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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for nkx2.3+nkx2.7

Z-value: 1.08

Motif logo

Transcription factors associated with nkx2.3+nkx2.7

Gene Symbol Gene ID Gene Info
ENSDARG00000021232 NK2 transcription factor related 7
ENSDARG00000039095 NK2 homeobox 3
ENSDARG00000113490 NK2 homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
nkx2.3dr11_v1_chr13_-_40411908_40411917-0.881.4e-06Click!
nkx2.7dr11_v1_chr8_-_50287949_50287949-0.512.9e-02Click!

Activity profile of nkx2.3+nkx2.7 motif

Sorted Z-values of nkx2.3+nkx2.7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_21001264 3.78 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr23_+_28322986 3.48 ENSDART00000134710
baculoviral IAP repeat containing 5b
chr19_-_868187 3.36 ENSDART00000186626
eomesodermin homolog a
chr11_-_6452444 2.90 ENSDART00000137879
ENSDART00000134957
ENSDART00000004483
La ribonucleoprotein domain family, member 6b
chr8_+_45334255 2.86 ENSDART00000126848
ENSDART00000134161
ENSDART00000142322
ENSDART00000145011
ENSDART00000183560
poly(A) binding protein, cytoplasmic 1-like
chr10_-_34002185 2.47 ENSDART00000046599
zygote arrest 1-like
chr19_+_42886413 2.45 ENSDART00000151298
cAMP-regulated phosphoprotein, 21
chr5_-_29512538 2.44 ENSDART00000098364
euchromatic histone-lysine N-methyltransferase 1a
chr23_-_33558161 2.16 ENSDART00000018301
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr7_-_51727760 2.15 ENSDART00000174180
histone deacetylase 8
chr1_-_45213565 2.14 ENSDART00000145757
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Aa
chr15_-_35112937 2.11 ENSDART00000154565
ENSDART00000099642
zgc:77118
chr7_+_27603211 2.10 ENSDART00000148782
cytochrome P450, family 2, subfamily R, polypeptide 1
chr22_-_22147375 2.09 ENSDART00000149304
cell division cycle 34 homolog (S. cerevisiae) a
chr14_-_14687004 2.06 ENSDART00000169970
germ cell nuclear acidic peptidase
chr5_-_23596339 1.88 ENSDART00000024815
family with sequence similarity 76, member B
chr23_+_9508538 1.87 ENSDART00000010697
oxysterol binding protein-like 2b
chr4_-_4259079 1.86 ENSDART00000135352
ENSDART00000026559
CD9 molecule b
chr1_-_6028876 1.81 ENSDART00000168117
si:ch1073-345a8.1
chr17_+_43867889 1.81 ENSDART00000132673
ENSDART00000167214
zgc:66313
chr11_+_11303458 1.80 ENSDART00000162486
ENSDART00000160703
si:dkey-23f9.4
chr16_-_7793457 1.78 ENSDART00000113483
tripartite motif containing 71, E3 ubiquitin protein ligase
chr24_+_12835935 1.76 ENSDART00000114762
nanog homeobox
chr16_-_34195002 1.69 ENSDART00000054026
regulator of chromosome condensation 1
chr12_+_22407852 1.67 ENSDART00000178840
high density lipoprotein binding protein b
chr5_+_25304499 1.66 ENSDART00000163425
carnosine N-methyltransferase 1
chr8_-_19467011 1.62 ENSDART00000162010
zgc:92140
chr7_-_26270014 1.61 ENSDART00000079347
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr25_-_29074064 1.60 ENSDART00000165603
AT rich interactive domain 3B (BRIGHT-like)
chr12_-_26538823 1.60 ENSDART00000143213
acyl-CoA synthetase family member 2
chr22_-_14272699 1.55 ENSDART00000190121
si:ch211-246m6.5
chr17_+_19630272 1.55 ENSDART00000104895
regulator of G protein signaling 7a
chr12_-_10508952 1.53 ENSDART00000152806
zgc:152977
chr18_-_35407695 1.53 ENSDART00000191845
ENSDART00000141703
small nuclear ribonucleoprotein polypeptide A
chr6_+_4528631 1.50 ENSDART00000122042
ring finger protein 219
chr7_-_39360325 1.49 ENSDART00000098033
ENSDART00000173695
ENSDART00000173466
ENSDART00000173734
autophagy/beclin-1 regulator 1a
chr23_-_36303216 1.49 ENSDART00000188720
chromobox homolog 5 (HP1 alpha homolog, Drosophila)
chr17_+_12075805 1.47 ENSDART00000155329
consortin, connexin sorting protein a
chr18_-_35407289 1.47 ENSDART00000012018
small nuclear ribonucleoprotein polypeptide A
chr18_-_35407530 1.46 ENSDART00000137663
small nuclear ribonucleoprotein polypeptide A
chr8_-_20230559 1.46 ENSDART00000193677
MLLT1, super elongation complex subunit a
chr9_-_22057658 1.43 ENSDART00000101944
crystallin, gamma MX, like 1
chr14_+_29609245 1.43 ENSDART00000043058
si:dkey-34l15.2
chr5_-_65662996 1.43 ENSDART00000147707
calmodulin regulated spectrin-associated protein 1b
chr19_+_20201254 1.42 ENSDART00000010140
insulin-like growth factor 2 mRNA binding protein 3
chr13_+_25397098 1.42 ENSDART00000132953
glutathione S-transferase omega 2
chr5_+_36896933 1.41 ENSDART00000151984
serine/arginine-rich splicing factor 7a
chr7_+_24023653 1.40 ENSDART00000141165
TERF1 (TRF1)-interacting nuclear factor 2
chr21_+_34088110 1.40 ENSDART00000145123
ENSDART00000029599
ENSDART00000147519
myotubularin related protein 1b
chr9_+_32178050 1.40 ENSDART00000169526
coenzyme Q10B
chr13_+_25396896 1.39 ENSDART00000041257
glutathione S-transferase omega 2
chr7_-_26497947 1.38 ENSDART00000058910
SRY (sex determining region Y)-box 19b
chr8_-_20230802 1.38 ENSDART00000063400
MLLT1, super elongation complex subunit a
chr4_-_837768 1.38 ENSDART00000185280
ENSDART00000135618
sine oculis binding protein homolog (Drosophila) b
chr7_+_39418869 1.37 ENSDART00000169195

chr11_-_35171162 1.34 ENSDART00000017393
TRAF-interacting protein
chr3_-_30488063 1.33 ENSDART00000055393
ENSDART00000151367
mediator complex subunit 25
chr19_-_25119443 1.33 ENSDART00000148953
protein tyrosine phosphatase type IVA, member 3
chr22_-_21897203 1.33 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr14_+_30340251 1.31 ENSDART00000148448
microtubule associated tumor suppressor 1a
chr9_+_32178374 1.30 ENSDART00000078576
coenzyme Q10B
chr16_+_39159752 1.30 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr7_+_24528430 1.29 ENSDART00000133022
si:dkeyp-75h12.2
chr5_+_37406358 1.29 ENSDART00000162811
kelch-like family member 13
chr24_-_25166720 1.27 ENSDART00000141601
pleckstrin homology-like domain, family B, member 2b
chr12_+_38563373 1.25 ENSDART00000134670
ENSDART00000193668
tweety family member 2
chr8_-_9570511 1.25 ENSDART00000044000
plexin A3
chr16_-_41646164 1.24 ENSDART00000184257
ATPase secretory pathway Ca2+ transporting 1
chr21_-_36453594 1.24 ENSDART00000193176
CCR4-NOT transcription complex, subunit 8
chr15_-_31109760 1.23 ENSDART00000154254
kinase suppressor of ras 1b
chr7_+_40083601 1.23 ENSDART00000099046
zgc:112356
chr20_+_33987465 1.23 ENSDART00000061751
zona pellucida glycoprotein 3a, tandem duplicate 2
chr19_+_20201593 1.22 ENSDART00000163026
insulin-like growth factor 2 mRNA binding protein 3
chr6_+_58280936 1.21 ENSDART00000155244
Ral GTPase activating protein, beta subunit (non-catalytic)
chr17_-_6641535 1.21 ENSDART00000154540
ENSDART00000180384
si:ch211-189e2.3
chr2_+_32846602 1.21 ENSDART00000056649
transmembrane protein 53
chr20_-_34028967 1.20 ENSDART00000153408
ENSDART00000033817
SCY1-like, kinase-like 3
chr7_+_34794829 1.19 ENSDART00000009698
ENSDART00000075089
ENSDART00000173456
epithelial splicing regulatory protein 2
chr22_-_20695237 1.19 ENSDART00000112722
oogenesis-related gene
chr17_+_28628404 1.18 ENSDART00000032975
ENSDART00000143607
HEAT repeat containing 5a
chr22_-_10541372 1.17 ENSDART00000179708
si:dkey-42i9.4
chr16_-_17347727 1.17 ENSDART00000144392
zyxin
chr17_-_2590222 1.16 ENSDART00000185711

chr19_-_11315224 1.15 ENSDART00000104933
endonuclease/exonuclease/phosphatase family domain containing 1
chr11_+_31323746 1.15 ENSDART00000180220
ENSDART00000189937
signal-induced proliferation-associated 1 like 2
chr19_+_7552699 1.14 ENSDART00000180788
ENSDART00000115058
pre-B-cell leukemia homeobox interacting protein 1a
chr19_-_34873566 1.14 ENSDART00000016057
catenin (cadherin-associated protein), alpha-like 1
chr17_+_25849332 1.13 ENSDART00000191994
acyl-CoA synthetase short chain family member 1
chr17_+_50701748 1.13 ENSDART00000191938
ENSDART00000183220
ENSDART00000049464
fermitin family member 2
chr12_-_18578218 1.13 ENSDART00000125803
zinc finger, DHHC-type containing 4
chr8_+_42917515 1.13 ENSDART00000021715
solute carrier family 23 (ascorbic acid transporter), member 2
chr12_-_18578432 1.13 ENSDART00000122858
zinc finger, DHHC-type containing 4
chr5_+_25733774 1.11 ENSDART00000137088
ENSDART00000098467
abhydrolase domain containing 17B
chr16_+_35916371 1.11 ENSDART00000167208
SH3 domain containing 21
chr14_+_34490445 1.09 ENSDART00000132193
ENSDART00000148044
wingless-type MMTV integration site family, member 8a
chr20_+_27712714 1.08 ENSDART00000008306
zinc finger and BTB domain containing 1
chr2_-_21820697 1.08 ENSDART00000135230
chromodomain helicase DNA binding protein 7
chr13_+_5978809 1.07 ENSDART00000102563
ENSDART00000121598
PHD finger protein 10
chr13_-_4018888 1.05 ENSDART00000058238
tight junction associated protein 1 (peripheral)
chr17_-_8656155 1.03 ENSDART00000148990
C-terminal binding protein 2a
chr19_-_34742440 1.02 ENSDART00000122625
ENSDART00000175621
elongator acetyltransferase complex subunit 2
chr13_+_7665890 1.02 ENSDART00000046792
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr10_-_33297864 1.02 ENSDART00000163360
PR/SET domain 15
chr16_-_13680692 1.01 ENSDART00000047452
ubiquitin-conjugating enzyme E2S
chr1_-_53407448 1.01 ENSDART00000160033
ENSDART00000172322
ELMO/CED-12 domain containing 2
chr16_-_35427060 1.00 ENSDART00000172294
CTP synthase 1b
chr8_+_20488322 1.00 ENSDART00000036630
zgc:101100
chr15_-_26931541 0.99 ENSDART00000027563
coiled-coil domain containing 9
chr12_+_33320504 0.99 ENSDART00000021491
casein kinase 1, delta b
chr8_+_16676894 0.98 ENSDART00000076586
si:ch211-198n5.11
chr21_+_27513859 0.98 ENSDART00000065420
phosphofurin acidic cluster sorting protein 1a
chr19_+_42086862 0.97 ENSDART00000151605
nuclear transcription factor Y, gamma
chr24_+_25794318 0.97 ENSDART00000143395
SH3-domain kinase binding protein 1
chr10_+_37181780 0.95 ENSDART00000187625
kinase suppressor of ras 1a
chr12_-_48188928 0.95 ENSDART00000184384
phosphatase domain containing, paladin 1a
chr3_+_46271911 0.95 ENSDART00000186557
ENSDART00000113531
MKL/myocardin-like 2b
chr19_+_2685779 0.93 ENSDART00000160533
ENSDART00000097531
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr8_+_26874924 0.93 ENSDART00000141794
ribosomal modification protein rimK-like family member A
chr15_+_30310843 0.93 ENSDART00000112784
LYR motif containing 9
chr20_+_33991801 0.93 ENSDART00000061744
zona pellucida glycoprotein 3a, tandem duplicate 1
chr8_-_15129573 0.92 ENSDART00000142358
BCAR3, NSP family adaptor protein
chr3_-_27647845 0.92 ENSDART00000151625
si:ch211-157c3.4
chr1_+_8521323 0.91 ENSDART00000121439
ENSDART00000103626
ENSDART00000141283
mitochondrial elongation factor 2
chr22_+_14117078 0.91 ENSDART00000013575
basic leucine zipper and W2 domains 1a
chr8_-_50888806 0.91 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr4_+_9467049 0.91 ENSDART00000012659
zgc:55888
chr18_+_26086803 0.90 ENSDART00000187911
zinc finger protein 710a
chr13_-_35892051 0.90 ENSDART00000145884
transforming, acidic coiled-coil containing protein 3
chr20_-_28800999 0.90 ENSDART00000049462
RAB15, member RAS oncogene family
chr15_+_23657051 0.89 ENSDART00000078336
kinesin light chain 3
chr11_+_31324335 0.89 ENSDART00000088093
signal-induced proliferation-associated 1 like 2
chr16_+_54209504 0.88 ENSDART00000020033
X-ray repair complementing defective repair in Chinese hamster cells 1
chr21_+_4509483 0.88 ENSDART00000025612
phytanoyl-CoA dioxygenase domain containing 1
chr23_-_40194732 0.88 ENSDART00000164931
transglutaminase 1 like 2
chr22_+_23430688 0.88 ENSDART00000160457
DENN/MADD domain containing 1B
chr11_-_26832685 0.87 ENSDART00000153519
IQ motif and Sec7 domain 1b
chr2_-_38206034 0.86 ENSDART00000144518
ENSDART00000137395
apoptotic chromatin condensation inducer 1a
chr8_-_29930821 0.86 ENSDART00000125173
excision repair cross-complementation group 6-like 2
chr23_-_14990865 0.85 ENSDART00000147799
ndrg family member 3b
chr14_+_30413758 0.85 ENSDART00000092953
CCR4-NOT transcription complex, subunit 7
chr24_-_19719240 0.85 ENSDART00000135405
cysteine-serine-rich nuclear protein 1b
chr3_-_32873641 0.84 ENSDART00000075277
zgc:113090
chr17_+_1496107 0.84 ENSDART00000187804

chr9_-_31915423 0.84 ENSDART00000060051
fibroblast growth factor 14
chr1_-_23110740 0.83 ENSDART00000171848
ENSDART00000086797
ENSDART00000189344
ENSDART00000190858
adhesion G protein-coupled receptor L3.1
chr21_-_36453417 0.83 ENSDART00000018350
CCR4-NOT transcription complex, subunit 8
chr9_+_43799829 0.83 ENSDART00000186240
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr13_-_35892243 0.82 ENSDART00000002750
ENSDART00000122810
ENSDART00000162399
transforming, acidic coiled-coil containing protein 3
chr15_+_34069746 0.82 ENSDART00000163513
ADP-ribosylation factor-like 4aa
chr12_+_23812530 0.81 ENSDART00000066331
supervillin a
chr12_-_8958011 0.81 ENSDART00000141212
cytochrome P450, family 26, subfamily A, polypeptide 1
chr3_+_35611625 0.80 ENSDART00000190995
TNF receptor-associated factor 7
chr12_+_34953038 0.80 ENSDART00000187022
ENSDART00000123988
ENSDART00000027034
QKI, KH domain containing, RNA binding 2
chr8_-_944055 0.79 ENSDART00000092773
mitochondrial ribosomal protein S27
chr16_-_42965192 0.79 ENSDART00000113714
metaxin 1a
chr23_+_4348479 0.79 ENSDART00000182425
v-myb avian myeloblastosis viral oncogene homolog-like 2a
chr19_+_15440841 0.79 ENSDART00000182329
lin-28 homolog A (C. elegans)
chr19_+_6990970 0.79 ENSDART00000158758
ENSDART00000160482
ENSDART00000193566
kinesin family member C1
chr11_+_31380495 0.79 ENSDART00000185073
signal-induced proliferation-associated 1 like 2
chr16_-_24642814 0.78 ENSDART00000153987
ENSDART00000154319
FXYD domain containing ion transport regulator 6 like
chr20_-_51186524 0.78 ENSDART00000027836
ENSDART00000114407
RNA binding motif protein 25b
chr22_-_10397600 0.78 ENSDART00000181964
ENSDART00000142886
nischarin
chr23_+_19590006 0.78 ENSDART00000021231
sarcolemma associated protein b
chr19_-_5865766 0.78 ENSDART00000191007

chr13_-_33114933 0.78 ENSDART00000140543
ENSDART00000075953
zinc finger, FYVE domain containing 26
chr5_-_1869982 0.78 ENSDART00000055878
RNA terminal phosphate cyclase-like 1
chr23_+_43684494 0.77 ENSDART00000149878
OTU deubiquitinase 4
chr2_+_44972720 0.77 ENSDART00000075146
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)
chr20_-_33512443 0.77 ENSDART00000061836
papilin b, proteoglycan-like sulfated glycoprotein
chr9_+_38457806 0.77 ENSDART00000142512
minichromosome maintenance complex component 3 associated protein
chr13_-_33227411 0.77 ENSDART00000057386
golgin A5
chr20_+_36812368 0.77 ENSDART00000062931
ABRA C-terminal like
chr18_-_15532016 0.77 ENSDART00000165279
PTPRF interacting protein, binding protein 1b (liprin beta 1)
chr5_+_65086856 0.77 ENSDART00000169209
ENSDART00000162409
peptidyl-tRNA hydrolase 1 homolog
chr3_+_18807006 0.76 ENSDART00000180091
transportin 2 (importin 3, karyopherin beta 2b)
chr19_+_15441022 0.76 ENSDART00000098970
ENSDART00000140276
lin-28 homolog A (C. elegans)
chr23_-_36441693 0.76 ENSDART00000024354
cysteine sulfinic acid decarboxylase
chr1_+_513986 0.76 ENSDART00000109083
ENSDART00000081945
thioredoxin-like 4B
chr15_+_15771418 0.75 ENSDART00000153831
si:ch211-33e4.3
chr15_-_17138640 0.75 ENSDART00000080777
mitochondrial ribosomal protein L28
chr2_-_57837838 0.74 ENSDART00000010699
splicing factor 3a, subunit 2
chr21_+_4508959 0.74 ENSDART00000140432
ENSDART00000147187
ENSDART00000148910
phytanoyl-CoA dioxygenase domain containing 1
chr5_+_65086668 0.73 ENSDART00000183746
peptidyl-tRNA hydrolase 1 homolog
chr7_+_48297842 0.73 ENSDART00000052123
solute carrier family 25, member 44 b
chr9_+_16241656 0.73 ENSDART00000154326
si:ch211-261p9.4
chr17_+_13664442 0.73 ENSDART00000171689
leucine rich repeat and fibronectin type III domain containing 5a
chr5_-_20921677 0.72 ENSDART00000158030
si:ch211-225b11.4
chr19_+_28187480 0.72 ENSDART00000183825
iroquois homeobox 4b
chr23_+_20518504 0.71 ENSDART00000114246
activity-dependent neuroprotector homeobox b
chr8_-_51507144 0.70 ENSDART00000024882
ENSDART00000135166
fibroblast growth factor receptor 1a
chr15_-_43284021 0.70 ENSDART00000041677
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr15_+_15266025 0.70 ENSDART00000112974
ENSDART00000184450
C2 calcium-dependent domain containing 3
chr12_+_21298317 0.70 ENSDART00000178562
carbonic anhydrase Xa
chr24_+_22759451 0.70 ENSDART00000135392
si:dkey-7n6.2
chr2_+_25315591 0.69 ENSDART00000161386
fibronectin type III domain containing 3Ba
chr23_+_2914577 0.69 ENSDART00000184897
zgc:158828
chr12_-_8958353 0.69 ENSDART00000041728
cytochrome P450, family 26, subfamily A, polypeptide 1
chr15_-_20745513 0.69 ENSDART00000187438
tyrosylprotein sulfotransferase 1
chr25_+_7299488 0.69 ENSDART00000184836
high mobility group 20A
chr2_-_26590628 0.69 ENSDART00000025120
NDC1 transmembrane nucleoporin

Network of associatons between targets according to the STRING database.

First level regulatory network of nkx2.3+nkx2.7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0000212 meiotic spindle organization(GO:0000212)
1.1 3.4 GO:0055109 invagination involved in gastrulation with mouth forming second(GO:0055109) morphogenesis of an epithelial fold(GO:0060571)
0.5 1.5 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.4 3.6 GO:0031670 cellular response to nutrient(GO:0031670) cellular response to vitamin(GO:0071295)
0.4 1.6 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.4 1.1 GO:0015882 L-ascorbic acid transport(GO:0015882) L-ascorbic acid metabolic process(GO:0019852)
0.4 1.1 GO:0039015 spinal cord anterior/posterior patterning(GO:0021512) cell proliferation involved in pronephros development(GO:0039015) cell proliferation involved in kidney development(GO:0072111)
0.4 2.2 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.4 1.8 GO:0010586 miRNA metabolic process(GO:0010586)
0.3 1.3 GO:0060074 synapse maturation(GO:0060074)
0.3 0.9 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.3 2.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.3 2.9 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.3 1.0 GO:0060965 negative regulation of posttranscriptional gene silencing(GO:0060149) negative regulation of gene silencing by miRNA(GO:0060965) negative regulation of gene silencing by RNA(GO:0060967)
0.3 1.0 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.2 1.2 GO:0055071 manganese ion homeostasis(GO:0055071)
0.2 1.7 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.2 0.7 GO:0010863 positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274)
0.2 1.4 GO:0048755 branching morphogenesis of a nerve(GO:0048755)
0.2 0.8 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.2 0.6 GO:1904983 transmembrane glycine transport from cytosol to mitochondrion(GO:1904983)
0.2 1.1 GO:0019427 acetate metabolic process(GO:0006083) acetyl-CoA biosynthetic process from acetate(GO:0019427)
0.2 0.6 GO:0048917 posterior lateral line ganglion development(GO:0048917)
0.2 1.4 GO:0031113 regulation of microtubule polymerization(GO:0031113)
0.2 0.9 GO:0000012 single strand break repair(GO:0000012)
0.2 1.0 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.2 0.5 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.2 1.1 GO:2001106 regulation of guanyl-nucleotide exchange factor activity(GO:1905097) regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.2 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.1 1.2 GO:0031063 regulation of histone deacetylation(GO:0031063)
0.1 1.2 GO:0006478 protein sulfation(GO:0006477) peptidyl-tyrosine sulfation(GO:0006478)
0.1 1.0 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.1 1.0 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 1.0 GO:0006552 leucine catabolic process(GO:0006552)
0.1 0.6 GO:0048532 anatomical structure arrangement(GO:0048532)
0.1 0.7 GO:0072575 hepatocyte proliferation(GO:0072574) epithelial cell proliferation involved in liver morphogenesis(GO:0072575)
0.1 0.5 GO:0003322 pancreatic A cell development(GO:0003322)
0.1 2.2 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.1 2.5 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 0.4 GO:0043416 regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 0.5 GO:0001712 ectodermal cell fate commitment(GO:0001712) ectodermal cell fate specification(GO:0001715) ectodermal cell differentiation(GO:0010668) regulation of ectodermal cell fate specification(GO:0042665) regulation of ectoderm development(GO:2000383)
0.1 1.4 GO:1904356 regulation of telomere maintenance via telomere lengthening(GO:1904356)
0.1 0.4 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.4 GO:0003228 atrial cardiac muscle tissue development(GO:0003228)
0.1 0.5 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490)
0.1 0.4 GO:0042754 negative regulation of circadian rhythm(GO:0042754)
0.1 0.6 GO:0048069 eye pigmentation(GO:0048069)
0.1 0.4 GO:0051660 establishment of centrosome localization(GO:0051660)
0.1 1.1 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 7.0 GO:0051028 mRNA transport(GO:0051028)
0.1 1.1 GO:0048798 rRNA transcription(GO:0009303) swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 0.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 0.6 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1 0.4 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.1 0.3 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 1.0 GO:0061154 endothelial tube morphogenesis(GO:0061154) blood vessel lumenization(GO:0072554)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553) negative regulation of lipid kinase activity(GO:0090219)
0.1 0.3 GO:0042766 nucleosome mobilization(GO:0042766)
0.1 1.3 GO:0060021 palate development(GO:0060021)
0.1 0.2 GO:0010874 regulation of cholesterol efflux(GO:0010874)
0.1 0.8 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 0.5 GO:0021634 optic nerve formation(GO:0021634)
0.1 0.1 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 0.6 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 2.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 0.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.2 GO:0089709 L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.0 0.2 GO:0016322 neuron remodeling(GO:0016322)
0.0 0.3 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 1.4 GO:0055008 cardiac muscle tissue morphogenesis(GO:0055008)
0.0 0.1 GO:1901890 positive regulation of cell junction assembly(GO:1901890)
0.0 1.7 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 1.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 2.0 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.3 GO:0048823 nucleate erythrocyte development(GO:0048823)
0.0 0.9 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 1.0 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.9 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.2 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577) regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1902514)
0.0 1.8 GO:0060968 regulation of gene silencing(GO:0060968)
0.0 0.9 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.4 GO:0060004 reflex(GO:0060004) vestibular reflex(GO:0060005)
0.0 2.4 GO:0034968 histone lysine methylation(GO:0034968)
0.0 0.5 GO:1901534 positive regulation of hematopoietic progenitor cell differentiation(GO:1901534)
0.0 0.6 GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome(GO:0098943)
0.0 0.4 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.9 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.8 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.1 GO:0051014 actin filament severing(GO:0051014)
0.0 0.5 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 4.3 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0061635 regulation of protein complex stability(GO:0061635)
0.0 0.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.5 GO:0021772 olfactory bulb development(GO:0021772) olfactory lobe development(GO:0021988)
0.0 1.4 GO:0007338 single fertilization(GO:0007338)
0.0 0.1 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 2.0 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 0.2 GO:0060827 regulation of canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060827)
0.0 0.9 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 1.0 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.9 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 0.5 GO:0045841 mitotic spindle assembly checkpoint(GO:0007094) spindle checkpoint(GO:0031577) negative regulation of mitotic metaphase/anaphase transition(GO:0045841) spindle assembly checkpoint(GO:0071173) mitotic spindle checkpoint(GO:0071174)
0.0 0.9 GO:0032456 endocytic recycling(GO:0032456)
0.0 8.5 GO:0000398 RNA splicing, via transesterification reactions(GO:0000375) RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.2 GO:0060754 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 2.4 GO:0061640 cytoskeleton-dependent cytokinesis(GO:0061640)
0.0 0.2 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.6 GO:0006491 N-glycan processing(GO:0006491)
0.0 1.1 GO:0051225 spindle assembly(GO:0051225)
0.0 1.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.7 GO:0038061 NIK/NF-kappaB signaling(GO:0038061)
0.0 0.1 GO:0021742 abducens nucleus development(GO:0021742)
0.0 0.1 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.5 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 1.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 1.3 GO:0001508 action potential(GO:0001508)
0.0 1.4 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 0.3 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 0.3 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.6 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.7 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0015682 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0 1.1 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744) single-organism nuclear import(GO:1902593)
0.0 0.6 GO:0070593 dendrite self-avoidance(GO:0070593)
0.0 0.6 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.1 GO:0018103 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.3 GO:0090329 regulation of DNA-dependent DNA replication(GO:0090329)
0.0 0.4 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.0 1.3 GO:0014904 myotube cell development(GO:0014904) skeletal muscle fiber development(GO:0048741)
0.0 0.9 GO:0030901 midbrain development(GO:0030901)
0.0 0.4 GO:1902285 semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0 0.1 GO:0019405 alditol catabolic process(GO:0019405)
0.0 0.1 GO:0031179 peptide modification(GO:0031179)
0.0 0.0 GO:0009193 pyrimidine ribonucleoside diphosphate metabolic process(GO:0009193) UDP metabolic process(GO:0046048)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:1902292 cell cycle DNA replication initiation(GO:1902292) nuclear cell cycle DNA replication initiation(GO:1902315) mitotic DNA replication initiation(GO:1902975)
0.0 0.1 GO:0045176 asymmetric protein localization(GO:0008105) apical protein localization(GO:0045176)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.3 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.1 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.1 GO:0070207 protein homotrimerization(GO:0070207)
0.0 0.4 GO:0090148 membrane fission(GO:0090148)
0.0 0.5 GO:0030851 granulocyte differentiation(GO:0030851)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0072116 kidney rudiment formation(GO:0072003) pronephros formation(GO:0072116)
0.0 0.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 1.7 GO:0000209 protein polyubiquitination(GO:0000209)
0.0 0.7 GO:0051402 neuron apoptotic process(GO:0051402)
0.0 0.1 GO:0014036 neural crest cell fate commitment(GO:0014034) neural crest cell fate specification(GO:0014036)
0.0 1.2 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 0.1 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.3 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.1 GO:0034122 negative regulation of toll-like receptor signaling pathway(GO:0034122)
0.0 0.0 GO:1901017 negative regulation of potassium ion transmembrane transporter activity(GO:1901017) negative regulation of potassium ion transmembrane transport(GO:1901380) negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0 0.5 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 1.3 GO:0070507 regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.1 GO:0006032 chitin catabolic process(GO:0006032)
0.0 0.7 GO:1902668 negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0 0.1 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.6 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 2.4 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 0.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.1 GO:0070266 necroptotic process(GO:0070266)
0.0 0.2 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173) inositol phosphate-mediated signaling(GO:0048016)
0.0 0.8 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.2 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0097189 apoptotic body(GO:0097189)
0.3 1.0 GO:0097268 cytoophidium(GO:0097268)
0.2 2.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 4.5 GO:0005685 U1 snRNP(GO:0005685)
0.2 1.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 1.4 GO:0005682 U5 snRNP(GO:0005682)
0.2 0.8 GO:0070390 transcription export complex 2(GO:0070390)
0.1 1.4 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.4 GO:1990429 Pex17p-Pex14p docking complex(GO:1990415) peroxisomal importomer complex(GO:1990429)
0.1 1.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.8 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 1.4 GO:0070187 telosome(GO:0070187)
0.1 1.3 GO:0045180 basal cortex(GO:0045180)
0.1 1.0 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 4.0 GO:0005876 spindle microtubule(GO:0005876)
0.1 0.9 GO:0098799 mitochondrial outer membrane translocase complex(GO:0005742) outer mitochondrial membrane protein complex(GO:0098799)
0.1 1.4 GO:0071564 npBAF complex(GO:0071564)
0.1 0.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 2.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.1 1.6 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.1 0.3 GO:0044609 DBIRD complex(GO:0044609)
0.1 0.7 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.7 GO:0005844 polysome(GO:0005844)
0.1 3.1 GO:0030496 midbody(GO:0030496)
0.1 0.3 GO:0042584 chromaffin granule membrane(GO:0042584)
0.1 0.7 GO:0071010 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.1 0.4 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306)
0.1 0.6 GO:0035101 FACT complex(GO:0035101)
0.1 1.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 2.1 GO:0008305 integrin complex(GO:0008305)
0.0 0.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 0.3 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024) nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908)
0.0 0.3 GO:0000974 Prp19 complex(GO:0000974)
0.0 1.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.9 GO:0016592 mediator complex(GO:0016592)
0.0 0.4 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 3.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0016600 flotillin complex(GO:0016600)
0.0 1.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.7 GO:0016607 nuclear speck(GO:0016607)
0.0 0.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 1.6 GO:0005871 kinesin complex(GO:0005871)
0.0 2.2 GO:0005925 focal adhesion(GO:0005925)
0.0 0.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.3 GO:0044545 NSL complex(GO:0044545)
0.0 0.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.0 GO:0000776 kinetochore(GO:0000776)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.8 GO:0031985 Golgi cisterna(GO:0031985)
0.0 0.9 GO:0030139 endocytic vesicle(GO:0030139)
0.0 3.5 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0045174 glutathione dehydrogenase (ascorbate) activity(GO:0045174)
0.6 4.5 GO:0030619 U1 snRNA binding(GO:0030619)
0.5 1.6 GO:0031956 medium-chain fatty acid-CoA ligase activity(GO:0031956) butyrate-CoA ligase activity(GO:0047760)
0.5 1.5 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.4 1.5 GO:0071253 connexin binding(GO:0071253)
0.3 1.0 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.3 0.9 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590) citrate-L-glutamate ligase activity(GO:0072591)
0.3 2.7 GO:0048039 ubiquinone binding(GO:0048039)
0.3 3.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028)
0.3 1.0 GO:0003883 CTP synthase activity(GO:0003883)
0.2 1.5 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.2 1.2 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.2 2.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 2.2 GO:0035804 structural constituent of egg coat(GO:0035804)
0.2 2.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.8 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 1.1 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 1.8 GO:0035198 miRNA binding(GO:0035198)
0.2 1.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.2 2.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.1 1.3 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 1.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 2.4 GO:0002039 p53 binding(GO:0002039)
0.1 1.5 GO:0043495 protein anchor(GO:0043495)
0.1 0.5 GO:0008117 sphinganine-1-phosphate aldolase activity(GO:0008117)
0.1 0.5 GO:0030586 [methionine synthase] reductase activity(GO:0030586)
0.1 1.0 GO:0008494 translation activator activity(GO:0008494)
0.1 2.2 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.3 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 4.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.1 0.9 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.0 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.1 1.6 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 0.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.9 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 0.6 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 0.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 1.3 GO:0019894 kinesin binding(GO:0019894)
0.1 1.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.2 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 1.6 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0017064 fatty acid amide hydrolase activity(GO:0017064)
0.0 0.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 0.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 3.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.4 GO:0038064 protein tyrosine kinase collagen receptor activity(GO:0038062) collagen receptor activity(GO:0038064)
0.0 0.4 GO:0030172 troponin C binding(GO:0030172) troponin I binding(GO:0031013)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 1.7 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.2 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.4 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 0.2 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 3.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.6 GO:0019211 phosphatase activator activity(GO:0019211) protein phosphatase activator activity(GO:0072542)
0.0 7.0 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.6 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.2 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.5 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.6 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.9 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.0 0.1 GO:1903924 estradiol binding(GO:1903924)
0.0 1.0 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.2 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 1.3 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.6 GO:0098632 protein binding involved in cell adhesion(GO:0098631) protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.7 GO:0015036 disulfide oxidoreductase activity(GO:0015036)
0.0 0.1 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.0 0.0 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 0.4 GO:0031267 small GTPase binding(GO:0031267)
0.0 0.1 GO:0000048 peptidyltransferase activity(GO:0000048) glutathione hydrolase activity(GO:0036374)
0.0 0.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.0 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.8 GO:0004521 endoribonuclease activity(GO:0004521)
0.0 0.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.4 GO:0051018 protein kinase A binding(GO:0051018)
0.0 2.0 GO:0060090 binding, bridging(GO:0060090)
0.0 0.1 GO:0004568 chitinase activity(GO:0004568)
0.0 0.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 4.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0034632 retinol transporter activity(GO:0034632)
0.0 0.5 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.2 GO:0016854 racemase and epimerase activity(GO:0016854)
0.0 2.0 GO:0042802 identical protein binding(GO:0042802)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.1 3.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 2.8 PID AURORA B PATHWAY Aurora B signaling
0.1 1.7 PID AURORA A PATHWAY Aurora A signaling
0.1 0.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 1.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 1.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.7 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.0 1.0 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.8 PID ARF 3PATHWAY Arf1 pathway
0.0 2.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.6 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.0 0.5 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.7 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.2 PID CONE PATHWAY Visual signal transduction: Cones
0.0 0.2 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 2.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 2.9 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 3.6 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.1 1.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.0 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 1.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.7 REACTOME KINESINS Genes involved in Kinesins
0.1 2.0 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 0.9 REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway
0.1 1.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 1.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 2.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 0.2 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.9 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.0 2.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 1.1 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.8 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.5 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.8 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.0 0.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.3 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 3.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.5 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.9 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.0 1.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.2 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 2.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.7 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.2 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination