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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for nr2f1b+nr2f5
Z-value: 0.95
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Transcription factors associated with nr2f1b+nr2f5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nr2f1b | dr11_v1_chr10_+_43797130_43797130 | -0.93 | 1.5e-08 | Click! |
| nr2f5 | dr11_v1_chr16_+_46294337_46294337 | 0.73 | 5.7e-04 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_-_16906623 Show fit | 2.60 |
ENSDART00000012859
ENSDART00000171628 |
proteasome subunit alpha 6b |
|
| chr11_+_6010177 Show fit | 2.14 |
ENSDART00000170047
ENSDART00000022526 ENSDART00000161001 ENSDART00000188999 |
GTP binding protein 3, mitochondrial |
|
| chr22_-_26834043 Show fit | 1.91 |
ENSDART00000087202
|
si:dkey-44g23.5 |
|
| chr18_+_1145571 Show fit | 1.88 |
ENSDART00000135055
|
REC114 meiotic recombination protein |
|
| chr24_+_42149453 Show fit | 1.69 |
ENSDART00000128766
|
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3 |
|
| chr8_-_13442871 Show fit | 1.58 |
ENSDART00000144887
|
Pim proto-oncogene, serine/threonine kinase, related 106 |
|
| chr24_+_42127983 Show fit | 1.56 |
ENSDART00000190157
ENSDART00000176032 ENSDART00000175790 |
WW domain containing E3 ubiquitin protein ligase 1 |
|
| chr1_-_40132831 Show fit | 1.50 |
ENSDART00000135647
|
si:ch211-113e8.10 |
|
| chr24_+_42149296 Show fit | 1.50 |
ENSDART00000154231
|
serpin peptidase inhibitor, clade B (ovalbumin), member 1, like 3 |
|
| chr24_+_42132962 Show fit | 1.49 |
ENSDART00000187739
|
WW domain containing E3 ubiquitin protein ligase 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nr2f1b+nr2f5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.0 | 4.2 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.0 | 3.0 | GO:0045732 | positive regulation of protein catabolic process(GO:0045732) |
| 0.1 | 2.6 | GO:0010499 | proteasomal ubiquitin-independent protein catabolic process(GO:0010499) |
| 0.1 | 2.1 | GO:0002098 | tRNA wobble uridine modification(GO:0002098) |
| 0.2 | 1.6 | GO:0031643 | positive regulation of myelination(GO:0031643) |
| 0.3 | 1.1 | GO:0060074 | synapse maturation(GO:0060074) |
| 0.3 | 0.8 | GO:0052575 | carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576) |
| 0.1 | 0.8 | GO:0001678 | cellular glucose homeostasis(GO:0001678) |
| 0.0 | 0.7 | GO:0030968 | endoplasmic reticulum unfolded protein response(GO:0030968) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 1.9 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 1.4 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970) |
| 0.2 | 1.1 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.1 | 0.7 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.5 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.3 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.2 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.0 | 0.1 | GO:0031313 | extrinsic component of endosome membrane(GO:0031313) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.2 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.4 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 1.1 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 1.0 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 1.0 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.2 | 0.9 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.1 | 0.9 | GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) |
| 0.2 | 0.8 | GO:0004645 | phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184) |
| 0.1 | 0.8 | GO:0004396 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
| 0.0 | 0.7 | GO:0035497 | cAMP response element binding(GO:0035497) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.0 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | REACTOME SIGNALING BY ERBB4 | Genes involved in Signaling by ERBB4 |
| 0.0 | 1.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.0 | 0.8 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 0.6 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.2 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |