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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for osr1
Z-value: 1.05
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Transcription factors associated with osr1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| osr1 | dr11_v1_chr13_+_32148338_32148338 | 0.89 | 6.7e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_34750169 Show fit | 4.19 |
ENSDART00000149380
|
si:dkey-151m22.8 |
|
| chr2_-_49557932 Show fit | 4.00 |
ENSDART00000141902
|
si:ch211-209f23.3 |
|
| chr5_-_61787969 Show fit | 3.50 |
ENSDART00000112744
|
growth arrest specific 2 like 2 |
|
| chr3_+_15805917 Show fit | 3.33 |
ENSDART00000055834
|
phosphatase, orphan 1 |
|
| chr18_-_29961784 Show fit | 3.00 |
ENSDART00000135601
ENSDART00000140661 |
si:ch73-103b9.2 |
|
| chr2_-_43942595 Show fit | 2.81 |
ENSDART00000147925
|
si:ch211-195h23.4 |
|
| chr2_+_49799470 Show fit | 2.77 |
ENSDART00000146325
|
si:ch211-190k17.19 |
|
| chr7_+_24391129 Show fit | 2.77 |
ENSDART00000108753
|
polymerase (DNA directed) nu |
|
| chr18_+_46382484 Show fit | 2.65 |
ENSDART00000024202
ENSDART00000142790 |
dynein assembly factor with WDR repeat domains 1 |
|
| chr10_+_2587234 Show fit | 2.54 |
ENSDART00000126937
|
wu:fb59d01 |
Network of associatons between targets according to the STRING database.
First level regulatory network of osr1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.1 | 3.9 | GO:0022900 | electron transport chain(GO:0022900) |
| 0.2 | 3.5 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.1 | 3.3 | GO:0070167 | regulation of bone mineralization(GO:0030500) regulation of biomineral tissue development(GO:0070167) |
| 0.7 | 2.8 | GO:0070987 | error-free translesion synthesis(GO:0070987) |
| 0.2 | 2.7 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
| 0.0 | 2.3 | GO:0006414 | translational elongation(GO:0006414) |
| 0.0 | 2.3 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 2.1 | GO:0006956 | complement activation(GO:0006956) |
| 0.3 | 1.9 | GO:0003356 | regulation of cilium beat frequency(GO:0003356) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 3.4 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.6 | 1.9 | GO:0001534 | radial spoke(GO:0001534) |
| 0.0 | 1.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.9 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 1.7 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.5 | 1.4 | GO:0034457 | Mpp10 complex(GO:0034457) |
| 0.2 | 1.4 | GO:0030897 | HOPS complex(GO:0030897) |
| 0.0 | 1.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.4 | 1.2 | GO:0098556 | cytoplasmic side of rough endoplasmic reticulum membrane(GO:0098556) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 3.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 3.3 | GO:0016651 | oxidoreductase activity, acting on NAD(P)H(GO:0016651) |
| 0.0 | 2.8 | GO:0004527 | exonuclease activity(GO:0004527) |
| 0.1 | 2.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 1.9 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.2 | 1.8 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.1 | 1.7 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.1 | 1.6 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.0 | 1.5 | GO:0042803 | protein homodimerization activity(GO:0042803) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.9 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.0 | 0.7 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 0.5 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 0.2 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.3 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.0 | 3.0 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 1.0 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 1.0 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 0.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 0.6 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.0 | 0.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.5 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |