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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nr2f6a+nr2f6b

Z-value: 0.50

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Transcription factors associated with nr2f6a+nr2f6b

Gene Symbol Gene ID Gene Info
nr2f6b
ENSDARG00000003165 nuclear receptor subfamily 2, group F, member 6b
nr2f6a
ENSDARG00000003607 nuclear receptor subfamily 2, group F, member 6a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr2f6adr11_v1_chr2_+_24376373_24376373-0.644.6e-03Click!
nr2f6bdr11_v1_chr11_+_6116503_6116503-0.331.8e-01Click!

Activity profile of nr2f6a+nr2f6b motif

Sorted Z-values of nr2f6a+nr2f6b motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_57076687 0.71 ENSDART00000161523
slc25a42
solute carrier family 25, member 42
chr25_+_418932 0.68 ENSDART00000059193
prtgb
protogenin homolog b (Gallus gallus)
chr25_+_20119466 0.66 ENSDART00000104304
bpgm
2,3-bisphosphoglycerate mutase
chr18_+_27515640 0.63 ENSDART00000181593
tp53i11b
tumor protein p53 inducible protein 11b
chr12_+_48681601 0.56 ENSDART00000187831
uros
uroporphyrinogen III synthase
chr22_-_11833317 0.51 ENSDART00000125423
ENSDART00000000192
ptpn4b
protein tyrosine phosphatase, non-receptor type 4b
chr18_-_12957451 0.50 ENSDART00000140403
srgap1a
SLIT-ROBO Rho GTPase activating protein 1a
chr17_+_33418475 0.50 ENSDART00000169145
snap23.1
synaptosomal-associated protein 23.1
chr9_+_34380299 0.49 ENSDART00000131705
lamp1
lysosomal-associated membrane protein 1
chr7_+_25000060 0.46 ENSDART00000039265
ENSDART00000141814
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr9_-_28990649 0.44 ENSDART00000078823
ptpn4a
protein tyrosine phosphatase, non-receptor type 4a
chr21_+_1119046 0.44 ENSDART00000184678
CABZ01088049.1

chr8_+_39802506 0.43 ENSDART00000018862
hnf1a
HNF1 homeobox a
chr4_-_858434 0.41 ENSDART00000006961
sobpb
sine oculis binding protein homolog (Drosophila) b
chr14_+_30413758 0.41 ENSDART00000092953
cnot7
CCR4-NOT transcription complex, subunit 7
chr3_-_34561624 0.41 ENSDART00000129313
sept9a
septin 9a
chr14_+_30413312 0.40 ENSDART00000186864
cnot7
CCR4-NOT transcription complex, subunit 7
chr4_-_75172216 0.40 ENSDART00000127522
naa40
N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog (S. cerevisiae)
chr22_-_3595439 0.39 ENSDART00000083308
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr23_-_45504991 0.37 ENSDART00000148761
col24a1
collagen type XXIV alpha 1
chr23_+_30730121 0.37 ENSDART00000134141
asxl1
additional sex combs like transcriptional regulator 1
chr8_+_16676894 0.37 ENSDART00000076586
si:ch211-198n5.11
si:ch211-198n5.11
chr24_-_7587401 0.36 ENSDART00000093163
galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)
chr11_-_44999858 0.36 ENSDART00000167759
ENSDART00000126845
ldb1b
LIM-domain binding 1b
chr6_+_60055168 0.35 ENSDART00000008752
pck1
phosphoenolpyruvate carboxykinase 1 (soluble)
chr24_+_39034090 0.32 ENSDART00000185763
capn15
calpain 15
chr23_-_42810664 0.31 ENSDART00000102328
pfkfb2a
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2a
chr25_+_18587338 0.30 ENSDART00000180287
met
MET proto-oncogene, receptor tyrosine kinase
chr10_+_11265387 0.30 ENSDART00000038888
hsdl2
hydroxysteroid dehydrogenase like 2
chr17_-_6954719 0.27 ENSDART00000188180
zbtb24
zinc finger and BTB domain containing 24
chr2_-_22659450 0.26 ENSDART00000115025
thap4
THAP domain containing 4
chr17_-_25303486 0.26 ENSDART00000162235
ppie
peptidylprolyl isomerase E (cyclophilin E)
chr22_-_38274188 0.26 ENSDART00000139420
ENSDART00000015117
elavl2
ELAV like neuron-specific RNA binding protein 2
chr23_+_44634187 0.25 ENSDART00000143688
si:ch73-265d7.2
si:ch73-265d7.2
chr23_+_44633858 0.25 ENSDART00000180728
si:ch73-265d7.2
si:ch73-265d7.2
chr24_+_39137001 0.25 ENSDART00000181086
ENSDART00000183724
ENSDART00000193466
tbc1d24
TBC1 domain family, member 24
chr17_+_23926796 0.23 ENSDART00000021177
pex13
peroxisomal biogenesis factor 13
chr16_-_24605969 0.20 ENSDART00000163305
ENSDART00000167121
fxyd6l
FXYD domain containing ion transport regulator 6 like
chr18_-_7810214 0.20 ENSDART00000139505
ENSDART00000139188
shank3a
SH3 and multiple ankyrin repeat domains 3a
chr15_+_47618221 0.20 ENSDART00000168722
paf1
PAF1 homolog, Paf1/RNA polymerase II complex component
chr24_+_81527 0.19 ENSDART00000192139
reck
reversion-inducing-cysteine-rich protein with kazal motifs
chr19_+_2631565 0.19 ENSDART00000171487
fam126a
family with sequence similarity 126, member A
chr13_-_37127970 0.19 ENSDART00000135510
syne2b
spectrin repeat containing, nuclear envelope 2b
chr1_-_58868306 0.18 ENSDART00000166615
dnm2b
dynamin 2b
chr2_+_6067371 0.18 ENSDART00000053868
ENSDART00000145244
aldh9a1b
aldehyde dehydrogenase 9 family, member A1b
chr25_+_22017182 0.18 ENSDART00000156517
si:dkey-217l24.1
si:dkey-217l24.1
chr8_-_8698607 0.18 ENSDART00000046712
zgc:86609
zgc:86609
chr15_+_47386939 0.17 ENSDART00000128224
FO904873.1

chr9_-_15208129 0.16 ENSDART00000137043
ENSDART00000131512
pard3bb
par-3 family cell polarity regulator beta b
chr7_+_38267136 0.15 ENSDART00000173613
gpatch1
G patch domain containing 1
chr3_+_1179601 0.14 ENSDART00000173378
triobpb
TRIO and F-actin binding protein b
chr4_+_12031958 0.14 ENSDART00000044154
tnnt2c
troponin T2c, cardiac
chr12_+_49125510 0.14 ENSDART00000185804
FO704607.1

chr1_+_12195700 0.13 ENSDART00000040307
tdrd7a
tudor domain containing 7 a
chr17_-_25737452 0.13 ENSDART00000152021
si:ch211-214p16.3
si:ch211-214p16.3
chr24_-_1021318 0.12 ENSDART00000181403
ralaa
v-ral simian leukemia viral oncogene homolog Aa (ras related)
chr10_-_44027391 0.12 ENSDART00000145404
crybb1
crystallin, beta B1
chr18_-_1185772 0.11 ENSDART00000143245
nptnb
neuroplastin b
chr1_+_58353661 0.10 ENSDART00000140074
si:dkey-222h21.2
si:dkey-222h21.2
chr7_-_36113098 0.08 ENSDART00000064913
fto
fat mass and obesity associated
chr23_-_46126444 0.08 ENSDART00000030004
CABZ01071903.1

chr8_+_999421 0.07 ENSDART00000149528
fabp1b.1
fatty acid binding protein 1b, tandem duplicate 1
chr7_-_24046999 0.07 ENSDART00000144616
ENSDART00000124653
ENSDART00000127813
dhrs4
dehydrogenase/reductase (SDR family) member 4
chr1_+_58303892 0.05 ENSDART00000147678
CR769768.1

chr8_-_979735 0.05 ENSDART00000149612
znf366
zinc finger protein 366
chr9_+_32860345 0.04 ENSDART00000121751
si:dkey-145p14.5
si:dkey-145p14.5
chr8_-_4097722 0.04 ENSDART00000135006
cux2b
cut-like homeobox 2b
chr1_+_58182400 0.03 ENSDART00000144784
si:ch211-15j1.1
si:ch211-15j1.1
chr1_+_58442694 0.03 ENSDART00000160897
zgc:194906
zgc:194906
chr18_-_48550426 0.03 ENSDART00000145189
kcnj1a.1
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr7_+_34296789 0.02 ENSDART00000052471
ENSDART00000173798
ENSDART00000173778
bbox1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr18_+_16330025 0.02 ENSDART00000142353
nts
neurotensin
chr24_-_25186895 0.02 ENSDART00000081029
plcxd2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr7_+_48297842 0.02 ENSDART00000052123
slc25a44b
solute carrier family 25, member 44 b
chr3_-_41292275 0.02 ENSDART00000144088
sdk1a
sidekick cell adhesion molecule 1a
chr1_+_58312680 0.02 ENSDART00000138007
si:dkey-222h21.10
si:dkey-222h21.10
chr22_-_16997887 0.02 ENSDART00000138233
nfia
nuclear factor I/A
chr20_+_2281933 0.02 ENSDART00000137579
si:ch73-18b11.2
si:ch73-18b11.2
chr13_-_37254777 0.02 ENSDART00000139734
syne2b
spectrin repeat containing, nuclear envelope 2b
chr20_+_46286082 0.01 ENSDART00000073519
taar14f
trace amine associated receptor 14f
chr22_-_16997475 0.01 ENSDART00000090237
nfia
nuclear factor I/A
chr18_-_7400075 0.01 ENSDART00000101250
si:dkey-30c15.13
si:dkey-30c15.13
chr9_+_32859967 0.01 ENSDART00000168992
si:dkey-145p14.5
si:dkey-145p14.5
chr8_+_36803415 0.01 ENSDART00000111680
iqsec2b
IQ motif and Sec7 domain 2b
chr18_-_7399767 0.00 ENSDART00000181689
si:dkey-30c15.13
si:dkey-30c15.13
chr6_+_1787160 0.00 ENSDART00000113505
myl9b
myosin, light chain 9b, regulatory
chr25_+_15647993 0.00 ENSDART00000186578
ENSDART00000031828
spon1b
spondin 1b
chr16_+_54875530 0.00 ENSDART00000149795
nr0b2a
nuclear receptor subfamily 0, group B, member 2a

Network of associatons between targets according to the STRING database.

First level regulatory network of nr2f6a+nr2f6b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0019626 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) short-chain fatty acid catabolic process(GO:0019626) response to dexamethasone(GO:0071548)
0.1 0.8 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 0.2 GO:1905048 regulation of metallopeptidase activity(GO:1905048)
0.1 0.4 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063) collagen-activated signaling pathway(GO:0038065)
0.1 0.9 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.4 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.2 GO:0051660 establishment of centrosome localization(GO:0051660)
0.0 0.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.2 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.4 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.3 GO:0021681 cerebellar granular layer development(GO:0021681) cerebellar granular layer morphogenesis(GO:0021683) cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.1 GO:0042245 RNA repair(GO:0042245)
0.0 0.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.5 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0 0.5 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 0.4 GO:0003323 type B pancreatic cell development(GO:0003323)
0.0 0.7 GO:0007006 mitochondrial membrane organization(GO:0007006)
0.0 0.1 GO:0030719 P granule organization(GO:0030719)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005592 collagen type XI trimer(GO:0005592)
0.1 0.2 GO:1990415 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 0.8 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 0.4 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.3 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.4 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0071077 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 0.9 GO:0043998 H2A histone acetyltransferase activity(GO:0043998)
0.1 0.7 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619)
0.1 0.4 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.1 0.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 0.2 GO:0043878 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity(GO:0043878)
0.1 0.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.4 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0035516 oxidative DNA demethylase activity(GO:0035516) DNA-N1-methyladenine dioxygenase activity(GO:0043734) RNA N6-methyladenosine dioxygenase activity(GO:1990931)
0.0 0.3 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0031013 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 0.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID ARF6 PATHWAY Arf6 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 0.8 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.4 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling