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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for pou2f3
Z-value: 1.25
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Transcription factors associated with pou2f3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pou2f3 | dr11_v1_chr5_+_58550291_58550291 | 0.69 | 1.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_38049130 Show fit | 2.97 |
ENSDART00000097533
|
WW domain containing transcription regulator 1 |
|
| chr5_-_6567464 Show fit | 2.38 |
ENSDART00000184985
|
tankyrase 1 binding protein 1 |
|
| chr21_+_36623162 Show fit | 2.36 |
ENSDART00000027459
|
G protein-coupled receptor kinase 6 |
|
| chr10_+_39084354 Show fit | 2.14 |
ENSDART00000158245
|
si:ch73-1a9.3 |
|
| chr17_-_6451801 Show fit | 2.10 |
ENSDART00000064700
|
alpha-L-fucosidase 2 |
|
| chr25_+_3058924 Show fit | 1.96 |
ENSDART00000029580
|
ferritin, heavy polypeptide 1b |
|
| chr7_+_13582256 Show fit | 1.65 |
ENSDART00000158477
|
ankyrin repeat and death domain containing 1A |
|
| chr21_-_37733571 Show fit | 1.59 |
ENSDART00000176214
|
membrane protein, palmitoylated 1 |
|
| chr18_-_29962234 Show fit | 1.54 |
ENSDART00000144996
|
si:ch73-103b9.2 |
|
| chr7_-_1504382 Show fit | 1.52 |
ENSDART00000172770
|
si:zfos-405g10.4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of pou2f3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.0 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.3 | 2.1 | GO:0016139 | glycoside metabolic process(GO:0016137) glycoside catabolic process(GO:0016139) |
| 0.3 | 2.0 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.0 | 2.0 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 1.9 | GO:0008285 | negative regulation of cell proliferation(GO:0008285) |
| 0.3 | 1.8 | GO:0032743 | neutrophil apoptotic process(GO:0001781) regulation of T-helper 1 type immune response(GO:0002825) positive regulation of T-helper 1 type immune response(GO:0002827) negative regulation of type 2 immune response(GO:0002829) inflammatory cell apoptotic process(GO:0006925) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of phospholipase A2 activity(GO:0032429) interleukin-2 production(GO:0032623) regulation of interleukin-2 production(GO:0032663) positive regulation of interleukin-2 production(GO:0032743) myeloid cell apoptotic process(GO:0033028) regulation of neutrophil apoptotic process(GO:0033029) positive regulation of neutrophil apoptotic process(GO:0033031) regulation of myeloid cell apoptotic process(GO:0033032) positive regulation of myeloid cell apoptotic process(GO:0033034) T-helper 1 type immune response(GO:0042088) positive regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043372) T-helper 1 cell differentiation(GO:0045063) positive regulation of T-helper cell differentiation(GO:0045624) regulation of T-helper 1 cell differentiation(GO:0045625) positive regulation of T-helper 1 cell differentiation(GO:0045627) regulation of T-helper 2 cell differentiation(GO:0045628) negative regulation of T-helper 2 cell differentiation(GO:0045629) positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of alpha-beta T cell differentiation(GO:0046638) neutrophil clearance(GO:0097350) negative regulation of phospholipase A2 activity(GO:1900138) positive regulation of CD4-positive, alpha-beta T cell activation(GO:2000516) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
| 0.2 | 1.3 | GO:0071800 | podosome assembly(GO:0071800) |
| 0.2 | 1.3 | GO:0030242 | pexophagy(GO:0030242) |
| 0.2 | 1.2 | GO:1901906 | diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911) |
| 0.4 | 1.1 | GO:0071830 | chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.5 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 2.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 2.3 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.1 | 1.8 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.3 | 1.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.0 | 1.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 1.1 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 1.1 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 1.1 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 1.1 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 3.5 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.1 | 2.9 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.1 | 2.4 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.7 | 2.1 | GO:0004560 | alpha-L-fucosidase activity(GO:0004560) fucosidase activity(GO:0015928) |
| 0.2 | 2.0 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.0 | 1.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.3 | 1.8 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 1.7 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.1 | 1.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 1.6 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.1 | 1.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 1.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 0.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 0.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.6 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 2.4 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.0 | 2.2 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.0 | 1.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 1.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.0 | 1.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.1 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.0 | 1.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.0 | 1.0 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 0.9 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |