ISMARA results: phf21ab+rfx5

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for phf21ab+rfx5

Z-value: 0.92

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Transcription factors associated with phf21ab+rfx5

Gene Symbol	Gene ID	Gene Info
phf21ab NCBI UniProt	ENSDARG00000021378	PHD finger protein 21Ab
rfx5 NCBI UniProt	ENSDARG00000063258	regulatory factor X, 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
phf21ab	dr11_v1_chr25_-_7753207_7753207	0.98	5.0e-12	Click!
rfx5	dr11_v1_chr19_-_7495006_7495006	0.94	6.9e-09	Click!

Activity profile of phf21ab+rfx5 motif

Sorted Z-values of phf21ab+rfx5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_40352215 Show fit	5.15	ENSDART00000103992	ttll3 NCBI UniProt Show fit	tubulin tyrosine ligase-like family, member 3
chr9_-_41077934 Show fit	4.13	ENSDART00000100342	ankar NCBI UniProt Show fit	ankyrin and armadillo repeat containing
chr19_+_27589201 Show fit	3.52	ENSDART00000182060	si:dkeyp-46h3.1 NCBI UniProt Show fit	si:dkeyp-46h3.1
chr14_+_6954579 Show fit	2.79	ENSDART00000060998	nme5 NCBI UniProt Show fit	NME/NM23 family member 5
chr19_-_7110617 Show fit	2.74	ENSDART00000104838	psmb8a NCBI UniProt Show fit	proteasome subunit beta 8A
chr20_+_43396318 Show fit	2.67	ENSDART00000060910	pimr138 NCBI UniProt Show fit	Pim proto-oncogene, serine/threonine kinase, related 138
chr23_+_45538932 Show fit	2.52	ENSDART00000135602	si:ch73-290k24.6 NCBI UniProt Show fit	si:ch73-290k24.6
chr25_+_27873671 Show fit	2.32	ENSDART00000088817	iqub NCBI UniProt Show fit	IQ motif and ubiquitin domain containing
chr25_+_27873836 Show fit	2.17	ENSDART00000163801	iqub NCBI UniProt Show fit	IQ motif and ubiquitin domain containing
chr15_+_46386261 Show fit	2.14	ENSDART00000191793	igsf11 NCBI UniProt Show fit	immunoglobulin superfamily member 11

Showing 1 to 10 of 73 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of phf21ab+rfx5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.1	GO:0035082	axoneme assembly(GO:0035082)
0.0	5.0	GO:0046777	protein autophosphorylation(GO:0046777)
0.9	2.8	GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176)
0.1	2.7	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1	2.1	GO:0097324	melanocyte migration(GO:0097324)
0.1	2.0	GO:0007130	synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.1	1.9	GO:0032309	icosanoid secretion(GO:0032309) arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0	1.7	GO:0032922	circadian regulation of gene expression(GO:0032922)
0.5	1.6	GO:0010934	macrophage cytokine production(GO:0010934) regulation of macrophage cytokine production(GO:0010935) positive regulation of macrophage cytokine production(GO:0060907) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0	1.6	GO:0032880	regulation of protein localization(GO:0032880)

Showing 1 to 10 of 23 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.9	GO:0005930	axoneme(GO:0005930)
0.1	2.7	GO:0005839	proteasome core complex(GO:0005839)
0.3	2.0	GO:0000801	central element(GO:0000801)
0.0	1.6	GO:0036064	ciliary basal body(GO:0036064)
0.1	1.5	GO:0098844	postsynaptic endocytic zone membrane(GO:0098844)
0.2	1.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.6	GO:0036038	MKS complex(GO:0036038)

Showing 1 to 7 of 7 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	5.1	GO:0070738	protein-glycine ligase activity(GO:0070735) tubulin-glycine ligase activity(GO:0070738)
0.1	2.8	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.1	2.7	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	1.9	GO:0004623	phospholipase A2 activity(GO:0004623)
0.1	1.6	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	1.2	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	1.1	GO:0008201	heparin binding(GO:0008201)
0.1	1.0	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.5	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.4	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)

Showing 1 to 10 of 12 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
1.2	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.4	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.2	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.2	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle

Showing 1 to 5 of 5 entries

Results for phf21ab+rfx5

Z-value: 0.92

Motif logo

Transcription factors associated with phf21ab+rfx5

Activity-expression correlation:

Activity profile of phf21ab+rfx5 motif

Sorted Z-values of phf21ab+rfx5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of phf21ab+rfx5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: