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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nkx3-1

Z-value: 1.03

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Transcription factors associated with nkx3-1

Gene Symbol Gene ID Gene Info
ENSDARG00000078280 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx3-1dr11_v1_chr8_-_50259448_50259448-0.903.1e-07Click!

Activity profile of nkx3-1 motif

Sorted Z-values of nkx3-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_+_8396755 5.57 ENSDART00000043067
zgc:171776
chr22_+_25236657 5.41 ENSDART00000138012
zgc:172218
chr5_+_16117871 4.70 ENSDART00000090657
zinc and ring finger 3
chr9_+_44994214 4.52 ENSDART00000141434
retinol saturase (all-trans-retinol 13,14-reductase) like
chr22_+_25249193 4.16 ENSDART00000171851
si:ch211-226h8.11
chr10_-_34915886 3.37 ENSDART00000141201
ENSDART00000002166
cyclin A1
chr10_-_34916208 3.08 ENSDART00000187371
cyclin A1
chr7_+_17947217 2.74 ENSDART00000101601
cysteine three histidine 1
chr15_+_29025090 1.97 ENSDART00000131755
si:ch211-137a8.2
chr3_-_31875138 1.96 ENSDART00000155298
LIM domain containing 2
chr22_-_10541712 1.96 ENSDART00000013933
si:dkey-42i9.4
chr17_-_43031763 1.95 ENSDART00000132754
ENSDART00000050399
Niemann-Pick disease, type C2
chr5_-_10082244 1.94 ENSDART00000036421
checkpoint kinase 2
chr16_+_54641230 1.92 ENSDART00000157641
ENSDART00000159540
F-box protein 43
chr9_-_8296723 1.86 ENSDART00000139867
si:ch211-145c1.1
chr9_-_12888082 1.84 ENSDART00000133135
ENSDART00000134415
si:ch211-167j6.3
chr16_-_42175617 1.77 ENSDART00000084715
alkB homolog 8, tRNA methyltransferase
chr1_-_55248496 1.76 ENSDART00000098615
nanos homolog 3
chr7_-_26532089 1.76 ENSDART00000121698
SUMO1/sentrin/SMT3 specific peptidase 3b
chr12_+_14079097 1.70 ENSDART00000078033
si:ch211-217a12.1
chr15_-_4415917 1.70 ENSDART00000062874
ATPase Na+/K+ transporting subunit beta 3b
chr7_+_10911396 1.63 ENSDART00000167273
ENSDART00000081323
ENSDART00000170655
abhydrolase domain containing 17C
chr6_+_10338554 1.62 ENSDART00000186936
cordon-bleu WH2 repeat protein-like 1a
chr24_-_31904924 1.60 ENSDART00000156060
ENSDART00000129741
ENSDART00000154276
si:ch73-78o10.1
chr4_+_3312852 1.59 ENSDART00000084691
FYVE, RhoGEF and PH domain containing 4b
chr5_+_36666715 1.57 ENSDART00000097686
zgc:153990
chr11_-_23697217 1.52 ENSDART00000124810
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr19_-_47587719 1.47 ENSDART00000111108

chr19_-_31707892 1.45 ENSDART00000088427
RHO family interacting cell polarization regulator 2
chr20_-_13625588 1.43 ENSDART00000078893
synaptotagmin-like 3
chr10_+_585719 1.40 ENSDART00000180167
SMAD family member 4a
chr10_+_3153973 1.35 ENSDART00000183223
hypermethylated in cancer 2
chr6_-_49537646 1.34 ENSDART00000180438

chr10_-_3427589 1.32 ENSDART00000133452
ENSDART00000037183
transmembrane p24 trafficking protein 2
chr3_-_26806032 1.30 ENSDART00000143710
phosphatidylinositol glycan anchor biosynthesis, class Q
chr9_+_22632126 1.30 ENSDART00000139434
ets variant 5a
chr13_-_36680531 1.29 ENSDART00000085298
L-2-hydroxyglutarate dehydrogenase
chr8_-_16675464 1.29 ENSDART00000191982
oxysterol binding protein-like 9
chr7_-_58098814 1.25 ENSDART00000147287
ENSDART00000043984
ankyrin 2b, neuronal
chr21_+_18907102 1.24 ENSDART00000160185
ENSDART00000190175
ENSDART00000017937
ENSDART00000191546
ENSDART00000130519
ENSDART00000137143
sphingomyelin phosphodiesterase 4
chr7_-_26518086 1.22 ENSDART00000058913
eukaryotic translation initiation factor 4A1A
chr12_-_10476448 1.22 ENSDART00000106172
Rac family small GTPase 1a
chr17_-_18898115 1.21 ENSDART00000028044
galactosylceramidase b
chr14_+_14806851 1.19 ENSDART00000169235
FH2 domain containing 2
chr13_-_32726178 1.19 ENSDART00000012232
prenyl (decaprenyl) diphosphate synthase, subunit 2
chr3_-_26805455 1.18 ENSDART00000180648
phosphatidylinositol glycan anchor biosynthesis, class Q
chr5_+_27137473 1.15 ENSDART00000181833
unc-5 netrin receptor Db
chr1_-_354115 1.13 ENSDART00000141590
ENSDART00000098627
protein S
chr24_-_32522587 1.13 ENSDART00000048968
ENSDART00000143781
zgc:56676
chr24_-_26518972 1.12 ENSDART00000097792
TRAF2 and NCK interacting kinase b
chr8_-_38317914 1.10 ENSDART00000125920
PDZ and LIM domain 2 (mystique)
chr16_-_41535690 1.09 ENSDART00000102662
ribonuclease P/MRP 25 subunit-like
chr23_+_27782071 1.09 ENSDART00000131379
lysine (K)-specific methyltransferase 2D
chr19_+_32401278 1.08 ENSDART00000184353
ataxin 1a
chr16_+_16253710 1.07 ENSDART00000137672
SET domain containing 2
chr15_-_28805493 1.07 ENSDART00000179617
CD3e molecule, epsilon associated protein
chr21_-_11286483 1.03 ENSDART00000074845
rhotekin 2b
chr17_-_43623356 1.02 ENSDART00000075596
ENSDART00000136431
rhotekin 2a
chr7_-_41013575 1.02 ENSDART00000150139
insulin induced gene 1
chr17_-_24703778 1.02 ENSDART00000156061
si:ch211-15d5.12
chr2_+_11031360 1.01 ENSDART00000180020
ENSDART00000145093
acyl-CoA thioesterase 11a
chr9_+_48123224 1.00 ENSDART00000141610
kelch-like family member 23
chr12_+_23850661 0.99 ENSDART00000152921
supervillin a
chr24_+_24086491 0.98 ENSDART00000145092
lipase, member Ib
chr2_+_15100742 0.97 ENSDART00000027171
coagulation factor IIIb
chr9_-_51563575 0.97 ENSDART00000167034
ENSDART00000148918
TRAF family member-associated NFKB activator
chr9_-_46072805 0.97 ENSDART00000169682
histone deacetylase 4
chr9_+_48123002 0.97 ENSDART00000099794
ENSDART00000169733
kelch-like family member 23
chr21_-_2042037 0.94 ENSDART00000171131
ENSDART00000160144
adducin 1 (alpha)
chr21_-_35325466 0.94 ENSDART00000134780
ENSDART00000145930
ENSDART00000076715
ENSDART00000065341
ENSDART00000162189
ubiquitin-like domain containing CTD phosphatase 1
chr17_+_22577472 0.93 ENSDART00000045099
Yip1 domain family, member 4
chr24_+_26328787 0.92 ENSDART00000003884
myoneurin
chr2_-_29923630 0.89 ENSDART00000158844
ENSDART00000031130
PAX interacting (with transcription-activation domain) protein 1
chr7_-_64770456 0.89 ENSDART00000192618
zinc finger, DHHC-type containing 21
chr24_+_16140423 0.89 ENSDART00000105955
si:dkey-118j18.1
chr9_-_52598343 0.88 ENSDART00000167922
X-ray repair complementing defective repair in Chinese hamster cells 5
chr25_+_34862225 0.85 ENSDART00000149782
zgc:194879
chr9_-_14273652 0.85 ENSDART00000135458
ATP-binding cassette, sub-family B (MDR/TAP), member 6b
chr7_-_32875552 0.84 ENSDART00000132504
anoctamin 5b
chr16_+_33142734 0.84 ENSDART00000138244
rhomboid, veinlet-like 2 (Drosophila)
chr4_-_77252368 0.83 ENSDART00000111941
zgc:174310
chr3_+_36222799 0.83 ENSDART00000113105
dihydrouridine synthase 1-like (S. cerevisiae)
chr12_+_33361948 0.82 ENSDART00000124982
fatty acid synthase
chr5_+_18012154 0.81 ENSDART00000139431
ENSDART00000048859
activating signal cointegrator 1 complex subunit 2
chr10_-_8957480 0.81 ENSDART00000150049
molybdenum cofactor synthesis 2
chr14_+_48903640 0.81 ENSDART00000165323
zgc:154054
chr25_+_3788074 0.80 ENSDART00000154008
chitinase domain containing 1
chr3_-_15668433 0.79 ENSDART00000115022
zgc:66474
chr20_-_25902141 0.78 ENSDART00000142611
ENSDART00000024821
ELM2 and Myb/SANT-like domain containing 1a
chr7_-_58178980 0.78 ENSDART00000073635
neutral sphingomyelinase (N-SMase) activation associated factor
chr9_+_28140089 0.78 ENSDART00000046880
pleckstrin homology domain containing, family M, member 3
chr2_-_10877228 0.77 ENSDART00000138718
ENSDART00000034246
cell division cycle 7 homolog (S. cerevisiae)
chr20_+_46620374 0.77 ENSDART00000005548
basic leucine zipper transcription factor, ATF-like
chr11_+_30636351 0.76 ENSDART00000087909
transmembrane protein 246
chr17_+_10578823 0.76 ENSDART00000134610
MGA, MAX dimerization protein a
chr4_-_4570475 0.75 ENSDART00000184955
Ras association (RalGDS/AF-6) domain family member 3
chr1_-_51261420 0.74 ENSDART00000168685
kinesin family member 16Ba
chr3_-_18189283 0.73 ENSDART00000049240
transducer of ERBB2, 1a
chr22_+_2769236 0.71 ENSDART00000141836
si:dkey-20i20.10
chr19_-_10330778 0.70 ENSDART00000081465
ENSDART00000136653
ENSDART00000171232
coiled-coil domain containing 106b
chr6_-_8465656 0.70 ENSDART00000178887
si:dkey-217d24.6
chr25_-_24240797 0.69 ENSDART00000132790
SPT2 chromatin protein domain containing 1
chr14_+_14806692 0.68 ENSDART00000193050
FH2 domain containing 2
chr6_+_21992820 0.68 ENSDART00000147507
THUMP domain containing 3
chr7_-_30280934 0.68 ENSDART00000126741
small EDRK-rich factor 2
chr7_-_34192834 0.68 ENSDART00000125131
SMAD family member 6a
chr21_-_4250682 0.68 ENSDART00000099389
DNL-type zinc finger
chr6_-_19351495 0.68 ENSDART00000164287
growth factor receptor-bound protein 2a
chr2_+_45696743 0.68 ENSDART00000114225
ENSDART00000169279

chr25_-_34973211 0.68 ENSDART00000045177
cyclin-dependent kinase 10
chr3_-_36420397 0.67 ENSDART00000167896
component of oligomeric golgi complex 1
chr19_-_3821678 0.67 ENSDART00000169639
si:dkey-206d17.12
chr7_+_30725473 0.67 ENSDART00000085716
myotubularin related protein 10
chr12_-_25150239 0.65 ENSDART00000038415
ENSDART00000135368
ras homolog family member Q
chr13_+_7242916 0.65 ENSDART00000184238
apoptosis-inducing factor, mitochondrion-associated, 2
chr3_-_36419641 0.65 ENSDART00000173545
component of oligomeric golgi complex 1
chr11_+_2649664 0.63 ENSDART00000166357
si:ch211-160o17.4
chr23_-_4019928 0.62 ENSDART00000021062
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr23_-_4019699 0.62 ENSDART00000159780
solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
chr17_+_6538733 0.61 ENSDART00000193712
solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
chr7_+_37742299 0.61 ENSDART00000143300
bromodomain containing 7
chr5_-_23795688 0.61 ENSDART00000099084
globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, like 4
chr5_+_31965845 0.61 ENSDART00000112968
myosin IHb
chr6_+_9981300 0.61 ENSDART00000151482
abl-interactor 2b
chr11_+_2649891 0.59 ENSDART00000093052
si:ch211-160o17.4
chr14_-_33978117 0.59 ENSDART00000128515
forkhead box A sequence
chr1_-_49950643 0.59 ENSDART00000138301
sphingomyelin synthase 2
chr25_+_31122806 0.58 ENSDART00000067039
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8a
chr25_+_34749187 0.58 ENSDART00000141473
WW domain containing E3 ubiquitin protein ligase 2
chr2_+_50477779 0.58 ENSDART00000122716

chr16_-_42238120 0.58 ENSDART00000084730
zgc:162160
chr9_-_50001606 0.58 ENSDART00000161648
ENSDART00000168514
sodium channel, voltage-gated, type I, alpha
chr19_+_7424347 0.57 ENSDART00000004622
splicing factor 3b, subunit 4
chr5_-_25576462 0.57 ENSDART00000165147
si:dkey-229d2.4
chr15_+_41836104 0.57 ENSDART00000137434
2-phosphoxylose phosphatase 1
chr6_+_21993613 0.54 ENSDART00000160750
ENSDART00000083070
THUMP domain containing 3
chr3_+_25849560 0.54 ENSDART00000007119
major facilitator superfamily domain containing 6-like
chr5_-_57204352 0.54 ENSDART00000171252
ENSDART00000180727
mannosidase, alpha, class 2A, member 1
chr2_+_10642047 0.53 ENSDART00000091570
family with sequence similarity 69, member Aa
chr7_-_20464468 0.53 ENSDART00000134700
canopy4
chr12_+_32729470 0.52 ENSDART00000175712
RNA binding fox-1 homolog 3a
chr20_-_18535502 0.52 ENSDART00000049437
CDC42 binding protein kinase beta (DMPK-like)
chr14_+_29581710 0.52 ENSDART00000188820
ENSDART00000193874
si:dkey-34l15.2
chr17_+_13664442 0.51 ENSDART00000171689
leucine rich repeat and fibronectin type III domain containing 5a
chr18_+_6558338 0.50 ENSDART00000110892
beta-1,4-N-acetyl-galactosaminyl transferase 3b
chr3_-_13599482 0.49 ENSDART00000166639
Tu translation elongation factor, mitochondrial
chr11_+_25157374 0.48 ENSDART00000019450
transient receptor potential cation channel, subfamily C, member 4 associated protein a
chr5_+_30596477 0.48 ENSDART00000124487
histone H4 transcription factor
chr4_-_16706776 0.48 ENSDART00000079461
DENN/MADD domain containing 5B
chr9_-_32804953 0.47 ENSDART00000134763
zgc:112056
chr19_-_12315693 0.47 ENSDART00000151158
neurocalcin delta b
chr4_+_76466751 0.47 ENSDART00000164709
zgc:153116
chr25_+_22587306 0.47 ENSDART00000067479
stimulated by retinoic acid 6
chr9_+_35016201 0.47 ENSDART00000182404
GA binding protein transcription factor, alpha subunit
chr20_-_38525467 0.45 ENSDART00000061417
si:ch211-245h14.1
chr21_+_19547806 0.45 ENSDART00000159707
ENSDART00000184869
ENSDART00000181321
ENSDART00000058487
ENSDART00000058485
retinoic acid induced 14
chr8_+_46939391 0.43 ENSDART00000146631
espin
chr21_-_14815952 0.42 ENSDART00000134278
ENSDART00000067004
phosphohistidine phosphatase 1
chr14_-_48786708 0.42 ENSDART00000169730
si:ch211-199b20.3
chr15_+_17848590 0.42 ENSDART00000168940
zgc:113279
chr14_-_31814149 0.42 ENSDART00000173393
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
chr4_-_7673165 0.41 ENSDART00000028171
leukotriene A4 hydrolase
chr5_+_30596632 0.41 ENSDART00000051414
histone H4 transcription factor
chr3_+_32389904 0.41 ENSDART00000154788
adaptor-related protein complex 2, alpha 1 subunit
chr18_+_35861930 0.40 ENSDART00000185223
protein phosphatase 1, regulatory subunit 13 like
chr2_-_27575803 0.40 ENSDART00000014568
uroporphyrinogen decarboxylase
chr19_+_20793237 0.39 ENSDART00000014774
thioredoxin-like 4A
chr11_-_7156620 0.39 ENSDART00000172823
ENSDART00000172879
ENSDART00000078916
small integral membrane protein 7
chr10_+_44373349 0.38 ENSDART00000172191
small nuclear ribonucleoprotein 35 (U11/U12)
chr5_+_5406503 0.38 ENSDART00000124022
mitogen-activated protein kinase associated protein 1
chr1_+_44056129 0.38 ENSDART00000161114

chr15_+_25452092 0.37 ENSDART00000009545
p21 protein (Cdc42/Rac)-activated kinase 4
chr21_-_25623342 0.37 ENSDART00000101201
transmembrane protein 223
chr25_+_34748860 0.37 ENSDART00000087364
WW domain containing E3 ubiquitin protein ligase 2
chr5_-_24882357 0.37 ENSDART00000127773
ENSDART00000003998
ENSDART00000143851
EWS RNA-binding protein 1b
chr14_+_50937757 0.37 ENSDART00000163865
ring finger protein 44
chr8_-_22326073 0.36 ENSDART00000084965
centrosomal protein 104
chr20_-_33507458 0.35 ENSDART00000140287
papilin b, proteoglycan-like sulfated glycoprotein
chr14_+_35013656 0.35 ENSDART00000164974
early B cell factor 3a
chr1_+_32054159 0.33 ENSDART00000181442
steroid sulfatase (microsomal), isozyme S
chr5_-_55752169 0.33 ENSDART00000097424
potassium channel modulatory factor 1
chr7_+_41322407 0.32 ENSDART00000114076
ENSDART00000139093
DPH2 homolog (S. cerevisiae)
chr12_-_4424424 0.32 ENSDART00000152314
si:ch211-173d10.1
chr22_+_28818291 0.31 ENSDART00000136032
tumor protein p53 binding protein, 2b
chr4_+_76671012 0.31 ENSDART00000005585
membrane-spanning 4-domains, subfamily A, member 17a.2
chr20_+_36623807 0.31 ENSDART00000149171
ENSDART00000062895
signal recognition particle 9
chr9_-_52386733 0.29 ENSDART00000171721
death associated protein 1b
chr16_+_43368572 0.28 ENSDART00000032778
ENSDART00000193897
ring finger protein 144B
chr24_+_26017094 0.27 ENSDART00000137851
transferrin receptor 1b
chr19_+_33139164 0.27 ENSDART00000043039
family with sequence similarity 84, member B
chr1_-_59169815 0.27 ENSDART00000100163
wu:fk65c09
chr16_-_47427016 0.27 ENSDART00000074575
septin 7b
chr8_-_22826996 0.27 ENSDART00000146563
MAGI family member, X-linked a
chr12_-_33579873 0.26 ENSDART00000184661
tudor and KH domain containing
chr3_-_27915270 0.26 ENSDART00000115370
methyltransferase like 22
chr18_-_12416019 0.26 ENSDART00000144799
si:ch211-1e14.1
chr2_-_11101329 0.26 ENSDART00000164416
leucine rich repeat containing 53
chr4_+_74928675 0.25 ENSDART00000192755
nucleoporin 50
chr24_+_30521619 0.25 ENSDART00000162903
dihydropyrimidine dehydrogenase a, tandem duplicate 3
chr1_-_53273500 0.24 ENSDART00000150352
zinc finger protein 330

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.7 GO:0032801 receptor catabolic process(GO:0032801)
0.5 1.5 GO:2000405 response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869) negative regulation of lymphocyte migration(GO:2000402) negative regulation of T cell migration(GO:2000405)
0.4 1.1 GO:0042730 fibrinolysis(GO:0042730)
0.3 1.0 GO:2000638 response to sterol(GO:0036314) cellular response to sterol(GO:0036315) SREBP-SCAP complex retention in endoplasmic reticulum(GO:0036316) regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.3 2.0 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.3 0.9 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.3 0.8 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
0.2 1.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.2 1.0 GO:0090299 regulation of neural crest formation(GO:0090299)
0.2 1.9 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
0.2 0.7 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.2 0.8 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.2 1.1 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.2 0.9 GO:0071480 response to gamma radiation(GO:0010332) cellular response to gamma radiation(GO:0071480)
0.2 0.7 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2 0.5 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 0.6 GO:0015887 biotin transport(GO:0015878) pantothenate transmembrane transport(GO:0015887) coenzyme transport(GO:0051182)
0.2 1.2 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.1 1.0 GO:0031106 septin ring organization(GO:0031106) septin cytoskeleton organization(GO:0032185)
0.1 0.4 GO:0035971 peptidyl-histidine dephosphorylation(GO:0035971)
0.1 1.3 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 1.6 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 1.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.1 1.1 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.1 1.1 GO:0003428 growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428)
0.1 0.6 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.1 0.7 GO:0016572 histone phosphorylation(GO:0016572)
0.1 1.8 GO:0016926 protein desumoylation(GO:0016926)
0.1 1.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 0.7 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 0.8 GO:0002360 T-helper cell lineage commitment(GO:0002295) T cell lineage commitment(GO:0002360) alpha-beta T cell lineage commitment(GO:0002363) CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) T-helper 2 cell differentiation(GO:0045064) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540)
0.1 4.9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1 0.5 GO:0035461 vitamin transmembrane transport(GO:0035461) vitamin A transport(GO:0071938) vitamin A import(GO:0071939)
0.1 3.2 GO:0030488 tRNA methylation(GO:0030488)
0.1 1.7 GO:0036376 cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436)
0.1 0.8 GO:0015886 heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.1 0.4 GO:0006691 leukotriene metabolic process(GO:0006691) leukotriene biosynthetic process(GO:0019370)
0.1 2.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.1 1.2 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 0.8 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1 1.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 0.4 GO:0090133 mesendoderm migration(GO:0090133) cell migration involved in mesendoderm migration(GO:0090134)
0.1 0.6 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 1.9 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.1 2.2 GO:0048264 determination of ventral identity(GO:0048264)
0.1 1.0 GO:0060021 palate development(GO:0060021)
0.1 0.3 GO:0015682 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.1 1.2 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 1.0 GO:0019433 triglyceride catabolic process(GO:0019433)
0.1 0.3 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.8 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 1.2 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.2 GO:0019860 uracil catabolic process(GO:0006212) beta-alanine metabolic process(GO:0019482) beta-alanine biosynthetic process(GO:0019483) uracil metabolic process(GO:0019860) 'de novo' UMP biosynthetic process(GO:0044205)
0.0 0.3 GO:0006013 mannose metabolic process(GO:0006013)
0.0 1.6 GO:0046847 filopodium assembly(GO:0046847)
0.0 1.2 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.0 0.1 GO:0021985 parturition(GO:0007567) neurohypophysis development(GO:0021985) multi-multicellular organism process(GO:0044706) maternal process involved in parturition(GO:0060137)
0.0 0.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.3 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.0 0.1 GO:1902975 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.0 0.5 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.2 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005) atrial cardiac muscle cell development(GO:0055014)
0.0 0.9 GO:0051014 actin filament severing(GO:0051014)
0.0 0.1 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.0 0.4 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.9 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.4 GO:0051453 regulation of intracellular pH(GO:0051453)
0.0 2.1 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 0.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.7 GO:0008637 apoptotic mitochondrial changes(GO:0008637)
0.0 0.1 GO:0032119 sequestering of zinc ion(GO:0032119) regulation of sequestering of zinc ion(GO:0061088)
0.0 0.7 GO:0050821 protein stabilization(GO:0050821)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0000393 spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.0 0.3 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:0039703 viral genome replication(GO:0019079) negative stranded viral RNA replication(GO:0039689) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) multi-organism biosynthetic process(GO:0044034)
0.0 0.2 GO:0070365 hepatocyte differentiation(GO:0070365)
0.0 0.6 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.0 0.0 GO:0010747 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) plasma membrane long-chain fatty acid transport(GO:0015911) positive regulation of lipid transport(GO:0032370) fatty acid transmembrane transport(GO:1902001) positive regulation of anion transmembrane transport(GO:1903961) regulation of fatty acid transport(GO:2000191) positive regulation of fatty acid transport(GO:2000193)
0.0 0.1 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 1.3 GO:0007030 Golgi organization(GO:0007030)
0.0 0.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.6 GO:0099515 vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515)
0.0 1.1 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.3 GO:0009247 glycolipid biosynthetic process(GO:0009247)
0.0 0.8 GO:1902476 chloride transmembrane transport(GO:1902476)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.4 2.5 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.4 1.5 GO:0060171 stereocilium membrane(GO:0060171)
0.3 1.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.2 1.7 GO:0090533 sodium:potassium-exchanging ATPase complex(GO:0005890) cation-transporting ATPase complex(GO:0090533)
0.2 1.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 1.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 0.8 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 2.8 GO:0071141 SMAD protein complex(GO:0071141)
0.1 2.0 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.3 GO:0017119 Golgi transport complex(GO:0017119)
0.1 1.7 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.1 0.5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 1.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.0 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.4 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.5 GO:0030315 T-tubule(GO:0030315)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 0.8 GO:0043186 P granule(GO:0043186)
0.0 1.1 GO:0031941 filamentous actin(GO:0031941)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 3.9 GO:0005764 lysosome(GO:0005764)
0.0 1.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.6 GO:0005902 microvillus(GO:0005902)
0.0 1.2 GO:0044309 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 0.9 GO:0014069 postsynaptic density(GO:0014069)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.4 1.5 GO:0071889 14-3-3 protein binding(GO:0071889)
0.4 2.5 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.2 0.7 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.2 0.8 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.2 1.0 GO:0008142 oxysterol binding(GO:0008142)
0.2 0.6 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.1 1.0 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.4 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.8 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.7 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.1 0.4 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 1.1 GO:0005042 netrin receptor activity(GO:0005042)
0.1 1.2 GO:0005451 monovalent cation:proton antiporter activity(GO:0005451) sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1 1.8 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 0.4 GO:0101006 protein histidine phosphatase activity(GO:0101006)
0.1 0.8 GO:0015232 heme transporter activity(GO:0015232)
0.1 2.1 GO:0070411 I-SMAD binding(GO:0070411)
0.1 0.5 GO:0033842 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity(GO:0033842)
0.1 1.0 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 1.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 1.7 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.5 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.5 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 1.6 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.6 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 4.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.3 GO:0070513 death domain binding(GO:0070513)
0.1 1.0 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.3 GO:0004998 transferrin receptor activity(GO:0004998)
0.1 0.5 GO:0034632 retinol transporter activity(GO:0034632)
0.1 1.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 1.2 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 17.3 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.2 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 1.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.1 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 3.2 GO:0032934 sterol binding(GO:0032934)
0.0 1.2 GO:0004659 prenyltransferase activity(GO:0004659)
0.0 0.3 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.1 GO:0031530 gonadotropin hormone-releasing hormone activity(GO:0005183) gonadotropin-releasing hormone receptor binding(GO:0031530)
0.0 0.1 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
0.0 0.1 GO:0004990 oxytocin receptor activity(GO:0004990)
0.0 0.7 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.9 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.7 GO:0030170 pyridoxal phosphate binding(GO:0030170)
0.0 1.8 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.7 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 1.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.7 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0048407 platelet-derived growth factor-activated receptor activity(GO:0005017) platelet-derived growth factor binding(GO:0048407)
0.0 0.7 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.4 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0002039 p53 binding(GO:0002039)
0.0 1.3 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.6 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.4 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.4 GO:0017069 snRNA binding(GO:0017069)
0.0 0.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.0 GO:0030273 melanin-concentrating hormone receptor activity(GO:0030273)
0.0 6.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.9 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.0 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 1.7 PID ATM PATHWAY ATM pathway
0.0 0.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.3 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.4 PID ARF 3PATHWAY Arf1 pathway
0.0 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 6.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.3 1.9 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 1.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 0.9 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 2.5 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 0.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 0.8 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.9 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.0 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 1.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME KERATAN SULFATE KERATIN METABOLISM Genes involved in Keratan sulfate/keratin metabolism
0.0 0.4 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 1.3 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.4 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 1.1 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.7 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.8 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 1.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.1 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.2 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells