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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nkx3.3-1

Z-value: 0.58

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Transcription factors associated with nkx3.3-1

Gene Symbol Gene ID Gene Info
ENSDARG00000110589 NK3 homeobox 3

Activity profile of nkx3.3-1 motif

Sorted Z-values of nkx3.3-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_9467049 1.63 ENSDART00000012659
zgc:55888
chr6_-_31739709 1.44 ENSDART00000087964
cache domain containing 1
chr24_-_33308045 1.34 ENSDART00000149711
solute carrier family 4 (anion exchanger), member 2b
chr9_+_8380728 1.29 ENSDART00000133501
si:ch1073-75o15.4
chr3_-_60886984 1.20 ENSDART00000170974
phosphatidylinositol transfer protein, cytoplasmic 1
chr20_+_23498255 1.18 ENSDART00000149922
palladin, cytoskeletal associated protein
chr19_-_43757568 1.12 ENSDART00000058491
palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile)
chr6_-_1820606 1.08 ENSDART00000183228

chr13_+_33462232 1.08 ENSDART00000177841
zgc:136302
chr6_-_31987940 1.02 ENSDART00000132280
receptor tyrosine kinase-like orphan receptor 1
chr23_+_25292147 0.99 ENSDART00000131486
proliferation-associated 2G4, b
chr7_-_30272871 0.99 ENSDART00000099586
zgc:162945
chr25_+_2361721 0.95 ENSDART00000172905
zmp:0000000932
chr5_+_44846280 0.94 ENSDART00000084370
KN motif and ankyrin repeat domains 1a
chr15_+_45595385 0.93 ENSDART00000161937
ENSDART00000170214
ENSDART00000157450
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr22_+_724639 0.92 ENSDART00000105323
zgc:162255
chr2_-_57900430 0.92 ENSDART00000132245
ENSDART00000140060
si:dkeyp-68b7.7
chr1_-_58887610 0.91 ENSDART00000180647
microfibril-associated glycoprotein 4-like precursor
chr19_-_11031145 0.90 ENSDART00000151375
ENSDART00000027598
ENSDART00000137865
ENSDART00000188025
tropomyosin 3
chr10_+_10387328 0.90 ENSDART00000080904
sarcosine dehydrogenase
chr7_+_36467796 0.87 ENSDART00000146202
akt interacting protein
chr10_+_10386435 0.87 ENSDART00000179214
ENSDART00000189799
ENSDART00000193875
sarcosine dehydrogenase
chr5_-_54712159 0.85 ENSDART00000149207
cyclin B1
chr11_+_19370717 0.77 ENSDART00000165906
prickle homolog 2b
chr16_+_46725087 0.73 ENSDART00000008920
RAB11a, member RAS oncogene family, like
chr4_-_10835620 0.73 ENSDART00000150739
PTPRF interacting protein, binding protein 1a (liprin beta 1)
chr13_-_50463938 0.72 ENSDART00000083857
cyclin J
chr3_+_11926030 0.72 ENSDART00000081367
DnaJ (Hsp40) homolog, subfamily A, member 3A
chr8_+_10869183 0.70 ENSDART00000188111
bromodomain and PHD finger containing, 3b
chr5_-_57820873 0.70 ENSDART00000089961
salt-inducible kinase 2a
chr2_-_57918314 0.69 ENSDART00000138265
si:dkeyp-68b7.7
chr2_-_55797318 0.68 ENSDART00000158147
calreticulin 3b
chr19_+_791538 0.67 ENSDART00000146554
ENSDART00000138406
transmembrane protein 79a
chr14_-_41478265 0.66 ENSDART00000149886
ENSDART00000016002
tetraspanin 7
chr5_-_38248347 0.66 ENSDART00000084917
ENSDART00000139479
solute carrier family 12, member 9
chr25_+_28282274 0.66 ENSDART00000164502
aminoadipate-semialdehyde synthase
chr3_-_52899394 0.65 ENSDART00000128223
coiled-coil-helix-coiled-coil-helix domain containing 5
chr14_+_21722235 0.63 ENSDART00000183667
syntaxin 3A
chr6_-_41135215 0.62 ENSDART00000001861
solute carrier family 6 member 22, tandem duplicate 1
chr5_-_55848511 0.60 ENSDART00000183503
calcium/calmodulin-dependent protein kinase IV
chr23_+_12840080 0.59 ENSDART00000081016
ENSDART00000121697
structural maintenance of chromosomes 1A, like
chr4_+_13931578 0.59 ENSDART00000142466
periphilin 1
chr20_+_46741074 0.59 ENSDART00000145294
si:ch211-57i17.1
chr12_+_16087077 0.59 ENSDART00000141898
zinc finger protein 281b
chr15_+_2475894 0.59 ENSDART00000035939
pannexin 1a
chr19_-_29302249 0.57 ENSDART00000188751
serum response factor binding protein 1
chr19_-_6840506 0.56 ENSDART00000081568
transcription factor 19 (SC1), like
chr12_-_3053699 0.55 ENSDART00000139721
dicarbonyl/L-xylulose reductase
chr23_-_26227805 0.54 ENSDART00000158082

chr23_-_29812667 0.54 ENSDART00000006120
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr11_+_19271557 0.52 ENSDART00000190559
prickle homolog 2b
chr8_-_14554785 0.51 ENSDART00000057645
quiescin Q6 sulfhydryl oxidase 1
chr9_-_1604601 0.51 ENSDART00000143130
alkylglycerone phosphate synthase
chr23_-_24542952 0.51 ENSDART00000088777
ATPase 13A2
chr12_+_22580579 0.50 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr11_+_19370447 0.49 ENSDART00000186154
prickle homolog 2b
chr15_+_20281305 0.49 ENSDART00000155065
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
chr16_-_26132122 0.48 ENSDART00000157787
lipase, hormone-sensitive b
chr24_-_25166720 0.48 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr19_+_32321797 0.47 ENSDART00000167664
ataxin 1a
chr21_-_21527983 0.47 ENSDART00000014254
diablo, IAP-binding mitochondrial protein b
chr16_+_38240027 0.47 ENSDART00000111081
prune exopolyphosphatase
chr4_-_13931508 0.47 ENSDART00000067174
zinc finger CCHC-type and RNA binding motif 1
chr22_+_32228882 0.46 ENSDART00000092082
mesencephalic astrocyte-derived neurotrophic factor
chr23_-_18568522 0.46 ENSDART00000004655
selenophosphate synthetase 2
chr20_+_34151670 0.46 ENSDART00000152870
ENSDART00000010329
ENSDART00000145852
actin related protein 2/3 complex, subunit 5B
chr18_-_22094102 0.45 ENSDART00000100904
par-6 family cell polarity regulator alpha
chr21_-_30026359 0.44 ENSDART00000153645
PWWP domain containing 2A
chr9_-_34882516 0.44 ENSDART00000011163
acetylserotonin O-methyltransferase-like
chr25_+_33033633 0.44 ENSDART00000192336
talin 2b
chr7_-_40578733 0.44 ENSDART00000173926
ENSDART00000010035
DnaJ (Hsp40) homolog, subfamily B, member 6b
chr10_-_38456382 0.44 ENSDART00000182129
glycerophosphodiester phosphodiesterase domain containing 5a
chr15_-_20709289 0.43 ENSDART00000136767
tyrosylprotein sulfotransferase 1
chr16_-_22585289 0.43 ENSDART00000134239
ENSDART00000193959
ENSDART00000077998
si:dkey-238m4.3
cingulin a
chr1_-_30568225 0.43 ENSDART00000144297
ENSDART00000164204
UBA domain containing 2
chr17_-_51262430 0.43 ENSDART00000163222
trafficking protein particle complex 12
chr11_+_31680513 0.43 ENSDART00000139900
ENSDART00000040305
diaphanous-related formin 3
chr1_-_49950643 0.43 ENSDART00000138301
sphingomyelin synthase 2
chr4_-_73756673 0.42 ENSDART00000174274
ENSDART00000192913
ENSDART00000113546

si:dkey-262g12.14
zgc:171551
chr5_-_26764880 0.42 ENSDART00000140392
ENSDART00000134728
ring finger protein 181
chr8_-_25814263 0.41 ENSDART00000143397
TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr19_-_34970312 0.39 ENSDART00000102896
N-myc downstream regulated 1a
chr23_-_21534455 0.39 ENSDART00000139092
regulator of chromosome condensation 2
chr5_-_26765188 0.39 ENSDART00000029450
ring finger protein 181
chr16_+_25137483 0.39 ENSDART00000155666
zinc finger protein 576, tandem duplicate 1
chr23_-_21534738 0.39 ENSDART00000134587
regulator of chromosome condensation 2
chr7_-_23777445 0.38 ENSDART00000173527
si:ch211-200p22.4
chr5_-_23117078 0.38 ENSDART00000051529
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr5_-_57204352 0.36 ENSDART00000171252
ENSDART00000180727
mannosidase, alpha, class 2A, member 1
chr7_+_20260172 0.36 ENSDART00000012450
dishevelled segment polarity protein 2
chr20_-_28698172 0.35 ENSDART00000190635
signal-induced proliferation-associated 1 like 1
chr12_-_26022663 0.35 ENSDART00000166769
bone morphogenetic protein receptor, type IAb
chr3_-_18384501 0.34 ENSDART00000027630
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2a
chr2_-_9527129 0.34 ENSDART00000157422
ENSDART00000004398
coatomer protein complex, subunit epsilon
chr12_+_27243059 0.33 ENSDART00000066269
ADP-ribosylation factor-like 4D
chr20_-_53078607 0.33 ENSDART00000163494
ENSDART00000191730

chr3_-_34753605 0.32 ENSDART00000000160
thyroid hormone receptor alpha a
chr11_+_23933016 0.32 ENSDART00000000486
contactin 2
chr6_+_58622831 0.31 ENSDART00000128793
Sp7 transcription factor
chr13_-_35892051 0.31 ENSDART00000145884
transforming, acidic coiled-coil containing protein 3
chr22_+_2830703 0.31 ENSDART00000145463
ENSDART00000144785
si:dkey-20i20.8
chr10_-_38468847 0.30 ENSDART00000133914
glycerophosphodiester phosphodiesterase domain containing 5a
chr18_+_22174630 0.30 ENSDART00000089549
RHO family interacting cell polarization regulator 1
chr19_+_8612839 0.30 ENSDART00000144925
sorting nexin family member 27a
chr23_-_21535040 0.30 ENSDART00000010647
regulator of chromosome condensation 2
chr9_-_7390388 0.30 ENSDART00000132392
solute carrier family 23, member 3
chr17_+_23554932 0.29 ENSDART00000135814
pantothenate kinase 1a
chr15_+_15771418 0.28 ENSDART00000153831
si:ch211-33e4.3
chr9_+_51655636 0.28 ENSDART00000169908
RNA binding motif single stranded interacting protein 1
chr3_-_31069776 0.28 ENSDART00000167462
elongin B
chr16_+_3982590 0.28 ENSDART00000149295
zinc finger CCCH-type containing 12A
chr14_+_49152341 0.27 ENSDART00000084114
nuclear receptor binding SET domain protein 1a
chr19_-_35155722 0.27 ENSDART00000151924
microtubule-actin crosslinking factor 1a
chr19_+_46222428 0.27 ENSDART00000183984
vacuolar protein sorting 28 (yeast)
chr14_+_26759332 0.27 ENSDART00000088484
AHNAK nucleoprotein
chr2_-_11504778 0.27 ENSDART00000186556
short chain dehydrogenase/reductase family 16C, member 5a
chr25_-_37284370 0.26 ENSDART00000103222
nudix (nucleoside diphosphate linked moiety X)-type motif 7
chr23_-_17003533 0.26 ENSDART00000080545
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.2
chr13_+_23093743 0.26 ENSDART00000148034
phosphoinositide-3-kinase adaptor protein 1
chr1_-_26045560 0.26 ENSDART00000172737
ENSDART00000076120
ENSDART00000193593
G patch domain and ankyrin repeats 1
chr25_+_25124684 0.25 ENSDART00000167542
lactate dehydrogenase A4
chr20_-_33675676 0.25 ENSDART00000147168
rho-associated, coiled-coil containing protein kinase 2b
chr5_+_57726425 0.25 ENSDART00000134684
ferredoxin-fold anticodon binding domain containing 1
chr19_+_40248697 0.25 ENSDART00000151269
cyclin-dependent kinase 6
chr23_+_25172976 0.25 ENSDART00000140789
si:dkey-151g10.3
chr22_-_16755885 0.25 ENSDART00000036467
PATJ, crumbs cell polarity complex component
chr17_-_16069905 0.24 ENSDART00000110383
microtubule-associated protein 7a
chr11_-_36446655 0.24 ENSDART00000179025
zinc finger and BTB domain containing 40
chr14_-_51014292 0.24 ENSDART00000029797
Fas associated factor family member 2
chr19_+_3206263 0.23 ENSDART00000020344
zgc:86598
chr13_+_27040887 0.23 ENSDART00000132714
heme-binding protein soul2
chr21_-_2158298 0.23 ENSDART00000182199
expressed sequence AI877918
chr2_-_5199431 0.23 ENSDART00000063384
prohibitin 2a
chr17_+_15388479 0.23 ENSDART00000052439
si:ch211-266g18.6
chr2_+_24868010 0.23 ENSDART00000078838
RAB3A, member RAS oncogene family, a
chr3_+_14581643 0.23 ENSDART00000182840
zinc finger protein 653
chr6_-_52235118 0.22 ENSDART00000191243
translocase of outer mitochondrial membrane 34
chr11_-_5953636 0.21 ENSDART00000140960
ENSDART00000123601
DET1 and DDB1 associated 1
chr10_-_29831944 0.21 ENSDART00000063923
ENSDART00000136264
ZPR1 zinc finger
chr3_-_41795917 0.21 ENSDART00000182662
galectin-related inter-fiber protein
chr25_+_10547228 0.21 ENSDART00000067678
zgc:110339
chr22_+_28803739 0.21 ENSDART00000129476
ENSDART00000189726
tumor protein p53 binding protein, 2b
chr2_+_30463825 0.21 ENSDART00000092356
neuropilin (NRP) and tolloid (TLL)-like 1
chr12_+_18458502 0.20 ENSDART00000108745
ring finger protein 151
chr8_-_51507144 0.20 ENSDART00000024882
ENSDART00000135166
fibroblast growth factor receptor 1a
chr7_-_5487593 0.20 ENSDART00000136594
Rho guanine nucleotide exchange factor (GEF) 11
chr4_-_2059233 0.20 ENSDART00000188177
ENSDART00000129521
ENSDART00000082289
cleavage and polyadenylation specific factor 6
chr21_-_2162850 0.20 ENSDART00000159731
expressed sequence AI877918
chr8_+_24281512 0.19 ENSDART00000062845
matrix metallopeptidase 9
chr21_+_34814444 0.18 ENSDART00000161816
WD repeat domain 55
chr10_-_33343244 0.18 ENSDART00000164191
C2 calcium-dependent domain containing 2
chr25_+_10416583 0.18 ENSDART00000073907
ets homologous factor
chr14_-_31814149 0.18 ENSDART00000173393
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr8_+_49766338 0.18 ENSDART00000060657
RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)
chr11_-_2221159 0.18 ENSDART00000189292
single-strand-selective monofunctional uracil-DNA glycosylase 1
chr5_+_13870340 0.18 ENSDART00000160690
hexokinase 2
chr2_+_51028269 0.17 ENSDART00000161254
eukaryotic translation elongation factor 1 delta a (guanine nucleotide exchange protein)
chr13_+_18371208 0.17 ENSDART00000138172
cell division cycle and apoptosis regulator 1
chr12_+_17754859 0.17 ENSDART00000112119
basic helix-loop-helix family, member a15
chr10_+_35358675 0.17 ENSDART00000193263
si:dkey-259j3.5
chr8_+_23788981 0.17 ENSDART00000144229
si:ch211-163l21.8
chr22_-_31020690 0.16 ENSDART00000130604
ssu-2 homolog, tandem duplicate 4
chr7_+_17063761 0.16 ENSDART00000182880
HIV-1 Tat interactive protein 2
chr6_+_41808673 0.16 ENSDART00000038163
RAD18 E3 ubiquitin protein ligase
chr7_+_50796422 0.16 ENSDART00000123868
death domain containing 1
chr5_+_37890521 0.15 ENSDART00000140207
transmembrane protease, serine 4b
chr10_-_39052264 0.15 ENSDART00000144036
immunoglobulin superfamily, member 5a
chr10_+_37268854 0.15 ENSDART00000131897
neurofibromin 1b
chr6_-_59381391 0.14 ENSDART00000157066
protein phosphatase 1, regulatory subunit 16B
chr17_-_25831569 0.14 ENSDART00000148743
hedgehog acyltransferase
chr8_-_43689324 0.13 ENSDART00000159904
E1A binding protein p400
chr4_-_20521441 0.12 ENSDART00000066895
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8b
chr1_+_35862550 0.12 ENSDART00000132118
si:ch211-194g2.4
chr12_+_2381213 0.12 ENSDART00000188007

chr10_+_40684758 0.12 ENSDART00000133648
trace amine associated receptor 19h
chr4_-_5077158 0.12 ENSDART00000155915
adenosylhomocysteinase-like 2
chr23_+_7518294 0.11 ENSDART00000081536
HCK proto-oncogene, Src family tyrosine kinase
chr21_+_1380099 0.11 ENSDART00000184516
transcription factor 4
chr20_+_44311448 0.10 ENSDART00000114660
opsin 8, group member b
chr22_+_19188809 0.10 ENSDART00000134791
ENSDART00000133682
si:dkey-21e2.8
chr16_-_9675982 0.10 ENSDART00000113724
mal, T cell differentiation protein 2 (gene/pseudogene)
chr3_-_5393909 0.10 ENSDART00000031885
si:ch73-106l15.2
chr18_+_33675664 0.10 ENSDART00000140043
si:dkey-47k20.8
chr19_+_43256986 0.09 ENSDART00000182336
diacylglycerol kinase delta
chr4_+_19534833 0.09 ENSDART00000140028
leucine rich repeat containing 4.1
chr1_-_11519934 0.09 ENSDART00000162060
sidekick cell adhesion molecule 1b
chr21_+_39948300 0.09 ENSDART00000137740
solute carrier family 47 (multidrug and toxin extrusion), member 1
chr14_+_26719691 0.09 ENSDART00000078522
ENSDART00000172927
eukaryotic translation elongation factor 1 gamma
chr16_-_38609146 0.09 ENSDART00000144651
eukaryotic translation initiation factor 3, subunit E, a
chr16_+_49647402 0.09 ENSDART00000015694
ENSDART00000132547
RAB5A, member RAS oncogene family, b
chr4_-_75982054 0.08 ENSDART00000168369
si:ch211-232d10.1
chr20_-_46053720 0.08 ENSDART00000136254
trace amine associated receptor 12h
chr4_-_62503772 0.08 ENSDART00000108891
si:dkey-165b20.1
chr6_+_13606410 0.08 ENSDART00000104716
acid-sensing (proton-gated) ion channel family member 4b
chr6_+_47424266 0.08 ENSDART00000171087
si:ch211-286o17.1
chr5_-_57655092 0.08 ENSDART00000074290
melanoma inhibitory activity
chr2_+_30281444 0.08 ENSDART00000172756
si:dkey-82k12.13
chr8_+_22289320 0.08 ENSDART00000075126
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7, like
chr25_+_20091021 0.08 ENSDART00000187545
ENSDART00000053265
troponin I4b, tandem duplicate 2
chr4_-_71708567 0.08 ENSDART00000182645
si:dkeyp-4f2.1

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3.3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:1901052 sarcosine metabolic process(GO:1901052)
0.2 0.7 GO:0009085 lysine biosynthetic process(GO:0009085) lysine biosynthetic process via aminoadipic acid(GO:0019878) L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.2 0.9 GO:0039694 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.2 0.6 GO:0005997 xylulose metabolic process(GO:0005997)
0.2 0.5 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1 0.6 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.1 0.6 GO:0097355 protein localization to heterochromatin(GO:0097355)
0.1 0.3 GO:0060912 cardiac cell fate specification(GO:0060912)
0.1 0.9 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 0.3 GO:0048677 axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.1 0.9 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.1 0.5 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 0.4 GO:1903573 negative regulation of response to endoplasmic reticulum stress(GO:1903573)
0.1 1.1 GO:0002084 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.6 GO:0032732 positive regulation of interleukin-1 production(GO:0032732)
0.1 0.7 GO:0035188 hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.1 0.2 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.1 0.3 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.1 0.2 GO:0010863 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.1 0.2 GO:1990120 regulation of nucleobase-containing compound transport(GO:0032239) positive regulation of nucleobase-containing compound transport(GO:0032241) positive regulation of nucleocytoplasmic transport(GO:0046824) regulation of RNA export from nucleus(GO:0046831) positive regulation of RNA export from nucleus(GO:0046833) messenger ribonucleoprotein complex assembly(GO:1990120)
0.1 0.2 GO:0002432 granuloma formation(GO:0002432) chronic inflammatory response(GO:0002544) regulation of granuloma formation(GO:0002631) regulation of chronic inflammatory response(GO:0002676)
0.1 0.5 GO:0021588 cerebellum formation(GO:0021588)
0.1 0.3 GO:0033688 regulation of osteoblast proliferation(GO:0033688) craniofacial suture morphogenesis(GO:0097094)
0.1 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.9 GO:0045022 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.1 0.4 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 0.3 GO:0032776 DNA methylation on cytosine(GO:0032776)
0.1 0.4 GO:0090177 establishment of planar polarity of embryonic epithelium(GO:0042249) establishment of planar polarity involved in neural tube closure(GO:0090177) regulation of establishment of planar polarity involved in neural tube closure(GO:0090178) planar cell polarity pathway involved in neural tube closure(GO:0090179)
0.1 0.7 GO:0044154 histone H3-K14 acetylation(GO:0044154)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 1.8 GO:0032402 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.0 0.4 GO:0006477 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.3 GO:0060832 oocyte animal/vegetal axis specification(GO:0060832)
0.0 1.0 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.0 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling(GO:0014068)
0.0 0.4 GO:0006797 polyphosphate metabolic process(GO:0006797) polyphosphate catabolic process(GO:0006798)
0.0 0.5 GO:0048669 collateral sprouting in absence of injury(GO:0048669) regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.3 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.3 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.6 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.0 0.7 GO:0009408 response to heat(GO:0009408)
0.0 0.1 GO:0048169 regulation of long-term neuronal synaptic plasticity(GO:0048169)
0.0 0.5 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0043697 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.0 0.9 GO:0014866 skeletal myofibril assembly(GO:0014866)
0.0 0.2 GO:0060465 pharynx development(GO:0060465)
0.0 0.2 GO:0070475 rRNA base methylation(GO:0070475)
0.0 0.7 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 0.1 GO:0060251 regulation of glial cell proliferation(GO:0060251)
0.0 0.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0045056 transcytosis(GO:0045056)
0.0 0.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.5 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 0.2 GO:0044090 positive regulation of vacuole organization(GO:0044090)
0.0 0.7 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 1.4 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.2 GO:1903288 positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:1901888 regulation of cell junction assembly(GO:1901888)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.4 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.0 GO:0070257 regulation of mucus secretion(GO:0070255) positive regulation of mucus secretion(GO:0070257)
0.0 0.0 GO:0060959 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171) Schwann cell migration(GO:0036135) cardiac neuron differentiation(GO:0060945) cardiac neuron development(GO:0060959)
0.0 0.2 GO:0001678 cellular glucose homeostasis(GO:0001678)
0.0 0.6 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.5 GO:0001841 neural tube formation(GO:0001841)
0.0 0.4 GO:0048814 regulation of dendrite morphogenesis(GO:0048814)
0.0 1.4 GO:1903706 regulation of hemopoiesis(GO:1903706)
0.0 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 0.9 GO:0070695 FHF complex(GO:0070695)
0.1 0.2 GO:0042382 paraspeckles(GO:0042382)
0.1 0.3 GO:0043034 costamere(GO:0043034)
0.0 0.6 GO:0030893 meiotic cohesin complex(GO:0030893)
0.0 0.3 GO:0030891 VCB complex(GO:0030891)
0.0 0.7 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 0.7 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 2.0 GO:0030496 midbody(GO:0030496)
0.0 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835) extrinsic component of presynaptic membrane(GO:0098888) extrinsic component of presynaptic endocytic zone(GO:0098894)
0.0 0.3 GO:0032019 mitochondrial cloud(GO:0032019)
0.0 0.1 GO:0098842 postsynaptic early endosome(GO:0098842)
0.0 0.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.6 GO:0005921 gap junction(GO:0005921)
0.0 1.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.5 GO:0045180 basal cortex(GO:0045180)
0.0 0.6 GO:0030686 90S preribosome(GO:0030686)
0.0 0.2 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0071540 eukaryotic translation initiation factor 3 complex, eIF3e(GO:0071540)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.0 1.8 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.9 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.9 GO:0001726 ruffle(GO:0001726)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.2 0.5 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.6 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.1 0.3 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 0.2 GO:0016436 rRNA (uridine) methyltransferase activity(GO:0016436)
0.1 0.4 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 0.2 GO:0048030 disaccharide binding(GO:0048030)
0.1 0.2 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.1 1.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.7 GO:0043994 H3 histone acetyltransferase activity(GO:0010484) histone acetyltransferase activity (H3-K23 specific)(GO:0043994)
0.0 0.5 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
0.0 0.3 GO:0004594 pantothenate kinase activity(GO:0004594)
0.0 0.6 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.4 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 1.0 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.4 GO:0004309 exopolyphosphatase activity(GO:0004309)
0.0 0.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0017020 myosin phosphatase regulator activity(GO:0017020)
0.0 0.2 GO:0072518 Rho-dependent protein serine/threonine kinase activity(GO:0072518)
0.0 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) glucose binding(GO:0005536) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.7 GO:0015379 cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379)
0.0 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.7 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.4 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 0.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 1.1 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.3 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.0 GO:0031781 type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.2 GO:0002039 p53 binding(GO:0002039)
0.0 0.3 GO:0016289 CoA hydrolase activity(GO:0016289)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.5 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.9 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.6 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.6 REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.0 0.2 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.5 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 1.0 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.3 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers