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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for pax3a+pax3b
Z-value: 0.80
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Transcription factors associated with pax3a+pax3b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| pax3b | dr11_v1_chr15_-_42206890_42206890 | 0.87 | 2.4e-06 | Click! |
| pax3a | dr11_v1_chr2_-_47431205_47431205 | 0.75 | 3.3e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_-_28727763 Show fit | 2.57 |
ENSDART00000149575
|
DC-STAMP domain containing 1 |
|
| chr20_-_2667902 Show fit | 2.15 |
ENSDART00000036373
|
cilia and flagella associated protein 206 |
|
| chr12_-_23128746 Show fit | 2.02 |
ENSDART00000170018
|
armadillo repeat containing 4 |
|
| chr23_-_35483163 Show fit | 2.02 |
ENSDART00000138660
ENSDART00000113643 ENSDART00000189269 |
F-box protein 25 |
|
| chr12_-_20796430 Show fit | 1.99 |
ENSDART00000064339
|
NME/NM23 nucleoside diphosphate kinase 2a |
|
| chr25_+_32530976 Show fit | 1.93 |
ENSDART00000156190
ENSDART00000103324 |
S-phase cyclin A-associated protein in the ER |
|
| chr20_-_52666150 Show fit | 1.92 |
ENSDART00000146716
ENSDART00000134155 |
si:ch211-221n20.4 |
|
| chr9_+_2507526 Show fit | 1.90 |
ENSDART00000166579
|
WAS/WASL interacting protein family, member 1a |
|
| chr18_+_25752592 Show fit | 1.90 |
ENSDART00000111767
|
si:ch211-39k3.2 |
|
| chr20_-_51697437 Show fit | 1.90 |
ENSDART00000145391
|
si:ch211-14a11.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of pax3a+pax3b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0009612 | response to mechanical stimulus(GO:0009612) |
| 0.0 | 2.5 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.2 | 2.3 | GO:0061333 | renal tubule morphogenesis(GO:0061333) nephron tubule morphogenesis(GO:0072078) nephron epithelium morphogenesis(GO:0072088) |
| 0.4 | 2.2 | GO:0003356 | regulation of cilium beat frequency(GO:0003356) |
| 0.1 | 2.0 | GO:0006228 | UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051) |
| 0.0 | 1.9 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.2 | 1.6 | GO:0021634 | optic nerve formation(GO:0021634) |
| 0.2 | 1.6 | GO:0015800 | acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490) |
| 0.4 | 1.4 | GO:0048939 | Golgi vesicle docking(GO:0048211) anterior lateral line nerve glial cell differentiation(GO:0048913) myelination of anterior lateral line nerve axons(GO:0048914) anterior lateral line nerve glial cell development(GO:0048939) anterior lateral line nerve glial cell morphogenesis involved in differentiation(GO:0048940) |
| 0.2 | 1.4 | GO:2000312 | regulation of kainate selective glutamate receptor activity(GO:2000312) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0001534 | radial spoke(GO:0001534) |
| 0.0 | 1.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 1.4 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.1 | 1.0 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 1.0 | GO:0031514 | motile cilium(GO:0031514) |
| 0.1 | 0.9 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.8 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 0.7 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.7 | GO:0043186 | P granule(GO:0043186) |
| 0.1 | 0.6 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.0 | 1.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 1.6 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.0 | 1.4 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.1 | 1.0 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.2 | 0.9 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
| 0.2 | 0.9 | GO:0046592 | polyamine oxidase activity(GO:0046592) |
| 0.0 | 0.9 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 0.9 | GO:0015370 | solute:sodium symporter activity(GO:0015370) |
| 0.0 | 0.8 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 0.8 | PID P73PATHWAY | p73 transcription factor network |
| 0.0 | 0.5 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.0 | 0.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 1.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.1 | 1.1 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 1.1 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 0.7 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.0 | 0.3 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.0 | 0.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |