ISMARA results: nr5a1a+nr5a2+nr5a5

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nr5a1a+nr5a2+nr5a5

Z-value: 1.04

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Transcription factors associated with nr5a1a+nr5a2+nr5a5

Gene Symbol	Gene ID	Gene Info
nr5a5 NCBI UniProt	ENSDARG00000039116	nuclear receptor subfamily 5, group A, member 5
nr5a2 NCBI UniProt	ENSDARG00000100940	nuclear receptor subfamily 5, group A, member 2
nr5a1a NCBI UniProt	ENSDARG00000103176	nuclear receptor subfamily 5, group A, member 1a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
nr5a1a	dr11_v1_chr8_-_52871056_52871056	0.89	7.7e-07	Click!
nr5a2	dr11_v1_chr22_-_22719440_22719440	0.64	3.9e-03	Click!
nr5a5	dr11_v1_chr3_-_53465223_53465249	0.51	3.0e-02	Click!

Activity profile of nr5a1a+nr5a2+nr5a5 motif

Sorted Z-values of nr5a1a+nr5a2+nr5a5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_24488652 Show fit	5.31	ENSDART00000052067	insl3 NCBI UniProt Show fit	insulin-like 3 (Leydig cell)
chr13_+_50375800 Show fit	4.45	ENSDART00000099537	cox5b2 NCBI UniProt Show fit	cytochrome c oxidase subunit Vb 2
chr21_+_198269 Show fit	3.73	ENSDART00000193485 ENSDART00000163696	gsdf NCBI UniProt Show fit	gonadal somatic cell derived factor
chr15_-_20916251 Show fit	3.40	ENSDART00000134053	usp2a NCBI UniProt Show fit	ubiquitin specific peptidase 2a
chr7_-_59256806 Show fit	2.98	ENSDART00000167955	m1ap NCBI UniProt Show fit	meiosis 1 associated protein
chr16_+_52512025 Show fit	2.96	ENSDART00000056095	fabp10a NCBI UniProt Show fit	fatty acid binding protein 10a, liver basic
chr8_-_36554675 Show fit	2.93	ENSDART00000132804 ENSDART00000078746	ccdc157 NCBI UniProt Show fit	coiled-coil domain containing 157
chr19_-_12145765 Show fit	2.85	ENSDART00000032474	pabpc1b NCBI UniProt Show fit	poly A binding protein, cytoplasmic 1 b
chr22_+_7439476 Show fit	2.78	ENSDART00000021594 ENSDART00000063389	zgc:92041 NCBI UniProt Show fit	zgc:92041
chr9_+_21194445 Show fit	2.61	ENSDART00000061321	hsd3b1 NCBI UniProt Show fit	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of nr5a1a+nr5a2+nr5a5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	12.8	GO:0046777	protein autophosphorylation(GO:0046777)
0.5	6.1	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1	5.3	GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193)
0.6	3.0	GO:0007060	male meiosis chromosome segregation(GO:0007060)
0.1	2.8	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.1	2.5	GO:0021884	forebrain neuron development(GO:0021884)
0.2	2.4	GO:0036158	outer dynein arm assembly(GO:0036158)
0.1	2.3	GO:0006144	purine nucleobase metabolic process(GO:0006144)
0.1	2.1	GO:0001556	oocyte maturation(GO:0001556)
0.0	2.0	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)

Showing 1 to 10 of 122 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0005930	axoneme(GO:0005930)
0.1	2.9	GO:0030964	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1	2.8	GO:0016605	PML body(GO:0016605)
0.2	2.4	GO:0036157	outer dynein arm(GO:0036157)
0.8	2.3	GO:1902560	GMP reductase complex(GO:1902560)
0.0	2.2	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	2.1	GO:0000786	nucleosome(GO:0000786)
0.0	1.9	GO:0005814	centriole(GO:0005814)
0.1	1.6	GO:0002178	palmitoyltransferase complex(GO:0002178)
0.1	1.6	GO:0045277	respiratory chain complex IV(GO:0045277)

Showing 1 to 10 of 38 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.7	GO:0005179	hormone activity(GO:0005179)
0.3	7.0	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	5.9	GO:0008083	growth factor activity(GO:0008083)
0.0	5.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.5	3.0	GO:0032052	bile acid binding(GO:0032052)
0.3	2.6	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2	2.4	GO:0045503	dynein light chain binding(GO:0045503)
0.8	2.3	GO:0003920	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.3	2.3	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	2.0	GO:0031490	chromatin DNA binding(GO:0031490)

Showing 1 to 10 of 91 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.0	3.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	2.8	PID ALK2 PATHWAY	ALK2 signaling events
0.1	1.7	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.5	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	1.4	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	1.3	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	0.9	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.7	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.7	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	6.5	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	2.6	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.3	2.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.2	2.3	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.4	1.9	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	1.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	1.6	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	1.4	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	1.3	REACTOME RESPIRATORY ELECTRON TRANSPORT	Genes involved in Respiratory electron transport
0.0	1.2	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins

Showing 1 to 10 of 25 entries

Results for nr5a1a+nr5a2+nr5a5

Z-value: 1.04

Motif logo

Transcription factors associated with nr5a1a+nr5a2+nr5a5

Activity-expression correlation:

Activity profile of nr5a1a+nr5a2+nr5a5 motif

Sorted Z-values of nr5a1a+nr5a2+nr5a5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of nr5a1a+nr5a2+nr5a5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: