ISMARA results: olig3_olig2+olig4

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for olig3_olig2+olig4_olig1

Z-value: 1.85

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Transcription factors associated with olig3_olig2+olig4_olig1

Gene Symbol	Gene ID	Gene Info
olig3 NCBI UniProt	ENSDARG00000074253	oligodendrocyte transcription factor 3
olig2 NCBI UniProt	ENSDARG00000040946	oligodendrocyte lineage transcription factor 2
olig4 NCBI UniProt	ENSDARG00000052610	oligodendrocyte transcription factor 4
olig4 NCBI UniProt	ENSDARG00000116678	oligodendrocyte transcription factor 4
olig1 NCBI UniProt	ENSDARG00000040948	oligodendrocyte transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
olig4	dr11_v1_chr13_+_45967179_45967179	-0.92	4.7e-08	Click!
olig1	dr11_v1_chr9_-_32730487_32730487	-0.52	2.7e-02	Click!
olig2	dr11_v1_chr9_-_32753535_32753535	-0.31	2.2e-01	Click!

Activity profile of olig3_olig2+olig4_olig1 motif

Sorted Z-values of olig3_olig2+olig4_olig1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_46020508 Show fit	6.83	ENSDART00000170294	ccne1 NCBI UniProt Show fit	cyclin E1
chr1_-_43712120 Show fit	6.62	ENSDART00000074600	SLC9B2 NCBI UniProt Show fit	si:dkey-162b23.4
chr16_-_39267185 Show fit	6.22	ENSDART00000058550 ENSDART00000133642	gpd1l NCBI UniProt Show fit	glycerol-3-phosphate dehydrogenase 1 like
chr12_-_17863467 Show fit	6.16	ENSDART00000042006	baiap2l1a NCBI UniProt Show fit	BAI1-associated protein 2-like 1a
chr17_-_15189397 Show fit	5.57	ENSDART00000133710 ENSDART00000110507	wdhd1 NCBI UniProt Show fit	WD repeat and HMG-box DNA binding protein 1
chr19_-_8798178 Show fit	5.49	ENSDART00000188232	cers2a NCBI UniProt Show fit	ceramide synthase 2a
chr18_-_40708537 Show fit	5.25	ENSDART00000077577	si:ch211-132b12.8 NCBI UniProt Show fit	si:ch211-132b12.8
chr8_+_1009831 Show fit	5.03	ENSDART00000172414	fabp1b.2 NCBI UniProt Show fit	fatty acid binding protein 1b, liver, tandem duplicate 2
chr19_-_12212692 Show fit	4.49	ENSDART00000142077 ENSDART00000151599 ENSDART00000140834 ENSDART00000078781	znf706 NCBI UniProt Show fit	zinc finger protein 706
chr3_+_43374571 Show fit	4.33	ENSDART00000182497	zfand2a NCBI UniProt Show fit	zinc finger, AN1-type domain 2A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of olig3_olig2+olig4_olig1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	9.6	GO:1904029	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0	9.1	GO:0008380	RNA splicing(GO:0008380)
0.9	7.4	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1	7.4	GO:0006261	DNA-dependent DNA replication(GO:0006261)
0.3	5.5	GO:0035196	production of miRNAs involved in gene silencing by miRNA(GO:0035196)
1.2	4.9	GO:0046168	NADH oxidation(GO:0006116) glycerol-3-phosphate catabolic process(GO:0046168)
0.3	4.6	GO:0051897	positive regulation of protein kinase B signaling(GO:0051897)
0.1	4.4	GO:0071599	otic vesicle development(GO:0071599)
0.5	4.3	GO:0055129	proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1	4.2	GO:0051170	nuclear import(GO:0051170)

Showing 1 to 10 of 257 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	15.5	GO:0000323	lytic vacuole(GO:0000323)
0.0	13.2	GO:0005743	mitochondrial inner membrane(GO:0005743)
2.5	10.1	GO:0097134	cyclin E1-CDK2 complex(GO:0097134)
0.3	8.9	GO:0043596	nuclear replication fork(GO:0043596)
0.1	7.7	GO:0016607	nuclear speck(GO:0016607)
0.0	7.1	GO:0005912	adherens junction(GO:0005912)
0.2	6.6	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.8	4.9	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
1.0	4.1	GO:0005965	protein farnesyltransferase complex(GO:0005965)
0.2	3.6	GO:0005686	U2 snRNP(GO:0005686)

Showing 1 to 10 of 121 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	9.6	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0	6.1	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	5.4	GO:0035091	phosphatidylinositol binding(GO:0035091)
0.5	5.3	GO:0035198	miRNA binding(GO:0035198)
1.2	4.9	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	4.7	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0	4.6	GO:0005096	GTPase activator activity(GO:0005096)
0.1	4.4	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.9	4.3	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
1.0	4.1	GO:0004660	protein farnesyltransferase activity(GO:0004660)

Showing 1 to 10 of 187 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	9.6	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	7.0	PID AURORA B PATHWAY	Aurora B signaling
0.2	3.9	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	3.7	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	3.7	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.1	3.3	PID ARF6 PATHWAY	Arf6 signaling events
0.1	3.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.1	2.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	2.6	ST GAQ PATHWAY	G alpha q Pathway
0.1	2.5	PID FOXO PATHWAY	FoxO family signaling

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	9.6	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.3	6.2	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	4.0	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	3.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.2	3.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	3.0	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	2.8	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	2.6	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.2	2.5	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	2.5	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

Showing 1 to 10 of 65 entries

Results for olig3_olig2+olig4_olig1

Z-value: 1.85

Motif logo

Transcription factors associated with olig3_olig2+olig4_olig1

Activity-expression correlation:

Activity profile of olig3_olig2+olig4_olig1 motif

Sorted Z-values of olig3_olig2+olig4_olig1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of olig3_olig2+olig4_olig1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: