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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for runx1

Z-value: 0.56

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Transcription factors associated with runx1

Gene Symbol Gene ID Gene Info
ENSDARG00000087646 RUNX family transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
runx1dr11_v1_chr1_-_1402303_1402303-0.872.1e-06Click!

Activity profile of runx1 motif

Sorted Z-values of runx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_9989634 2.60 ENSDART00000115275
zgc:152652
chr15_-_45538773 1.21 ENSDART00000113494
Mab-21 domain containing 2
chr9_+_38883388 1.19 ENSDART00000135902
microtubule-associated protein 2
chr10_+_15255012 1.15 ENSDART00000023766
very low density lipoprotein receptor
chr15_+_25489406 1.13 ENSDART00000162482
zgc:152863
chr11_-_44999858 1.12 ENSDART00000167759
ENSDART00000126845
LIM-domain binding 1b
chr10_+_15255198 1.08 ENSDART00000139047
ENSDART00000172107
ENSDART00000183413
ENSDART00000185314
very low density lipoprotein receptor
chr15_+_39977461 0.93 ENSDART00000063786
calcium binding protein 39
chr1_+_604127 0.90 ENSDART00000133165
junctional adhesion molecule 2a
chr3_-_31879201 0.90 ENSDART00000076189
zgc:171779
chr15_-_17025212 0.86 ENSDART00000014465
huntingtin interacting protein 1
chr18_+_45573251 0.86 ENSDART00000191309
kinesin family member C3
chr3_-_79366 0.84 ENSDART00000114289
zgc:165518
chr3_+_28576173 0.84 ENSDART00000151189
septin 12
chr13_+_25396896 0.84 ENSDART00000041257
glutathione S-transferase omega 2
chr10_-_8053385 0.81 ENSDART00000142714
si:ch211-251f6.7
chr24_-_9991153 0.80 ENSDART00000137794
ENSDART00000106252
ENSDART00000188309
ENSDART00000188266
ENSDART00000188660
ENSDART00000185713
ENSDART00000179773
zgc:152652
chr16_-_42175617 0.79 ENSDART00000084715
alkB homolog 8, tRNA methyltransferase
chr18_+_45573416 0.78 ENSDART00000132184
ENSDART00000145288
kinesin family member C3
chr12_-_3978306 0.78 ENSDART00000149473
ENSDART00000114857
protein phosphatase 4, catalytic subunit b
chr16_+_46410520 0.77 ENSDART00000131072
rapunzel 2
chr7_+_58751504 0.77 ENSDART00000024185
zgc:56231
chr10_+_15608326 0.76 ENSDART00000188770
zinc finger, AN1-type domain 5b
chr8_-_7308373 0.76 ENSDART00000132009
ENSDART00000145345
glutamate receptor interacting protein 2a
chr19_-_8798178 0.73 ENSDART00000188232
ceramide synthase 2a
chr24_-_9979342 0.71 ENSDART00000138576
ENSDART00000191206
zgc:171977
chr17_+_19630272 0.71 ENSDART00000104895
regulator of G protein signaling 7a
chr20_+_54034677 0.70 ENSDART00000173317
ENSDART00000173215
si:dkey-241l7.2
chr15_+_12435975 0.70 ENSDART00000168011
transmembrane protease, serine 4a
chr15_+_12436220 0.69 ENSDART00000169894
transmembrane protease, serine 4a
chr9_-_27410597 0.69 ENSDART00000135652
ENSDART00000042297
KDEL (Lys-Asp-Glu-Leu) containing 1
chr3_-_5664123 0.68 ENSDART00000145866
si:ch211-106h11.1
chr14_-_46198373 0.67 ENSDART00000031640
ENSDART00000132966
zgc:113425
chr4_+_23117557 0.66 ENSDART00000066909
solute carrier family 35, member E3
chr16_+_28547157 0.65 ENSDART00000109450
ENSDART00000165687
family with sequence similarity 171, member A1
chr16_-_9869056 0.65 ENSDART00000149312
neurocalcin delta a
chr18_+_45571378 0.65 ENSDART00000077251
kinesin family member C3
chr3_+_14512670 0.64 ENSDART00000161403
RAB3D, member RAS oncogene family, b
chr8_-_22531817 0.64 ENSDART00000140606
cold shock domain containing E1, RNA-binding
chr20_-_165818 0.64 ENSDART00000123860
si:ch211-241j12.3
chr10_-_24765988 0.63 ENSDART00000064463
translocase of inner mitochondrial membrane 10 homolog B (yeast)
chr14_+_24845941 0.62 ENSDART00000187513
Rho guanine nucleotide exchange factor (GEF) 37
chr10_-_32877348 0.62 ENSDART00000018977
ENSDART00000133421
RAB guanine nucleotide exchange factor (GEF) 1
chr23_-_27822920 0.61 ENSDART00000023094
activin A receptor type 1Ba
chr20_+_54027943 0.61 ENSDART00000153400
ENSDART00000152961
si:dkey-241l7.3
chr1_+_594584 0.61 ENSDART00000135944
junctional adhesion molecule 2a
chr6_-_7769178 0.61 ENSDART00000191701
ENSDART00000149823
myosin, heavy chain 9a, non-muscle
chr19_-_12212692 0.61 ENSDART00000142077
ENSDART00000151599
ENSDART00000140834
ENSDART00000078781
zinc finger protein 706
chr8_+_3434146 0.60 ENSDART00000164426
cytosolic thiouridylase subunit 1 homolog (S. pombe)
chr7_-_33829824 0.59 ENSDART00000074729
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr17_+_19630068 0.58 ENSDART00000182619
regulator of G protein signaling 7a
chr1_-_34447515 0.58 ENSDART00000143048
LIM domain 7b
chr9_-_40683722 0.58 ENSDART00000141979
ENSDART00000181228
BRCA1 associated RING domain 1
chr19_+_42886413 0.57 ENSDART00000151298
cAMP-regulated phosphoprotein, 21
chr17_+_691453 0.57 ENSDART00000159271
Fanconi anemia, complementation group M
chr2_-_11027258 0.56 ENSDART00000081072
ENSDART00000193824
ENSDART00000187036
ENSDART00000097741
single stranded DNA binding protein 3a
chr19_+_7552699 0.56 ENSDART00000180788
ENSDART00000115058
pre-B-cell leukemia homeobox interacting protein 1a
chr21_-_35324091 0.56 ENSDART00000185042
ubiquitin-like domain containing CTD phosphatase 1
chr21_+_7605803 0.55 ENSDART00000121813
WD repeat domain 41
chr21_-_30082414 0.54 ENSDART00000157307
ENSDART00000155188
cyclin J-like
chr2_-_27619954 0.54 ENSDART00000144826
trimethylguanosine synthase 1
chr8_-_12847483 0.54 ENSDART00000146186
si:dkey-104n9.1
chr6_+_38626926 0.54 ENSDART00000190339
ATPase phospholipid transporting 10A
chr22_-_3284023 0.54 ENSDART00000170992
si:zfos-943e10.1
chr3_+_43774369 0.53 ENSDART00000157964
zinc finger CCCH-type containing 7A
chr1_-_45213565 0.53 ENSDART00000145757
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa
chr2_+_205763 0.52 ENSDART00000160164
ENSDART00000101071
zgc:113293
chr19_-_432083 0.52 ENSDART00000165371
dihydrouridine synthase 3-like (S. cerevisiae)
chr13_-_33317323 0.52 ENSDART00000110295
ENSDART00000144848
ENSDART00000136701
transmembrane protein 234
chr23_-_24542156 0.51 ENSDART00000132265
ATPase 13A2
chr16_-_32672883 0.51 ENSDART00000124515
ENSDART00000190920
ENSDART00000188776
PNN-interacting serine/arginine-rich protein
chr4_-_13613148 0.51 ENSDART00000067164
ENSDART00000111247
interferon regulatory factor 5
chr2_-_21786826 0.51 ENSDART00000016208
chromodomain helicase DNA binding protein 7
chr3_+_49074008 0.51 ENSDART00000168864
zgc:112146
chr4_+_3312852 0.51 ENSDART00000084691
FYVE, RhoGEF and PH domain containing 4b
chr5_-_22600881 0.50 ENSDART00000176442
non-POU domain containing, octamer-binding
chr9_+_50175366 0.50 ENSDART00000170352
cordon-bleu WH2 repeat protein-like 1b
chr15_+_30310843 0.50 ENSDART00000112784
LYR motif containing 9
chr8_-_43716897 0.50 ENSDART00000163237
E1A binding protein p400
chr4_-_4261673 0.50 ENSDART00000150694
CD9 molecule b
chr9_+_38888025 0.49 ENSDART00000148306
microtubule-associated protein 2
chr22_+_24623936 0.49 ENSDART00000160924
mucolipin 2
chr19_-_3821678 0.49 ENSDART00000169639
si:dkey-206d17.12
chr13_+_11829072 0.49 ENSDART00000079356
ENSDART00000170160
suppressor of fused homolog (Drosophila)
chr7_-_24112484 0.49 ENSDART00000111923
ajuba LIM protein
chr16_+_50741154 0.48 ENSDART00000101627
zgc:110372
chr24_+_19518570 0.48 ENSDART00000056081
sulfatase 1
chr2_+_24936766 0.48 ENSDART00000025962
glycogenin 1a
chr11_-_34572202 0.48 ENSDART00000077883
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4a
chr19_+_27859546 0.48 ENSDART00000161908
NOP2/Sun RNA methyltransferase family, member 2
chr14_+_35405518 0.47 ENSDART00000171565
zinc finger and BTB domain containing 3
chr6_+_10338554 0.47 ENSDART00000186936
cordon-bleu WH2 repeat protein-like 1a
chr22_-_37738203 0.47 ENSDART00000143190
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr3_+_54012708 0.47 ENSDART00000154542
olfactomedin 2a
chr8_+_23174137 0.47 ENSDART00000189470
DnaJ (Hsp40) homolog, subfamily C, member 5aa
chr12_-_13905307 0.47 ENSDART00000152400
DBF4 zinc finger B
chr7_+_56735195 0.47 ENSDART00000082830
KIAA0895 like
chr16_+_26439518 0.47 ENSDART00000041787
tripartite motif containing 35-28
chr18_-_21725805 0.46 ENSDART00000182185
FANCD2/FANCI-associated nuclease 1
chr5_-_23596339 0.46 ENSDART00000024815
family with sequence similarity 76, member B
chr6_-_27108844 0.46 ENSDART00000073883
deoxythymidylate kinase (thymidylate kinase)
chr13_+_11440389 0.45 ENSDART00000186463
zinc finger and BTB domain containing 18
chr13_-_24263682 0.45 ENSDART00000176800
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr19_+_9111550 0.45 ENSDART00000088336
SET domain, bifurcated 1a
chr3_+_15773991 0.45 ENSDART00000089923
zinc finger protein 652
chr7_-_26262978 0.44 ENSDART00000137769
adaptor-related protein complex 1, sigma 1 subunit
chr3_+_35611625 0.44 ENSDART00000190995
TNF receptor-associated factor 7
chr1_+_5422439 0.44 ENSDART00000055047
ENSDART00000142248
serine/threonine kinase 16
chr14_-_41478265 0.44 ENSDART00000149886
ENSDART00000016002
tetraspanin 7
chr7_+_27691647 0.44 ENSDART00000079091
cytochrome P450, family 2, subfamily R, polypeptide 1
chr3_-_32362872 0.44 ENSDART00000035545
ENSDART00000012630
protein arginine methyltransferase 1
chr4_+_13909398 0.44 ENSDART00000187959
ENSDART00000184926
periphilin 1
chr25_+_8921425 0.44 ENSDART00000128591
1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
chr8_-_49207319 0.43 ENSDART00000022870
family with sequence similarity 110, member A
chr20_-_30035326 0.43 ENSDART00000141068
SRY (sex determining region Y)-box 11b
chr8_-_28408410 0.43 ENSDART00000062693
protein tyrosine phosphatase, non-receptor type 1
chr3_+_54168007 0.43 ENSDART00000109894
olfactomedin 2a
chr18_+_18612388 0.42 ENSDART00000186455
ST3 beta-galactoside alpha-2,3-sialyltransferase 2
chr21_-_32060993 0.42 ENSDART00000131651
si:ch211-160j14.2
chr13_+_22698215 0.42 ENSDART00000137467
si:ch211-134m17.9
chr10_+_15970 0.42 ENSDART00000040240
TIP41, TOR signaling pathway regulator-like (S. cerevisiae)
chr14_-_897874 0.42 ENSDART00000167395
regulator of G protein signaling 14a
chr15_+_22435460 0.42 ENSDART00000031976
transmembrane protein 136a
chr22_-_7025393 0.41 ENSDART00000003422
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr11_-_12800945 0.41 ENSDART00000191178
taxilin gamma
chr10_+_10387328 0.41 ENSDART00000080904
sarcosine dehydrogenase
chr16_+_22345513 0.41 ENSDART00000078000
zgc:123238
chr11_-_43226255 0.41 ENSDART00000172929
spectrin, beta, non-erythrocytic 1
chr9_+_500052 0.41 ENSDART00000166707

chr22_-_38934989 0.40 ENSDART00000008365
nuclear cap binding protein subunit 2
chr13_+_32454262 0.40 ENSDART00000057421
retinol dehydrogenase 14a
chr11_-_12801157 0.40 ENSDART00000103449
taxilin gamma
chr22_-_20924564 0.40 ENSDART00000100642
ENSDART00000032770
elongation factor RNA polymerase II
chr14_+_38786298 0.40 ENSDART00000164440
si:ch211-195b11.3
chr15_-_41677689 0.40 ENSDART00000187063
splA/ryanodine receptor domain and SOCS box containing 4b
chr6_-_44161262 0.40 ENSDART00000035513
SHQ1, H/ACA ribonucleoprotein assembly factor
chr23_-_29357764 0.40 ENSDART00000156512
si:ch211-129o18.4
chr25_+_28279577 0.39 ENSDART00000073502
ENSDART00000148600
aminoadipate-semialdehyde synthase
chr10_+_17371356 0.39 ENSDART00000122663
signal peptide peptidase 3
chr3_-_58650057 0.39 ENSDART00000057640
dehydrogenase/reductase (SDR family) member 7Ca
chr14_-_26498196 0.39 ENSDART00000054175
ENSDART00000145625
ENSDART00000183347
ENSDART00000191084
ENSDART00000191143
SMAD family member 5
chr19_+_32321797 0.39 ENSDART00000167664
ataxin 1a
chr6_-_3992942 0.39 ENSDART00000182328
unc-50 homolog (C. elegans)
chr25_+_14697247 0.39 ENSDART00000180747
metallophosphoesterase domain containing 2b
chr11_-_27057572 0.39 ENSDART00000043091
IQ motif and Sec7 domain 1b
chr3_+_22036391 0.39 ENSDART00000147721
cell division cycle 27
chr6_-_34838397 0.38 ENSDART00000060169
ENSDART00000169605
mesoderm induction early response 1a, transcriptional regulator
chr1_-_39859626 0.38 ENSDART00000053763
dCMP deaminase
chr23_+_24989387 0.38 ENSDART00000172299
ENSDART00000145307
Rho GTPase activating protein 4a
chr7_+_30779761 0.37 ENSDART00000066806
ENSDART00000173671
methylmalonyl CoA epimerase
chr1_+_1712140 0.37 ENSDART00000081047
ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 1
chr11_+_12811906 0.37 ENSDART00000123445
regulator of telomere elongation helicase 1
chr25_-_25058508 0.37 ENSDART00000087570
ENSDART00000178891

chr23_-_2880191 0.37 ENSDART00000022413
zinc fingers and homeoboxes 3
chr1_+_49878000 0.37 ENSDART00000047876
lymphoid enhancer-binding factor 1
chr5_-_22573624 0.37 ENSDART00000131889
ENSDART00000080886
ENSDART00000147513
ENSDART00000080882
apoptosis-inducing factor, mitochondrion-associated 1
chr22_-_3275888 0.37 ENSDART00000164743
si:zfos-943e10.1
chr13_-_23067381 0.37 ENSDART00000078140
vacuolar protein sorting 26 homolog A (S. pombe)
chr7_-_59514547 0.37 ENSDART00000168457
SLX1 homolog B, structure-specific endonuclease subunit
chr5_-_28968964 0.37 ENSDART00000184936
ENSDART00000016628
family with sequence similarity 129, member Bb
chr21_-_18275226 0.36 ENSDART00000126672
ENSDART00000135239
bromodomain containing 3a
chr6_+_27667359 0.36 ENSDART00000159624
ENSDART00000049177
RAB6B, member RAS oncogene family a
chr5_-_30080332 0.36 ENSDART00000140049
beta-carotene oxygenase 2a
chr1_+_10003193 0.36 ENSDART00000162675
tripartite motif containing 2b
chr12_+_1609563 0.36 ENSDART00000163559
solute carrier family 39 member 11
chr6_+_296130 0.36 ENSDART00000073985
RNA binding fox-1 homolog 2
chr21_+_21201346 0.36 ENSDART00000142961
RPTOR independent companion of MTOR, complex 2b
chr14_+_26224541 0.36 ENSDART00000128971
GM2 ganglioside activator
chr17_+_51744450 0.36 ENSDART00000190955
ENSDART00000149807
ornithine decarboxylase 1
chr23_-_4975452 0.35 ENSDART00000105241
ENSDART00000169978
nerve growth factor a (beta polypeptide)
chr16_+_32082359 0.35 ENSDART00000140794
ENSDART00000137029
PRP31 pre-mRNA processing factor 31 homolog (yeast)
chr21_-_44081540 0.35 ENSDART00000130833

chr22_-_37565348 0.35 ENSDART00000149482
ENSDART00000104478
fragile X mental retardation, autosomal homolog 1
chr21_-_37435162 0.35 ENSDART00000133585
family with sequence similarity 114, member A2
chr24_+_39277043 0.35 ENSDART00000165458
si:ch73-103b11.2
chr6_-_40651944 0.35 ENSDART00000187423
peptidylprolyl isomerase (cyclophilin)-like 1
chr14_+_21820034 0.35 ENSDART00000122739
C-terminal binding protein 1
chr9_+_29520696 0.35 ENSDART00000144430
ferredoxin 1
chr8_+_14959587 0.35 ENSDART00000138548
ENSDART00000041697
c-abl oncogene 2, non-receptor tyrosine kinase
chr16_+_13860299 0.35 ENSDART00000121998
glutamate-rich WD repeat containing 1
chr5_+_61467618 0.34 ENSDART00000074073
ENSDART00000182094
alkB homolog 4, lysine demthylase
chr10_+_24692076 0.34 ENSDART00000181600
transmembrane phosphatase with tensin homology
chr12_+_8474868 0.34 ENSDART00000062858
2-aminoethanethiol (cysteamine) dioxygenase a
chr2_-_45663945 0.34 ENSDART00000075080
pre-mRNA processing factor 38B
chr23_-_18567088 0.34 ENSDART00000192371
selenophosphate synthetase 2
chr6_-_19310660 0.34 ENSDART00000171110
small ubiquitin-like modifier 2a
chr6_-_21830405 0.34 ENSDART00000151803
ENSDART00000113497
SET domain containing 5
chr8_-_30742233 0.34 ENSDART00000098986
guanylyl cyclase domain containing 1
chr18_+_49969568 0.34 ENSDART00000126916
MOB kinase activator 2b
chr7_+_73308566 0.34 ENSDART00000187039
ENSDART00000174244

chr11_+_24313931 0.34 ENSDART00000017599
ENSDART00000166045
RAS (RAD and GEM)-like GTP-binding 1
chr17_-_6613458 0.34 ENSDART00000175024
si:ch211-189e2.3
chr16_+_27957808 0.34 ENSDART00000133696
zinc finger protein 804B
chr11_+_506465 0.33 ENSDART00000082519
Raf-1 proto-oncogene, serine/threonine kinase b
chr12_+_13905286 0.33 ENSDART00000147186
FK506 binding protein 10b
chr19_-_34011340 0.33 ENSDART00000172618
engulfment and cell motility 1 (ced-12 homolog, C. elegans)
chr23_-_36446307 0.33 ENSDART00000136623
zgc:174906
chr15_+_784149 0.33 ENSDART00000155114
zinc finger protein 970
chr14_-_33425170 0.33 ENSDART00000124629
ENSDART00000105800
ENSDART00000001318
NFKB activating protein
chr8_+_47099033 0.33 ENSDART00000142979
Rho guanine nucleotide exchange factor (GEF) 16

Network of associatons between targets according to the STRING database.

First level regulatory network of runx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0009265 pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) deoxyribose phosphate biosynthetic process(GO:0046385)
0.2 0.6 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.2 0.5 GO:2000637 negative regulation of hippo signaling(GO:0035331) positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.1 0.1 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.1 0.1 GO:1990120 messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 0.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.4 GO:1901052 sarcosine metabolic process(GO:1901052)
0.1 0.4 GO:0046824 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833)
0.1 0.4 GO:0019878 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.1 0.5 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.5 GO:0046823 regulation of protein import into nucleus(GO:0042306) negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of protein localization to nucleus(GO:1900181) regulation of protein import(GO:1904589) negative regulation of protein import(GO:1904590)
0.1 0.6 GO:0072103 renal system vasculature morphogenesis(GO:0061438) kidney vasculature morphogenesis(GO:0061439) glomerulus vasculature morphogenesis(GO:0072103) glomerular capillary formation(GO:0072104)
0.1 0.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.4 GO:0034969 histone arginine methylation(GO:0034969)
0.1 0.8 GO:0021588 cerebellum formation(GO:0021588)
0.1 0.3 GO:0048677 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 0.6 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143) protein urmylation(GO:0032447)
0.1 0.3 GO:0045040 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.9 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.4 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 0.2 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228) protein localization to nuclear envelope(GO:0090435)
0.1 0.2 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.1 0.6 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.4 GO:0060784 regulation of cell proliferation involved in tissue homeostasis(GO:0060784)
0.1 0.4 GO:0071305 vitamin D3 metabolic process(GO:0070640) cellular response to vitamin D(GO:0071305)
0.1 0.2 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1 0.2 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1 0.3 GO:1901842 regulation of high voltage-gated calcium channel activity(GO:1901841) negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.1 0.4 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.5 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 1.0 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.1 1.3 GO:0008354 germ cell migration(GO:0008354)
0.1 0.3 GO:0036037 CD8-positive, alpha-beta T cell activation(GO:0036037)
0.1 0.6 GO:0001709 cell fate determination(GO:0001709)
0.1 0.5 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.1 0.5 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.3 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 0.5 GO:0006465 signal peptide processing(GO:0006465)
0.1 0.3 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.5 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.4 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.1 0.3 GO:0072574 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.0 0.2 GO:0019860 uracil catabolic process(GO:0006212) uracil metabolic process(GO:0019860)
0.0 0.3 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 1.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.4 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.3 GO:0018160 peptidyl-pyrromethane cofactor linkage(GO:0018160)
0.0 0.3 GO:1904086 regulation of epiboly involved in gastrulation with mouth forming second(GO:1904086)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.3 GO:0097107 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.8 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.1 GO:0016446 somatic diversification of immune receptors via somatic mutation(GO:0002566) pyrimidine dimer repair(GO:0006290) somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0 0.4 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.5 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.3 GO:0044211 CTP salvage(GO:0044211)
0.0 0.2 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 1.2 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.5 GO:0090109 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109)
0.0 0.1 GO:0006178 guanine salvage(GO:0006178) GMP salvage(GO:0032263) guanine biosynthetic process(GO:0046099)
0.0 0.4 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.4 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 0.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:0016119 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.0 0.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.8 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.3 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.0 0.4 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.3 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631) regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.3 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0 0.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.4 GO:1902101 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.2 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.0 0.4 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.2 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.0 0.5 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.2 GO:0061055 myotome development(GO:0061055)
0.0 0.2 GO:2001287 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.0 0.3 GO:0035284 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 1.4 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.5 GO:0035196 production of miRNAs involved in gene silencing by miRNA(GO:0035196)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.2 GO:0060827 canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060823) regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.0 0.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.4 GO:1902254 regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902253) negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902254)
0.0 0.1 GO:1903504 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0071501 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.2 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.0 0.7 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0006972 hyperosmotic response(GO:0006972)
0.0 0.1 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.0 0.2 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.0 0.2 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 1.9 GO:1902652 cholesterol metabolic process(GO:0008203) secondary alcohol metabolic process(GO:1902652)
0.0 0.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.0 0.6 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.0 0.1 GO:0060967 regulation of posttranscriptional gene silencing(GO:0060147) negative regulation of posttranscriptional gene silencing(GO:0060149) regulation of gene silencing by miRNA(GO:0060964) negative regulation of gene silencing by miRNA(GO:0060965) regulation of gene silencing by RNA(GO:0060966) negative regulation of gene silencing by RNA(GO:0060967)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0034111 negative regulation of homotypic cell-cell adhesion(GO:0034111) negative regulation of T cell activation(GO:0050868) negative regulation of leukocyte cell-cell adhesion(GO:1903038)
0.0 0.1 GO:0032615 interleukin-12 production(GO:0032615) regulation of interleukin-12 production(GO:0032655)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.2 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.0 0.9 GO:0046847 filopodium assembly(GO:0046847)
0.0 0.0 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.7 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.6 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.1 GO:0033688 regulation of osteoblast proliferation(GO:0033688)
0.0 0.2 GO:0009204 deoxyribonucleoside triphosphate catabolic process(GO:0009204)
0.0 0.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.2 GO:0097340 inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341)
0.0 0.2 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.2 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 0.8 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.0 0.2 GO:0045117 azole transport(GO:0045117)
0.0 0.1 GO:1990575 mitochondrial ornithine transport(GO:0000066) mitochondrial L-ornithine transmembrane transport(GO:1990575)
0.0 0.2 GO:0050714 positive regulation of protein secretion(GO:0050714)
0.0 0.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.3 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.1 GO:0015840 urea transport(GO:0015840)
0.0 0.2 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.0 0.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.0 0.3 GO:0036065 fucosylation(GO:0036065)
0.0 0.1 GO:0031061 negative regulation of histone methylation(GO:0031061)
0.0 0.3 GO:0030537 larval locomotory behavior(GO:0008345) larval behavior(GO:0030537)
0.0 0.1 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.2 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.0 0.3 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.9 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0 0.6 GO:1901800 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)
0.0 0.5 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.5 GO:0039021 pronephric glomerulus development(GO:0039021)
0.0 0.3 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0097241 hematopoietic stem cell migration to bone marrow(GO:0097241)
0.0 0.1 GO:0035093 spermatid nucleus differentiation(GO:0007289) sperm chromatin condensation(GO:0035092) spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 0.1 GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence(GO:0045050)
0.0 0.1 GO:0030828 regulation of cGMP metabolic process(GO:0030823) positive regulation of cGMP metabolic process(GO:0030825) regulation of cGMP biosynthetic process(GO:0030826) positive regulation of cGMP biosynthetic process(GO:0030828) regulation of guanylate cyclase activity(GO:0031282) positive regulation of guanylate cyclase activity(GO:0031284)
0.0 0.5 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 0.2 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.3 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.0 0.1 GO:0021553 olfactory nerve development(GO:0021553) olfactory nerve morphogenesis(GO:0021627) olfactory nerve formation(GO:0021628)
0.0 0.4 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.3 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.1 GO:1902946 protein localization to early endosome(GO:1902946)
0.0 0.3 GO:1903845 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.7 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0031048 chromatin silencing by small RNA(GO:0031048)
0.0 0.2 GO:0019730 antimicrobial humoral response(GO:0019730)
0.0 0.1 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 1.0 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.1 GO:0016559 peroxisome fission(GO:0016559) mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.2 GO:0072531 nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine-containing compound transmembrane transport(GO:0072531) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 0.0 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0 0.4 GO:0042129 regulation of T cell proliferation(GO:0042129)
0.0 0.4 GO:0051896 regulation of protein kinase B signaling(GO:0051896)
0.0 0.6 GO:0051607 defense response to virus(GO:0051607)
0.0 0.1 GO:0071684 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.1 GO:0070307 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.2 GO:0060021 palate development(GO:0060021)
0.0 0.3 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 0.0 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.2 GO:0022011 myelination in peripheral nervous system(GO:0022011)
0.0 0.4 GO:0043534 blood vessel endothelial cell migration(GO:0043534)
0.0 0.0 GO:0070221 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0098890 extrinsic component of postsynaptic membrane(GO:0098890)
0.2 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719) mitochondrial inner membrane protein insertion complex(GO:0042721)
0.2 2.2 GO:0034361 very-low-density lipoprotein particle(GO:0034361)
0.1 0.5 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.1 0.3 GO:0033065 Rad51C-XRCC3 complex(GO:0033065)
0.1 0.4 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.1 0.3 GO:0031213 RSF complex(GO:0031213)
0.1 0.4 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 0.4 GO:1902737 dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)
0.1 0.4 GO:0008091 spectrin(GO:0008091)
0.1 0.2 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.1 0.3 GO:0070319 Golgi to plasma membrane transport vesicle(GO:0070319)
0.1 0.2 GO:0030689 Noc complex(GO:0030689)
0.1 0.6 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 0.4 GO:0033557 Slx1-Slx4 complex(GO:0033557)
0.1 0.4 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.5 GO:0071005 U2-type precatalytic spliceosome(GO:0071005)
0.1 0.2 GO:0000818 nuclear MIS12/MIND complex(GO:0000818)
0.1 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 0.3 GO:0070390 transcription export complex 2(GO:0070390)
0.0 0.3 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.6 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0032301 MutSalpha complex(GO:0032301)
0.0 0.2 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.8 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0005784 Sec61 translocon complex(GO:0005784)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.3 GO:0030904 retromer complex(GO:0030904)
0.0 0.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.3 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 1.2 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.0 0.9 GO:0005940 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 0.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007)
0.0 0.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.6 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.2 GO:0070938 contractile ring(GO:0070938)
0.0 0.4 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 2.0 GO:0016607 nuclear speck(GO:0016607)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.4 GO:0032039 integrator complex(GO:0032039)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.5 GO:0005680 nuclear ubiquitin ligase complex(GO:0000152) anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 1.1 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0 0.1 GO:0032019 mitochondrial cloud(GO:0032019)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.2 GO:0030315 T-tubule(GO:0030315)
0.0 0.3 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.8 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.4 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.1 GO:0038039 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor heterodimeric complex(GO:0038039) G-protein coupled receptor complex(GO:0097648)
0.0 0.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.0 GO:0061702 inflammasome complex(GO:0061702)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.3 0.8 GO:0045174 glutathione dehydrogenase (ascorbate) activity(GO:0045174)
0.3 0.8 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 0.6 GO:0070336 flap-structured DNA binding(GO:0070336)
0.2 1.1 GO:0030274 LIM domain binding(GO:0030274)
0.2 0.5 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.7 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.5 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.1 0.5 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1 0.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.4 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.1 0.6 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.4 GO:0019948 SUMO activating enzyme activity(GO:0019948)
0.1 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.1 0.7 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.4 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 0.5 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.3 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.1 0.2 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 0.3 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
0.1 2.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.2 GO:0030623 U5 snRNA binding(GO:0030623)
0.1 0.2 GO:0070051 fibrinogen binding(GO:0070051)
0.1 0.5 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.2 GO:0043621 protein self-association(GO:0043621)
0.1 0.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 0.3 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 1.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.5 GO:0035198 miRNA binding(GO:0035198)
0.1 0.4 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1 0.2 GO:0042806 fucose binding(GO:0042806)
0.0 0.4 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.2 GO:0002061 uracil binding(GO:0002058) pyrimidine nucleobase binding(GO:0002061) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.0 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.2 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.0 1.0 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.4 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.3 GO:0004418 hydroxymethylbilane synthase activity(GO:0004418)
0.0 0.3 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.4 GO:0004586 ornithine decarboxylase activity(GO:0004586)
0.0 0.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.0 0.2 GO:0004997 thyrotropin-releasing hormone receptor activity(GO:0004997)
0.0 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.3 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.1 GO:0004422 hypoxanthine phosphoribosyltransferase activity(GO:0004422)
0.0 0.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.8 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.0 0.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252)
0.0 0.3 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.0 0.3 GO:0015154 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.2 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0 1.0 GO:0017069 snRNA binding(GO:0017069)
0.0 0.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.0 0.1 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.2 GO:0030548 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.4 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.0 0.1 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.0 0.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.0 0.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.7 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.2 GO:0015386 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.3 GO:2001069 glycogen binding(GO:2001069)
0.0 0.5 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.1 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 0.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.5 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.3 GO:0004382 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.3 GO:0022884 macromolecule transmembrane transporter activity(GO:0022884)
0.0 0.3 GO:0061608 nuclear import signal receptor activity(GO:0061608)
0.0 0.4 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.6 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.2 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:1900750 oligopeptide binding(GO:1900750)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.5 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 1.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0042923 neuropeptide binding(GO:0042923)
0.0 0.4 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0035925 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.9 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.1 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.1 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.4 GO:0035014 phosphatidylinositol 3-kinase regulator activity(GO:0035014)
0.0 0.2 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.1 GO:0097363 protein N-acetylglucosaminyltransferase activity(GO:0016262) protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.0 1.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.0 GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID REELIN PATHWAY Reelin signaling pathway
0.1 2.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.4 PID LKB1 PATHWAY LKB1 signaling events
0.1 0.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 0.7 PID BARD1 PATHWAY BARD1 signaling events
0.1 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 0.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.4 PID ALK2 PATHWAY ALK2 signaling events
0.0 1.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.1 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.3 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.4 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 0.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 0.3 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.3 PID ATM PATHWAY ATM pathway
0.0 0.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID AURORA B PATHWAY Aurora B signaling
0.0 0.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.0 ST STAT3 PATHWAY STAT3 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 0.9 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 0.6 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 0.4 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 2.1 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.6 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.2 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.7 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 0.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.8 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.3 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.1 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 0.4 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.1 REACTOME DOWNSTREAM TCR SIGNALING Genes involved in Downstream TCR signaling
0.0 0.2 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 0.4 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.3 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade