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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for runx2a+runx2b
Z-value: 0.83
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Transcription factors associated with runx2a+runx2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| runx2a | dr11_v1_chr17_+_5351922_5351922 | -0.32 | 2.0e-01 | Click! |
| runx2b | dr11_v1_chr20_-_44055095_44055123 | 0.25 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_24488652 Show fit | 2.52 |
ENSDART00000052067
|
insulin-like 3 (Leydig cell) |
|
| chr24_+_31361407 Show fit | 1.79 |
ENSDART00000162668
|
cAMP responsive element modulator b |
|
| chr24_+_17269849 Show fit | 1.75 |
ENSDART00000017605
|
sperm associated antigen 6 |
|
| chr17_+_21295132 Show fit | 1.74 |
ENSDART00000103845
|
enolase family member 4 |
|
| chr16_+_28727383 Show fit | 1.56 |
ENSDART00000149753
|
DC-STAMP domain containing 2 |
|
| chr17_+_26815021 Show fit | 1.48 |
ENSDART00000086885
|
acetylserotonin O-methyltransferase 2 |
|
| chr5_+_13359146 Show fit | 1.38 |
ENSDART00000179839
|
chemokine (C-C motif) ligand 19a, tandem duplicate 1 |
|
| chr22_-_36934040 Show fit | 1.36 |
ENSDART00000151666
|
Pim proto-oncogene, serine/threonine kinase, related 206 |
|
| chr24_+_17270129 Show fit | 1.35 |
ENSDART00000186729
|
sperm associated antigen 6 |
|
| chr18_+_5543677 Show fit | 1.26 |
ENSDART00000146161
ENSDART00000136189 |
nicotinamide nucleotide transhydrogenase 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of runx2a+runx2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.1 | 3.4 | GO:0048247 | lymphocyte chemotaxis(GO:0048247) |
| 0.0 | 2.4 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.1 | 2.0 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.2 | 1.8 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.0 | 1.8 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.2 | 1.7 | GO:0032889 | regulation of vacuole fusion, non-autophagic(GO:0032889) |
| 0.4 | 1.6 | GO:0033301 | cell cycle comprising mitosis without cytokinesis(GO:0033301) |
| 0.5 | 1.5 | GO:0030186 | melatonin metabolic process(GO:0030186) |
| 0.3 | 1.3 | GO:0006740 | NADPH regeneration(GO:0006740) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | GO:0031010 | ISWI-type complex(GO:0031010) |
| 0.1 | 1.8 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.2 | 1.7 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 1.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 1.1 | GO:0000801 | central element(GO:0000801) |
| 0.1 | 1.0 | GO:0031680 | G-protein beta/gamma-subunit complex(GO:0031680) |
| 0.0 | 1.0 | GO:0044447 | axoneme part(GO:0044447) |
| 0.0 | 0.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.2 | 0.8 | GO:0070390 | transcription export complex 2(GO:0070390) |
| 0.1 | 0.8 | GO:0016328 | lateral plasma membrane(GO:0016328) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 2.7 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 1.7 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.2 | 1.6 | GO:0001130 | bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217) |
| 0.1 | 1.5 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.3 | 1.3 | GO:0016652 | NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652) |
| 0.1 | 1.3 | GO:0019870 | chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 1.2 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.1 | 1.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.0 | 1.1 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.0 | 2.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.2 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.9 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.7 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.0 | 0.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.9 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 1.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 1.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 0.9 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 0.9 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.0 | 0.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 0.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 0.7 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.1 | 0.6 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |