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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for pou6f1

Z-value: 0.45

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Transcription factors associated with pou6f1

Gene Symbol Gene ID Gene Info
ENSDARG00000011570 POU class 6 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pou6f1dr11_v1_chr23_-_33702900_337029000.881.2e-06Click!

Activity profile of pou6f1 motif

Sorted Z-values of pou6f1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr21_+_25777425 1.00 ENSDART00000021620
claudin d
chr1_-_53468160 0.96 ENSDART00000143349
zgc:66455
chr7_-_19364813 0.89 ENSDART00000173977
netrin 4
chr16_-_29387215 0.74 ENSDART00000148787
S100 calcium binding protein A1
chr21_-_13690712 0.65 ENSDART00000065817
POU domain, class 5, transcription factor 3
chr7_+_38717624 0.51 ENSDART00000132522
synaptotagmin XIII
chr9_+_34151367 0.47 ENSDART00000143991
G protein-coupled receptor 161
chr15_-_931815 0.45 ENSDART00000106627
ENSDART00000102239
ENSDART00000184754
ENSDART00000186733
zgc:162936
chr15_-_33172246 0.44 ENSDART00000158666
neurobeachin b
chr18_-_43866001 0.40 ENSDART00000150218
trehalase (brush-border membrane glycoprotein)
chr3_+_1219344 0.38 ENSDART00000161945
ribosomal RNA processing 7 homolog A
chr18_-_43866526 0.37 ENSDART00000111309
trehalase (brush-border membrane glycoprotein)
chr10_-_45058886 0.36 ENSDART00000159347
mitochondrial ribosomal protein S24
chr13_+_43400443 0.35 ENSDART00000084321
dishevelled-binding antagonist of beta-catenin 2
chr1_-_51710225 0.35 ENSDART00000057601
ENSDART00000152745
small nuclear ribonucleoprotein polypeptide B2
chr4_-_72609118 0.34 ENSDART00000174077
si:cabz01054396.2
chr2_-_21625493 0.30 ENSDART00000137169
zgc:55781
chr2_-_20981907 0.29 ENSDART00000113384
LYR motif containing 4
chr18_+_34181655 0.29 ENSDART00000130831
ENSDART00000109535
guanine monophosphate synthase
chr18_-_20608025 0.27 ENSDART00000090156
ENSDART00000151980
BCL2 like 13
chr2_-_37312927 0.27 ENSDART00000141214
SKI-like proto-oncogene a
chr5_-_39736383 0.27 ENSDART00000127123
RasGEF domain family, member 1Ba
chr24_-_25096199 0.26 ENSDART00000185076
pleckstrin homology-like domain, family B, member 2b
chr2_+_29249204 0.26 ENSDART00000168957
cadherin 18, type 2a
chr14_-_28565675 0.26 ENSDART00000193961
preproinsulin b
chr14_-_28566238 0.25 ENSDART00000172547
preproinsulin b
chr18_+_3243292 0.25 ENSDART00000166580
p21 protein (Cdc42/Rac)-activated kinase 1
chr9_-_16218097 0.25 ENSDART00000190503
myosin IB
chr7_+_13988075 0.24 ENSDART00000186812
furin (paired basic amino acid cleaving enzyme) a
chr15_-_5720583 0.24 ENSDART00000158034
ENSDART00000190332
ENSDART00000109599
URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
chr16_-_25368048 0.24 ENSDART00000132445
ribosome binding factor A
chr4_-_2380173 0.24 ENSDART00000177727
nucleosome assembly protein 1-like 1
chr7_+_48297842 0.24 ENSDART00000052123
solute carrier family 25, member 44 b
chr24_-_16979728 0.24 ENSDART00000005331
kelch-like family member 15
chr2_+_38892631 0.23 ENSDART00000134040
si:ch211-119o8.4
chr22_-_11829436 0.22 ENSDART00000126784
protein tyrosine phosphatase, non-receptor type 4b
chr12_+_32729470 0.22 ENSDART00000175712
RNA binding fox-1 homolog 3a
chr2_+_29249561 0.20 ENSDART00000099157
cadherin 18, type 2a
chr1_+_50968908 0.19 ENSDART00000150353
ENSDART00000012842
malate dehydrogenase 1Aa, NAD (soluble)
chr1_+_19649545 0.19 ENSDART00000054575
transmembrane protein 192
chr6_-_9676108 0.18 ENSDART00000169915
NOP58 ribonucleoprotein homolog (yeast)
chr17_-_24587686 0.17 ENSDART00000143084
aftiphilin b
chr21_+_40292801 0.17 ENSDART00000174220
si:ch211-218m3.16
chr25_-_8625601 0.17 ENSDART00000155280
zgc:153343
chr25_+_28555584 0.17 ENSDART00000157046
si:ch211-190o6.3
chr7_+_53498152 0.16 ENSDART00000184497
zinc finger protein 609b
chr25_-_20666754 0.16 ENSDART00000158418
C-terminal Src kinase
chr14_+_3287740 0.15 ENSDART00000186290
caudal type homeobox 1a
chr11_+_11303458 0.15 ENSDART00000162486
ENSDART00000160703
si:dkey-23f9.4
chr22_-_11520405 0.15 ENSDART00000063157
solute carrier family 26 (anion exchanger), member 11
chr9_-_6624663 0.15 ENSDART00000092537
si:dkeyp-118h3.5
chr2_-_27619954 0.15 ENSDART00000144826
trimethylguanosine synthase 1
chr3_-_34136368 0.14 ENSDART00000136900
ENSDART00000186125
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr21_-_40938382 0.14 ENSDART00000008593
Yip1 domain family, member 5
chr11_-_14813029 0.13 ENSDART00000004920
ENSDART00000122645
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr1_-_34335752 0.12 ENSDART00000140157
si:dkey-24h22.5
chr3_-_34136778 0.12 ENSDART00000131951
caseinolytic mitochondrial matrix peptidase proteolytic subunit
chr8_+_37168570 0.12 ENSDART00000098636
colony stimulating factor 1b (macrophage)
chr11_+_41981959 0.12 ENSDART00000055707
hairy and enhancer of split-related 15, tandem duplicate 1
chr7_+_41147732 0.12 ENSDART00000185388
poly-U binding splicing factor b
chr25_-_20666328 0.11 ENSDART00000098076
C-terminal Src kinase
chr18_-_40773413 0.11 ENSDART00000133797
vasodilator stimulated phosphoprotein b
chr14_+_46003973 0.11 ENSDART00000145241
ENSDART00000141545
SLU7 homolog, splicing factor
chr24_-_32408404 0.11 ENSDART00000144157
si:ch211-56a11.2
chr22_+_34710473 0.10 ENSDART00000155906
4-hydroxy-2-oxoglutarate aldolase 1
chr14_-_31465905 0.10 ENSDART00000173108
glypican 3
chr22_+_34710036 0.10 ENSDART00000025820
4-hydroxy-2-oxoglutarate aldolase 1
chr2_-_12243213 0.09 ENSDART00000113081
G protein-coupled receptor 158b
chr21_-_30166097 0.09 ENSDART00000130676
heparin-binding EGF-like growth factor b
chr9_-_38036984 0.09 ENSDART00000134574
3-hydroxyacyl-CoA dehydratase 2
chr11_+_33628104 0.09 ENSDART00000165318
thrombospondin, type I, domain containing 7Bb
chr17_+_8799451 0.09 ENSDART00000189814
ENSDART00000191577
tonsoku-like, DNA repair protein
chr18_+_33276609 0.09 ENSDART00000137208
vomeronasal 2 receptor, x3
chr13_+_3938526 0.08 ENSDART00000012759
Yip1 domain family, member 3
chr22_-_15385442 0.08 ENSDART00000090975
transmembrane protein 264
chr13_-_46200240 0.08 ENSDART00000056984
finTRIM family, member 69
chr23_+_45860676 0.07 ENSDART00000012234
synapse associated protein 1
chr4_-_75505048 0.07 ENSDART00000163665
si:dkey-71l4.5
chr9_-_44953349 0.07 ENSDART00000135156
villin 1
chr9_-_1469083 0.07 ENSDART00000144096
RNA binding motif protein 45
chr9_+_11034314 0.07 ENSDART00000032695
acid-sensing (proton-gated) ion channel family member 4a
chr1_+_11992 0.06 ENSDART00000161842
centrosomal protein 97
chr22_+_2793382 0.06 ENSDART00000144980
si:dkey-20i20.8
chr1_+_52633367 0.06 ENSDART00000134658
solute carrier family 44 (choline transporter), member 1a
chr1_+_33634186 0.06 ENSDART00000075626
5-hydroxytryptamine (serotonin) receptor 1Fb
chr4_-_19028861 0.06 ENSDART00000166374
si:dkey-31f5.11
chr4_+_25431990 0.06 ENSDART00000176982
protein kinase C, theta
chr10_+_36345176 0.06 ENSDART00000099397
odorant receptor, family C, subfamily 105, member 1
chr21_-_7953792 0.06 ENSDART00000124486
si:dkey-163m14.10
chr3_+_40796110 0.05 ENSDART00000014729
actin related protein 2/3 complex, subunit 1A
chr6_+_52938534 0.05 ENSDART00000174150

chr2_-_21349425 0.05 ENSDART00000171699
hedgehog acyltransferase like, a
chr1_+_58535306 0.05 ENSDART00000165673
zgc:172091
chr4_+_14826299 0.05 ENSDART00000067035
shisa like 1a
chr4_-_31784872 0.05 ENSDART00000182911
si:dkey-19c16.12
chr13_-_24825691 0.05 ENSDART00000142745
STE20-like kinase a
chr17_-_30366705 0.04 ENSDART00000154906
si:ch211-139l2.1
chr24_+_22485710 0.04 ENSDART00000146058
si:dkey-40h20.1
chr2_+_29842878 0.04 ENSDART00000131376
si:ch211-207d6.2
chr2_-_57941037 0.04 ENSDART00000131420
si:dkeyp-68b7.5
chr13_+_18533005 0.04 ENSDART00000136024
finTRIM family, member 14-like
chr4_+_47751483 0.04 ENSDART00000160043
si:ch211-196f19.1
chr19_+_10847118 0.04 ENSDART00000189784
apolipoprotein A-IV a
chr13_+_25434932 0.04 ENSDART00000128562
si:dkey-51a16.9
chr21_-_26918901 0.04 ENSDART00000100685
leucine rich repeat and fibronectin type III domain containing 4a
chr23_+_35650771 0.03 ENSDART00000005158
cyclin T1
chr17_-_49443399 0.03 ENSDART00000155293
glycoprotein hormones, alpha polypeptide
chr15_-_33640890 0.03 ENSDART00000167705
StAR-related lipid transfer (START) domain containing 13b
chr17_-_2817035 0.03 ENSDART00000152002
G protein-coupled receptor 65
chr22_+_25672155 0.03 ENSDART00000087769
si:ch211-250e5.2
chr15_+_46357080 0.03 ENSDART00000155571
ENSDART00000156541
wu:fb18f06
chr22_+_2504524 0.03 ENSDART00000136686
zinc finger protein 1170
chr16_-_11798994 0.03 ENSDART00000135408
cornifelin
chr5_-_35953472 0.02 ENSDART00000143448
relaxin/insulin-like family peptide receptor 2, like
chr4_+_5848229 0.02 ENSDART00000161101
ENSDART00000067357
LYR motif containing 5a
chr19_-_5265155 0.02 ENSDART00000145003
perforin 1.3
chr16_-_21038015 0.02 ENSDART00000059239
sorting nexin 10b
chr2_+_6243144 0.02 ENSDART00000058258
guanine nucleotide binding protein (G protein), gamma 5
chr3_-_21288202 0.02 ENSDART00000191766
ENSDART00000187319
family with sequence similarity 171, member A2a
chr15_+_24704798 0.02 ENSDART00000192470
si:dkey-151p21.7
chr1_+_45121393 0.02 ENSDART00000142702
mucin 13a, cell surface associated
chr21_+_25231160 0.02 ENSDART00000063089
ENSDART00000139127
guanine nucleotide binding protein (G protein), gamma 8
chr6_-_54107269 0.02 ENSDART00000190017
hyaluronoglucosaminidase 2a
chr2_-_27319914 0.02 ENSDART00000182011
dermatan sulfate epimerase-like a
chr9_-_44953664 0.02 ENSDART00000188558
ENSDART00000185210
villin 1
chr3_-_28250722 0.02 ENSDART00000165936
RNA binding fox-1 homolog 1
chr9_-_22339582 0.02 ENSDART00000134805
crystallin, gamma M2d1
chr18_+_50523870 0.01 ENSDART00000151593
ubiquitin-like 7b (bone marrow stromal cell-derived)
chr20_-_10288156 0.01 ENSDART00000064110
si:dkey-63b1.1
chr15_-_16098531 0.01 ENSDART00000080377
aldolase C, fructose-bisphosphate, a
chr24_-_21404367 0.01 ENSDART00000152093
ATPase phospholipid transporting 8A2
chr17_+_12698532 0.00 ENSDART00000064509
ENSDART00000136830
stathmin-like 4, like
chr25_+_3648497 0.00 ENSDART00000160017

chr1_+_11822 0.00 ENSDART00000166393
centrosomal protein 97
chr25_+_31958911 0.00 ENSDART00000191394
ENSDART00000090727
ENSDART00000185893
dual oxidase
chr3_+_33341640 0.00 ENSDART00000186352
peptide YYa

Network of associatons between targets according to the STRING database.

First level regulatory network of pou6f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0005991 trehalose metabolic process(GO:0005991)
0.2 1.0 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.2 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.1 0.6 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.1 0.4 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.1 0.3 GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.0 0.1 GO:1903646 regulation of protein folding(GO:1903332) positive regulation of protein folding(GO:1903334) regulation of chaperone-mediated protein folding(GO:1903644) positive regulation of chaperone-mediated protein folding(GO:1903646)
0.0 0.9 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.3 GO:0003232 bulbus arteriosus development(GO:0003232)
0.0 0.2 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.9 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.3 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.0 0.2 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.0 0.1 GO:0072673 lamellipodium morphogenesis(GO:0072673) regulation of lamellipodium morphogenesis(GO:2000392)
0.0 0.2 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.0 GO:0060262 N-terminal protein palmitoylation(GO:0006500) negative regulation of lipoprotein metabolic process(GO:0050748) regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.0 0.3 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0060976 coronary vasculature development(GO:0060976)
0.0 0.0 GO:0010893 positive regulation of steroid biosynthetic process(GO:0010893)
0.0 0.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.0 0.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.1 GO:2000273 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) positive regulation of receptor activity(GO:2000273)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0032545 CURI complex(GO:0032545) UTP-C complex(GO:0034456)
0.0 0.1 GO:0072380 TRC complex(GO:0072380)
0.0 0.9 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0032433 filopodium tip(GO:0032433)
0.0 0.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.4 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.2 GO:0005903 brush border(GO:0005903)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.0 0.4 GO:0030619 U1 snRNA binding(GO:0030619)
0.0 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.3 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:0018812 3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.3 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.0 0.5 GO:0001786 phosphatidylserine binding(GO:0001786)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 0.3 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis