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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for pax8

Z-value: 0.34

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Transcription factors associated with pax8

Gene Symbol Gene ID Gene Info
pax8
ENSDARG00000015879 paired box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
pax8dr11_v1_chr5_-_72415578_724155780.944.9e-09Click!

Activity profile of pax8 motif

Sorted Z-values of pax8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_-_7520937 1.55 ENSDART00000170050
cdkn1cb
cyclin-dependent kinase inhibitor 1Cb
chr10_+_2715548 0.78 ENSDART00000130793
grk5
G protein-coupled receptor kinase 5
chr9_+_17348745 0.67 ENSDART00000147488
slain1a
SLAIN motif family, member 1a
chr1_+_55239710 0.66 ENSDART00000174846
si:ch211-286b5.2
si:ch211-286b5.2
chr9_+_38712474 0.63 ENSDART00000182874
kansl1l
KAT8 regulatory NSL complex subunit 1-like
chr22_-_31752937 0.62 ENSDART00000169611
CABZ01028298.1

chr23_+_42813415 0.59 ENSDART00000055577
myl9a
myosin, light chain 9a, regulatory
chr7_+_19374683 0.59 ENSDART00000162700
snrpf
small nuclear ribonucleoprotein polypeptide F
chr6_-_47840465 0.55 ENSDART00000141986
lrig2
leucine-rich repeats and immunoglobulin-like domains 2
chr15_+_16387088 0.51 ENSDART00000101789
flot2b
flotillin 2b
chr22_-_25033105 0.50 ENSDART00000124220
nptxrb
neuronal pentraxin receptor b
chr7_-_52388090 0.46 ENSDART00000174104
wdr93
WD repeat domain 93
chr23_+_26733232 0.37 ENSDART00000035080
zgc:158263
zgc:158263
chr4_+_25630555 0.37 ENSDART00000133425
acot15
acyl-CoA thioesterase 15
chr7_+_19552381 0.35 ENSDART00000169060
si:ch211-212k18.5
si:ch211-212k18.5
chr14_+_48062180 0.34 ENSDART00000056713
ppid
peptidylprolyl isomerase D
chr6_+_168962 0.32 ENSDART00000182631
CABZ01066694.1

chr19_+_46372115 0.32 ENSDART00000163935
med30
mediator complex subunit 30
chr21_-_22928214 0.32 ENSDART00000182760
dub
duboraya
chr16_+_43347966 0.30 ENSDART00000171308
zmp:0000000930
zmp:0000000930
chr11_-_165288 0.29 ENSDART00000108703
ENSDART00000173151
tegt
testis enhanced gene transcript (BAX inhibitor 1)
chr7_-_28549361 0.29 ENSDART00000173918
ENSDART00000054368
ENSDART00000113313
st5
suppression of tumorigenicity 5
chr11_+_355305 0.28 ENSDART00000147426
pdrg1
p53 and DNA-damage regulated 1
chr7_+_10610791 0.27 ENSDART00000166064
fah
fumarylacetoacetate hydrolase (fumarylacetoacetase)
chr6_-_436658 0.27 ENSDART00000191515
grap2b
GRB2-related adaptor protein 2b
chr12_-_13556536 0.26 ENSDART00000166396
CR354395.1

chr25_-_3139805 0.25 ENSDART00000166625
epx
eosinophil peroxidase
chr5_-_68826177 0.24 ENSDART00000136605
si:ch211-283h6.4
si:ch211-283h6.4
chr25_-_17579701 0.20 ENSDART00000073684
mmp15a
matrix metallopeptidase 15a
chr23_+_32039386 0.20 ENSDART00000133801
mylk2
myosin light chain kinase 2
chr20_+_32224405 0.19 ENSDART00000062993
ENSDART00000147448
sesn1
sestrin 1
chr7_+_20019125 0.18 ENSDART00000186391
bcl6b
B-cell CLL/lymphoma 6, member B
chr11_-_37693019 0.17 ENSDART00000102898
zgc:158258
zgc:158258
chr1_-_30457062 0.17 ENSDART00000185318
ENSDART00000157924
ENSDART00000161380
igf2bp2b
insulin-like growth factor 2 mRNA binding protein 2b
chr20_+_35445462 0.17 ENSDART00000124497
tdrd6
tudor domain containing 6
chr6_-_130849 0.16 ENSDART00000108710
LRRC8E
si:zfos-323e3.4
chr2_+_45479841 0.16 ENSDART00000151856
si:ch211-66k16.28
si:ch211-66k16.28
chr24_-_35699595 0.15 ENSDART00000167990
mapre2
microtubule-associated protein, RP/EB family, member 2
chr8_+_4809156 0.14 ENSDART00000143720
tmem127
transmembrane protein 127
chr14_-_29906209 0.14 ENSDART00000192952
sorbs2b
sorbin and SH3 domain containing 2b
chr7_-_8981507 0.13 ENSDART00000161422
si:ch211-183d5.2
si:ch211-183d5.2
chr10_+_40598791 0.13 ENSDART00000131895
taar17a
trace amine associated receptor 17a
chr17_-_33405301 0.13 ENSDART00000157089
BX323819.1

chr23_+_44049509 0.13 ENSDART00000102003
txk
TXK tyrosine kinase
chr12_+_4900981 0.12 ENSDART00000171507
cd79b
CD79b molecule, immunoglobulin-associated beta
chr6_+_25215944 0.12 ENSDART00000165456
si:ch73-97h19.2
si:ch73-97h19.2
chr23_+_7505943 0.12 ENSDART00000135787
hck
HCK proto-oncogene, Src family tyrosine kinase
chr20_-_14680897 0.11 ENSDART00000063857
ENSDART00000161314
scrn2
secernin 2
chr3_+_46444999 0.11 ENSDART00000186530
si:ch211-66e2.3
si:ch211-66e2.3
chr10_+_24660017 0.11 ENSDART00000079597
vps36
vacuolar protein sorting 36 homolog (S. cerevisiae)
chr6_-_10927766 0.11 ENSDART00000134327
ccr7
chemokine (C-C motif) receptor 7
chr15_+_15314189 0.09 ENSDART00000156830
camkk1b
calcium/calmodulin-dependent protein kinase kinase 1, alpha b
chr21_-_45891262 0.09 ENSDART00000169816
galnt10
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)
chr10_+_24660225 0.09 ENSDART00000190695
vps36
vacuolar protein sorting 36 homolog (S. cerevisiae)
chr9_+_23665777 0.08 ENSDART00000060905
gypc
glycophorin C (Gerbich blood group)
chr22_+_2598998 0.07 ENSDART00000176665
CU570894.1

chr14_-_32491127 0.06 ENSDART00000186724
mcf2a
MCF.2 cell line derived transforming sequence a
chr2_-_5942355 0.06 ENSDART00000110469
tmem125b
transmembrane protein 125b
chr6_-_9565526 0.06 ENSDART00000151470
map3k2
mitogen-activated protein kinase kinase kinase 2
chr16_-_31435020 0.06 ENSDART00000138508
zgc:194210
zgc:194210
chr15_+_638457 0.06 ENSDART00000157162
znf1013
zinc finger protein 1013
chr25_+_10834903 0.05 ENSDART00000155247
si:ch211-147g22.5
si:ch211-147g22.5
chr24_+_684924 0.05 ENSDART00000186103
si:ch211-188f17.1
si:ch211-188f17.1
chr22_+_1751640 0.05 ENSDART00000162093
znf1169
zinc finger protein 1169
chr22_-_16412496 0.04 ENSDART00000137497
cts12
cathepsin 12
chr23_+_43255328 0.04 ENSDART00000102712
tgm2a
transglutaminase 2, C polypeptide A
chr1_+_51721851 0.04 ENSDART00000040397
prdx2
peroxiredoxin 2
chr4_+_36489448 0.03 ENSDART00000143181
znf1149
zinc finger protein 1149
chr2_+_45552901 0.03 ENSDART00000131701
fndc7a
fibronectin type III domain containing 7a
chr5_-_27438812 0.03 ENSDART00000078755
drd7
dopamine receptor D7
chr7_+_2797795 0.02 ENSDART00000161208
si:ch211-217i17.1
si:ch211-217i17.1
chr6_-_131401 0.02 ENSDART00000151251
LRRC8E
si:zfos-323e3.4
chr16_+_41135018 0.02 ENSDART00000139435
si:ch211-53m15.2
si:ch211-53m15.2
chr5_-_29112956 0.02 ENSDART00000132726
whrnb
whirlin b
chr22_+_5959984 0.02 ENSDART00000179378
ENSDART00000178985
ENSDART00000174635
BX322587.2

chr22_-_4813345 0.02 ENSDART00000190650
CU570881.2

chr4_-_17803784 0.01 ENSDART00000187195
spi2
Spi-2 proto-oncogene
chr15_-_34892664 0.01 ENSDART00000153787
ENSDART00000099721
rnf183
ring finger protein 183
chr2_-_985417 0.01 ENSDART00000140540
si:ch211-241e1.3
si:ch211-241e1.3
chr14_-_1313480 0.00 ENSDART00000097748
il21
interleukin 21
chr16_+_49601838 0.00 ENSDART00000168570
ENSDART00000159236
si:dkey-82o10.4
si:dkey-82o10.4
chr5_+_20437124 0.00 ENSDART00000159001
tmem119a
transmembrane protein 119a
chr25_+_37285737 0.00 ENSDART00000126879
tmed6
transmembrane p24 trafficking protein 6
chr5_+_4298636 0.00 ENSDART00000100061
prdx4
peroxiredoxin 4
chr10_+_36037977 0.00 ENSDART00000164678
katnal1
katanin p60 subunit A-like 1
chr10_+_25726694 0.00 ENSDART00000140308
ugt5d1
UDP glucuronosyltransferase 5 family, polypeptide D1
chr3_-_16110100 0.00 ENSDART00000051807
lasp1
LIM and SH3 protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of pax8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.1 0.3 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341)
0.1 0.3 GO:0035994 response to muscle stretch(GO:0035994)
0.0 0.3 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.5 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.0 0.2 GO:1901031 response to leucine(GO:0043201) cellular response to leucine(GO:0071233) regulation of response to reactive oxygen species(GO:1901031)
0.0 0.1 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:1904825 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.0 0.2 GO:0030719 P granule organization(GO:0030719)
0.0 0.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0016600 flotillin complex(GO:0016600)
0.1 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.6 GO:0044545 NSL complex(GO:0044545)
0.0 0.2 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.3 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.6 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 0.4 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.3 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.8 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.0 0.2 GO:0070728 leucine binding(GO:0070728)
0.0 0.1 GO:0070004 cysteine-type exopeptidase activity(GO:0070004)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.3 GO:0008307 structural constituent of muscle(GO:0008307)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines