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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nr1d2a

Z-value: 0.28

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Transcription factors associated with nr1d2a

Gene Symbol Gene ID Gene Info
nr1d2a
ENSDARG00000003820 nuclear receptor subfamily 1, group D, member 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nr1d2adr11_v1_chr16_+_50089417_50089417-0.591.0e-02Click!

Activity profile of nr1d2a motif

Sorted Z-values of nr1d2a motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr25_-_17918810 0.86 ENSDART00000023959
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr25_-_17918536 0.85 ENSDART00000148660
arntl1a
aryl hydrocarbon receptor nuclear translocator-like 1a
chr15_+_12435975 0.66 ENSDART00000168011
tmprss4a
transmembrane protease, serine 4a
chr11_-_39118882 0.60 ENSDART00000113185
ENSDART00000156526
ap5b1
adaptor-related protein complex 5, beta 1 subunit
chr3_-_26190804 0.49 ENSDART00000136001
ypel3
yippee-like 3
chr8_+_21225064 0.48 ENSDART00000129210
cry1ba
cryptochrome circadian clock 1ba
chr17_-_29271359 0.47 ENSDART00000104219
rcor1
REST corepressor 1
chr4_-_9780931 0.47 ENSDART00000134280
ENSDART00000150664
ENSDART00000150304
ENSDART00000080744
svopl
SVOP-like
chr16_-_29387215 0.46 ENSDART00000148787
s100a1
S100 calcium binding protein A1
chr8_+_42917515 0.45 ENSDART00000021715
slc23a2
solute carrier family 23 (ascorbic acid transporter), member 2
chr22_+_17828267 0.43 ENSDART00000136016
hapln4
hyaluronan and proteoglycan link protein 4
chr7_+_22313533 0.43 ENSDART00000123457
TMEM102
si:dkey-11f12.2
chr17_+_14965570 0.42 ENSDART00000066604
gpr137c
G protein-coupled receptor 137c
chr22_-_6420239 0.42 ENSDART00000148385
zgc:171699
zgc:171699
chr10_+_15454745 0.42 ENSDART00000129441
ENSDART00000123935
ENSDART00000163446
ENSDART00000087680
ENSDART00000193752
erbin
erbb2 interacting protein
chr12_+_30789611 0.41 ENSDART00000181501
aldh18a1
aldehyde dehydrogenase 18 family, member A1
chr16_+_26612401 0.38 ENSDART00000145571
epb41l4b
erythrocyte membrane protein band 4.1 like 4B
chr2_-_42558549 0.38 ENSDART00000025997
dip2cb
disco-interacting protein 2 homolog Cb
chr5_-_24029228 0.36 ENSDART00000051546
rps6ka3a
ribosomal protein S6 kinase a, polypeptide 3a
chr6_-_40768654 0.36 ENSDART00000184668
ENSDART00000146470
arpc4
actin related protein 2/3 complex, subunit 4
chr8_-_18899427 0.36 ENSDART00000079840
rorca
RAR-related orphan receptor C a
chr21_-_32781612 0.34 ENSDART00000031028
cnot6a
CCR4-NOT transcription complex, subunit 6a
chr4_-_7875808 0.34 ENSDART00000162276
nudt5
nudix (nucleoside diphosphate linked moiety X)-type motif 5
chr22_-_18546241 0.32 ENSDART00000105404
ENSDART00000105405
cirbpb
cold inducible RNA binding protein b
chr1_-_21714025 0.32 ENSDART00000129066
zcchc7
zinc finger, CCHC domain containing 7
chr10_+_28160265 0.31 ENSDART00000022484
rnft1
ring finger protein, transmembrane 1
chr8_-_25771474 0.30 ENSDART00000193883
suv39h1b
suppressor of variegation 3-9 homolog 1b
chr24_-_23716097 0.30 ENSDART00000084954
ENSDART00000129028
pign
phosphatidylinositol glycan anchor biosynthesis, class N
chr16_-_47427016 0.27 ENSDART00000074575
sept7b
septin 7b
chr20_+_46620374 0.26 ENSDART00000005548
batf
basic leucine zipper transcription factor, ATF-like
chr17_-_15528597 0.26 ENSDART00000150232
fyna
FYN proto-oncogene, Src family tyrosine kinase a
chr15_-_34878388 0.25 ENSDART00000154094
mgat1a
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase a
chr9_-_43207768 0.25 ENSDART00000192523
sestd1
SEC14 and spectrin domains 1
chr23_+_41831224 0.24 ENSDART00000171885
scp2b
sterol carrier protein 2b
chr3_+_34985895 0.24 ENSDART00000121981
smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chr12_-_7234915 0.24 ENSDART00000048866
ipmkb
inositol polyphosphate multikinase b
chr12_+_1286642 0.24 ENSDART00000157467
pemt
phosphatidylethanolamine N-methyltransferase
chr23_-_27442544 0.23 ENSDART00000019521
dip2ba
disco-interacting protein 2 homolog Ba
chr19_+_24896409 0.23 ENSDART00000049840
eya3
EYA transcriptional coactivator and phosphatase 3
chr16_+_26738404 0.23 ENSDART00000163110
fsbp
fibrinogen silencer binding protein
chr15_+_2559875 0.22 ENSDART00000178505
SH2B2
SH2B adaptor protein 2
chr8_-_2602572 0.21 ENSDART00000110482
zdhhc12a
zinc finger, DHHC-type containing 12a
chr15_+_17100697 0.20 ENSDART00000183565
ENSDART00000123197
relb
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr10_+_44692272 0.20 ENSDART00000157458
ubc
ubiquitin C
chr19_+_18797623 0.20 ENSDART00000166172
ddah2
dimethylarginine dimethylaminohydrolase 2
chr11_+_5666325 0.20 ENSDART00000092270
r3hdm4
R3H domain containing 4
chr6_-_8244474 0.20 ENSDART00000151358
rgl3a
ral guanine nucleotide dissociation stimulator-like 3a
chr5_-_11573490 0.20 ENSDART00000109577
FO704871.1

chr23_+_44427188 0.19 ENSDART00000160207
eif4e2rs1
eukaryotic translation initiation factor 4E family member 2 related sequence 1
chr17_+_49500820 0.19 ENSDART00000170306
AREL1
apoptosis resistant E3 ubiquitin protein ligase 1
chr22_+_786556 0.19 ENSDART00000125347
cry1bb
cryptochrome circadian clock 1bb
chr22_-_15704704 0.19 ENSDART00000017838
ENSDART00000130238
safb
scaffold attachment factor B
chr6_-_21726758 0.18 ENSDART00000083085
mtmr14
myotubularin related protein 14
chr6_-_45995401 0.18 ENSDART00000154392
ca16b
carbonic anhydrase XVI b
chr5_-_13778726 0.18 ENSDART00000051655
snrnp27
small nuclear ribonucleoprotein 27 (U4/U6.U5)
chr6_+_37752781 0.18 ENSDART00000154364
herc2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
chr24_+_31379318 0.18 ENSDART00000183707
cpne3
copine III
chr9_+_28116079 0.18 ENSDART00000101338
idh1
isocitrate dehydrogenase 1 (NADP+), soluble
chr21_+_26606741 0.17 ENSDART00000002767
esrra
estrogen-related receptor alpha
chr8_+_2530065 0.17 ENSDART00000063943
mrpl40
mitochondrial ribosomal protein L40
chr3_+_32698424 0.17 ENSDART00000055340
fus
FUS RNA binding protein
chr5_+_43470544 0.17 ENSDART00000111587
rhobtb2a
Rho-related BTB domain containing 2a
chr12_+_23912074 0.16 ENSDART00000152864
svila
supervillin a
chr8_+_21146262 0.15 ENSDART00000045684
porcn
porcupine O-acyltransferase
chr18_-_42313798 0.15 ENSDART00000098639
cntn5
contactin 5
chr9_-_43213229 0.15 ENSDART00000139775
sestd1
SEC14 and spectrin domains 1
chr12_-_979789 0.14 ENSDART00000128188
daglb
diacylglycerol lipase, beta
chr23_-_5683147 0.14 ENSDART00000102766
ENSDART00000067351
tnnt2a
troponin T type 2a (cardiac)
chr15_+_17100412 0.14 ENSDART00000154418
relb
v-rel avian reticuloendotheliosis viral oncogene homolog B
chr2_-_37743834 0.14 ENSDART00000088040
ENSDART00000191057
myo9b
myosin IXb
chr21_-_40557281 0.13 ENSDART00000172327
taok1b
TAO kinase 1b
chr9_+_17982737 0.12 ENSDART00000192569
akap11
A kinase (PRKA) anchor protein 11
chr21_-_40049642 0.12 ENSDART00000124416
med31
mediator complex subunit 31
chr6_-_49159207 0.12 ENSDART00000041942
tspan2a
tetraspanin 2a
chr9_-_43213057 0.11 ENSDART00000059448
ENSDART00000133589
sestd1
SEC14 and spectrin domains 1
chr18_+_6162194 0.11 ENSDART00000177153
otogl
otogelin-like
chr19_-_10295173 0.11 ENSDART00000136697
cnot3b
CCR4-NOT transcription complex, subunit 3b
chr3_+_52684556 0.10 ENSDART00000139037
pgls
6-phosphogluconolactonase
chr15_-_31419805 0.10 ENSDART00000060111
or111-11
odorant receptor, family D, subfamily 111, member 11
chr13_-_9111927 0.10 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
HTRA2 (1 of many)
si:dkey-112g5.12
si:dkey-19p15.4
si:dkey-112g5.12
chr10_+_9561066 0.09 ENSDART00000136281
si:ch211-243g18.2
si:ch211-243g18.2
chr8_+_23034718 0.09 ENSDART00000184512
ythdf1
YTH N(6)-methyladenosine RNA binding protein 1
chr18_+_907266 0.09 ENSDART00000171729
pkma
pyruvate kinase M1/2a
chr23_-_36003282 0.09 ENSDART00000103150
calcoco1a
calcium binding and coiled-coil domain 1a
chr2_+_35733335 0.08 ENSDART00000113489
rasal2
RAS protein activator like 2
chr7_-_28058442 0.07 ENSDART00000173842
si:ch211-235p24.2
si:ch211-235p24.2
chr5_-_65021736 0.05 ENSDART00000162368
ENSDART00000161876
anxa1c
annexin A1c
chr9_+_35860975 0.05 ENSDART00000134447
rcan1a
regulator of calcineurin 1a
chr10_-_25628555 0.05 ENSDART00000143978
tiam1a
T cell lymphoma invasion and metastasis 1a
chr18_-_39473055 0.05 ENSDART00000122930
scg3
secretogranin III
chr22_+_36704764 0.05 ENSDART00000146662
trim35-33
tripartite motif containing 35-33
chr21_+_4348600 0.05 ENSDART00000138463
HTRA2 (1 of many)
si:dkey-84o3.2
chr9_+_33267211 0.05 ENSDART00000025635
usp9
ubiquitin specific peptidase 9
chr8_+_14890821 0.04 ENSDART00000190966
soat1
sterol O-acyltransferase 1
chr15_+_19681718 0.03 ENSDART00000164803
si:dkey-4p15.5
si:dkey-4p15.5
chr24_-_32408404 0.03 ENSDART00000144157
si:ch211-56a11.2
si:ch211-56a11.2
chr18_-_15559817 0.03 ENSDART00000061681
si:ch211-245j22.3
si:ch211-245j22.3
chr6_+_32415132 0.02 ENSDART00000155790
kank4
KN motif and ankyrin repeat domains 4
chr2_+_58841181 0.02 ENSDART00000164102
cirbpa
cold inducible RNA binding protein a
chr20_+_46191630 0.02 ENSDART00000100520
taar13d
trace amine associated receptor 13d
chr2_-_8648440 0.02 ENSDART00000135743
si:ch211-71m22.3
si:ch211-71m22.3
chr18_+_33570170 0.01 ENSDART00000133276
si:dkey-47k20.3
si:dkey-47k20.3
chr11_-_21303946 0.01 ENSDART00000185786
RASSF5
si:dkey-85p17.3
chr12_-_9533956 0.01 ENSDART00000188940
nudt13
nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr20_-_9980318 0.01 ENSDART00000080664
ACTC1
zgc:86709
chr10_-_7555660 0.01 ENSDART00000163689
wrn
Werner syndrome
chr2_-_38337122 0.01 ENSDART00000076523
ENSDART00000187473
slc7a8b
solute carrier family 7 (amino acid transporter light chain, L system), member 8b
chr3_+_60761811 0.01 ENSDART00000053482
tsen54
TSEN54 tRNA splicing endonuclease subunit
chr3_+_57997980 0.01 ENSDART00000168477
ENSDART00000193840
pycr1a
pyrroline-5-carboxylate reductase 1a
chr1_-_33353778 0.01 ENSDART00000041191
gyg2
glycogenin 2
chr19_+_4990496 0.01 ENSDART00000151050
ENSDART00000017535
zgc:91968
zgc:91968
chr15_+_19682013 0.00 ENSDART00000127368
si:dkey-4p15.5
si:dkey-4p15.5
chr15_+_17030941 0.00 ENSDART00000062069
plin2
perilipin 2
chr10_-_7555326 0.00 ENSDART00000162191
ENSDART00000186945
wrn
Werner syndrome
chr14_-_42997145 0.00 ENSDART00000172801
pcdh10b
protocadherin 10b

Network of associatons between targets according to the STRING database.

First level regulatory network of nr1d2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0015882 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.1 0.3 GO:0001562 response to protozoan(GO:0001562) defense response to protozoan(GO:0042832)
0.1 0.3 GO:1904292 regulation of ERAD pathway(GO:1904292)
0.1 0.2 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.2 GO:0061355 Wnt protein secretion(GO:0061355)
0.0 0.2 GO:1903428 regulation of nitric oxide biosynthetic process(GO:0045428) positive regulation of nitric oxide biosynthetic process(GO:0045429) positive regulation of reactive oxygen species biosynthetic process(GO:1903428) positive regulation of nitric oxide metabolic process(GO:1904407)
0.0 0.2 GO:0032370 positive regulation of lipid transport(GO:0032370)
0.0 0.4 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0 0.5 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 0.1 GO:0098921 endocannabinoid signaling pathway(GO:0071926) retrograde trans-synaptic signaling by lipid(GO:0098920) retrograde trans-synaptic signaling by endocannabinoid(GO:0098921)
0.0 0.1 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.0 0.4 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.3 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.4 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.2 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.1 GO:0019566 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.9 GO:0009648 photoperiodism(GO:0009648)
0.0 0.2 GO:2000758 positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.2 GO:1901099 histone dephosphorylation(GO:0016576) negative regulation of signal transduction in absence of ligand(GO:1901099) regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001239) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001240)
0.0 0.2 GO:0003160 endocardium morphogenesis(GO:0003160)
0.0 0.3 GO:0009409 response to cold(GO:0009409)
0.0 0.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.3 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.2 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.5 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.6 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.1 0.4 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.3 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.3 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.4 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling