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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for pknox2
Z-value: 0.82
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Transcription factors associated with pknox2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pknox2 | dr11_v1_chr10_-_31220558_31220558 | 0.58 | 1.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_41468892 Show fit | 3.44 |
ENSDART00000173099
ENSDART00000003170 |
MID1 interacting protein 1, like |
|
| chr12_-_48168135 Show fit | 2.92 |
ENSDART00000186624
|
phosphatase domain containing, paladin 1a |
|
| chr2_-_11027258 Show fit | 2.87 |
ENSDART00000081072
ENSDART00000193824 ENSDART00000187036 ENSDART00000097741 |
single stranded DNA binding protein 3a |
|
| chr3_+_7771420 Show fit | 2.70 |
ENSDART00000156809
ENSDART00000156309 |
hook microtubule-tethering protein 2 |
|
| chr8_-_32385989 Show fit | 2.62 |
ENSDART00000143716
ENSDART00000098850 |
lipase, endothelial |
|
| chr8_-_18613948 Show fit | 2.21 |
ENSDART00000089172
|
coproporphyrinogen oxidase |
|
| chr5_-_32489796 Show fit | 2.12 |
ENSDART00000168870
|
G protein-coupled receptor 107 |
|
| chr4_-_20081621 Show fit | 2.11 |
ENSDART00000024647
|
DENN/MADD domain containing 6B |
|
| chr17_-_7792376 Show fit | 2.05 |
ENSDART00000064655
|
zinc finger and BTB domain containing 2a |
|
| chr23_+_13528053 Show fit | 1.98 |
ENSDART00000162217
|
uridine-cytidine kinase 1-like 1b |
Network of associatons between targets according to the STRING database.
First level regulatory network of pknox2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.6 | GO:0030336 | negative regulation of cell migration(GO:0030336) |
| 0.1 | 3.4 | GO:0071166 | ribonucleoprotein complex localization(GO:0071166) |
| 0.1 | 2.9 | GO:0048936 | peripheral nervous system neuron axonogenesis(GO:0048936) |
| 0.0 | 2.8 | GO:0051453 | regulation of intracellular pH(GO:0051453) |
| 0.0 | 2.7 | GO:0031122 | cytoplasmic microtubule organization(GO:0031122) |
| 0.2 | 2.6 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.1 | 2.6 | GO:0046856 | phosphatidylinositol dephosphorylation(GO:0046856) |
| 0.0 | 2.5 | GO:0072583 | clathrin-mediated endocytosis(GO:0072583) |
| 0.1 | 2.2 | GO:0046501 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.3 | 2.0 | GO:0045053 | protein retention in Golgi apparatus(GO:0045053) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 2.8 | GO:0048475 | membrane coat(GO:0030117) coated membrane(GO:0048475) |
| 0.0 | 2.5 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.1 | 2.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.0 | 1.8 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.1 | 1.7 | GO:0005956 | protein kinase CK2 complex(GO:0005956) |
| 0.0 | 1.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 1.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 1.4 | GO:0032156 | septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.2 | 1.3 | GO:0031261 | DNA replication preinitiation complex(GO:0031261) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 5.6 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 5.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 4.0 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.1 | 2.7 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
| 0.2 | 2.6 | GO:0004465 | lipoprotein lipase activity(GO:0004465) |
| 0.1 | 2.6 | GO:0004438 | phosphatidylinositol-3-phosphatase activity(GO:0004438) |
| 0.2 | 2.2 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.2 | 2.1 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.2 | 2.0 | GO:0004849 | uridine kinase activity(GO:0004849) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 0.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.2 | 2.7 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.2 | 2.2 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.1 | 1.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 1.3 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.0 | 1.3 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.2 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.8 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.7 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |