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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for rest

Z-value: 1.41

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Transcription factors associated with rest

Gene Symbol Gene ID Gene Info
ENSDARG00000103046 Danio rerio RE1-silencing transcription factor (rest), mRNA.

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
restdr11_v1_chr14_-_52433292_52433292-0.798.5e-05Click!

Activity profile of rest motif

Sorted Z-values of rest motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_54911458 3.78 ENSDART00000089603
golgin A7 family, member Ba
chr22_-_25033105 3.65 ENSDART00000124220
neuronal pentraxin receptor b
chr5_-_26093945 3.52 ENSDART00000010199
ENSDART00000145096
family with sequence similarity 219, member Ab
chr25_+_5035343 3.10 ENSDART00000011751
parvin, beta
chr25_-_19443421 2.84 ENSDART00000067362
cocaine- and amphetamine-regulated transcript 2
chr4_+_357810 2.74 ENSDART00000163436
ENSDART00000103645
transmembrane protein 181
chr25_-_31863374 2.61 ENSDART00000028338
secretory carrier membrane protein 5a
chr15_+_41027466 2.56 ENSDART00000075940
melatonin receptor type 1Ba
chr21_+_6751405 2.49 ENSDART00000037265
ENSDART00000146371
olfactomedin 1b
chr18_+_28988373 2.41 ENSDART00000018685
synaptotagmin IXa
chr19_-_11950434 2.36 ENSDART00000024861
cleavage and polyadenylation specific factor 1
chr19_+_26718074 2.33 ENSDART00000134455
zgc:100906
chr19_-_19339285 2.33 ENSDART00000158413
ENSDART00000170479
chondroitin sulfate proteoglycan 5b
chr12_-_1951233 2.30 ENSDART00000005676
ENSDART00000127937
SRY (sex determining region Y)-box 9a
chr6_+_21740672 2.22 ENSDART00000193734
lipoma HMGIC fusion partner-like 4a
chr19_-_11949996 2.14 ENSDART00000163478
ENSDART00000167299
cleavage and polyadenylation specific factor 1
chr21_+_6751760 2.14 ENSDART00000135914
olfactomedin 1b
chr18_+_50089000 2.04 ENSDART00000058936
secretory carrier membrane protein 5b
chr15_-_22147860 1.96 ENSDART00000149784
sodium channel, voltage-gated, type III, beta
chr23_+_28693278 1.95 ENSDART00000078148
structural maintenance of chromosomes 1A
chr9_-_34915351 1.86 ENSDART00000100728
ENSDART00000139608
UPF3A, regulator of nonsense mediated mRNA decay
chr15_-_47841259 1.83 ENSDART00000155384
kelch repeat and BTB (POZ) domain containing 3
chr17_-_12385308 1.79 ENSDART00000080927
synaptosomal-associated protein, 25b
chr23_+_35759843 1.75 ENSDART00000047082
ganglioside induced differentiation associated protein 1-like 1
chr18_+_36806545 1.70 ENSDART00000098958
tetratricopeptide repeat domain 9B
chr6_-_30210378 1.69 ENSDART00000157359
ENSDART00000113924
leucine rich repeat containing 7
chr7_+_40228422 1.55 ENSDART00000052222
protein tyrosine phosphatase, receptor type, N polypeptide 2
chr6_+_43903209 1.52 ENSDART00000006435
G protein-coupled receptor 27
chr1_+_40794395 1.40 ENSDART00000111656
G protein-coupled receptor 78a
chr10_-_29892486 1.39 ENSDART00000099983
brain-specific homeobox
chr5_-_29750377 1.29 ENSDART00000051474
BarH-like homeobox 1a
chr15_+_36156986 1.27 ENSDART00000059791
somatostatin 1, tandem duplicate 1
chr7_+_23907692 1.25 ENSDART00000045479
synaptotagmin IV
chr7_-_17337233 1.14 ENSDART00000050236
ENSDART00000102141
novel immune-type receptor 8
chr3_-_26204867 1.14 ENSDART00000103748
glycerophosphodiester phosphodiesterase domain containing 3a
chr1_+_17676745 1.08 ENSDART00000030665
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr16_+_46148990 1.07 ENSDART00000083919
synaptic vesicle glycoprotein 2A
chr23_+_41800052 1.06 ENSDART00000141484
prodynorphin
chr19_-_42244358 1.03 ENSDART00000102697
cocaine- and amphetamine-regulated transcript 4
chr10_+_25219728 0.96 ENSDART00000193829
glutamate receptor, metabotropic 5a
chr24_+_854877 0.96 ENSDART00000188408
piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2
chr7_-_69521481 0.94 ENSDART00000148465
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
chr20_+_34913069 0.93 ENSDART00000007584
synaptosomal-associated protein, 25a
chr21_+_11468934 0.92 ENSDART00000126045
ENSDART00000129744
ENSDART00000102368
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr11_-_25538341 0.87 ENSDART00000171560
si:dkey-245f22.3
chr18_+_660578 0.86 ENSDART00000161203
si:dkey-205h23.2
chr2_+_45049290 0.78 ENSDART00000075152
protease, serine, 56
chr20_+_41640687 0.78 ENSDART00000138686
family with sequence similarity 184, member A
chr19_-_9648542 0.75 ENSDART00000172628
chloride channel, voltage-sensitive 1a
chr12_+_24342303 0.74 ENSDART00000111239
neurexin 1a
chr1_-_38538284 0.74 ENSDART00000009777
glycine receptor, alpha 3
chr10_+_23022263 0.69 ENSDART00000138955
si:dkey-175g6.2
chr11_+_33426510 0.68 ENSDART00000163106
contactin associated protein-like 5 like
chr24_+_26742226 0.67 ENSDART00000079721
growth hormone secretagogue receptor b
chr14_-_2004291 0.66 ENSDART00000114039
protocadherin 2 gamma 5
chr4_-_5302866 0.65 ENSDART00000138590
si:ch211-214j24.9
chr7_-_52876683 0.63 ENSDART00000172910
microtubule-associated protein 1Aa
chr21_+_11468642 0.61 ENSDART00000041869
glutamate receptor, ionotropic, N-methyl D-aspartate 1a
chr20_+_27020201 0.60 ENSDART00000126919
ENSDART00000016014
chromogranin A
chr1_+_10720294 0.60 ENSDART00000139387
ATPase Na+/K+ transporting subunit beta 1b
chr7_-_31940590 0.58 ENSDART00000131009
brain-derived neurotrophic factor
chr12_+_19305390 0.51 ENSDART00000183987
ENSDART00000066391
casein kinase 1, epsilon
chr10_+_21588002 0.51 ENSDART00000100596
protocadherin 1 alpha 6
chr11_+_77526 0.51 ENSDART00000193521

chr18_+_26337869 0.50 ENSDART00000109257
si:ch211-234p18.3
chr23_+_40452157 0.47 ENSDART00000113106
ENSDART00000140136
SOGA family member 3b
chr20_-_39391833 0.47 ENSDART00000135149
si:dkey-217m5.8
chr12_-_16524727 0.47 ENSDART00000166645

chr22_+_1751640 0.46 ENSDART00000162093
zinc finger protein 1169
chr23_+_45579497 0.42 ENSDART00000110381
early growth response 4
chr9_-_27649406 0.41 ENSDART00000181270
ENSDART00000187112
syntaxin binding protein 5-like
chr7_+_26224211 0.41 ENSDART00000173999
VGF nerve growth factor inducible
chr7_+_31879986 0.41 ENSDART00000138491
myosin binding protein C, cardiac
chr20_+_27427112 0.40 ENSDART00000153459
si:dkey-22l1.1
chr11_+_33426254 0.39 ENSDART00000111193
contactin associated protein-like 5 like
chr7_-_30087048 0.37 ENSDART00000112743
neuromedin Bb
chr2_-_5776030 0.36 ENSDART00000133851
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2b
chr21_-_42100471 0.35 ENSDART00000166148
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr20_-_39391492 0.35 ENSDART00000184886
si:dkey-217m5.8
chr4_-_5302162 0.32 ENSDART00000177099
si:ch211-214j24.9
chr20_+_38724575 0.32 ENSDART00000015095
ENSDART00000152972
urotensin 1
chr23_-_30785382 0.32 ENSDART00000136156
ENSDART00000131285
myelin transcription factor 1a
chr6_+_41255485 0.30 ENSDART00000042683
ENSDART00000186013
Ca2+-dependent activator protein for secretion b
chr16_-_40727455 0.27 ENSDART00000162331
si:dkey-22o22.2
chr14_-_1998501 0.25 ENSDART00000189052
protocadherin 2 gamma 5
chr3_-_13921173 0.24 ENSDART00000159177
ENSDART00000165174
si:dkey-61n16.5
chr14_-_2032753 0.24 ENSDART00000111335
protocadherin 2 gamma 5
chr13_+_25846528 0.23 ENSDART00000087426
B cell CLL/lymphoma 11Aa
chr9_+_40546677 0.23 ENSDART00000132911
von Willebrand factor C domain containing protein 2-like
chr2_-_4642407 0.19 ENSDART00000162044

chr10_+_21807497 0.16 ENSDART00000164634
protocadherin 1 gamma 32
chr19_-_43552252 0.15 ENSDART00000138308
G protein-coupled receptor 186
chr7_+_59739164 0.14 ENSDART00000110412
G protein-coupled receptor 78b
chr20_+_19212962 0.13 ENSDART00000063706
fibronectin type III domain containing 4a
chr7_+_17229980 0.10 ENSDART00000184910
solute carrier family 6 (neurotransmitter transporter), member 5
chr21_-_17482465 0.10 ENSDART00000004548
BarH-like homeobox 1b
chr17_-_10249095 0.08 ENSDART00000159963
somatostatin receptor 1a
chr24_+_6353394 0.07 ENSDART00000165118

chr3_+_33341640 0.06 ENSDART00000186352
peptide YYa
chr7_+_17229282 0.05 ENSDART00000097982
solute carrier family 6 (neurotransmitter transporter), member 5
chr14_-_2193248 0.04 ENSDART00000128659
protocadherin 2 alpha b 10
chr4_-_17391091 0.03 ENSDART00000056002
tyrosine hydroxylase 2
chr15_+_35709223 0.01 ENSDART00000155840
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2a
chr18_-_44611252 0.01 ENSDART00000173095
sprouty-related, EVH1 domain containing 3
chr5_+_71802014 0.01 ENSDART00000124939
ENSDART00000097164
LIM homeobox 3
chr10_-_36927594 0.00 ENSDART00000162046
seizure related 6 homolog a
chr3_-_37476475 0.00 ENSDART00000148107
si:ch211-278a6.1

Network of associatons between targets according to the STRING database.

First level regulatory network of rest

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.2 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.5 2.0 GO:0086005 ventricular cardiac muscle cell action potential(GO:0086005)
0.4 2.8 GO:0008343 adult feeding behavior(GO:0008343)
0.3 3.3 GO:0099550 trans-synaptic signalling, modulating synaptic transmission(GO:0099550)
0.3 1.1 GO:0015868 intracellular nucleoside transport(GO:0015859) purine nucleoside transmembrane transport(GO:0015860) purine nucleotide transport(GO:0015865) ATP transport(GO:0015867) purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) mitochondrial ATP transmembrane transport(GO:1990544)
0.2 0.6 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.2 1.4 GO:0021982 pineal gland development(GO:0021982)
0.2 4.5 GO:0043631 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
0.2 2.3 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.1 3.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 1.8 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 1.7 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.1 1.0 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.1 3.8 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 2.6 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.1 0.4 GO:0003210 cardiac atrium formation(GO:0003210)
0.1 3.7 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 1.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.1 0.3 GO:0070208 protein heterotrimerization(GO:0070208)
0.1 0.9 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 1.9 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 0.2 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.0 1.1 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.6 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.4 GO:0046887 positive regulation of hormone secretion(GO:0046887)
0.0 1.5 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 0.9 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.6 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.0 0.5 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.6 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.4 GO:0050708 regulation of protein secretion(GO:0050708)
0.0 2.6 GO:0048511 rhythmic process(GO:0048511)
0.0 0.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0060077 inhibitory synapse(GO:0060077)
0.5 2.7 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.3 4.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.3 3.8 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.2 4.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.2 2.4 GO:0031045 dense core granule(GO:0031045)
0.2 1.9 GO:0030893 meiotic cohesin complex(GO:0030893)
0.1 0.6 GO:0042583 chromaffin granule(GO:0042583)
0.1 2.0 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 3.1 GO:0030018 Z disc(GO:0030018)
0.0 1.1 GO:0043679 axon terminus(GO:0043679)
0.0 1.0 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.0 1.7 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.5 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 1.8 GO:0070382 exocytic vesicle(GO:0070382)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0008502 melatonin receptor activity(GO:0008502)
0.3 1.1 GO:0005471 ATP:ADP antiporter activity(GO:0005471)
0.2 2.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 1.0 GO:0099530 G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential(GO:0099530)
0.1 2.2 GO:0050811 GABA receptor binding(GO:0050811)
0.1 4.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 3.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.7 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.1 GO:0031628 opioid receptor binding(GO:0031628)
0.1 3.7 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 2.7 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 1.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 1.9 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.6 GO:0005165 nerve growth factor receptor binding(GO:0005163) neurotrophin receptor binding(GO:0005165)
0.0 0.7 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.4 GO:0045159 myosin II binding(GO:0045159)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 1.0 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.5 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.3 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237) benzodiazepine receptor activity(GO:0008503) GABA-gated chloride ion channel activity(GO:0022851)
0.0 1.6 GO:0005179 hormone activity(GO:0005179)
0.0 0.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 4.2 GO:0003682 chromatin binding(GO:0003682)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.1 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 1.9 PID ATM PATHWAY ATM pathway
0.0 0.5 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 4.5 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.9 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 0.5 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.1 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 0.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.1 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 1.9 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.5 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters