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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for plag1+plagx

Z-value: 0.24

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Transcription factors associated with plag1+plagx

Gene Symbol Gene ID Gene Info
plagx
ENSDARG00000036855 pleiomorphic adenoma gene X
plag1
ENSDARG00000051926 pleiomorphic adenoma gene 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
plag1dr11_v1_chr7_+_58730201_58730201-0.437.3e-02Click!
plagxdr11_v1_chr23_+_32011768_320117680.361.4e-01Click!

Activity profile of plag1+plagx motif

Sorted Z-values of plag1+plagx motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_568819 0.73 ENSDART00000173716
nrxn2b
neurexin 2b
chr22_-_15957041 0.68 ENSDART00000149236
ENSDART00000187500
ENSDART00000176304
ENSDART00000080047
ENSDART00000190068
eps15l1a
epidermal growth factor receptor pathway substrate 15-like 1a
chr16_-_35586401 0.60 ENSDART00000169868
ENSDART00000166606
ENSDART00000162562
scmh1
Scm polycomb group protein homolog 1
chr19_-_4010263 0.52 ENSDART00000159605
ENSDART00000165541
map7d1b
MAP7 domain containing 1b
chr21_+_7823146 0.51 ENSDART00000030579
crhbp
corticotropin releasing hormone binding protein
chr7_+_44608224 0.30 ENSDART00000005033
cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr7_-_41403022 0.29 ENSDART00000174285
BX322787.1

chr24_+_42131564 0.24 ENSDART00000153854
wwp1
WW domain containing E3 ubiquitin protein ligase 1
chr9_+_22359919 0.24 ENSDART00000009591
crygs4
crystallin, gamma S4
chr1_+_49568335 0.23 ENSDART00000142957
col17a1a
collagen, type XVII, alpha 1a
chr11_+_13630107 0.23 ENSDART00000172220
si:ch211-1a19.3
si:ch211-1a19.3
chr7_+_39399747 0.21 ENSDART00000147037
tnni2b.1
troponin I type 2b (skeletal, fast), tandem duplicate 1
chr9_-_3496548 0.20 ENSDART00000102876
cybrd1
cytochrome b reductase 1
chr21_+_5801105 0.18 ENSDART00000151225
ENSDART00000184487
ccng2
cyclin G2
chr24_+_35564668 0.17 ENSDART00000122734
cebpd
CCAAT/enhancer binding protein (C/EBP), delta
chr13_+_11876437 0.16 ENSDART00000179753
trim8a
tripartite motif containing 8a
chr7_+_44608478 0.15 ENSDART00000149981
cmtm3
CKLF-like MARVEL transmembrane domain containing 3
chr14_-_33177935 0.14 ENSDART00000180583
ENSDART00000078856
dlg3
discs, large homolog 3 (Drosophila)
chr4_+_59320243 0.13 ENSDART00000150611
znf1084
zinc finger protein 1084
chr24_-_26383978 0.13 ENSDART00000031426
skilb
SKI-like proto-oncogene b
chr2_+_2470687 0.13 ENSDART00000184024
ENSDART00000061955
myl13
myosin, light chain 13
chr20_-_14665002 0.13 ENSDART00000152816
scrn2
secernin 2
chr12_+_16440708 0.11 ENSDART00000113810
ankrd1b
ankyrin repeat domain 1b (cardiac muscle)
chr20_+_28245164 0.10 ENSDART00000103320
dll4
delta-like 4 (Drosophila)
chr6_-_35401282 0.10 ENSDART00000127612
rgs5a
regulator of G protein signaling 5a
chr4_+_21741228 0.09 ENSDART00000112035
ENSDART00000127664
myf5
myogenic factor 5
chr21_-_21020708 0.08 ENSDART00000064032
eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
chr23_+_43954809 0.08 ENSDART00000164080
corin
corin, serine peptidase
chr6_-_29105727 0.07 ENSDART00000184355
fam69ab
family with sequence similarity 69, member Ab
chr19_+_37620342 0.07 ENSDART00000158960
thsd7aa
thrombospondin, type I, domain containing 7Aa
chr14_-_1958994 0.07 ENSDART00000161783
pcdh2g5
protocadherin 2 gamma 5
chr24_-_21490628 0.06 ENSDART00000181546
atp8a2
ATPase phospholipid transporting 8A2
chr16_+_11834516 0.05 ENSDART00000146611
cxcr3.3
chemokine (C-X-C motif) receptor 3, tandem duplicate 3
chr16_-_36798783 0.04 ENSDART00000145697
calb1
calbindin 1
chr12_-_30345444 0.03 ENSDART00000152985
vwa2
von Willebrand factor A domain containing 2
chr23_+_44732863 0.03 ENSDART00000160044
ENSDART00000172268
atp1b2a
ATPase Na+/K+ transporting subunit beta 2a
chr24_-_35534273 0.03 ENSDART00000026578
ube2v2
ubiquitin-conjugating enzyme E2 variant 2
chr12_-_25916530 0.02 ENSDART00000186386
sncgb
synuclein, gamma b (breast cancer-specific protein 1)
chr19_-_20093341 0.01 ENSDART00000129917
mpp6b
membrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6)
chr5_-_23878809 0.01 ENSDART00000160603
si:ch211-135f11.4
si:ch211-135f11.4
chr22_-_4798738 0.01 ENSDART00000114465
zgc:195170
zgc:195170
chr1_+_47446032 0.01 ENSDART00000126904
ENSDART00000007262
gja8b
gap junction protein alpha 8 paralog b
chr2_+_13069168 0.01 ENSDART00000192832
prkag2b
protein kinase, AMP-activated, gamma 2 non-catalytic subunit b
chr12_-_46112892 0.00 ENSDART00000187128
ENSDART00000114268
zgc:153932
zgc:153932

Network of associatons between targets according to the STRING database.

First level regulatory network of plag1+plagx

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0090278 negative regulation of peptide secretion(GO:0002792) negative regulation of peptide hormone secretion(GO:0090278)
0.1 0.2 GO:0010039 response to iron ion(GO:0010039)
0.0 0.1 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.0 0.2 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0 0.1 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 0.5 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.0 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.2 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport