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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for pknox2

Z-value: 0.82

Motif logo

Transcription factors associated with pknox2

Gene Symbol Gene ID Gene Info
ENSDARG00000055349 pbx/knotted 1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pknox2dr11_v1_chr10_-_31220558_312205580.581.1e-02Click!

Activity profile of pknox2 motif

Sorted Z-values of pknox2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_41468892 3.44 ENSDART00000173099
ENSDART00000003170
MID1 interacting protein 1, like
chr12_-_48168135 2.92 ENSDART00000186624
phosphatase domain containing, paladin 1a
chr2_-_11027258 2.87 ENSDART00000081072
ENSDART00000193824
ENSDART00000187036
ENSDART00000097741
single stranded DNA binding protein 3a
chr3_+_7771420 2.70 ENSDART00000156809
ENSDART00000156309
hook microtubule-tethering protein 2
chr8_-_32385989 2.62 ENSDART00000143716
ENSDART00000098850
lipase, endothelial
chr8_-_18613948 2.21 ENSDART00000089172
coproporphyrinogen oxidase
chr5_-_32489796 2.12 ENSDART00000168870
G protein-coupled receptor 107
chr4_-_20081621 2.11 ENSDART00000024647
DENN/MADD domain containing 6B
chr17_-_7792376 2.05 ENSDART00000064655
zinc finger and BTB domain containing 2a
chr23_+_13528053 1.98 ENSDART00000162217
uridine-cytidine kinase 1-like 1b
chr22_+_25086942 1.89 ENSDART00000061117
ribosome binding protein 1b
chr22_-_37834312 1.88 ENSDART00000076128
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr4_+_9279515 1.84 ENSDART00000048707
SLIT-ROBO Rho GTPase activating protein 1b
chr13_-_18011168 1.78 ENSDART00000144813
membrane-associated ring finger (C3HC4) 8
chr4_+_9279784 1.77 ENSDART00000014897
SLIT-ROBO Rho GTPase activating protein 1b
chr19_-_30800004 1.76 ENSDART00000128560
ENSDART00000045504
ENSDART00000125893
tRNA isopentenyltransferase 1
chr22_+_25086567 1.72 ENSDART00000192114
ENSDART00000177284
ENSDART00000180296
ENSDART00000190384
ribosome binding protein 1b
chr15_-_28587147 1.70 ENSDART00000156049
slingshot protein phosphatase 2a
chr14_+_30340251 1.67 ENSDART00000148448
microtubule associated tumor suppressor 1a
chr11_-_15874974 1.65 ENSDART00000166551
ENSDART00000129526
ENSDART00000165836
RAP1A, member of RAS oncogene family b
chr7_+_57089354 1.49 ENSDART00000140702
secretory carrier membrane protein 2, like
chr5_-_41124241 1.40 ENSDART00000083561
myotubularin related protein 12
chr3_+_28576173 1.37 ENSDART00000151189
septin 12
chr7_-_26262978 1.36 ENSDART00000137769
adaptor-related protein complex 1, sigma 1 subunit
chr4_+_26056548 1.36 ENSDART00000171204
si:ch211-244b2.1
chr7_-_26263183 1.35 ENSDART00000079357
ENSDART00000190369
ENSDART00000193154
ENSDART00000101109
adaptor-related protein complex 1, sigma 1 subunit
chr5_-_23675222 1.29 ENSDART00000135153
si:dkey-110k5.6
chr8_-_4760723 1.28 ENSDART00000064201
CDC45 cell division cycle 45 homolog (S. cerevisiae)
chr21_-_38153824 1.27 ENSDART00000151226
Kruppel-like factor 5 like
chr17_-_23673864 1.21 ENSDART00000104738
ENSDART00000128958
phosphatase and tensin homolog A
chr10_+_28160265 1.19 ENSDART00000022484
ring finger protein, transmembrane 1
chr11_-_10456387 1.17 ENSDART00000011087
ENSDART00000081827
epithelial cell transforming 2
chr23_-_21758253 1.12 ENSDART00000046613
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr22_-_17677947 1.11 ENSDART00000139911
tight junction protein 3
chr5_+_27137473 1.08 ENSDART00000181833
unc-5 netrin receptor Db
chr23_-_31060350 1.06 ENSDART00000145598
ENSDART00000191491
si:ch211-197l9.5
chr14_+_49152341 1.06 ENSDART00000084114
nuclear receptor binding SET domain protein 1a
chr7_-_56766100 1.05 ENSDART00000189934
casein kinase 2, alpha prime polypeptide a
chr13_+_22712406 1.05 ENSDART00000132847
si:ch211-134m17.9
chr23_+_33963619 0.97 ENSDART00000140666
ENSDART00000084792
pyridoxal phosphate binding protein
chr9_+_34151367 0.97 ENSDART00000143991
G protein-coupled receptor 161
chr20_+_27713210 0.97 ENSDART00000132222
zinc finger and BTB domain containing 1
chr15_-_20528494 0.97 ENSDART00000048423
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
chr20_+_27712714 0.96 ENSDART00000008306
zinc finger and BTB domain containing 1
chr23_-_4019928 0.93 ENSDART00000021062
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr7_-_29723761 0.93 ENSDART00000173560
vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr16_-_42770064 0.92 ENSDART00000112879
solute carrier family 4, sodium bicarbonate cotransporter, member 7
chr23_-_29667544 0.91 ENSDART00000059339
calsyntenin 1
chr23_-_4019699 0.90 ENSDART00000159780
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr8_+_25959940 0.90 ENSDART00000143011
ENSDART00000140626
si:dkey-72l14.4
chr10_+_10738880 0.89 ENSDART00000004181
solute carrier family 27 (fatty acid transporter), member 4
chr7_-_19369002 0.84 ENSDART00000165680
netrin 4
chr3_-_40836081 0.83 ENSDART00000143135
WD repeat domain, phosphoinositide interacting 2
chr20_+_21391181 0.82 ENSDART00000185158
ENSDART00000049586
ENSDART00000024922
jagged 2b
chr12_-_17201028 0.82 ENSDART00000020541
lipase, gastric
chr2_-_41723487 0.81 ENSDART00000170171
zgc:110158
chr10_+_20590190 0.81 ENSDART00000131819
leucine zipper-EF-hand containing transmembrane protein 2
chr5_-_13766651 0.78 ENSDART00000134064
MAX dimerization protein 1
chr19_-_81477 0.76 ENSDART00000159815
heterogeneous nuclear ribonucleoprotein R
chr23_+_39963599 0.75 ENSDART00000166539
FYVE and coiled-coil domain containing 1a
chr2_+_19195841 0.74 ENSDART00000163137
ENSDART00000161095
ELOVL fatty acid elongase 1a
chr5_-_18911114 0.73 ENSDART00000014434
bri3 binding protein
chr10_+_20589969 0.73 ENSDART00000183042
leucine zipper-EF-hand containing transmembrane protein 2
chr7_+_30725759 0.71 ENSDART00000127131
myotubularin related protein 10
chr20_-_20270191 0.71 ENSDART00000009356
protein phosphatase 2, regulatory subunit B', epsilon isoform a
chr8_+_44623540 0.70 ENSDART00000141513
G protein-coupled receptor kinase 5 like
chr2_-_41723165 0.70 ENSDART00000155577
zgc:110158
chr10_+_36695597 0.69 ENSDART00000169015
ENSDART00000171392
RAB6A, member RAS oncogene family
chr19_+_25465025 0.68 ENSDART00000018553
replication protein A3
chr9_+_6009077 0.68 ENSDART00000057484
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2a
chr8_-_17184482 0.64 ENSDART00000025803
polymerase (DNA directed), alpha 2
chr18_+_22793743 0.64 ENSDART00000150106
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
chr23_+_1661743 0.63 ENSDART00000044776
syntaxin binding protein 3
chr7_-_56766973 0.62 ENSDART00000020967
casein kinase 2, alpha prime polypeptide a
chr14_-_689841 0.61 ENSDART00000125969
ubiquitin-conjugating enzyme E2Ka (UBC1 homolog, yeast)
chr17_-_11418513 0.61 ENSDART00000064412
ENSDART00000151847
AT rich interactive domain 4A (RBP1-like)
chr15_+_23528010 0.61 ENSDART00000152786
si:dkey-182i3.8
chr9_+_27876146 0.61 ENSDART00000133997
armadillo repeat containing 8
chr17_-_14780578 0.60 ENSDART00000154690
si:ch211-266o15.1
chr22_+_18316144 0.58 ENSDART00000137985
GATA zinc finger domain containing 2Ab
chr10_+_37500234 0.57 ENSDART00000132096
ENSDART00000099473
musashi RNA-binding protein 2a
chr17_-_11417904 0.55 ENSDART00000103228
AT rich interactive domain 4A (RBP1-like)
chr10_+_42521943 0.54 ENSDART00000010420
ENSDART00000075303
ARP1 actin related protein 1, centractin
chr2_-_38117538 0.53 ENSDART00000013676
chromodomain helicase DNA binding protein 8
chr9_-_12885201 0.53 ENSDART00000124957
ankyrin repeat and zinc finger domain containing 1
chr5_+_72145468 0.53 ENSDART00000148626
c-abl oncogene 1, non-receptor tyrosine kinase
chr14_+_29941266 0.53 ENSDART00000112757
family with sequence similarity 149 member A
chr25_-_21894317 0.52 ENSDART00000089642
F-box protein 31
chr13_-_7233811 0.51 ENSDART00000162026
ninein-like
chr24_+_33392698 0.50 ENSDART00000122579
si:ch73-173p19.1
chr13_-_42749916 0.48 ENSDART00000140019
calpain 2, (m/II) large subunit a
chr3_+_14463941 0.47 ENSDART00000170927
calponin 1, basic, smooth muscle, b
chr14_-_21238046 0.47 ENSDART00000129743
si:ch211-175m2.5
chr13_+_35765317 0.46 ENSDART00000100156
ENSDART00000167650
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
chr7_+_30725473 0.46 ENSDART00000085716
myotubularin related protein 10
chr20_-_28433990 0.44 ENSDART00000182824
ENSDART00000193381
WD repeat domain 21
chr15_+_23528310 0.42 ENSDART00000152523
si:dkey-182i3.8
chr20_+_32478151 0.42 ENSDART00000145269
osteopetrosis associated transmembrane protein 1
chr5_-_35200590 0.41 ENSDART00000051271
FCH domain only 2
chr16_+_44768361 0.41 ENSDART00000036302
uroplakin 1a
chr4_+_25693463 0.41 ENSDART00000132864
acyl-CoA thioesterase 18
chr16_-_7239457 0.40 ENSDART00000148992
ENSDART00000149260
5'-nucleotidase, cytosolic IIIA
chr17_+_33999630 0.39 ENSDART00000167085
ENSDART00000155030
ENSDART00000168522
ENSDART00000191799
ENSDART00000189684
ENSDART00000153942
ENSDART00000187272
ENSDART00000127692
gephyrin a
chr2_+_15128418 0.33 ENSDART00000141921
Rho GTPase activating protein 29b
chr17_+_27158706 0.33 ENSDART00000151829
ribosomal protein S6 kinase a, polypeptide 1
chr21_-_34658266 0.33 ENSDART00000023038
dachshund a
chr15_-_46718759 0.32 ENSDART00000085926
ENSDART00000154577
zgc:162872
chr19_+_18799319 0.30 ENSDART00000171843
dimethylarginine dimethylaminohydrolase 2
chr2_+_30489846 0.30 ENSDART00000145732
membrane-associated ring finger (C3HC4) 6
chr12_-_33659328 0.29 ENSDART00000153457
transmembrane protein 94
chr22_-_21046843 0.28 ENSDART00000133982
single stranded DNA binding protein 4
chr5_+_6796291 0.27 ENSDART00000166868
ENSDART00000165308
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr11_+_5880562 0.26 ENSDART00000129663
ENSDART00000130768
ENSDART00000160909
DAZ associated protein 1
chr25_+_3549401 0.26 ENSDART00000166312
coiled-coil domain containing 77
chr20_-_28433616 0.26 ENSDART00000169289
WD repeat domain 21
chr5_+_19320554 0.25 ENSDART00000165119
RUN and SH3 domain containing 2
chr22_-_21046654 0.23 ENSDART00000064902
single stranded DNA binding protein 4
chr11_+_28218141 0.23 ENSDART00000043756
eph receptor B2b
chr16_-_31622777 0.23 ENSDART00000137311
ENSDART00000002930
PHD finger protein 20 like 1
chr20_+_329032 0.20 ENSDART00000036635
FYN proto-oncogene, Src family tyrosine kinase b
chr6_+_41452979 0.15 ENSDART00000007353
WD repeat domain 82
chr20_-_27857676 0.15 ENSDART00000192934
synapse differentiation inducing 1-like
chr12_-_22039350 0.14 ENSDART00000153187
thyroid hormone receptor alpha b
chr1_+_19849168 0.13 ENSDART00000111454
si:dkey-82j4.2
chr23_+_24705424 0.13 ENSDART00000104029
C1q and TNF related 12
chr13_+_45524475 0.11 ENSDART00000074567
ENSDART00000019113
macoilin 1b
chr25_+_14870043 0.11 ENSDART00000035714
ENSDART00000171835
DnaJ (Hsp40) homolog, subfamily C, member 24
chr3_-_20793655 0.10 ENSDART00000163473
ENSDART00000159457
speckle-type POZ protein
chr22_-_22231720 0.09 ENSDART00000160165
adaptor-related protein complex 3, delta 1 subunit
chr7_-_66864756 0.09 ENSDART00000184462
ENSDART00000189424
adenosine monophosphate deaminase 3a
chr1_-_14234076 0.09 ENSDART00000040049
calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 2
chr11_-_19598809 0.09 ENSDART00000110499
ataxin 7
chr16_-_563732 0.08 ENSDART00000183394
iroquois homeobox 2a
chr24_+_29352039 0.07 ENSDART00000101641
protein arginine methyltransferase 6
chr16_-_563235 0.07 ENSDART00000016303
iroquois homeobox 2a
chr19_+_42693855 0.07 ENSDART00000136873
cytoplasmic linker associated protein 2
chr3_-_30384353 0.06 ENSDART00000186832
leucine rich repeat containing 4Ba
chr5_+_22307605 0.05 ENSDART00000138154
Rho GTPase activating protein 20b
chr11_+_2506516 0.05 ENSDART00000130886
ENSDART00000189767
si:ch73-190f16.2
chr2_+_394166 0.05 ENSDART00000155733
myosin light chain kinase family, member 4a
chr23_+_18103080 0.04 ENSDART00000010270
major facilitator superfamily domain containing 4Ab
chr23_+_34005792 0.04 ENSDART00000132668
si:ch211-207e14.4
chr15_+_16897554 0.04 ENSDART00000154679
yippee-like 2b
chr22_-_23253252 0.04 ENSDART00000175556
LIM homeobox 9
chr6_+_38381957 0.04 ENSDART00000087300
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr12_-_44307963 0.03 ENSDART00000161009
si:ch73-329n5.1
chr20_-_46114467 0.03 ENSDART00000126495
trace amine associated receptor 12i
chr15_+_21862295 0.03 ENSDART00000154449
ENSDART00000180774
si:dkey-103g5.3
chr13_+_33655404 0.03 ENSDART00000023379
mitochondrial genome maintenance exonuclease 1
chr19_-_9712530 0.02 ENSDART00000134816
solute carrier family 2 (facilitated glucose transporter), member 3a
chr8_+_45294767 0.01 ENSDART00000191527
ubiquitin associated protein 2b
chr9_+_33267211 0.01 ENSDART00000025635
ubiquitin specific peptidase 9
chr24_-_21511737 0.01 ENSDART00000109587
ring finger protein (C3H2C3 type) 6
chr23_-_11128601 0.01 ENSDART00000131232
contactin 3a, tandem duplicate 2
chr4_-_16345227 0.00 ENSDART00000079521
keratocan

Network of associatons between targets according to the STRING database.

First level regulatory network of pknox2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.3 1.7 GO:1902804 negative regulation of neurotransmitter secretion(GO:0046929) response to cAMP(GO:0051591) cellular response to cAMP(GO:0071320) negative regulation of synaptic vesicle transport(GO:1902804) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 2.0 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 2.0 GO:0044211 CTP salvage(GO:0044211)
0.2 1.2 GO:0031174 lifelong otolith mineralization(GO:0031174)
0.2 1.2 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.2 0.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 2.6 GO:0019433 triglyceride catabolic process(GO:0019433)
0.2 0.8 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.1 1.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 2.2 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.4 GO:0007529 establishment of synaptic specificity at neuromuscular junction(GO:0007529) molybdenum incorporation into molybdenum-molybdopterin complex(GO:0018315) metal incorporation into metallo-molybdopterin complex(GO:0042040) glycine receptor clustering(GO:0072579)
0.1 0.9 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 2.9 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.1 1.1 GO:0030104 water homeostasis(GO:0030104)
0.1 0.5 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
0.1 0.5 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.1 1.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 1.2 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 0.1 GO:0070142 synaptic vesicle budding(GO:0070142)
0.1 0.5 GO:2000178 negative regulation of neural precursor cell proliferation(GO:2000178)
0.1 1.9 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.3 GO:0045428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.1 0.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 2.6 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 3.4 GO:0071166 ribonucleoprotein complex localization(GO:0071166)
0.1 1.0 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.1 1.0 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.9 GO:0032418 lysosome localization(GO:0032418)
0.1 3.6 GO:0030336 negative regulation of cell migration(GO:0030336)
0.1 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 2.8 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 2.7 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 0.7 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.7 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.7 GO:0031952 regulation of protein autophosphorylation(GO:0031952)
0.0 0.1 GO:0046324 regulation of glucose import(GO:0046324)
0.0 0.8 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.8 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.7 GO:0006298 mismatch repair(GO:0006298)
0.0 0.3 GO:0006108 malate metabolic process(GO:0006108)
0.0 1.7 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 2.5 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.0 0.1 GO:0023041 neuronal signal transduction(GO:0023041)
0.0 1.8 GO:0006400 tRNA modification(GO:0006400)
0.0 1.7 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 1.4 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.1 GO:0034969 histone arginine methylation(GO:0034969)
0.0 0.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.0 0.8 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.1 0.6 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 1.7 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.6 GO:0034657 GID complex(GO:0034657)
0.1 0.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 1.0 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 1.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.2 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.0 2.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 1.0 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.4 GO:0032156 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 4.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 0.6 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.8 GO:0031901 early endosome membrane(GO:0031901)
0.0 2.8 GO:0048475 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.0 0.5 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.7 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0044545 NSL complex(GO:0044545)
0.0 1.6 GO:0055037 recycling endosome(GO:0055037)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0005844 polysome(GO:0005844)
0.0 0.8 GO:0016528 sarcoplasm(GO:0016528) sarcoplasmic reticulum(GO:0016529)
0.0 0.8 GO:0005776 autophagosome(GO:0005776)
0.0 0.7 GO:0032580 Golgi cisterna membrane(GO:0032580)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity(GO:0051717) phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity(GO:0051800)
0.2 2.0 GO:0004849 uridine kinase activity(GO:0004849)
0.2 2.2 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.2 2.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.2 1.8 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 2.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.4 GO:0061599 molybdopterin adenylyltransferase activity(GO:0061598) molybdopterin molybdotransferase activity(GO:0061599)
0.1 0.6 GO:0051430 mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 1.1 GO:0005042 netrin receptor activity(GO:0005042)
0.1 2.6 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1 0.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 0.3 GO:0004471 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.1 1.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 2.7 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 0.9 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 5.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 1.8 GO:0042287 MHC protein binding(GO:0042287)
0.1 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.5 GO:0051920 peroxiredoxin activity(GO:0051920)
0.1 0.5 GO:0030332 cyclin binding(GO:0030332)
0.1 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.7 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 1.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 1.7 GO:0019003 GDP binding(GO:0019003)
0.0 0.7 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 4.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 0.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.7 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 5.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0002039 p53 binding(GO:0002039)
0.0 1.5 GO:0043022 ribosome binding(GO:0043022)
0.0 0.3 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 1.8 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.4 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 1.0 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 5.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0008469 histone-arginine N-methyltransferase activity(GO:0008469)
0.0 0.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.7 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2 2.2 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 1.3 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.0 0.7 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 2.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.3 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.8 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes