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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for otx5
Z-value: 0.82
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Transcription factors associated with otx5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| otx5 | dr11_v1_chr15_+_47903864_47903864 | -0.93 | 1.5e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_4301234 Show fit | 3.70 |
ENSDART00000152377
ENSDART00000152521 |
carbonic anhydrase XVb |
|
| chr4_-_77125693 Show fit | 3.30 |
ENSDART00000174256
|
|
|
| chr22_+_25140904 Show fit | 2.86 |
ENSDART00000143114
|
si:dkeyp-20e4.8 |
|
| chr4_-_77130289 Show fit | 2.68 |
ENSDART00000174380
|
|
|
| chr23_-_45955177 Show fit | 1.92 |
ENSDART00000165963
ENSDART00000186649 ENSDART00000185773 |
|
|
| chr3_-_26184018 Show fit | 1.79 |
ENSDART00000191604
|
si:ch211-11k18.4 |
|
| chr16_+_40043673 Show fit | 1.78 |
ENSDART00000102552
ENSDART00000125484 |
tRNA methyltransferase 11 homolog (S. cerevisiae) |
|
| chr17_+_16046132 Show fit | 1.62 |
ENSDART00000155005
|
si:ch73-204p21.2 |
|
| chr3_-_26183699 Show fit | 1.55 |
ENSDART00000147517
ENSDART00000140731 |
si:ch211-11k18.4 |
|
| chr17_+_16046314 Show fit | 1.46 |
ENSDART00000154554
ENSDART00000154338 ENSDART00000155336 |
si:ch73-204p21.2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of otx5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.7 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.0 | 3.5 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.0 | 3.0 | GO:0016197 | endosomal transport(GO:0016197) |
| 0.4 | 2.7 | GO:0031119 | tRNA pseudouridine synthesis(GO:0031119) |
| 0.6 | 1.7 | GO:0090008 | hypoblast development(GO:0090008) |
| 0.0 | 1.3 | GO:0030038 | contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149) |
| 0.4 | 1.2 | GO:1903441 | receptor localization to nonmotile primary cilium(GO:0097500) protein localization to ciliary membrane(GO:1903441) |
| 0.2 | 1.2 | GO:0031053 | primary miRNA processing(GO:0031053) |
| 0.0 | 1.2 | GO:0038202 | TORC1 signaling(GO:0038202) |
| 0.0 | 1.2 | GO:0051209 | release of sequestered calcium ion into cytosol(GO:0051209) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.1 | 1.2 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.1 | 1.2 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 1.1 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.1 | 1.0 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.1 | 1.0 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 1.0 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 1.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 0.9 | GO:0017177 | glucosidase II complex(GO:0017177) |
| 0.2 | 0.9 | GO:0033557 | Slx1-Slx4 complex(GO:0033557) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 2.7 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.4 | 1.8 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.1 | 1.7 | GO:0070697 | activin receptor binding(GO:0070697) |
| 0.1 | 1.2 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
| 0.0 | 1.2 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.4 | 1.1 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.1 | 1.0 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 1.0 | GO:0004382 | guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134) |
| 0.0 | 1.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 1.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.3 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 1.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 1.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 1.0 | ST G ALPHA S PATHWAY | G alpha s Pathway |
| 0.0 | 0.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 0.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.6 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 1.3 | REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION | Genes involved in Nuclear Events (kinase and transcription factor activation) |
| 0.2 | 1.2 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.1 | 1.2 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 1.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.0 | 1.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.0 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 0.9 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.0 | 0.8 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 0.6 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |