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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nkx6.3

Z-value: 0.25

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Transcription factors associated with nkx6.3

Gene Symbol Gene ID Gene Info
nkx6.3
ENSDARG00000060529 NK6 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx6.3dr11_v1_chr8_+_38415374_384153740.455.8e-02Click!

Activity profile of nkx6.3 motif

Sorted Z-values of nkx6.3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_17485419 0.54 ENSDART00000018764
foxl1
forkhead box L1
chr3_-_60175470 0.52 ENSDART00000156597
si:ch73-364h19.1
si:ch73-364h19.1
chr17_+_15433518 0.51 ENSDART00000026180
fabp7a
fatty acid binding protein 7, brain, a
chr2_-_9818640 0.50 ENSDART00000139499
ENSDART00000165548
ENSDART00000012442
ENSDART00000046587
ap2m1b
adaptor-related protein complex 2, mu 1 subunit, b
chr17_+_15433671 0.45 ENSDART00000149568
fabp7a
fatty acid binding protein 7, brain, a
chr11_-_2838699 0.44 ENSDART00000066189
lhfpl5a
LHFPL tetraspan subfamily member 5a
chr14_+_14662116 0.42 ENSDART00000161693
cetn2
centrin, EF-hand protein, 2
chr12_-_10409961 0.33 ENSDART00000149521
ENSDART00000052001
eef2k
eukaryotic elongation factor 2 kinase
chr11_-_2478374 0.33 ENSDART00000173205
si:ch73-267c23.10
si:ch73-267c23.10
chr16_+_46111849 0.32 ENSDART00000172232
sv2a
synaptic vesicle glycoprotein 2A
chr16_-_12173554 0.30 ENSDART00000110567
ENSDART00000155935
clstn3
calsyntenin 3
chr9_-_9415000 0.27 ENSDART00000146210
si:ch211-214p13.9
si:ch211-214p13.9
chr6_-_37469775 0.27 ENSDART00000156546
plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr20_-_9095105 0.26 ENSDART00000140792
oma1
OMA1 zinc metallopeptidase
chr16_-_12173399 0.26 ENSDART00000142574
clstn3
calsyntenin 3
chr25_-_8660726 0.22 ENSDART00000168010
ENSDART00000171709
ENSDART00000163426
unc45a
unc-45 myosin chaperone A
chr3_+_45687266 0.21 ENSDART00000131652
gpr146
G protein-coupled receptor 146
chr21_+_28445052 0.21 ENSDART00000077871
pygma
phosphorylase, glycogen, muscle A
chr9_-_31278048 0.17 ENSDART00000022204
zic5
zic family member 5 (odd-paired homolog, Drosophila)
chr23_-_16485190 0.16 ENSDART00000155038
si:dkeyp-100a5.4
si:dkeyp-100a5.4
chr3_-_21010979 0.16 ENSDART00000109578
fam117aa
family with sequence similarity 117, member Aa
chr2_-_55298075 0.12 ENSDART00000186404
ENSDART00000149062
rab8a
RAB8A, member RAS oncogene family
chr25_+_24291156 0.12 ENSDART00000083407
b4galnt4a
beta-1,4-N-acetyl-galactosaminyl transferase 4a
chr12_-_6880694 0.11 ENSDART00000171846
pcdh15b
protocadherin-related 15b
chr21_-_13123176 0.11 ENSDART00000144866
ENSDART00000024616
fam219aa
family with sequence similarity 219, member Aa
chr15_-_34668485 0.11 ENSDART00000186605
bag6
BCL2 associated athanogene 6
chr19_+_1688727 0.11 ENSDART00000115136
ENSDART00000166744
dennd3a
DENN/MADD domain containing 3a
chr6_+_4033832 0.10 ENSDART00000159952
sema5bb
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Bb
chr2_-_1486023 0.09 ENSDART00000113774
si:ch211-188c16.1
si:ch211-188c16.1
chr18_+_2228737 0.09 ENSDART00000165301
rab27a
RAB27A, member RAS oncogene family
chr2_+_2223837 0.07 ENSDART00000101038
ENSDART00000129354
tmie
transmembrane inner ear
chr13_+_22476742 0.07 ENSDART00000078759
ENSDART00000130101
ENSDART00000137220
ENSDART00000133065
ENSDART00000147348
ldb3a
LIM domain binding 3a
chr20_-_48485354 0.07 ENSDART00000124040
ENSDART00000148437
insm1a
insulinoma-associated 1a
chr23_-_35790235 0.07 ENSDART00000142369
ENSDART00000141141
ENSDART00000011004
mfsd5
major facilitator superfamily domain containing 5
chr3_-_58798377 0.07 ENSDART00000161248
si:ch73-281f12.4
si:ch73-281f12.4
chr20_-_40755614 0.06 ENSDART00000061247
cx32.3
connexin 32.3
chr20_+_40457599 0.06 ENSDART00000017553
serinc1
serine incorporator 1
chr6_-_16717878 0.05 ENSDART00000153552
nomo
nodal modulator
chr3_-_58798815 0.05 ENSDART00000082920
si:ch73-281f12.4
si:ch73-281f12.4
chr5_+_34623107 0.05 ENSDART00000184126
enc1
ectodermal-neural cortex 1
chr4_+_43522680 0.05 ENSDART00000182252
si:dkeyp-53e4.4
si:dkeyp-53e4.4
chr8_+_8927870 0.04 ENSDART00000081985
pim2
Pim-2 proto-oncogene, serine/threonine kinase
chr21_+_43328685 0.03 ENSDART00000109620
ENSDART00000139668
sept8a
septin 8a
chr19_-_205104 0.03 ENSDART00000011890
zbtb22a
zinc finger and BTB domain containing 22a
chr6_-_12588044 0.02 ENSDART00000047896
slc15a1b
solute carrier family 15 (oligopeptide transporter), member 1b
chr6_+_54187643 0.01 ENSDART00000056830
pacsin1b
protein kinase C and casein kinase substrate in neurons 1b
chr16_-_22294265 0.01 ENSDART00000124718
aqp10a
aquaporin 10a
chr5_-_30620625 0.00 ENSDART00000098273
tcnl
transcobalamin like

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx6.3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0052575 carbohydrate localization(GO:0052575) carbohydrate storage(GO:0052576)
0.1 0.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.3 GO:1990845 adaptive thermogenesis(GO:1990845)
0.0 0.1 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.0 0.2 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.3 GO:0061300 cerebellum vasculature development(GO:0061300)
0.0 0.4 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.5 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.4 GO:0007099 centriole replication(GO:0007099)
0.0 0.5 GO:0035138 pectoral fin morphogenesis(GO:0035138)
0.0 0.3 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:1900145 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.0 0.1 GO:0060221 retinal rod cell differentiation(GO:0060221)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.5 GO:0030122 AP-2 adaptor complex(GO:0030122)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0008184 phosphorylase activity(GO:0004645) glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.0 0.5 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling