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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Z-value: 0.68

Motif logo

Transcription factors associated with pbx1a+pbx1b+pbx2+pbx3a+pbx3b

Gene Symbol Gene ID Gene Info
ENSDARG00000013615 pre-B-cell leukemia homeobox 3b
ENSDARG00000019717 pre-B-cell leukemia homeobox 2
ENSDARG00000089262 pre-B-cell leukemia homeobox 3a
ENSDARG00000100494 pre-B-cell leukemia homeobox 1a
ENSDARG00000101131 pre-B-cell leukemia homeobox 1b
ENSDARG00000110194 pre-B-cell leukemia homeobox 3b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pbx1adr11_v1_chr2_-_18830722_18830783-0.814.1e-05Click!
pbx2dr11_v1_chr16_+_48631412_48631412-0.736.5e-04Click!
pbx3adr11_v1_chr5_-_5394335_53944680.672.4e-03Click!
pbx3bdr11_v1_chr8_-_34051548_34051548-0.428.1e-02Click!
pbx1bdr11_v1_chr6_+_2271559_2271559-0.223.9e-01Click!

Activity profile of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Sorted Z-values of pbx1a+pbx1b+pbx2+pbx3a+pbx3b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_50375800 2.41 ENSDART00000099537
cytochrome c oxidase subunit Vb 2
chr7_+_8670398 2.39 ENSDART00000164195
si:ch211-1o7.2
chr9_+_7732714 2.24 ENSDART00000145853
si:ch1073-349o24.2
chr4_-_13626831 2.06 ENSDART00000173077
si:dkeyp-81f3.4
chr3_+_17910569 2.02 ENSDART00000080946
tetratricopeptide repeat domain 25
chr2_-_53896300 1.92 ENSDART00000161221
calcyphosine-like a
chr14_+_80685 1.88 ENSDART00000188443
stromal antigen 3
chr3_-_19200571 1.75 ENSDART00000131503
ENSDART00000012335
regulatory factor X, 1a (influences HLA class II expression)
chr18_+_7611298 1.66 ENSDART00000062156
outer dense fiber of sperm tails 3B
chr24_+_12690163 1.66 ENSDART00000100644
REC8 meiotic recombination protein b
chr3_-_25646149 1.65 ENSDART00000122735
ubiquitin specific peptidase 43b
chr21_+_35215810 1.60 ENSDART00000135256
ubiquitin domain containing 2
chr5_-_19400166 1.60 ENSDART00000008994
forkhead box N4
chr20_+_29743904 1.55 ENSDART00000146366
ENSDART00000153154
kinase D-interacting substrate 220b
chr24_+_2843268 1.55 ENSDART00000170529
si:ch211-152c8.2
chr19_+_43995936 1.44 ENSDART00000130483
naked cuticle homolog 3
chr7_+_34688527 1.40 ENSDART00000108473
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr5_-_36949476 1.40 ENSDART00000047269
H3 histone, family 3C
chr6_+_120181 1.35 ENSDART00000151209
ENSDART00000185930
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr22_-_906757 1.34 ENSDART00000193182

chr23_-_23401305 1.32 ENSDART00000078936
hairy-related 9
chr19_-_31802296 1.28 ENSDART00000103640
hes-related family bHLH transcription factor with YRPW motif 1
chr10_-_26512742 1.24 ENSDART00000135951
si:dkey-5g14.1
chr15_-_19677511 1.23 ENSDART00000043743
si:dkey-4p15.3
chr1_-_44704261 1.23 ENSDART00000133210
si:dkey-28b4.8
chr2_-_879800 1.23 ENSDART00000019733
interferon regulatory factor 4a
chr1_+_49651016 1.17 ENSDART00000074380
ENSDART00000101017
testis specific, 10
chr3_+_60716904 1.17 ENSDART00000168280
forkhead box J1a
chr7_-_58729894 1.14 ENSDART00000149347
coiled-coil-helix-coiled-coil-helix domain containing 7
chr10_-_26512993 1.14 ENSDART00000188549
ENSDART00000193316
si:dkey-5g14.1
chr7_+_34687969 1.13 ENSDART00000182013
ENSDART00000188255
ENSDART00000182728
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr20_-_7080427 1.13 ENSDART00000140166
ENSDART00000023677
si:ch211-121a2.2
chr2_+_55365727 1.11 ENSDART00000162943

chr3_-_1190132 1.10 ENSDART00000149709
single-pass membrane protein with aspartate-rich tail 1a
chr7_-_29021757 1.09 ENSDART00000086905
neuritin 1-like b
chr25_+_32530976 1.07 ENSDART00000156190
ENSDART00000103324
S-phase cyclin A-associated protein in the ER
chr14_+_46410766 1.06 ENSDART00000032342
annexin A5a
chr14_+_33329420 1.06 ENSDART00000171090
ENSDART00000164062
sosondowah ankyrin repeat domain family d
chr3_-_62380146 1.05 ENSDART00000155853
G protein-coupled receptor, class C, group 5, member Ba
chr23_-_38054 1.05 ENSDART00000170393

chr8_+_7033049 1.03 ENSDART00000064172
ENSDART00000134440
glycerol-3-phosphate dehydrogenase 1a
chr13_+_35635672 1.03 ENSDART00000148481
thrombospondin 2a
chr1_-_58562129 1.03 ENSDART00000159070
solute carrier family 27 (fatty acid transporter), member 1b
chr16_-_32128345 0.99 ENSDART00000102100
ENSDART00000137699
CCR4-NOT transcription complex, subunit 3a
chr22_+_20720808 0.99 ENSDART00000171321
si:dkey-211f22.5
chr24_+_37903448 0.99 ENSDART00000155476
coiled-coil domain containing 78
chr12_-_26851726 0.99 ENSDART00000047724
zinc finger E-box binding homeobox 1b
chr10_-_320153 0.98 ENSDART00000161493
v-akt murine thymoma viral oncogene homolog 2, like
chr25_+_3326885 0.98 ENSDART00000104866
lactate dehydrogenase Bb
chr3_+_13190012 0.98 ENSDART00000179747
ENSDART00000109876
ENSDART00000124824
ENSDART00000130261
Sad1 and UNC84 domain containing 1
chr20_-_1239596 0.97 ENSDART00000049063
ENSDART00000140650
ankyrin repeat domain 6b
chr20_+_18225329 0.96 ENSDART00000144172
potassium channel tetramerization domain containing 1
chr1_-_46984142 0.96 ENSDART00000125032
pbx/knotted 1 homeobox 1.2
chr8_-_52715911 0.95 ENSDART00000168241
tubulin, beta 2b
chr8_-_36554675 0.93 ENSDART00000132804
ENSDART00000078746
coiled-coil domain containing 157
chr7_+_21321317 0.92 ENSDART00000173950
dynein, axonemal, heavy chain 2
chr13_-_37545487 0.90 ENSDART00000131269
synaptotagmin XVI
chr22_-_36514923 0.90 ENSDART00000187018

chr12_+_48841182 0.89 ENSDART00000109315
ENSDART00000185609
ENSDART00000187217
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr1_-_58561963 0.85 ENSDART00000165040
solute carrier family 27 (fatty acid transporter), member 1b
chr8_+_23213320 0.84 ENSDART00000032996
ENSDART00000137536
pancreatic progenitor cell differentiation and proliferation factor a
chr23_+_44157682 0.84 ENSDART00000164474
ENSDART00000149928
si:ch73-106g13.1
chr11_-_28614608 0.84 ENSDART00000065853
dehydrogenase/reductase (SDR family) member 3b
chr7_+_72460911 0.83 ENSDART00000160682
ENSDART00000168532
HECT domain E3 ubiquitin protein ligase 4
chr4_+_11464255 0.83 ENSDART00000008584
GDP dissociation inhibitor 2
chr20_-_53981626 0.83 ENSDART00000023550
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2
chr4_-_16001118 0.83 ENSDART00000041070
ENSDART00000125389
mesoderm specific transcript
chr7_-_51102479 0.83 ENSDART00000174023
collagen, type IV, alpha 6
chr7_-_27038488 0.82 ENSDART00000052731
ENSDART00000191382
nucleobindin 2a
chr11_+_7261981 0.82 ENSDART00000130400
ENSDART00000155427
receptor accessory protein 6
chr15_+_3284684 0.81 ENSDART00000179778
forkhead box O1 a
chr4_-_17725008 0.81 ENSDART00000016658
choline phosphotransferase 1
chr4_-_18595525 0.81 ENSDART00000049061
cyclin-dependent kinase inhibitor 1Ba
chr12_-_31103187 0.80 ENSDART00000005562
ENSDART00000031408
ENSDART00000125046
ENSDART00000009237
ENSDART00000122972
ENSDART00000153068
transcription factor 7 like 2
chr24_+_3963684 0.80 ENSDART00000182959
ENSDART00000185926
ENSDART00000167043
ENSDART00000033394
phosphofructokinase, platelet a
chr21_+_40589770 0.79 ENSDART00000164650
ENSDART00000161584
ENSDART00000161108
pyruvate dehydrogenase kinase, isozyme 3b
chr12_+_28854410 0.79 ENSDART00000152991
nuclear factor, erythroid 2-like 1b
chr1_+_22174251 0.78 ENSDART00000137429
dynein, axonemal, heavy chain 6
chr12_-_212843 0.78 ENSDART00000083574

chr17_+_16873417 0.77 ENSDART00000146276
iodothyronine deiodinase 2
chr3_+_29941777 0.77 ENSDART00000113889
interferon-induced protein 35
chr5_+_20922100 0.77 ENSDART00000131838
si:dkey-174n20.1
chr24_+_26345427 0.76 ENSDART00000089756
leucine rich repeat containing 34
chr22_-_21392748 0.76 ENSDART00000144648
ankyrin repeat domain 24
chr22_-_13851297 0.75 ENSDART00000080306
S100 calcium binding protein, beta (neural)
chr21_+_11415224 0.74 ENSDART00000049036
zgc:92275
chr15_+_36966369 0.74 ENSDART00000163622
kirre like nephrin family adhesion molecule 3, like
chr25_+_18563476 0.74 ENSDART00000170841
caveolin 1
chr25_-_19139259 0.74 ENSDART00000067327
abhydrolase domain containing 2b
chr1_-_17650223 0.74 ENSDART00000043484
si:dkey-256e7.5
chr7_+_24391129 0.73 ENSDART00000108753
polymerase (DNA directed) nu
chr3_-_32596394 0.73 ENSDART00000103239
tetraspanin 4b
chr9_-_21067971 0.73 ENSDART00000004333
T-box 15
chr12_-_14922955 0.72 ENSDART00000002078
neurogenic differentiation 2
chr7_+_71683853 0.72 ENSDART00000163002
elastin microfibril interfacer 2b
chr8_+_7144066 0.72 ENSDART00000146306
solute carrier family 6 (neurotransmitter transporter), member 6a
chr5_-_34185115 0.71 ENSDART00000192771
fibrinogen C domain containing 1
chr3_-_10779777 0.71 ENSDART00000153911
zinc finger protein 1004
chr12_+_36971952 0.71 ENSDART00000125900
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1b
chr13_-_18069421 0.71 ENSDART00000146772
ENSDART00000134477
zinc finger, AN1-type domain 4
chr6_-_8311044 0.71 ENSDART00000129674
solute carrier family 44 (choline transporter), member 2
chr15_+_3284416 0.70 ENSDART00000187665
ENSDART00000171723
forkhead box O1 a
chr7_-_51032128 0.70 ENSDART00000182781
ENSDART00000121574
collagen, type IV, alpha 6
chr20_+_54280549 0.69 ENSDART00000151048
ARP10 actin related protein 10 homolog
chr25_+_13791627 0.69 ENSDART00000159278
zgc:92873
chr3_+_62353650 0.69 ENSDART00000112428
IQ motif containing K
chr11_-_7261717 0.69 ENSDART00000128959
zgc:113223
chr19_+_712127 0.69 ENSDART00000093281
ENSDART00000180002
ENSDART00000146050
formin homology 2 domain containing 3a
chr25_+_3327071 0.68 ENSDART00000136131
ENSDART00000133243
lactate dehydrogenase Bb
chr2_+_2737422 0.68 ENSDART00000032459
aquaporin 1a (Colton blood group), tandem duplicate 1
chr24_-_4450238 0.66 ENSDART00000066835
frizzled class receptor 8a
chr12_-_17479078 0.66 ENSDART00000079115
3'-phosphoadenosine 5'-phosphosulfate synthase 2b
chr24_+_29381946 0.66 ENSDART00000189551
netrin g1a
chr1_+_10129099 0.66 ENSDART00000187740
RNA binding motif protein 46
chr5_-_20185665 0.65 ENSDART00000051612
D-amino-acid oxidase, tandem duplicate 2
chr2_+_26288301 0.65 ENSDART00000017668
polypyrimidine tract binding protein 1a
chr23_+_7471072 0.65 ENSDART00000135551
si:ch211-200e2.1
chr3_+_57038033 0.64 ENSDART00000162930
BAH domain and coiled-coil containing 1a
chr20_+_53541389 0.64 ENSDART00000100110
p21 protein (Cdc42/Rac)-activated kinase 6b
chr23_+_25893020 0.63 ENSDART00000144769
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr5_+_70155935 0.63 ENSDART00000165570
regulator of G protein signaling 3a
chr12_+_25600685 0.63 ENSDART00000077157
SIX homeobox 3b
chr16_+_34111919 0.63 ENSDART00000134037
ENSDART00000006061
ENSDART00000140552
transcription elongation factor A (SII), 3
chr1_-_54947592 0.63 ENSDART00000129710
cartilage acidic protein 1a
chr23_-_44871987 0.62 ENSDART00000085764
wu:fb72h05
chr10_+_9159279 0.62 ENSDART00000064968
RasGEF domain family, member 1Bb
chr2_-_45510699 0.62 ENSDART00000024034
ENSDART00000145634
G protein signaling modulator 2
chr24_+_9372292 0.62 ENSDART00000082422
ENSDART00000191127
ENSDART00000180510
si:ch211-285f17.1
chr2_-_26527730 0.61 ENSDART00000138693
si:ch211-106k21.5
chr14_+_30762131 0.61 ENSDART00000145039
si:ch211-145o7.3
chr24_+_12989727 0.61 ENSDART00000126842
ENSDART00000129309
hypothetical protein FLJ11011-like (H. sapiens)
chr14_+_45883687 0.60 ENSDART00000114790
fibronectin leucine rich transmembrane protein 1b
chr22_+_34663328 0.60 ENSDART00000183912
si:ch73-304f21.1
chr8_-_23573084 0.60 ENSDART00000139084
Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b
chr16_-_40508624 0.60 ENSDART00000075718
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr1_-_9195629 0.60 ENSDART00000143587
ENSDART00000192174
endoplasmic reticulum to nucleus signaling 2
chr1_-_46401385 0.60 ENSDART00000150029
ATPase phospholipid transporting 11A
chr3_+_59935606 0.59 ENSDART00000154157
Rho GDP dissociation inhibitor (GDI) alpha
chr12_-_20350629 0.57 ENSDART00000066384
hemoglobin beta embryonic-2
chr13_-_3155243 0.57 ENSDART00000139183
ENSDART00000050934
protein kinase domain containing, cytoplasmic a
chr13_-_5569562 0.57 ENSDART00000102576
Meis homeobox 1 b
chr21_+_30563115 0.56 ENSDART00000028566
si:ch211-200p22.4
chr1_-_6494384 0.56 ENSDART00000109356
Kruppel-like factor 7a
chr11_-_16395956 0.56 ENSDART00000115085
leucine-rich repeats and immunoglobulin-like domains 1
chr19_+_26718074 0.56 ENSDART00000134455
zgc:100906
chr20_+_29634653 0.55 ENSDART00000101556
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2b
chr24_+_26345609 0.55 ENSDART00000186844
leucine rich repeat containing 34
chr17_+_52822831 0.55 ENSDART00000193368
Meis homeobox 2a
chr4_+_9669717 0.55 ENSDART00000004604
si:dkey-153k10.9
chr7_-_27037990 0.55 ENSDART00000173561
nucleobindin 2a
chr17_+_35362851 0.55 ENSDART00000137659
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr1_-_54063520 0.54 ENSDART00000171722
single-pass membrane protein with aspartate-rich tail 1b
chr21_-_293146 0.54 ENSDART00000157781
plasminogen receptor, C-terminal lysine transmembrane protein
chr9_-_17286330 0.54 ENSDART00000039157
MYC binding protein 2
chr3_-_16537441 0.54 ENSDART00000080749
ENSDART00000133824
eps8-like1
chr16_+_41873708 0.54 ENSDART00000084631
ENSDART00000084639
ENSDART00000058611
sodium channel, voltage-gated, type I, beta a
chr3_-_61116258 0.54 ENSDART00000009194
ENSDART00000156978
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
chr16_-_52916248 0.53 ENSDART00000113931
zinc finger, DHHC-type containing 11
chr7_-_18547420 0.52 ENSDART00000173969
regulator of G protein signaling 12a
chr1_-_53987766 0.52 ENSDART00000167720
si:ch211-133l11.10
chr3_-_11828206 0.51 ENSDART00000018159
si:ch211-262e15.1
chr4_-_948776 0.51 ENSDART00000023483
single-minded family bHLH transcription factor 1b
chr16_+_23961276 0.50 ENSDART00000192754
apolipoprotein Eb
chr10_+_7636811 0.50 ENSDART00000160673
histidine triad nucleotide binding protein 1
chr1_+_2129164 0.50 ENSDART00000074923
ENSDART00000124534
muscleblind-like splicing regulator 2
chr20_-_54381034 0.49 ENSDART00000136779
ectonucleoside triphosphate diphosphohydrolase 5b
chr22_-_17729778 0.49 ENSDART00000192132
si:ch73-63e15.2
chr9_+_3283608 0.49 ENSDART00000192275
histone acetyltransferase 1
chr1_-_53988017 0.49 ENSDART00000003097
si:ch211-133l11.10
chr4_-_9764767 0.49 ENSDART00000164328
ENSDART00000147699
microtubule associated monooxygenase, calponin and LIM domain containing 3b
chr16_-_51966846 0.49 ENSDART00000153959
phosducin-like
chr12_-_8817999 0.48 ENSDART00000113148
jumonji domain containing 1Cb
chr3_-_42125655 0.48 ENSDART00000040753
nudix (nucleoside diphosphate linked moiety X)-type motif 1
chr5_-_323712 0.48 ENSDART00000188793
hook microtubule tethering protein 3
chr1_+_55478653 0.47 ENSDART00000152441
adhesion G protein-coupled receptor E9
chr20_-_4157138 0.47 ENSDART00000112999
zgc:194224
chr20_-_53996193 0.47 ENSDART00000004756
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1
chr12_+_48841419 0.47 ENSDART00000125331
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr3_+_311833 0.47 ENSDART00000187375

chr13_+_24584401 0.46 ENSDART00000057599
fucose mutarotase
chr5_+_15203421 0.46 ENSDART00000040826
T-box 1
chr4_-_63848305 0.46 ENSDART00000097308

chr24_+_41931585 0.46 ENSDART00000130310
erythrocyte membrane protein band 4.1-like 3a
chr1_-_47071979 0.46 ENSDART00000160817
intersectin 1 (SH3 domain protein)
chr23_+_37815645 0.46 ENSDART00000011627
iroquois homeobox 7
chr6_+_43903209 0.46 ENSDART00000006435
G protein-coupled receptor 27
chr20_-_54075136 0.45 ENSDART00000074255
mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr13_-_10261383 0.45 ENSDART00000080808
SIX homeobox 3a
chr24_+_854877 0.45 ENSDART00000188408
piezo-type mechanosensitive ion channel component 2a, tandem duplicate 2
chr25_-_16826219 0.45 ENSDART00000191299
ENSDART00000188504
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr20_-_47731768 0.45 ENSDART00000031167
transcription factor AP-2 delta (activating enhancer binding protein 2 delta)
chr16_+_5251768 0.45 ENSDART00000144558
plectin b
chr5_+_43870389 0.45 ENSDART00000141002
zgc:112966
chr11_+_6009984 0.44 ENSDART00000185680
GTP binding protein 3, mitochondrial
chr20_+_51197758 0.44 ENSDART00000020084
heat shock protein 90, alpha (cytosolic), class B member 1
chr24_-_2947393 0.44 ENSDART00000166661
ENSDART00000147110
tubulin, beta 6 class V
chr12_-_7824291 0.44 ENSDART00000148673
ENSDART00000149453
ankyrin 3b
chr25_-_7723685 0.44 ENSDART00000146882
PHD finger protein 21Ab
chr5_-_13645995 0.43 ENSDART00000099665
ENSDART00000166957
purine-rich element binding protein Ba
chr12_-_8817802 0.43 ENSDART00000180785
jumonji domain containing 1Cb

Network of associatons between targets according to the STRING database.

First level regulatory network of pbx1a+pbx1b+pbx2+pbx3a+pbx3b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 1.0 GO:0070587 regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.4 1.9 GO:0071072 heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)
0.3 1.2 GO:0002320 lymphoid progenitor cell differentiation(GO:0002320)
0.3 0.9 GO:0071830 chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831)
0.3 1.6 GO:0035881 amacrine cell differentiation(GO:0035881)
0.3 1.0 GO:0006116 NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.3 1.5 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.2 1.2 GO:0060295 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.2 0.7 GO:0003097 renal water homeostasis(GO:0003091) renal water transport(GO:0003097)
0.2 0.7 GO:0021531 spinal cord radial glial cell differentiation(GO:0021531) eye field cell fate commitment involved in camera-type eye formation(GO:0060898)
0.2 0.7 GO:0034036 sulfate assimilation(GO:0000103) purine ribonucleoside bisphosphate metabolic process(GO:0034035) purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428)
0.2 1.5 GO:0048745 smooth muscle tissue development(GO:0048745)
0.2 1.0 GO:0032289 central nervous system myelin formation(GO:0032289)
0.2 0.8 GO:0010226 response to lithium ion(GO:0010226)
0.2 2.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 0.7 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 0.5 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.2 0.7 GO:0060074 synapse maturation(GO:0060074)
0.2 0.5 GO:0048682 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.2 0.7 GO:0015871 choline transport(GO:0015871)
0.2 1.2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 0.7 GO:0009080 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.2 0.7 GO:0060471 negative regulation of fertilization(GO:0060467) prevention of polyspermy(GO:0060468) cortical granule exocytosis(GO:0060471)
0.2 1.7 GO:0034605 cellular response to heat(GO:0034605)
0.2 0.5 GO:0003156 regulation of organ formation(GO:0003156)
0.2 0.9 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.1 0.7 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.7 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
0.1 0.4 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1 1.7 GO:0051177 meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177)
0.1 1.4 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1 0.5 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.1 1.5 GO:0061620 glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.4 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 0.4 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 0.6 GO:2000051 regulation of Wnt signaling pathway, calcium modulating pathway(GO:0008591) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.4 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.1 0.6 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.1 0.8 GO:0042403 thyroid hormone metabolic process(GO:0042403)
0.1 1.1 GO:0050819 negative regulation of coagulation(GO:0050819)
0.1 0.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 0.4 GO:2000275 regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.1 1.0 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.1 0.3 GO:0048496 maintenance of organ identity(GO:0048496)
0.1 0.3 GO:0032640 tumor necrosis factor production(GO:0032640) tumor necrosis factor superfamily cytokine production(GO:0071706)
0.1 0.4 GO:0014743 regulation of muscle hypertrophy(GO:0014743)
0.1 0.4 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.1 0.8 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.1 1.5 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1 0.3 GO:0034086 maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.1 0.4 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.1 0.8 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.1 0.5 GO:0003319 cardioblast migration to the midline involved in heart rudiment formation(GO:0003319)
0.1 0.2 GO:0065001 specification of axis polarity(GO:0065001)
0.1 0.7 GO:1904861 excitatory synapse assembly(GO:1904861)
0.1 0.3 GO:0031448 regulation of twitch skeletal muscle contraction(GO:0014724) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) negative regulation of striated muscle contraction(GO:0045988) relaxation of skeletal muscle(GO:0090076)
0.1 0.4 GO:0010456 cell proliferation in dorsal spinal cord(GO:0010456)
0.1 0.5 GO:0006004 fucose metabolic process(GO:0006004)
0.1 0.5 GO:0086091 regulation of heart rate by cardiac conduction(GO:0086091)
0.1 0.5 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.8 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.3 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 1.0 GO:0061154 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.1 0.2 GO:0008343 adult feeding behavior(GO:0008343) negative regulation of lipid transport(GO:0032369)
0.1 0.2 GO:0021961 posterior commissure morphogenesis(GO:0021961)
0.1 0.5 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.1 0.2 GO:0015074 DNA integration(GO:0015074)
0.1 0.4 GO:0035777 pronephric distal tubule development(GO:0035777)
0.1 0.8 GO:2000601 positive regulation of actin nucleation(GO:0051127) positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.4 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.4 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
0.0 0.1 GO:0007008 outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.1 GO:0021611 facial nerve formation(GO:0021611)
0.0 0.2 GO:0003245 growth involved in heart morphogenesis(GO:0003241) cardiac chamber ballooning(GO:0003242) cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.0 0.3 GO:0021982 pineal gland development(GO:0021982)
0.0 0.4 GO:0071379 cellular response to prostaglandin stimulus(GO:0071379)
0.0 0.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.2 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.8 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 1.0 GO:0070831 basement membrane assembly(GO:0070831)
0.0 0.8 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 0.2 GO:0030326 embryonic limb morphogenesis(GO:0030326)
0.0 1.4 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.6 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.7 GO:0032330 regulation of chondrocyte differentiation(GO:0032330)
0.0 0.2 GO:0015697 quaternary ammonium group transport(GO:0015697)
0.0 1.0 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.7 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:0007343 egg activation(GO:0007343)
0.0 0.5 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.6 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.1 GO:0019408 dolichol biosynthetic process(GO:0019408)
0.0 0.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.9 GO:0060037 pharyngeal system development(GO:0060037)
0.0 0.5 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.0 0.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.4 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.0 1.0 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 1.1 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.0 0.6 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.1 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.3 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.1 GO:0097378 interneuron axon guidance(GO:0097376) spinal cord interneuron axon guidance(GO:0097377) dorsal spinal cord interneuron axon guidance(GO:0097378)
0.0 0.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.2 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.3 GO:0060324 face development(GO:0060324)
0.0 0.1 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 1.0 GO:0010842 retina layer formation(GO:0010842)
0.0 0.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.6 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.4 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.2 GO:0050688 regulation of defense response to virus(GO:0050688)
0.0 0.1 GO:1990108 protein linear deubiquitination(GO:1990108)
0.0 0.2 GO:0060971 embryonic heart tube left/right pattern formation(GO:0060971)
0.0 0.6 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 0.1 GO:0036268 swimming(GO:0036268)
0.0 0.3 GO:0021988 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 0.1 GO:0033153 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0007172 signal complex assembly(GO:0007172)
0.0 0.2 GO:0044247 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.2 GO:0030816 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.5 GO:0050727 regulation of inflammatory response(GO:0050727)
0.0 0.1 GO:0048769 sarcomerogenesis(GO:0048769)
0.0 0.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.2 GO:0048897 myelination of lateral line nerve axons(GO:0048897) posterior lateral line nerve glial cell differentiation(GO:0048931) myelination of posterior lateral line nerve axons(GO:0048932) lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048938) posterior lateral line nerve glial cell development(GO:0048941) posterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048942)
0.0 0.2 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.3 GO:0002027 regulation of heart rate(GO:0002027)
0.0 0.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.7 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 0.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.2 GO:0048923 posterior lateral line neuromast hair cell differentiation(GO:0048923)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.2 GO:0061074 regulation of neural retina development(GO:0061074)
0.0 0.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.5 GO:0042593 carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593)
0.0 0.5 GO:0044259 collagen metabolic process(GO:0032963) multicellular organismal macromolecule metabolic process(GO:0044259)
0.0 0.2 GO:1990035 inorganic cation import into cell(GO:0098659) calcium ion import across plasma membrane(GO:0098703) inorganic ion import into cell(GO:0099587) calcium ion import into cell(GO:1990035)
0.0 0.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.1 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.2 GO:0098962 regulation of postsynaptic neurotransmitter receptor activity(GO:0098962)
0.0 0.3 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
0.0 0.1 GO:0099612 protein localization to juxtaparanode region of axon(GO:0071205) protein localization to axon(GO:0099612)
0.0 0.1 GO:0031639 plasminogen activation(GO:0031639)
0.0 0.5 GO:0031017 exocrine pancreas development(GO:0031017) exocrine system development(GO:0035272)
0.0 0.1 GO:0051967 negative regulation of cytosolic calcium ion concentration(GO:0051481) negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.3 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.3 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.4 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.3 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.3 2.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 0.9 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.2 0.8 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.2 0.6 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 1.3 GO:0034990 nuclear cohesin complex(GO:0000798) mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990) nuclear meiotic cohesin complex(GO:0034991)
0.2 1.1 GO:0070062 extracellular exosome(GO:0070062)
0.2 0.7 GO:0097524 sperm plasma membrane(GO:0097524)
0.2 1.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 1.0 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 1.5 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.5 GO:1990246 uniplex complex(GO:1990246)
0.1 0.4 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.1 1.7 GO:0008278 cohesin complex(GO:0008278)
0.1 0.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.3 GO:0031673 H zone(GO:0031673)
0.1 1.4 GO:0043209 myelin sheath(GO:0043209)
0.1 1.0 GO:0005869 dynactin complex(GO:0005869)
0.1 0.4 GO:0016234 inclusion body(GO:0016234)
0.1 1.1 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 0.6 GO:0098888 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 1.1 GO:0005605 basal lamina(GO:0005605) laminin complex(GO:0043256)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.6 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.3 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 1.2 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 1.3 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.3 GO:0044545 NSL complex(GO:0044545)
0.0 0.1 GO:0033181 plasma membrane proton-transporting V-type ATPase complex(GO:0033181)
0.0 1.3 GO:0030286 dynein complex(GO:0030286)
0.0 1.6 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 0.3 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.1 GO:0098799 mitochondrial sorting and assembly machinery complex(GO:0001401) outer mitochondrial membrane protein complex(GO:0098799)
0.0 0.1 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.3 GO:0031430 M band(GO:0031430)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.8 GO:0005604 basement membrane(GO:0005604)
0.0 0.7 GO:0036379 striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
0.0 0.1 GO:0030904 retromer complex(GO:0030904)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 0.8 GO:0005093 Rab GDP-dissociation inhibitor activity(GO:0005093)
0.3 1.0 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 1.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.2 0.7 GO:0004779 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.2 1.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 0.7 GO:0044548 S100 protein binding(GO:0044548)
0.2 0.5 GO:0009041 uridylate kinase activity(GO:0009041)
0.2 0.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.2 0.7 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.2 0.5 GO:0042806 fucose binding(GO:0042806)
0.1 0.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.5 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 1.1 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 1.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 2.3 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.3 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1 0.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.8 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.1 0.4 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142)
0.1 2.3 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.1 0.4 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.1 0.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.7 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.3 GO:0033149 FFAT motif binding(GO:0033149)
0.1 0.4 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.9 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 1.8 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 0.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.4 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.5 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.0 0.6 GO:0031720 haptoglobin binding(GO:0031720)
0.0 0.2 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219) calcium-induced calcium release activity(GO:0048763)
0.0 0.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.3 GO:0070698 type I activin receptor binding(GO:0070698)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.2 GO:0004134 glycogen debranching enzyme activity(GO:0004133) 4-alpha-glucanotransferase activity(GO:0004134) amylo-alpha-1,6-glucosidase activity(GO:0004135)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.4 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0031544 procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.2 GO:1990931 RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 0.4 GO:0004046 aminoacylase activity(GO:0004046)
0.0 2.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 1.1 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.2 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0 0.9 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 1.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.5 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 1.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.3 GO:0031628 opioid receptor binding(GO:0031628)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.3 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 2.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.2 GO:0004096 catalase activity(GO:0004096)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 3.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.5 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 0.1 GO:0047777 (3S)-citramalyl-CoA lyase activity(GO:0047777)
0.0 0.7 GO:0005343 organic acid:sodium symporter activity(GO:0005343)
0.0 0.1 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) enone reductase activity(GO:0035671) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.1 GO:0019107 myristoyltransferase activity(GO:0019107)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.5 GO:0009055 electron carrier activity(GO:0009055)
0.0 0.1 GO:0070728 leucine binding(GO:0070728)
0.0 1.1 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.3 GO:0008320 protein transmembrane transporter activity(GO:0008320)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.3 GO:0030552 cAMP binding(GO:0030552)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.2 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) intracellular cAMP activated cation channel activity(GO:0005222) intracellular cGMP activated cation channel activity(GO:0005223) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.3 GO:0008201 heparin binding(GO:0008201)
0.0 0.2 GO:0052812 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.4 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 0.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 0.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.0 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.0 0.0 GO:0000035 acyl binding(GO:0000035)
0.0 0.2 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 1.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.1 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.8 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.2 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.3 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 0.7 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.4 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 1.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.4 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 1.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.4 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 1.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.2 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 1.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis