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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for smad2_smad10a+smad4a_smad1

Z-value: 0.75

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Transcription factors associated with smad2_smad10a+smad4a_smad1

Gene Symbol Gene ID Gene Info
ENSDARG00000006389 SMAD family member 2
ENSDARG00000045094 si_dkey-222b8.1
ENSDARG00000070428 si_dkey-222b8.1
ENSDARG00000075226 SMAD family member 4a
ENSDARG00000027199 SMAD family member 1
ENSDARG00000112617 SMAD family member 1
ENSDARG00000115674 SMAD family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
smad4adr11_v1_chr10_+_573667_5736670.617.5e-03Click!
si:dkey-239n17.4dr11_v1_chr16_-_28876479_28876479-0.419.1e-02Click!
smad2dr11_v1_chr10_-_14929392_149293920.233.6e-01Click!
si:dkey-222b8.1dr11_v1_chr19_+_23932259_239322590.194.4e-01Click!
smad1dr11_v1_chr1_-_35916247_35916247-0.068.1e-01Click!

Activity profile of smad2_smad10a+smad4a_smad1 motif

Sorted Z-values of smad2_smad10a+smad4a_smad1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_3960161 2.94 ENSDART00000111453
myosin XIX
chr6_-_31827597 2.67 ENSDART00000159400
receptor tyrosine kinase-like orphan receptor 1
chr10_-_10018794 2.47 ENSDART00000130734
spermatid perinuclear RNA binding protein
chr10_+_20364009 2.05 ENSDART00000186139
ENSDART00000080395
golgin A7
chr7_+_9290929 1.98 ENSDART00000128530
small nuclear ribonucleoprotein polypeptide A'
chr24_-_26632171 1.98 ENSDART00000008374
ENSDART00000017384
TRAF2 and NCK interacting kinase b
chr2_+_54755172 1.61 ENSDART00000097864
ankyrin repeat domain 12
chr16_+_40340222 1.57 ENSDART00000190631
methyltransferase like 6
chr10_+_37181780 1.53 ENSDART00000187625
kinase suppressor of ras 1a
chr13_+_31648271 1.44 ENSDART00000006648
MNAT CDK-activating kinase assembly factor 1
chr23_+_41831224 1.35 ENSDART00000171885
sterol carrier protein 2b
chr13_-_479129 1.23 ENSDART00000159803
ENSDART00000082127
HEAT repeat containing 5B
chr10_+_37182626 1.23 ENSDART00000137636
kinase suppressor of ras 1a
chr14_-_237130 1.22 ENSDART00000164988
biorientation of chromosomes in cell division 1-like 1
chr18_-_25051846 1.22 ENSDART00000013082
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr22_+_24559947 1.09 ENSDART00000169847
WD repeat domain 47b
chr23_+_36460239 1.06 ENSDART00000172441
LIM domain and actin binding 1a
chr5_+_3892551 1.05 ENSDART00000134396
RPA interacting protein
chr12_+_8822717 1.03 ENSDART00000021628
receptor accessory protein 3b
chr10_+_5744941 0.96 ENSDART00000159769
ENSDART00000184734
peptidylglycine alpha-amidating monooxygenase
chr19_+_41551335 0.94 ENSDART00000169193
si:ch211-57n23.4
chr4_-_21466825 0.89 ENSDART00000066897
PRKC, apoptosis, WT1, regulator
chr19_-_5380770 0.87 ENSDART00000000221
keratin 91
chr20_-_2355357 0.77 ENSDART00000085281
si:ch73-18b11.1
chr22_-_506522 0.74 ENSDART00000106645
ENSDART00000067637
dual serine/threonine and tyrosine protein kinase
chr23_-_32334208 0.73 ENSDART00000053472
ring finger protein 41
chr1_+_57347888 0.71 ENSDART00000104222
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1
chr17_+_45765164 0.71 ENSDART00000145882
asparaginase homolog (S. cerevisiae)
chr18_+_27337994 0.70 ENSDART00000136172
si:dkey-29p10.4
chr7_+_26998169 0.69 ENSDART00000128110
ENSDART00000101018
cell cycle associated protein 1a
chr13_+_15656042 0.67 ENSDART00000134240
MAP/microtubule affinity-regulating kinase 3a
chr8_-_30742233 0.66 ENSDART00000098986
guanylyl cyclase domain containing 1
chr9_+_44304980 0.65 ENSDART00000147990
sperm specific antigen 2
chr20_-_4049862 0.64 ENSDART00000158057
SprT-like N-terminal domain
chr25_+_418932 0.64 ENSDART00000059193
protogenin homolog b (Gallus gallus)
chr15_+_11427620 0.62 ENSDART00000168688
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr10_+_44581378 0.62 ENSDART00000190331
seizure related 6 homolog (mouse)-like
chr10_-_10018120 0.61 ENSDART00000132375
spermatid perinuclear RNA binding protein
chr8_+_30742898 0.61 ENSDART00000018475
small nuclear ribonucleoprotein D3 polypeptide
chr7_-_48173440 0.60 ENSDART00000124075
metastasis suppressor 1-like b
chr19_-_42503143 0.56 ENSDART00000007642
zgc:110239
chr19_-_3574060 0.56 ENSDART00000105120
transmembrane protein 170B
chr13_-_1427240 0.56 ENSDART00000145867
zinc finger protein 451
chr15_-_30984804 0.55 ENSDART00000157005
neurofibromin 1a
chr2_-_37098785 0.55 ENSDART00000003670
zgc:101744
chr17_-_21280185 0.52 ENSDART00000123198
heat shock protein 12A
chr3_-_21137362 0.47 ENSDART00000104051
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase)
chr14_+_4276394 0.45 ENSDART00000038301
glucosamine-6-phosphate deaminase 2
chr1_+_23372470 0.44 ENSDART00000187503
ENSDART00000087658
NEDD4 binding protein 2
chr20_+_23625387 0.41 ENSDART00000147945
ENSDART00000150497
palladin, cytoskeletal associated protein
chr2_-_57707039 0.41 ENSDART00000097685

chr1_-_23294753 0.40 ENSDART00000013263
UDP-glucose 6-dehydrogenase
chr12_+_33403694 0.40 ENSDART00000124083
fatty acid synthase
chr2_-_55317035 0.38 ENSDART00000169382
ENSDART00000097874
tropomyosin 4b
chr21_+_33249478 0.36 ENSDART00000169972
si:ch211-151g22.1
chr23_-_46040618 0.36 ENSDART00000161415

chr25_+_32496723 0.36 ENSDART00000087978
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr4_-_797831 0.36 ENSDART00000158970
ENSDART00000170012
microtubule-associated protein, RP/EB family, member 3b
chr15_-_47468085 0.36 ENSDART00000164438
inositol polyphosphate phosphatase-like 1a
chr11_-_44647286 0.35 ENSDART00000169329
ENSDART00000158939
translocase of outer mitochondrial membrane 20b
chr20_+_35085224 0.35 ENSDART00000040456
CDC42 binding protein kinase alpha (DMPK-like) b
chr25_-_12805295 0.34 ENSDART00000157629
carbonic anhydrase Va
chr18_+_50961953 0.34 ENSDART00000158768
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
chr9_+_12907574 0.34 ENSDART00000102348
si:dkey-230p4.1
chr22_+_21549419 0.33 ENSDART00000139411
phospholipid phosphatase 2b
chr24_-_37272116 0.33 ENSDART00000022999
ubiquitin-conjugating enzyme E2Ib
chr18_+_3169579 0.33 ENSDART00000164724
ENSDART00000186340
ENSDART00000181247
ENSDART00000168056
p21 protein (Cdc42/Rac)-activated kinase 1
chr14_-_6987649 0.33 ENSDART00000060990
eukaryotic translation initiation factor 4E binding protein 3, like
chr25_+_32496877 0.32 ENSDART00000132698
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2a
chr8_-_14126646 0.32 ENSDART00000027225
biglycan a
chr19_-_18152942 0.31 ENSDART00000190182
nuclear factor, erythroid 2-like 3
chr17_+_43863708 0.30 ENSDART00000133874
ENSDART00000140316
ENSDART00000142929
ENSDART00000148090
zgc:66313
chr17_+_21902058 0.30 ENSDART00000142178
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1a
chr12_+_48681601 0.30 ENSDART00000187831
uroporphyrinogen III synthase
chr25_-_27665978 0.28 ENSDART00000123590
si:ch211-91p5.3
chr14_+_44805649 0.28 ENSDART00000180361
solute carrier family 30 (zinc transporter), member 9
chr8_+_19621511 0.28 ENSDART00000017128
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3a
chr11_-_44999858 0.28 ENSDART00000167759
ENSDART00000126845
LIM-domain binding 1b
chr23_-_41762956 0.27 ENSDART00000128302
serine/threonine kinase 35
chr17_+_19626479 0.27 ENSDART00000044993
ENSDART00000131863
regulator of G protein signaling 7a
chr8_-_15520907 0.27 ENSDART00000133114
BEN domain containing 5
chr2_+_47944967 0.27 ENSDART00000135584
finTRIM family, member 19
chr1_-_43905252 0.26 ENSDART00000135477
ENSDART00000132089
si:dkey-22i16.3
chr13_-_15929402 0.26 ENSDART00000090273
tubulin tyrosine ligase
chr15_-_28904371 0.26 ENSDART00000155154
echinoderm microtubule associated protein like 2
chr19_-_11425542 0.26 ENSDART00000177875
ENSDART00000080762
septin 7a
chr2_-_49627099 0.26 ENSDART00000083710
ENSDART00000147421
cactin
chr5_-_70625697 0.26 ENSDART00000179538
ENSDART00000190540

chr3_-_1317290 0.25 ENSDART00000047094

chr21_+_15883546 0.25 ENSDART00000186325
family with sequence similarity 169, member Ab
chr8_+_13064750 0.25 ENSDART00000039878
SAP30 binding protein
chr14_+_34558480 0.24 ENSDART00000075170
pituitary tumor-transforming 1
chr17_+_10748366 0.24 ENSDART00000018683
ENSDART00000097274
zgc:113944
chr23_-_24226533 0.24 ENSDART00000109134
pleckstrin homology domain containing, family M (with RUN domain) member 2
chr23_-_29812667 0.23 ENSDART00000006120
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr10_-_35186310 0.23 ENSDART00000127805
POM121 transmembrane nucleoporin
chr13_+_22719789 0.23 ENSDART00000057672
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr19_-_81851 0.23 ENSDART00000172319
heterogeneous nuclear ribonucleoprotein R
chr3_-_37785873 0.23 ENSDART00000011691
BCL2 associated X, apoptosis regulator a
chr2_+_26240339 0.22 ENSDART00000191006
paralemmin 1b
chr20_-_31427390 0.22 ENSDART00000007735
uronyl-2-sulfotransferase
chr23_-_32156278 0.22 ENSDART00000157479
nuclear receptor subfamily 4, group A, member 1
chr16_-_30655980 0.22 ENSDART00000146508
low density lipoprotein receptor class A domain containing 4b
chr3_-_15352303 0.21 ENSDART00000104338
ENSDART00000145919
ENSDART00000132135
phosphatidylinositol transfer protein, beta, like
chr5_+_8964926 0.21 ENSDART00000091397
ENSDART00000164535
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase b
chr21_-_9466201 0.21 ENSDART00000167211
protein tyrosine phosphatase, non-receptor type 13
chr12_+_48511605 0.21 ENSDART00000168389
Rho GTPase activating protein 44
chr5_-_42180205 0.21 ENSDART00000145247
family with sequence similarity 222, member Ba
chr7_+_33424044 0.21 ENSDART00000180260
glucuronic acid epimerase b
chr12_-_5505205 0.20 ENSDART00000092319
ABI family, member 3b
chr5_-_23517747 0.20 ENSDART00000137655
stromal antigen 2a
chr5_-_58780160 0.20 ENSDART00000166955
Rho guanine nucleotide exchange factor (GEF) 12b
chr20_+_46572550 0.20 ENSDART00000139051
ENSDART00000161320
basic leucine zipper transcription factor, ATF-like
chr7_-_26601307 0.20 ENSDART00000188934
phospholipid scramblase 3b
chr14_+_45608576 0.20 ENSDART00000173248
si:ch211-276i12.11
chr10_+_1052591 0.20 ENSDART00000123405
unc-5 netrin receptor C
chr7_+_16352924 0.20 ENSDART00000158972
metallophosphoesterase domain containing 2a
chr6_-_7107868 0.20 ENSDART00000171123
nonhomologous end-joining factor 1
chr25_+_3231812 0.20 ENSDART00000163647
methionyl aminopeptidase 2b
chr9_-_32912638 0.20 ENSDART00000110582
family with sequence similarity 160, member A2
chr3_-_56569968 0.20 ENSDART00000165317
Danio rerio uncharacterized LOC797202 (LOC797202), mRNA.
chr21_-_34032650 0.20 ENSDART00000138575
ENSDART00000047515
ring finger protein 145b
chr22_-_16270462 0.20 ENSDART00000105681
cell division cycle 14Ab
chr23_+_9522942 0.19 ENSDART00000137751
oxysterol binding protein-like 2b
chr15_-_30867594 0.19 ENSDART00000154448
neurofibromin 1a
chr19_-_5058908 0.19 ENSDART00000130062
chromodomain helicase DNA binding protein 4a
chr17_+_1514711 0.19 ENSDART00000165641
v-akt murine thymoma viral oncogene homolog 1
chr16_+_54641230 0.19 ENSDART00000157641
ENSDART00000159540
F-box protein 43
chr19_+_41551543 0.19 ENSDART00000112364
si:ch211-57n23.4
chr6_+_44197348 0.19 ENSDART00000075486
protein phosphatase 4, regulatory subunit 2b
chr19_-_15192638 0.19 ENSDART00000048151
phosphatase and actin regulator 4a
chr8_-_30424182 0.19 ENSDART00000099021
dedicator of cytokinesis 8
chr12_-_628024 0.19 ENSDART00000158563
ENSDART00000152612
wu:fj29h11
si:ch73-301j1.1
chr6_+_44197099 0.19 ENSDART00000124168
protein phosphatase 4, regulatory subunit 2b
chr15_+_45595385 0.19 ENSDART00000161937
ENSDART00000170214
ENSDART00000157450
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr22_-_20419660 0.19 ENSDART00000105520
protein inhibitor of activated STAT, 4a
chr23_-_21535040 0.19 ENSDART00000010647
regulator of chromosome condensation 2
chr15_+_17345609 0.18 ENSDART00000111753
vacuole membrane protein 1
chr11_+_21586335 0.18 ENSDART00000091182
zgc:101564
chr20_-_2290529 0.18 ENSDART00000134695
si:ch73-18b11.1
chr23_+_30898013 0.18 ENSDART00000146859
Cdk5 and Abl enzyme substrate 2a
chr23_+_9522781 0.18 ENSDART00000136486
oxysterol binding protein-like 2b
chr1_-_50611031 0.18 ENSDART00000148285
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr12_+_19281189 0.18 ENSDART00000153428
trinucleotide repeat containing 6b
chr2_+_8649293 0.18 ENSDART00000081442
ENSDART00000186024
far upstream element (FUSE) binding protein 1
chr14_+_16036139 0.18 ENSDART00000190733
PRELI domain containing 1a
chr10_+_44956660 0.18 ENSDART00000169225
ENSDART00000189298
interleukin 1, beta
chr17_-_15546862 0.17 ENSDART00000091021
collagen, type X, alpha 1a
chr19_-_5058515 0.17 ENSDART00000150980
chromodomain helicase DNA binding protein 4a
chr12_+_22628704 0.17 ENSDART00000168935
major facilitator superfamily domain containing 8
chr4_-_5018705 0.17 ENSDART00000154025
striatin interacting protein 2
chr14_+_22397251 0.17 ENSDART00000185239
ENSDART00000124072
ENSDART00000054977
ATPase copper transporting alpha
chr23_+_12840080 0.17 ENSDART00000081016
ENSDART00000121697
structural maintenance of chromosomes 1A, like
chr24_+_31334209 0.17 ENSDART00000168837
ENSDART00000172473
family with sequence similarity 168, member B
chr7_-_60351876 0.17 ENSDART00000098563
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr24_-_16979728 0.17 ENSDART00000005331
kelch-like family member 15
chr20_-_1265562 0.17 ENSDART00000189866
large tumor suppressor kinase 1
chr3_-_40051425 0.17 ENSDART00000146700
lethal giant larvae homolog 1 (Drosophila)
chr14_+_50937757 0.17 ENSDART00000163865
ring finger protein 44
chr22_-_6420239 0.17 ENSDART00000148385
zgc:171699
chr8_+_10823069 0.17 ENSDART00000081341
mitogen-activated protein kinase 13
chr9_+_21793565 0.17 ENSDART00000134915
REV1, polymerase (DNA directed)
chr12_+_16953415 0.17 ENSDART00000020824
pantothenate kinase 1b
chr7_-_60351537 0.17 ENSDART00000159875
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr8_+_53311965 0.17 ENSDART00000130104
guanine nucleotide binding protein (G protein), beta polypeptide 1a
chr21_-_41369370 0.17 ENSDART00000159290
cytoplasmic polyadenylation element binding protein 4b
chr23_-_41762797 0.17 ENSDART00000186564
serine/threonine kinase 35
chr9_-_29579908 0.17 ENSDART00000140876
centromere protein J
chr20_-_34670236 0.16 ENSDART00000033325
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr15_-_30984557 0.16 ENSDART00000080328
neurofibromin 1a
chr25_-_21782435 0.16 ENSDART00000089616
base methyltransferase of 25S rRNA 2 homolog
chr13_-_21650404 0.16 ENSDART00000078352
tetraspanin 14
chr7_-_5375214 0.16 ENSDART00000033316
VANGL planar cell polarity protein 2
chr21_+_43199237 0.16 ENSDART00000151748
AF4/FMR2 family, member 4
chr24_-_26995164 0.16 ENSDART00000142864
stromal antigen 1b
chr20_+_21268795 0.16 ENSDART00000090016
nudix (nucleoside diphosphate linked moiety X)-type motif 14
chr16_+_13822137 0.16 ENSDART00000163251
folliculin
chr19_-_15192840 0.16 ENSDART00000151337
phosphatase and actin regulator 4a
chr4_+_20051478 0.16 ENSDART00000143642
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr5_+_40835601 0.16 ENSDART00000147767
si:dkey-3h3.3
chr11_-_23687158 0.16 ENSDART00000189599
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr17_+_20569806 0.16 ENSDART00000113936
zgc:162183
chr7_-_26270014 0.16 ENSDART00000079347
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr7_-_19638319 0.16 ENSDART00000163686
si:ch211-212k18.4
chr9_-_7213772 0.16 ENSDART00000174720
ENSDART00000092435
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
chr5_-_9678075 0.16 ENSDART00000097217
si:ch211-193c2.2
chr12_-_3978306 0.16 ENSDART00000149473
ENSDART00000114857
protein phosphatase 4, catalytic subunit b
chr21_-_41369539 0.16 ENSDART00000187546
cytoplasmic polyadenylation element binding protein 4b
chr2_+_44518636 0.16 ENSDART00000153733
PAS domain containing serine/threonine kinase
chr25_+_22281441 0.16 ENSDART00000089516
stomatin (EPB72)-like 1
chr25_-_32363341 0.16 ENSDART00000153892
ENSDART00000114385
centrosomal protein 152
chr7_+_24951552 0.16 ENSDART00000173644
MAP/microtubule affinity-regulating kinase 2b
chr23_-_27822920 0.15 ENSDART00000023094
activin A receptor type 1Ba
chr12_+_33894665 0.15 ENSDART00000004769
major facilitator superfamily domain containing 13A
chr17_+_10578823 0.15 ENSDART00000134610
MGA, MAX dimerization protein a
chr3_-_29968015 0.15 ENSDART00000077119
ENSDART00000139310
branched chain amino-acid transaminase 2, mitochondrial
chr17_+_23311377 0.15 ENSDART00000128073
protein phosphatase 1, regulatory subunit 3Ca
chr5_-_21422390 0.15 ENSDART00000144198
teneurin transmembrane protein 1
chr7_+_17096281 0.15 ENSDART00000035558
HIV-1 Tat interactive protein 2
chr2_-_2642476 0.15 ENSDART00000124032
SERPINE1 mRNA binding protein 1b

Network of associatons between targets according to the STRING database.

First level regulatory network of smad2_smad10a+smad4a_smad1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.3 1.3 GO:0032370 positive regulation of lipid transport(GO:0032370)
0.2 1.0 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.2 0.6 GO:0071788 endoplasmic reticulum tubular network maintenance(GO:0071788)
0.2 1.2 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.2 0.9 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.1 0.4 GO:0006041 glucosamine metabolic process(GO:0006041) glucosamine catabolic process(GO:0006043)
0.1 1.1 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 2.1 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.1 0.6 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 2.8 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.1 0.3 GO:0034382 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.1 0.3 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.1 0.7 GO:0060036 notochord cell vacuolation(GO:0060036)
0.1 0.3 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.1 0.3 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.1 0.4 GO:0051031 tRNA transport(GO:0051031)
0.1 1.2 GO:0043114 regulation of vascular permeability(GO:0043114)
0.1 0.4 GO:0003188 heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190)
0.1 0.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.1 0.2 GO:1904353 positive regulation of telomere maintenance(GO:0032206) regulation of telomere capping(GO:1904353) positive regulation of telomere capping(GO:1904355)
0.1 1.2 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.4 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.3 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.2 GO:0070084 protein initiator methionine removal(GO:0070084)
0.0 2.6 GO:0030050 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 0.3 GO:0071623 negative regulation of leukocyte chemotaxis(GO:0002689) negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) negative regulation of neutrophil migration(GO:1902623)
0.0 0.6 GO:2000142 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260) regulation of DNA-templated transcription, initiation(GO:2000142)
0.0 0.3 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 0.2 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.4 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.2 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.0 0.1 GO:0071470 cellular response to osmotic stress(GO:0071470)
0.0 0.3 GO:0061511 centriole elongation(GO:0061511)
0.0 0.2 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.2 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.0 0.1 GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.(GO:0002926)
0.0 0.2 GO:0019079 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.0 0.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.0 0.2 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.1 GO:0090299 regulation of neural crest formation(GO:0090299)
0.0 0.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair(GO:1901255)
0.0 0.1 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.0 0.2 GO:0008591 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591)
0.0 0.0 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0 0.1 GO:0002566 somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.2 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338) negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0 0.1 GO:0015878 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.0 0.1 GO:0048313 organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.0 0.3 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.6 GO:0097178 ruffle assembly(GO:0097178)
0.0 0.1 GO:2001014 skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle cell differentiation(GO:2001014)
0.0 0.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.1 GO:0060631 regulation of meiosis I(GO:0060631)
0.0 0.2 GO:0051013 microtubule severing(GO:0051013)
0.0 0.2 GO:1903729 regulation of plasma membrane organization(GO:1903729)
0.0 0.1 GO:0006266 DNA ligation(GO:0006266) DNA ligation involved in DNA repair(GO:0051103)
0.0 0.2 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.0 0.2 GO:0070874 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.2 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.4 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 2.9 GO:0007283 spermatogenesis(GO:0007283)
0.0 0.2 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0 0.2 GO:0001836 release of cytochrome c from mitochondria(GO:0001836)
0.0 0.1 GO:0002159 desmosome assembly(GO:0002159)
0.0 0.1 GO:0098535 de novo centriole assembly(GO:0098535)
0.0 0.3 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.4 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0 0.1 GO:0072149 glomerular visceral epithelial cell fate commitment(GO:0072149) glomerular epithelial cell fate commitment(GO:0072314)
0.0 0.1 GO:0006083 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.0 0.1 GO:0030952 establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0006178 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
0.0 0.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.2 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.2 GO:0046620 secondary heart field specification(GO:0003139) regulation of organ growth(GO:0046620)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:1902624 positive regulation of neutrophil migration(GO:1902624)
0.0 0.1 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.0 GO:0038093 Fc receptor signaling pathway(GO:0038093)
0.0 0.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.2 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.0 1.2 GO:0051170 nuclear import(GO:0051170)
0.0 0.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.0 GO:0070417 cellular response to cold(GO:0070417)
0.0 0.1 GO:1904036 negative regulation of epithelial cell apoptotic process(GO:1904036)
0.0 0.1 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.0 0.1 GO:0014015 positive regulation of gliogenesis(GO:0014015) positive regulation of glial cell differentiation(GO:0045687) positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 0.1 GO:0014045 establishment of endothelial blood-brain barrier(GO:0014045)
0.0 0.1 GO:0045064 T-helper 2 cell differentiation(GO:0045064)
0.0 0.1 GO:0060386 synapse assembly involved in innervation(GO:0060386)
0.0 0.1 GO:2000758 positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.1 GO:0001709 cell fate determination(GO:0001709)
0.0 0.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.8 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.3 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.0 1.0 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 0.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.2 GO:0055117 regulation of cardiac muscle contraction(GO:0055117)
0.0 0.0 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.0 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.1 GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0 0.1 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.2 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.1 GO:0006868 glutamine transport(GO:0006868)
0.0 0.1 GO:0035989 tendon development(GO:0035989)
0.0 0.2 GO:0098754 detoxification(GO:0098754)
0.0 0.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.0 0.2 GO:0033048 negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of chromosome segregation(GO:0051985) negative regulation of mitotic sister chromatid separation(GO:2000816)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 2.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.4 GO:0005675 holo TFIIH complex(GO:0005675)
0.1 0.4 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.1 2.1 GO:0005686 U2 snRNP(GO:0005686)
0.1 1.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.3 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 0.2 GO:0098536 deuterosome(GO:0098536)
0.1 0.3 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0005775 vacuolar lumen(GO:0005775) lysosomal lumen(GO:0043202)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0008352 katanin complex(GO:0008352)
0.0 0.1 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)
0.0 1.0 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 2.6 GO:0016459 myosin complex(GO:0016459)
0.0 0.2 GO:0032783 ELL-EAF complex(GO:0032783)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.1 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.0 0.1 GO:0031213 RSF complex(GO:0031213)
0.0 0.1 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.0 1.3 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.0 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.0 0.1 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.7 GO:0030496 midbody(GO:0030496)
0.0 0.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.1 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.1 GO:0030914 STAGA complex(GO:0030914)
0.0 0.1 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 1.3 GO:0030027 lamellipodium(GO:0030027)
0.0 0.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0030620 U2 snRNA binding(GO:0030620)
0.2 1.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.2 1.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.4 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 1.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 0.4 GO:0003979 UDP-glucose 6-dehydrogenase activity(GO:0003979)
0.1 0.7 GO:0004067 asparaginase activity(GO:0004067)
0.1 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.3 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.1 1.2 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.1 2.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.3 GO:0047464 heparosan-N-sulfate-glucuronate 5-epimerase activity(GO:0047464)
0.1 0.3 GO:0070412 R-SMAD binding(GO:0070412)
0.1 0.8 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.5 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 3.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 2.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 2.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.2 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.8 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.4 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.1 GO:0033897 ribonuclease T2 activity(GO:0033897)
0.0 0.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.1 GO:0047690 aspartyltransferase activity(GO:0047690)
0.0 0.5 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.1 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.0 0.1 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.0 0.1 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.0 0.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.1 GO:0008119 thiopurine S-methyltransferase activity(GO:0008119)
0.0 0.1 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.1 GO:0033745 L-methionine-(R)-S-oxide reductase activity(GO:0033745)
0.0 0.1 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.2 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.1 GO:0032357 guanine/thymine mispair binding(GO:0032137) single base insertion or deletion binding(GO:0032138) single thymine insertion binding(GO:0032143) oxidized DNA binding(GO:0032356) oxidized purine DNA binding(GO:0032357) mismatch repair complex binding(GO:0032404) MutLalpha complex binding(GO:0032405)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.2 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.2 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.0 0.1 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.0 0.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.3 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0004001 adenosine kinase activity(GO:0004001)
0.0 0.2 GO:0022884 protein transmembrane transporter activity(GO:0008320) macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.0 0.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.0 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)
0.0 0.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
0.0 0.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.2 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.3 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.4 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0019894 kinesin binding(GO:0019894)
0.0 0.0 GO:0004557 alpha-galactosidase activity(GO:0004557)
0.0 0.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 1.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.1 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.1 PID IGF1 PATHWAY IGF1 pathway
0.0 0.9 PID P73PATHWAY p73 transcription factor network
0.0 0.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.3 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 0.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 1.3 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.9 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 2.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 0.2 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.1 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.0 0.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.2 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription