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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for pparaa+pparda+ppardb

Z-value: 0.51

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Transcription factors associated with pparaa+pparda+ppardb

Gene Symbol Gene ID Gene Info
ppardb
ENSDARG00000009473 peroxisome proliferator-activated receptor delta b
pparaa
ENSDARG00000031777 peroxisome proliferator-activated receptor alpha a
pparda
ENSDARG00000044525 peroxisome proliferator-activated receptor delta a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pparaadr11_v1_chr4_-_18635005_186350050.911.2e-07Click!
ppardbdr11_v1_chr8_+_23711842_237118420.753.2e-04Click!
ppardadr11_v1_chr22_+_1006573_10065730.561.5e-02Click!

Activity profile of pparaa+pparda+ppardb motif

Sorted Z-values of pparaa+pparda+ppardb motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_12408109 1.63 ENSDART00000155509
ankef1b
ankyrin repeat and EF-hand domain containing 1b
chr25_+_21829777 1.32 ENSDART00000027393
ckmt1
creatine kinase, mitochondrial 1
chr10_-_44027391 1.31 ENSDART00000145404
crybb1
crystallin, beta B1
chr2_-_42960353 1.07 ENSDART00000098303
oc90
otoconin 90
chr19_+_40861853 1.05 ENSDART00000126470
zgc:85777
zgc:85777
chr5_-_323712 1.04 ENSDART00000188793
HOOK3
hook microtubule tethering protein 3
chr25_+_5288665 1.00 ENSDART00000169540
CABZ01039861.1

chr23_-_39636195 0.92 ENSDART00000144439
vwa1
von Willebrand factor A domain containing 1
chr5_-_36549024 0.83 ENSDART00000097671
zgc:158432
zgc:158432
chr3_-_53486169 0.83 ENSDART00000115243
soul5
heme-binding protein soul5
chr13_-_37127970 0.81 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr8_+_999421 0.81 ENSDART00000149528
fabp1b.1
fatty acid binding protein 1b, tandem duplicate 1
chr7_-_24046999 0.77 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dhrs4
dehydrogenase/reductase (SDR family) member 4
chr22_+_22888 0.75 ENSDART00000082471
mfap2
microfibril associated protein 2
chr20_+_54738210 0.73 ENSDART00000151399
pak7
p21 protein (Cdc42/Rac)-activated kinase 7
chr5_-_30984010 0.72 ENSDART00000182367
spns3
spinster homolog 3 (Drosophila)
chr18_+_16744307 0.72 ENSDART00000179872
ENSDART00000133490
lyve1b
lymphatic vessel endothelial hyaluronic receptor 1b
chr5_-_30984271 0.68 ENSDART00000051392
spns3
spinster homolog 3 (Drosophila)
chr13_+_28819768 0.65 ENSDART00000191401
ENSDART00000188895
ENSDART00000101653
CU639469.1

chr24_+_9590188 0.62 ENSDART00000137092
si:dkey-96n2.1
si:dkey-96n2.1
chr17_+_12408188 0.62 ENSDART00000105218
khk
ketohexokinase
chr17_+_32374876 0.59 ENSDART00000183851
ywhaqb
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b
chr21_+_26720803 0.59 ENSDART00000053797
slc3a2b
solute carrier family 3 (amino acid transporter heavy chain), member 2b
chr12_+_7491690 0.58 ENSDART00000152564
phyhiplb
phytanoyl-CoA 2-hydroxylase interacting protein-like b
chr12_-_684200 0.57 ENSDART00000152122
si:ch211-176g6.2
si:ch211-176g6.2
chr19_+_19652439 0.56 ENSDART00000165934
hibadha
3-hydroxyisobutyrate dehydrogenase a
chr22_-_38274188 0.49 ENSDART00000139420
ENSDART00000015117
elavl2
ELAV like neuron-specific RNA binding protein 2
chr11_+_11201096 0.47 ENSDART00000171916
ENSDART00000171521
ENSDART00000087105
ENSDART00000159603
myom2a
myomesin 2a
chr17_+_30545895 0.47 ENSDART00000076739
nhsl1a
NHS-like 1a
chr23_+_44634187 0.43 ENSDART00000143688
si:ch73-265d7.2
si:ch73-265d7.2
chr6_-_39764995 0.42 ENSDART00000085277
pfkmb
phosphofructokinase, muscle b
chr12_-_5120339 0.41 ENSDART00000168759
rbp4
retinol binding protein 4, plasma
chr7_-_29231686 0.40 ENSDART00000173780
herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr11_-_6974022 0.39 ENSDART00000172851
COMP
si:ch211-43f4.1
chr3_+_58167288 0.39 ENSDART00000155874
ENSDART00000010395
uqcrc2a
ubiquinol-cytochrome c reductase core protein 2a
chr23_-_45504991 0.38 ENSDART00000148761
col24a1
collagen type XXIV alpha 1
chr20_-_38836161 0.38 ENSDART00000061358
si:dkey-221h15.4
si:dkey-221h15.4
chr6_+_60055168 0.38 ENSDART00000008752
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr23_+_44633858 0.32 ENSDART00000180728
si:ch73-265d7.2
si:ch73-265d7.2
chr14_-_48103207 0.31 ENSDART00000056712
etfdh
electron-transferring-flavoprotein dehydrogenase
chr5_+_38276582 0.30 ENSDART00000158532
gnb2
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr20_-_26937453 0.29 ENSDART00000139756
ftr97
finTRIM family, member 97
chr6_-_39765546 0.28 ENSDART00000185767
pfkmb
phosphofructokinase, muscle b
chr6_-_18393476 0.28 ENSDART00000168309
trim25
tripartite motif containing 25
chr8_-_979735 0.28 ENSDART00000149612
znf366
zinc finger protein 366
chr12_-_5120175 0.26 ENSDART00000160729
rbp4
retinol binding protein 4, plasma
chr12_-_31457301 0.26 ENSDART00000043887
ENSDART00000148603
acsl5
acyl-CoA synthetase long chain family member 5
chr20_-_24443680 0.24 ENSDART00000191337
CR385053.3

chr5_+_43870389 0.24 ENSDART00000141002
zgc:112966
zgc:112966
chr24_-_1021318 0.23 ENSDART00000181403
ralaa
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr25_+_17405458 0.23 ENSDART00000186711
e2f4
E2F transcription factor 4
chr18_+_13315739 0.23 ENSDART00000143404
si:ch211-260p9.3
si:ch211-260p9.3
chr1_+_58353661 0.22 ENSDART00000140074
si:dkey-222h21.2
si:dkey-222h21.2
chr10_+_20128267 0.22 ENSDART00000064615
dmtn
dematin actin binding protein
chr13_+_829585 0.22 ENSDART00000029051
gsta.2
glutathione S-transferase, alpha tandem duplicate 2
chr17_+_12408405 0.22 ENSDART00000154827
ENSDART00000048440
ENSDART00000156429
khk
ketohexokinase
chr13_+_28821841 0.22 ENSDART00000179900
CU639469.1

chr19_-_7043355 0.21 ENSDART00000104845
tapbp.1
TAP binding protein (tapasin), tandem duplicate 1
chr19_+_3056450 0.19 ENSDART00000141324
ENSDART00000082353
hsf1
heat shock transcription factor 1
chr12_-_6033824 0.19 ENSDART00000131301
ENSDART00000139419
ENSDART00000032050
g6pca.1
glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1
chr19_+_7043634 0.19 ENSDART00000133954
mhc1uka
major histocompatibility complex class I UKA
chr25_+_17405201 0.19 ENSDART00000164349
e2f4
E2F transcription factor 4
chr5_-_66301142 0.19 ENSDART00000067541
prlrb
prolactin receptor b
chr7_+_17356482 0.18 ENSDART00000063629
nitr3r.1l
novel immune-type receptor 3, related 1-like
chr5_+_58421536 0.17 ENSDART00000173410
ccdc15
coiled-coil domain containing 15
chr8_-_20291922 0.17 ENSDART00000148304
myo1f
myosin IF
chr15_+_17030473 0.16 ENSDART00000129407
plin2
perilipin 2
chr6_+_43353271 0.16 ENSDART00000191775
BX927362.2

chr18_-_3456117 0.16 ENSDART00000158508
myo7aa
myosin VIIAa
chr20_+_43379029 0.16 ENSDART00000142486
ENSDART00000186486
unc93a
unc-93 homolog A
chr14_-_29826659 0.15 ENSDART00000138413
sorbs2b
sorbin and SH3 domain containing 2b
chr17_-_12196865 0.15 ENSDART00000154694
kif28
kinesin family member 28
chr20_-_26936887 0.15 ENSDART00000160827
ftr79
finTRIM family, member 79
chr4_+_67999732 0.14 ENSDART00000190597
si:ch211-133h13.1
si:ch211-133h13.1
chr5_-_41860556 0.14 ENSDART00000140154
si:dkey-65b12.12
si:dkey-65b12.12
chr17_+_450956 0.14 ENSDART00000183022
ENSDART00000171386
zgc:194887
zgc:194887
chr5_-_32890807 0.14 ENSDART00000007512
pole3
polymerase (DNA directed), epsilon 3 (p17 subunit)
chr8_-_8698607 0.13 ENSDART00000046712
zgc:86609
zgc:86609
chr20_+_15015557 0.13 ENSDART00000039345
myoc
myocilin
chr4_-_16451375 0.13 ENSDART00000192700
ENSDART00000128835
wu:fc23c09
wu:fc23c09
chr20_-_52967878 0.12 ENSDART00000164460
gata4
GATA binding protein 4
chr13_-_31878043 0.12 ENSDART00000187720
syt14a
synaptotagmin XIVa
chr13_-_31878263 0.12 ENSDART00000180411
syt14a
synaptotagmin XIVa
chr9_+_41224100 0.12 ENSDART00000141792
stat1b
signal transducer and activator of transcription 1b
chr25_+_36347126 0.12 ENSDART00000152449
si:ch211-113a14.22
si:ch211-113a14.22
chr23_+_36340520 0.12 ENSDART00000011201
copz1
coatomer protein complex, subunit zeta 1
chr7_+_34297271 0.11 ENSDART00000180342
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr17_+_30546579 0.11 ENSDART00000154385
nhsl1a
NHS-like 1a
chr24_+_2961098 0.11 ENSDART00000163760
ENSDART00000170835
eci2
enoyl-CoA delta isomerase 2
chr6_-_59563597 0.10 ENSDART00000166311
INHBE
inhibin beta E subunit
chr7_+_48675347 0.10 ENSDART00000157917
ENSDART00000185580
trpm5
transient receptor potential cation channel, subfamily M, member 5
chr1_-_58868306 0.10 ENSDART00000166615
dnm2b
dynamin 2b
chr19_+_32158010 0.10 ENSDART00000005255
mrpl53
mitochondrial ribosomal protein L53
chr16_+_28601974 0.10 ENSDART00000018235
crot
carnitine O-octanoyltransferase
chr25_-_19420949 0.09 ENSDART00000181338
map1ab
microtubule-associated protein 1Ab
chr15_+_404891 0.09 ENSDART00000155682
nipsnap2
nipsnap homolog 2
chr3_+_30257582 0.09 ENSDART00000159497
ENSDART00000103457
ENSDART00000121883
mybpc2a
myosin binding protein C, fast type a
chr4_-_20243021 0.09 ENSDART00000048023
cacna2d4a
calcium channel, voltage-dependent, alpha 2/delta subunit 4a
chr7_-_6279138 0.08 ENSDART00000173299
si:ch211-220f21.2
si:ch211-220f21.2
chr23_-_24488696 0.08 ENSDART00000155593
tmem82
transmembrane protein 82
chr17_-_20711735 0.07 ENSDART00000150056
ank3b
ankyrin 3b
chr18_+_27926839 0.06 ENSDART00000191835
hipk3b
homeodomain interacting protein kinase 3b
chr19_+_20274944 0.06 ENSDART00000151237
oxnad1
oxidoreductase NAD-binding domain containing 1
chr20_-_34164278 0.06 ENSDART00000153128
hmcn1
hemicentin 1
chr15_+_28268135 0.06 ENSDART00000152536
ENSDART00000188550
myo1cb
myosin Ic, paralog b
chr20_-_25877793 0.05 ENSDART00000177333
ENSDART00000184619
exoc1
exocyst complex component 1
chr9_-_1939232 0.05 ENSDART00000146131
hoxd3a
homeobox D3a
chr7_+_11459235 0.04 ENSDART00000159611
il16
interleukin 16
chr21_-_19006631 0.04 ENSDART00000080269
ENSDART00000191682
pgam2
phosphoglycerate mutase 2 (muscle)
chr5_+_38200807 0.04 ENSDART00000100769
hsd20b2
hydroxysteroid (20-beta) dehydrogenase 2
chr15_+_17031111 0.03 ENSDART00000175378
plin2
perilipin 2
chr10_-_17284055 0.03 ENSDART00000167464
GNAZ
G protein subunit alpha z
chr22_+_9239831 0.03 ENSDART00000133720
si:ch211-250k18.5
si:ch211-250k18.5
chr20_+_46286082 0.03 ENSDART00000073519
taar14f
trace amine associated receptor 14f
chr5_-_23362602 0.03 ENSDART00000137120
gria3a
glutamate receptor, ionotropic, AMPA 3a
chr1_+_40802454 0.03 ENSDART00000193568
cpz
carboxypeptidase Z
chr7_+_23940933 0.03 ENSDART00000173628
si:dkey-183c6.7
si:dkey-183c6.7
chr22_+_38229321 0.02 ENSDART00000132670
ENSDART00000104504
si:ch211-284e20.8
si:ch211-284e20.8
chr1_-_52292235 0.02 ENSDART00000132638
si:dkey-121b10.7
si:dkey-121b10.7
chr6_+_60036767 0.02 ENSDART00000155009
tgm8
transglutaminase 8
chr23_-_16734009 0.02 ENSDART00000125449
si:ch211-224l10.4
si:ch211-224l10.4
chr19_+_2275019 0.02 ENSDART00000136138
itgb8
integrin, beta 8
chr13_-_28688104 0.02 ENSDART00000133827
pcgf6
polycomb group ring finger 6
chr22_-_3595439 0.01 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr1_-_17797802 0.01 ENSDART00000041215
sorbs2a
sorbin and SH3 domain containing 2a
chr5_+_36974931 0.01 ENSDART00000193063
gjd1a
gap junction protein delta 1a
chr16_-_29480335 0.01 ENSDART00000148930
lingo4b
leucine rich repeat and Ig domain containing 4b
chr18_+_15182965 0.00 ENSDART00000137018
si:ch73-62b13.1
si:ch73-62b13.1
chr11_+_30981777 0.00 ENSDART00000148949
cacna1ab
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
chr1_+_25848231 0.00 ENSDART00000027973
fabp2
fatty acid binding protein 2, intestinal
chr19_-_43552252 0.00 ENSDART00000138308
gpr186
G protein-coupled receptor 186

Network of associatons between targets according to the STRING database.

First level regulatory network of pparaa+pparda+ppardb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0009750 response to fructose(GO:0009750)
0.1 1.3 GO:0006603 phosphagen metabolic process(GO:0006599) phosphocreatine metabolic process(GO:0006603) phosphagen biosynthetic process(GO:0042396) phosphocreatine biosynthetic process(GO:0046314)
0.1 0.7 GO:0034633 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.1 0.4 GO:0071548 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.1 0.6 GO:0006574 valine catabolic process(GO:0006574)
0.1 0.3 GO:0039531 RIG-I signaling pathway(GO:0039529) regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway(GO:0039531) regulation of RIG-I signaling pathway(GO:0039535)
0.1 0.3 GO:1902001 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.1 1.1 GO:0032309 icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.1 0.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 0.7 GO:0006735 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.6 GO:0060142 regulation of syncytium formation by plasma membrane fusion(GO:0060142)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.8 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0048795 swim bladder morphogenesis(GO:0048795)
0.0 0.2 GO:0019885 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous antigen(GO:0019883) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 1.6 GO:0002088 lens development in camera-type eye(GO:0002088)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005592 collagen type XI trimer(GO:0005592)
0.1 0.7 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.5 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0072546 ER membrane protein complex(GO:0072546)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity(GO:0008442)
0.1 0.3 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.1 1.3 GO:0016775 creatine kinase activity(GO:0004111) phosphotransferase activity, nitrogenous group as acceptor(GO:0016775)
0.1 0.7 GO:0034632 retinol transporter activity(GO:0034632)
0.1 0.7 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 0.8 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.7 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 1.1 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.8 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.3 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.3 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.6 GO:0051020 GTPase binding(GO:0051020)
0.0 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.0 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0016415 octanoyltransferase activity(GO:0016415)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 2.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.3 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.1 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)