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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for otpa+otpb

Z-value: 0.09

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Transcription factors associated with otpa+otpb

Gene Symbol Gene ID Gene Info
ENSDARG00000014201 orthopedia homeobox a
ENSDARG00000058379 orthopedia homeobox b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
otpadr11_v1_chr21_+_7582036_7582059-0.571.3e-02Click!
otpbdr11_v1_chr5_-_51619262_516193210.456.0e-02Click!

Activity profile of otpa+otpb motif

Sorted Z-values of otpa+otpb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr24_-_10006158 0.22 ENSDART00000106244
zgc:171750
chr9_+_54039006 0.19 ENSDART00000112441
toll-like receptor 7
chr14_-_33481428 0.17 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lysosomal-associated membrane protein 2
chr17_-_4245902 0.17 ENSDART00000151851
growth differentiation factor 3
chr25_+_22320738 0.15 ENSDART00000073566
cytochrome P450, family 11, subfamily A, polypeptide 1
chr10_-_34916208 0.14 ENSDART00000187371
cyclin A1
chr2_-_17392799 0.11 ENSDART00000136470
ENSDART00000141188
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr17_+_22577472 0.10 ENSDART00000045099
Yip1 domain family, member 4
chr23_+_36460239 0.10 ENSDART00000172441
LIM domain and actin binding 1a
chr5_+_29851433 0.10 ENSDART00000143434
ubiquitin associated and SH3 domain containing Ba
chr18_+_14619544 0.09 ENSDART00000010821
UTP4, small subunit processome component
chr9_-_27398369 0.09 ENSDART00000186499
testis expressed 30
chr2_-_17393216 0.09 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr6_+_12527725 0.08 ENSDART00000149328
serine/threonine kinase 24b (STE20 homolog, yeast)
chr22_+_2751887 0.08 ENSDART00000133652
si:dkey-20i20.11
chr17_-_40956035 0.08 ENSDART00000124715
si:dkey-16j16.4
chr21_+_27513859 0.08 ENSDART00000065420
phosphofurin acidic cluster sorting protein 1a
chr20_-_49889111 0.08 ENSDART00000058858
kinesin family member 13Bb
chr22_-_21897203 0.08 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr10_+_11261576 0.08 ENSDART00000155333
hydroxysteroid dehydrogenase like 2
chr24_-_16980337 0.08 ENSDART00000183812
kelch-like family member 15
chr11_-_10456387 0.08 ENSDART00000011087
ENSDART00000081827
epithelial cell transforming 2
chr22_-_14247276 0.07 ENSDART00000033332
si:ch211-246m6.5
chr3_+_26288981 0.07 ENSDART00000163500
ras homolog family member T1a
chr11_-_10456553 0.07 ENSDART00000169509
ENSDART00000185574
ENSDART00000188276
epithelial cell transforming 2
chr10_-_13343831 0.07 ENSDART00000135941
interleukin 11 receptor, alpha
chr16_+_25068576 0.06 ENSDART00000125838
im:7147486
chr18_+_35128685 0.06 ENSDART00000151579
si:ch211-195m9.3
chr14_-_1200854 0.06 ENSDART00000106672
ADP-ribosylation factor-like 9
chr6_-_33878665 0.06 ENSDART00000129916
transmembrane protein 69
chr12_+_36428052 0.06 ENSDART00000131300
unkempt family zinc finger
chr1_-_51038885 0.06 ENSDART00000035150
spastin
chr1_+_47499888 0.06 ENSDART00000027624
STN1, CST complex subunit
chr14_+_1170968 0.05 ENSDART00000125203
ENSDART00000193575
HOP homeobox
chr5_+_60590796 0.05 ENSDART00000159859
transmembrane protein 132E
chr20_+_32552912 0.05 ENSDART00000009691
Scm polycomb group protein like 4
chr3_+_23029484 0.05 ENSDART00000187900
N-acetylglutamate synthase
chr25_-_27621268 0.05 ENSDART00000146205
ENSDART00000073511
hyaluronoglucosaminidase 6
chr25_+_2263857 0.05 ENSDART00000076439
tyrosyl-tRNA synthetase 2, mitochondrial
chr16_+_54209504 0.05 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr5_+_41477526 0.05 ENSDART00000153567
protein inhibitor of activated STAT, 2
chr5_+_41477954 0.05 ENSDART00000185871
protein inhibitor of activated STAT, 2
chr24_+_19415124 0.05 ENSDART00000186931
sulfatase 1
chr9_+_24065855 0.04 ENSDART00000161468
ENSDART00000171577
ENSDART00000172743
ENSDART00000159324
ENSDART00000079689
ENSDART00000023196
ENSDART00000101577
leucine rich repeat (in FLII) interacting protein 1a
chr24_+_23202545 0.04 ENSDART00000143862
peroxisomal biogenesis factor 2
chr1_+_45663727 0.04 ENSDART00000038574
ENSDART00000141144
ENSDART00000149565
trafficking protein particle complex 5
chr3_+_26342768 0.04 ENSDART00000163832
si:ch211-156b7.4
chr7_-_57509447 0.04 ENSDART00000051973
ENSDART00000147036
sirtuin 3
chr21_-_2814709 0.04 ENSDART00000097664
semaphorin 4D
chr3_+_13848226 0.04 ENSDART00000184342
interleukin enhancer binding factor 3b
chr4_-_5019113 0.04 ENSDART00000189321
ENSDART00000081990
striatin interacting protein 2
chr9_+_2574122 0.04 ENSDART00000166326
ENSDART00000191822
si:ch73-167c12.2
chr10_+_1681518 0.04 ENSDART00000018532
TP53 regulated inhibitor of apoptosis 1
chr9_+_48761455 0.04 ENSDART00000139631
ATP-binding cassette, sub-family B (MDR/TAP), member 11a
chr23_+_12406722 0.03 ENSDART00000145008
phosphatidylinositol glycan anchor biosynthesis, class T
chr23_+_1029450 0.03 ENSDART00000189196
si:zfos-905g2.1
chr14_-_7207961 0.03 ENSDART00000167994
ENSDART00000166532
storkhead box 2b
chr22_-_16154771 0.03 ENSDART00000009464
solute carrier family 30 (zinc transporter), member 7
chr1_+_52792439 0.03 ENSDART00000123972
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr7_-_34448076 0.03 ENSDART00000170935
nuclear receptor subfamily 1, group H, member 3
chr11_+_17984354 0.03 ENSDART00000179986
RNA pseudouridylate synthase domain containing 4
chr7_+_24573721 0.03 ENSDART00000173938
ENSDART00000173681
si:dkeyp-75h12.7
chr5_-_11809710 0.03 ENSDART00000186998
ENSDART00000181363
ENSDART00000180681
neurofibromin 2a (merlin)
chr4_-_23759192 0.03 ENSDART00000014685
ENSDART00000131690
carboxypeptidase M
chr4_+_17655872 0.03 ENSDART00000066999
WASH complex subunit 3
chr1_-_31534089 0.03 ENSDART00000007770
ladybird homeobox 1b
chr7_-_30174882 0.03 ENSDART00000110409
FERM domain containing 5
chr11_+_17984167 0.03 ENSDART00000020283
ENSDART00000188329
RNA pseudouridylate synthase domain containing 4
chr14_+_989733 0.03 ENSDART00000161487
ENSDART00000127317
si:ch73-308l14.2
chr1_-_15797663 0.03 ENSDART00000177122
sarcoglycan zeta
chr22_+_34784075 0.02 ENSDART00000167538
ligand dependent nuclear receptor corepressor
chr14_-_26425416 0.02 ENSDART00000088690
lectin, mannose-binding 2
chr4_+_76426308 0.02 ENSDART00000180424
ENSDART00000159789

zgc:172128
chr18_+_41527877 0.02 ENSDART00000146972
selenoprotein T, 1b
chr6_-_51771634 0.02 ENSDART00000073847
bladder cancer associated protein
chr25_-_21031007 0.02 ENSDART00000138985
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide a
chr7_+_51774502 0.02 ENSDART00000007767
glutamic-oxaloacetic transaminase 2b, mitochondrial
chr23_+_16638639 0.02 ENSDART00000143545
syntaphilin b
chr7_+_21272833 0.02 ENSDART00000052942
serine (or cysteine) peptidase inhibitor, clade H, member 2
chr6_-_40029423 0.02 ENSDART00000103230
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4b
chr22_-_10156581 0.02 ENSDART00000168304
RanBP-type and C3HC4-type zinc finger containing 1
chr21_-_36571804 0.02 ENSDART00000138129
WW and C2 domain containing 1
chr17_+_49281597 0.02 ENSDART00000155599
zgc:113176
chr17_-_25831569 0.02 ENSDART00000148743
hedgehog acyltransferase
chr2_+_37140448 0.02 ENSDART00000045016
ENSDART00000142940
peroxisomal biogenesis factor 19
chr3_-_60142530 0.02 ENSDART00000153247
si:ch211-120g10.1
chr13_-_52089003 0.02 ENSDART00000187600
transmembrane protein 254
chr14_-_48765262 0.02 ENSDART00000166463
CCR4-NOT transcription complex, subunit 6b
chr5_-_12272689 0.02 ENSDART00000099810
nitric oxide synthase 1 (neuronal)
chr9_+_34127005 0.02 ENSDART00000167384
ENSDART00000078065
coagulation factor V
chr17_+_24821627 0.02 ENSDART00000112389
WD repeat domain 43
chr8_-_33381913 0.02 ENSDART00000076420
LIM homeobox transcription factor 1, beta b
chr18_+_17725410 0.02 ENSDART00000090608
ring finger and SPRY domain containing 1
chr2_+_50608099 0.02 ENSDART00000185805
ENSDART00000111135
neuronal differentiation 6b
chr4_-_1801519 0.02 ENSDART00000188604
ENSDART00000135749
nudix (nucleoside diphosphate linked moiety X)-type motif 4b
chr2_-_37140423 0.01 ENSDART00000144220
tetraspanin 37
chr9_-_3934963 0.01 ENSDART00000062336
ubiquitin protein ligase E3 component n-recognin 3
chr17_+_28533102 0.01 ENSDART00000156218
MAM domain containing glycosylphosphatidylinositol anchor 2a
chr8_+_36560019 0.01 ENSDART00000136418
ENSDART00000061378
ENSDART00000185237
splicing factor 3a, subunit 1
chr1_+_39482588 0.01 ENSDART00000181790
teneurin transmembrane protein 3
chr11_+_7214353 0.01 ENSDART00000156764
NACHT and WD repeat domain containing 1
chr5_+_33498253 0.01 ENSDART00000140993
membrane-spanning 4-domains, subfamily A, member 17c.2
chr1_-_25966411 0.01 ENSDART00000193375
synaptopodin 2b
chr6_-_35046735 0.01 ENSDART00000143649
UDP-N-acetylglucosamine pyrophosphorylase 1
chr23_-_16484383 0.01 ENSDART00000187839
si:dkeyp-100a5.4
chr13_-_38730267 0.01 ENSDART00000157524
LMBR1 domain containing 1
chr9_-_42418470 0.01 ENSDART00000144353
calcitonin receptor-like a
chr17_+_16564921 0.01 ENSDART00000151904
forkhead box N3
chr6_-_11768198 0.01 ENSDART00000183463
membrane-associated ring finger (C3HC4) 7
chr20_-_43663494 0.01 ENSDART00000144564

chr2_+_20605925 0.01 ENSDART00000191510
olfactomedin-like 2Bb
chr1_-_8963484 0.01 ENSDART00000188035
suppressor of cytokine signaling 1b
chr18_+_33272861 0.01 ENSDART00000131796
vomeronasal 2 receptor, a20
chr20_-_29864390 0.01 ENSDART00000161834
ENSDART00000132278
ring finger protein 144ab
chr20_+_98179 0.01 ENSDART00000022725
si:ch1073-155h21.1
chr22_-_9183944 0.01 ENSDART00000188599
si:ch211-213a13.5
chr25_-_27722614 0.01 ENSDART00000190154
zgc:153935
chr21_+_38634296 0.01 ENSDART00000114467

chr4_-_67980261 0.01 ENSDART00000182305
si:ch211-223k15.1
chr22_+_30137374 0.01 ENSDART00000187808
adducin 3 (gamma) a
chr17_-_2386569 0.01 ENSDART00000121614
phospholipase C beta 2
chr8_+_49065348 0.01 ENSDART00000032277
DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr4_+_54618332 0.01 ENSDART00000171824
si:ch211-227e10.2
chr18_+_18439332 0.01 ENSDART00000043843
siah E3 ubiquitin protein ligase 1
chr22_-_14739491 0.01 ENSDART00000133385
low density lipoprotein receptor-related protein 1Ba
chr8_-_53044300 0.01 ENSDART00000191653
nuclear receptor subfamily 6, group A, member 1a
chr17_-_16422654 0.01 ENSDART00000150149
tyrosyl-DNA phosphodiesterase 1
chr16_+_23796612 0.01 ENSDART00000131698
RAB13, member RAS oncogene family
chr15_+_37965953 0.01 ENSDART00000154192
si:dkey-238d18.10
chr19_+_46158078 0.01 ENSDART00000183933
ENSDART00000164055
CAP, adenylate cyclase-associated protein, 2 (yeast)
chr17_+_20589553 0.01 ENSDART00000154447
si:ch73-288o11.4
chr9_-_37749973 0.01 ENSDART00000087663
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Ba
chr4_+_59845617 0.01 ENSDART00000167626
ENSDART00000123157
si:dkey-196n19.2
chr22_+_5532003 0.00 ENSDART00000106174
si:ch73-256j6.2
chr4_-_2219705 0.00 ENSDART00000131046
si:ch73-278m9.1
chr8_-_33381430 0.00 ENSDART00000190019
LIM homeobox transcription factor 1, beta b
chr2_+_29842878 0.00 ENSDART00000131376
si:ch211-207d6.2
chr22_+_1568306 0.00 ENSDART00000163223
si:ch211-255f4.9
chr11_+_44617021 0.00 ENSDART00000158887
RNA binding motif protein 34
chr17_+_31914877 0.00 ENSDART00000177801
family with sequence similarity 196 member A
chr25_-_28674739 0.00 ENSDART00000067073
leucine rich repeat containing 10
chr16_+_23303859 0.00 ENSDART00000006093
solute carrier family 50 (sugar efflux transporter), member 1
chr25_+_13621563 0.00 ENSDART00000159428
si:ch211-172l8.4
chr4_+_13449775 0.00 ENSDART00000172552
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr21_-_22635245 0.00 ENSDART00000115224
ENSDART00000101782
nectin cell adhesion molecule 1a
chr7_-_71829649 0.00 ENSDART00000160449
calcium channel, voltage-dependent, beta 2a
chr3_-_48716422 0.00 ENSDART00000164979
si:ch211-114m9.1
chr4_+_19700308 0.00 ENSDART00000027919
paired box 4
chr5_+_71802014 0.00 ENSDART00000124939
ENSDART00000097164
LIM homeobox 3
chr1_-_25966068 0.00 ENSDART00000137869
ENSDART00000134192
synaptopodin 2b
chr9_-_32177117 0.00 ENSDART00000078568
splicing factor 3b, subunit 1
chr11_-_40742424 0.00 ENSDART00000173399
ENSDART00000021369
taste receptor, type 1, member 3
chr1_+_9086942 0.00 ENSDART00000055023
calcium channel, voltage-dependent, gamma subunit 3a
chr1_+_11882186 0.00 ENSDART00000193419
sorting nexin 8b
chr3_+_3681116 0.00 ENSDART00000109618
ADP-ribosyltransferase 4 (Dombrock blood group)
chr14_-_451555 0.00 ENSDART00000190906
FAT atypical cadherin 4
chr21_-_1644414 0.00 ENSDART00000105736
ENSDART00000124904
zgc:152948

Network of associatons between targets according to the STRING database.

First level regulatory network of otpa+otpb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
0.0 0.2 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.1 GO:0006700 C21-steroid hormone biosynthetic process(GO:0006700)
0.0 0.1 GO:0051228 protein hexamerization(GO:0034214) mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230)
0.0 0.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)
0.0 0.0 GO:1904729 regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.0 0.1 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.0 0.1 GO:1990879 CST complex(GO:1990879)
0.0 0.0 GO:1990072 TRAPPIII protein complex(GO:1990072)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016713 cholesterol monooxygenase (side-chain-cleaving) activity(GO:0008386) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0 0.2 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.1 GO:0034618 arginine binding(GO:0034618)
0.0 0.1 GO:0048487 beta-tubulin binding(GO:0048487)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR