chr19_-_5332784 0.24 ENSDART00000010373
keratin, type 1, gene 19d
chr12_-_3077395 0.23 ENSDART00000002867
ENSDART00000126315
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr16_+_13818743 0.23 ENSDART00000090191
folliculin
chr3_-_40232615 0.23 ENSDART00000155969
flightless I actin binding protein
chr2_-_898899 0.22 ENSDART00000058289
dual specificity phosphatase 22b
chr4_+_5317483 0.22 ENSDART00000150366
si:ch211-214j24.10
chr2_+_36015049 0.22 ENSDART00000158276
laminin, gamma 2
chr21_+_25765734 0.22 ENSDART00000021664
claudin b
chr6_-_8244474 0.22 ENSDART00000151358
ral guanine nucleotide dissociation stimulator-like 3a
chr2_-_39759059 0.22 ENSDART00000007333
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36a
chr25_+_7423770 0.21 ENSDART00000155458
ubiquitin associated protein 1-like a
chr8_+_19548985 0.21 ENSDART00000123104
notch 2
chr17_-_35076730 0.21 ENSDART00000146590
membrane bound O-acyltransferase domain containing 2a
chr3_+_35498119 0.21 ENSDART00000178963
trinucleotide repeat containing 6a
chr15_-_2657508 0.20 ENSDART00000102086
claudin a
chr22_+_17399124 0.20 ENSDART00000145769
RAB GTPase activating protein 1-like
chr2_+_25378457 0.20 ENSDART00000089108
fibronectin type III domain containing 3Ba
chr19_+_48359259 0.20 ENSDART00000167353
shugoshin 1
chr5_-_50992690 0.20 ENSDART00000149553
ENSDART00000097460
ENSDART00000192021
3-hydroxy-3-methylglutaryl-CoA reductase a
chr21_+_10866421 0.19 ENSDART00000137858
alpha-kinase 2
chr22_+_11775269 0.19 ENSDART00000140272
keratin 96
chr25_-_22187397 0.19 ENSDART00000123211
ENSDART00000139110
plakophilin 3a
chr22_+_797105 0.19 ENSDART00000128549
cryptochrome circadian clock 1bb
chr7_-_60351537 0.18 ENSDART00000159875
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr17_+_51744450 0.18 ENSDART00000190955
ENSDART00000149807
ornithine decarboxylase 1
chr12_+_23991639 0.18 ENSDART00000003143
proteasome activator subunit 4b
chr5_+_24089334 0.18 ENSDART00000183748
tumor protein p53
chr25_+_20119466 0.18 ENSDART00000104304
2,3-bisphosphoglycerate mutase
chr5_-_67629263 0.18 ENSDART00000133753
zinc finger and BTB domain containing 20
chr9_+_33154841 0.18 ENSDART00000132465
dopey family member 2
chr12_-_17147473 0.18 ENSDART00000106035
STAM binding protein-like 1
chr2_+_48288461 0.18 ENSDART00000141495
hes family bHLH transcription factor 6
chr12_-_27031060 0.18 ENSDART00000076103
charged multivesicular body protein 2A
chr14_+_24840669 0.17 ENSDART00000106039
Rho guanine nucleotide exchange factor (GEF) 37
chr14_+_22397251 0.17 ENSDART00000185239
ENSDART00000124072
ENSDART00000054977
ATPase copper transporting alpha
chr7_+_26649319 0.17 ENSDART00000173823
ENSDART00000101053
tumor protein p53 inducible protein 11a
chr6_-_60079551 0.17 ENSDART00000154753
prostate transmembrane protein, androgen induced 1
chr7_+_66884570 0.17 ENSDART00000082664
SET binding factor 2
chr1_+_46598502 0.17 ENSDART00000132861
calcium binding protein 39-like
chr9_+_41024973 0.17 ENSDART00000014660
ENSDART00000144467
ORMDL sphingolipid biosynthesis regulator 1
chr7_-_26262978 0.17 ENSDART00000137769
adaptor-related protein complex 1, sigma 1 subunit
chr10_+_16225117 0.17 ENSDART00000169885
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr25_+_14697247 0.17 ENSDART00000180747
metallophosphoesterase domain containing 2b
chr24_-_33366188 0.16 ENSDART00000074161
solute carrier family 4 (anion exchanger), member 2b
chr5_-_25582721 0.16 ENSDART00000123986
annexin A1a
chr20_+_38837238 0.16 ENSDART00000061334
intraflagellar transport 172
chr9_+_38481780 0.16 ENSDART00000087241
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr19_+_37120491 0.16 ENSDART00000032341
penta-EF-hand domain containing 1
chr5_+_63767376 0.16 ENSDART00000138898
regulator of G protein signaling 3b
chr18_-_12957451 0.16 ENSDART00000140403
SLIT-ROBO Rho GTPase activating protein 1a
chr4_+_6840223 0.16 ENSDART00000161329
dedicator of cytokinesis 4b
chr18_-_37355666 0.16 ENSDART00000098914
Yes-associated protein 1
chr2_+_3516913 0.16 ENSDART00000109346

chr18_+_34599315 0.16 ENSDART00000159306
ENSDART00000088675
TCDD-inducible poly(ADP-ribose) polymerase
chr10_-_2971407 0.16 ENSDART00000132526
MARVEL domain containing 2a
chr7_-_9674073 0.15 ENSDART00000187902
leucine-rich repeat kinase 1
chr3_+_50201240 0.15 ENSDART00000156347
epsin 3a
chr9_+_28140089 0.15 ENSDART00000046880
pleckstrin homology domain containing, family M, member 3
chr8_+_8671229 0.15 ENSDART00000131963
ubiquitin specific peptidase 11
chr5_+_65086856 0.15 ENSDART00000169209
ENSDART00000162409
peptidyl-tRNA hydrolase 1 homolog
chr19_+_26072624 0.15 ENSDART00000147627
jumonji, AT rich interactive domain 2b
chr18_+_15841449 0.15 ENSDART00000141800
ENSDART00000091349
early endosome antigen 1
chr7_-_20241346 0.15 ENSDART00000173619
ENSDART00000127699
si:ch73-335l21.4
chr7_+_34506937 0.15 ENSDART00000111303
regulatory factor X7a
chr19_-_7043355 0.14 ENSDART00000104845
TAP binding protein (tapasin), tandem duplicate 1
chr4_+_25181572 0.14 ENSDART00000078529
ENSDART00000136643
Kin17 DNA and RNA binding protein
chr14_+_23184517 0.14 ENSDART00000181410
ecto-NOX disulfide-thiol exchanger 2
chr8_+_53311965 0.14 ENSDART00000130104
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr18_+_3169579 0.14 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
p21 protein (Cdc42/Rac)-activated kinase 1
chr10_+_32050906 0.14 ENSDART00000137373
si:ch211-266i6.3
chr16_+_11242443 0.14 ENSDART00000024935
glycogen synthase kinase 3 alpha b
chr7_-_44963154 0.14 ENSDART00000073735
Ras-related associated with diabetes
chr2_-_27619954 0.14 ENSDART00000144826
trimethylguanosine synthase 1
chr7_-_60351876 0.14 ENSDART00000098563
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr15_+_15479442 0.14 ENSDART00000067095
NIMA-related kinase 8
chr11_-_45420212 0.14 ENSDART00000182042
ENSDART00000163185
ankyrin repeat domain 13C
chr8_-_11170114 0.14 ENSDART00000133532
si:ch211-204d2.4
chr25_-_22191733 0.13 ENSDART00000067478
plakophilin 3a
chr5_-_23464970 0.13 ENSDART00000141028
si:dkeyp-20g2.1
chr14_+_15768942 0.13 ENSDART00000158998
endoplasmic reticulum-golgi intermediate compartment 1
chr21_+_38745094 0.13 ENSDART00000113316
HEAT repeat containing 6
chr6_+_44197099 0.13 ENSDART00000124168
protein phosphatase 4, regulatory subunit 2b
chr2_-_26642831 0.13 ENSDART00000132854
ENSDART00000087714
ENSDART00000132651
U2 snRNP-associated SURP domain containing
chr15_-_1844048 0.13 ENSDART00000102410
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr10_-_74408 0.13 ENSDART00000100073
ENSDART00000141723
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a
chr16_+_42829735 0.13 ENSDART00000014956
polymerase (RNA) III (DNA directed) polypeptide G like b
chr7_-_5487593 0.13 ENSDART00000136594
Rho guanine nucleotide exchange factor (GEF) 11
chr22_+_23359369 0.13 ENSDART00000170886
DENN/MADD domain containing 1B
chr17_+_58211 0.13 ENSDART00000157642
si:ch1073-209e23.1
chr15_+_44201056 0.13 ENSDART00000162433
ENSDART00000148336

chr6_+_44197348 0.13 ENSDART00000075486
protein phosphatase 4, regulatory subunit 2b
chr7_+_35068036 0.13 ENSDART00000022139
zgc:136461
chr20_+_23501535 0.12 ENSDART00000177922
ENSDART00000058532
palladin, cytoskeletal associated protein
chr12_-_7639120 0.12 ENSDART00000126712
ENSDART00000126219
coiled-coil domain containing 6b
chr13_-_37474989 0.12 ENSDART00000114136
WD repeat domain 89
chr21_+_45717930 0.12 ENSDART00000164315
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr5_-_23485161 0.12 ENSDART00000170293
ENSDART00000134069
si:dkeyp-20g2.1
si:dkeyp-20g2.3
chr21_+_37513488 0.12 ENSDART00000185394
angiomotin
chr4_-_1757460 0.12 ENSDART00000144074
transmembrane 7 superfamily member 3
chr16_+_32136550 0.12 ENSDART00000147526
sphingosine kinase 2
chr15_-_19772372 0.12 ENSDART00000152729
phosphatidylinositol binding clathrin assembly protein b
chr16_+_54210554 0.12 ENSDART00000172622
X-ray repair complementing defective repair in Chinese hamster cells 1
chr16_-_2390931 0.12 ENSDART00000149463
HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
chr6_+_59642695 0.12 ENSDART00000166373
ENSDART00000161030
R3H domain containing 2
chr15_-_31177324 0.12 ENSDART00000008854
WD repeat and SOCS box containing 1
chr15_+_24704798 0.12 ENSDART00000192470
si:dkey-151p21.7
chr20_+_34770197 0.12 ENSDART00000018304
minichromosome maintenance complex component 3
chr17_+_15674052 0.12 ENSDART00000156726
BTB and CNC homology 1, basic leucine zipper transcription factor 2a
chr20_-_14462995 0.12 ENSDART00000152418
ENSDART00000044125
gene rich cluster, C10 gene
chr21_+_6328801 0.12 ENSDART00000163577
formin binding protein 1b
chr19_+_15440841 0.12 ENSDART00000182329
lin-28 homolog A (C. elegans)
chr11_-_29936755 0.12 ENSDART00000145251
pirin
chr25_-_3808635 0.11 ENSDART00000075659
ENSDART00000154691
glutamine amidotransferase like class 1 domain containing 1
chr6_+_11397269 0.11 ENSDART00000114260
SUMO1/sentrin/SMT3 specific peptidase 2
chr15_-_19771981 0.11 ENSDART00000175502
ENSDART00000159475
phosphatidylinositol binding clathrin assembly protein b
chr19_+_23932259 0.11 ENSDART00000139040
si:dkey-222b8.1
chr12_+_32292564 0.11 ENSDART00000152945
si:ch211-277e21.2
chr10_+_22771176 0.11 ENSDART00000192046
transmembrane protein 88 a
chr21_+_13327527 0.11 ENSDART00000114294
small nuclear ribonucleoprotein D3 polypeptide, like
chr23_-_14937101 0.11 ENSDART00000010258
ndrg family member 3b
chr1_+_51039558 0.11 ENSDART00000024743
dpy-30 histone methyltransferase complex regulatory subunit
chr1_-_34750169 0.11 ENSDART00000149380
si:dkey-151m22.8
chr8_-_16559181 0.11 ENSDART00000098692
ENSDART00000124257
epidermal growth factor receptor pathway substrate 15
chr7_-_7764287 0.11 ENSDART00000173021
ENSDART00000113131
inturned planar cell polarity protein
chr22_-_6562618 0.11 ENSDART00000106100
zgc:171490
chr13_-_26799244 0.11 ENSDART00000036419
vaccinia related kinase 2
chr15_-_38129845 0.11 ENSDART00000057095
si:dkey-24p1.1
chr10_+_5744941 0.11 ENSDART00000159769
ENSDART00000184734
peptidylglycine alpha-amidating monooxygenase
chr13_+_7575563 0.11 ENSDART00000146592
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr23_+_9268083 0.11 ENSDART00000055054
acyl-CoA synthetase short chain family member 2
chr19_+_1510971 0.11 ENSDART00000157721
solute carrier family 45 member 4
chr23_-_7799184 0.11 ENSDART00000190946
ENSDART00000165427
myelin transcription factor 1b
chr10_+_5234327 0.10 ENSDART00000133927
ENSDART00000063120
serine palmitoyltransferase, long chain base subunit 1
chr5_-_21888368 0.10 ENSDART00000020725
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr23_-_35694461 0.10 ENSDART00000185884
tubulin, alpha 1c
chr9_+_33261330 0.10 ENSDART00000135384
ubiquitin specific peptidase 9
chr2_+_31437547 0.10 ENSDART00000141170
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
chr2_+_15069011 0.10 ENSDART00000145893
calponin 3, acidic b
chr24_-_21973365 0.10 ENSDART00000081204
ENSDART00000030592
acyl-CoA thioesterase 9, tandem duplicate 1
chr21_-_9914745 0.10 ENSDART00000172124
Rho GTPase activating protein 24
chr2_+_37838259 0.10 ENSDART00000136796
poly (ADP-ribose) polymerase 2
chr2_-_32366287 0.10 ENSDART00000144758
upstream binding transcription factor, like
chr12_-_27212880 0.10 ENSDART00000002835
proteasome activator subunit 3
chr14_-_34605804 0.10 ENSDART00000144547
actin filament associated protein 1-like 1a
chr15_+_40188076 0.10 ENSDART00000063779
EF-hand domain family, member D1
chr16_-_13818061 0.10 ENSDART00000132982
ENSDART00000144856
leukocyte receptor cluster (LRC) member 9
chr22_+_465269 0.10 ENSDART00000145767
cadherin, EGF LAG seven-pass G-type receptor 2
chr7_+_34549198 0.10 ENSDART00000173784
formin homology 2 domain containing 1
chr22_-_881725 0.10 ENSDART00000035514
choline/ethanolamine phosphotransferase 1b
chr5_+_6670945 0.10 ENSDART00000185686
paxillin a
chr3_+_15358459 0.10 ENSDART00000141808
SH2B adaptor protein 1
chr5_+_61556172 0.10 ENSDART00000131937
ORAI calcium release-activated calcium modulator 2
chr22_+_16320076 0.10 ENSDART00000164161
oxysterol binding protein-like 1A
chr20_+_29209767 0.10 ENSDART00000141252
katanin p80 subunit B-like 1
chr9_+_426392 0.10 ENSDART00000172515
basic leucine zipper and W2 domains 1b
chr22_-_26595027 0.10 ENSDART00000184162

chr11_-_24681292 0.09 ENSDART00000089601
olfactomedin-like 3b
chr13_-_293250 0.09 ENSDART00000138581
chitin synthase 1
chr1_-_40227166 0.09 ENSDART00000146680
si:ch211-113e8.3
chr14_-_34605607 0.09 ENSDART00000191608
actin filament associated protein 1-like 1a
chr11_-_10770053 0.09 ENSDART00000179213
solute carrier family 4, sodium bicarbonate transporter, member 10a
chr5_+_4533244 0.09 ENSDART00000158826
Danio rerio thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 (LOC561325), mRNA.
chr6_+_56147812 0.09 ENSDART00000150219
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr16_-_51288178 0.09 ENSDART00000079864
zgc:173729
chr2_+_10709557 0.09 ENSDART00000183118
ENSDART00000109723
ecotropic viral integration site 5a
chr3_-_5644028 0.09 ENSDART00000019957
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Ab
chr7_+_26762717 0.09 ENSDART00000186464
tetraspanin 18a
chr16_-_21915223 0.09 ENSDART00000170634
SET domain, bifurcated 1b
chr2_-_42864472 0.09 ENSDART00000134139
adenylate cyclase 8 (brain)
chr9_+_7030016 0.09 ENSDART00000148047
ENSDART00000148181
inositol polyphosphate-4-phosphatase type I Aa
chr10_-_7988396 0.09 ENSDART00000141445
ENSDART00000024282
EWS RNA-binding protein 1a
chr21_-_30254185 0.09 ENSDART00000101054
DnaJ (Hsp40) homolog, subfamily C, member 18
chr20_+_29209926 0.09 ENSDART00000152949
ENSDART00000153016
katanin p80 subunit B-like 1
chr11_+_25693395 0.09 ENSDART00000110224
MON1 secretory trafficking family member Bb
chr16_-_13613475 0.09 ENSDART00000139102
D site albumin promoter binding protein b
chr2_-_49557932 0.09 ENSDART00000141902
si:ch211-209f23.3
chr13_+_7241170 0.09 ENSDART00000109434
apoptosis-inducing factor, mitochondrion-associated, 2
chr8_+_21229718 0.09 ENSDART00000100222
cryptochrome circadian clock 1ba
chr14_-_38889840 0.09 ENSDART00000035779
zgc:101583
chr24_-_24060460 0.09 ENSDART00000142813
ATP-binding cassette, sub-family C (CFTR/MRP), member 13
chr13_-_33134611 0.09 ENSDART00000026280
pleckstrin 2

Network of associatons between targets according to the STRING database.

First level regulatory network of smarcc1a+smarcc1b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0071896 protein localization to adherens junction(GO:0071896)
0.1 0.6 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 0.2 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 0.2 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.1 0.5 GO:1903846 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 0.2 GO:0010526 regulation of transposition, RNA-mediated(GO:0010525) negative regulation of transposition, RNA-mediated(GO:0010526) transposition, RNA-mediated(GO:0032197) positive regulation of neuron apoptotic process(GO:0043525) positive regulation of neuron death(GO:1901216)
0.1 0.2 GO:0071962 mitotic sister chromatid cohesion, centromeric(GO:0071962)
0.0 0.1 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.2 GO:0003322 pancreatic A cell development(GO:0003322)
0.0 0.3 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:1900060 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.1 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.1 GO:2000378 negative regulation of reactive oxygen species metabolic process(GO:2000378)
0.0 0.1 GO:0055026 negative regulation of striated muscle cell differentiation(GO:0051154) negative regulation of cardiac muscle tissue development(GO:0055026) cardiac muscle cell fate commitment(GO:0060923) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901296) negative regulation of cardiocyte differentiation(GO:1905208) negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.0 0.1 GO:0072003 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.2 GO:0003173 ventriculo bulbo valve development(GO:0003173)
0.0 0.2 GO:0035092 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.1 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.1 GO:0007624 ultradian rhythm(GO:0007624)
0.0 0.1 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.0 0.3 GO:0021707 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.2 GO:0045628 neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.0 0.1 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.7 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.3 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.0 0.1 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.2 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.3 GO:0090279 regulation of calcium ion import(GO:0090279)
0.0 0.1 GO:0006031 chitin biosynthetic process(GO:0006031) glucosamine-containing compound biosynthetic process(GO:1901073)
0.0 0.2 GO:0014036 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 0.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.1 GO:0048939 anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.1 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:1900028 wound healing, spreading of epidermal cells(GO:0035313) negative regulation of ruffle assembly(GO:1900028)
0.0 0.1 GO:0030219 megakaryocyte differentiation(GO:0030219)
0.0 0.1 GO:0071830 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.0 0.2 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.0 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.0 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.0 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.0 GO:0015824 proline transport(GO:0015824)
0.0 0.5 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.2 GO:0021754 facial nucleus development(GO:0021754)
0.0 0.1 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.1 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.2 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.1 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.2 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.1 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.1 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.0 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.0 0.1 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.1 GO:0048385 regulation of retinoic acid receptor signaling pathway(GO:0048385)
0.0 0.2 GO:0031468 nuclear envelope reassembly(GO:0031468)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.7 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.2 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0098894 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.1 GO:0030428 cell septum(GO:0030428)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.0 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 0.1 GO:0035098 ESC/E(Z) complex(GO:0035098)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.1 0.3 GO:0035197 siRNA binding(GO:0035197)
0.1 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.3 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0017050 D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.2 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.0 0.1 GO:0009384 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761) N-acylmannosamine kinase activity(GO:0009384)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:1990756 protein binding, bridging involved in substrate recognition for ubiquitination(GO:1990756)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.3 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.2 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.1 GO:0050218 propionate-CoA ligase activity(GO:0050218)
0.0 0.1 GO:0004903 growth hormone receptor activity(GO:0004903)
0.0 0.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 0.1 GO:0003913 DNA photolyase activity(GO:0003913)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.0 0.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.0 GO:0005183 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.0 0.2 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.0 0.1 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.1 GO:0019215 intermediate filament binding(GO:0019215)
0.0 0.1 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.1 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.0 0.0 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.1 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.1 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.0 0.0 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.3 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.0 0.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.1 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.2 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID RAS PATHWAY Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 0.6 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.5 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.1 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.4 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.2 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.1 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.1 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0 0.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport