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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for nkx2.1
Z-value: 0.22
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Transcription factors associated with nkx2.1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nkx2.1 | dr11_v1_chr17_+_38262408_38262408 | -0.34 | 1.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_26237322 Show fit | 0.45 |
ENSDART00000030520
|
paralemmin 1b |
|
| chr5_-_54712159 Show fit | 0.41 |
ENSDART00000149207
|
cyclin B1 |
|
| chr12_+_30788912 Show fit | 0.40 |
ENSDART00000160422
|
aldehyde dehydrogenase 18 family, member A1 |
|
| chr20_-_38827623 Show fit | 0.37 |
ENSDART00000153310
|
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
|
| chr14_-_33478963 Show fit | 0.36 |
ENSDART00000132813
|
lysosomal-associated membrane protein 2 |
|
| chr23_-_33558161 Show fit | 0.36 |
ENSDART00000018301
|
integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
|
| chr1_-_23294753 Show fit | 0.35 |
ENSDART00000013263
|
UDP-glucose 6-dehydrogenase |
|
| chr2_+_26240339 Show fit | 0.35 |
ENSDART00000191006
|
paralemmin 1b |
|
| chr17_-_12249990 Show fit | 0.33 |
ENSDART00000177889
ENSDART00000155545 |
AT hook containing transcription factor 1 |
|
| chr21_+_34132747 Show fit | 0.33 |
ENSDART00000148115
|
transient receptor potential cation channel, subfamily C, member 5b |
Network of associatons between targets according to the STRING database.
First level regulatory network of nkx2.1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 0.1 | 0.4 | GO:0021563 | glossopharyngeal nerve development(GO:0021563) |
| 0.1 | 0.4 | GO:0071800 | podosome assembly(GO:0071800) |
| 0.1 | 0.4 | GO:0090245 | axis elongation involved in somitogenesis(GO:0090245) |
| 0.1 | 0.4 | GO:0003188 | heart valve formation(GO:0003188) atrioventricular valve formation(GO:0003190) |
| 0.0 | 0.4 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.0 | 0.4 | GO:0055129 | proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129) |
| 0.0 | 0.4 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.1 | 0.3 | GO:0034773 | histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773) |
| 0.1 | 0.3 | GO:0051292 | nuclear pore complex assembly(GO:0051292) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.1 | 0.4 | GO:0031310 | integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310) |
| 0.1 | 0.4 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.2 | GO:0005915 | cell-cell adherens junction(GO:0005913) zonula adherens(GO:0005915) |
| 0.0 | 0.2 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.1 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.1 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.0 | 0.1 | GO:0034388 | Pwp2p-containing subcomplex of 90S preribosome(GO:0034388) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.5 | GO:0004113 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113) |
| 0.1 | 0.4 | GO:0016743 | carboxyl- or carbamoyltransferase activity(GO:0016743) |
| 0.1 | 0.4 | GO:0003979 | UDP-glucose 6-dehydrogenase activity(GO:0003979) |
| 0.1 | 0.4 | GO:0016774 | phosphotransferase activity, carboxyl group as acceptor(GO:0016774) |
| 0.0 | 0.4 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.0 | 0.4 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 0.3 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.0 | 0.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.1 | 0.2 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.0 | 0.2 | GO:0004459 | L-lactate dehydrogenase activity(GO:0004459) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.4 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 0.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.0 | 0.4 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.0 | 0.4 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.0 | 0.3 | REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES | Genes involved in p75NTR recruits signalling complexes |
| 0.0 | 0.2 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.2 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.0 | 0.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |