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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for nfixa+nfixb
Z-value: 0.47
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Transcription factors associated with nfixa+nfixb
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nfixa | dr11_v1_chr1_+_51896147_51896147 | 0.13 | 6.2e-01 | Click! |
| nfixb | dr11_v1_chr3_+_14768364_14768364 | 0.08 | 7.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_5207152 Show fit | 1.96 |
ENSDART00000172751
|
si:ch73-223f5.2 |
|
| chr25_-_16581233 Show fit | 1.80 |
ENSDART00000155312
|
structural maintenance of chromosomes 1B |
|
| chr2_-_24488652 Show fit | 1.48 |
ENSDART00000052067
|
insulin-like 3 (Leydig cell) |
|
| chr8_-_52715911 Show fit | 1.41 |
ENSDART00000168241
|
tubulin, beta 2b |
|
| chr13_+_50375800 Show fit | 1.40 |
ENSDART00000099537
|
cytochrome c oxidase subunit Vb 2 |
|
| chr2_-_14798295 Show fit | 1.23 |
ENSDART00000143430
ENSDART00000145869 |
si:ch73-366i20.1 |
|
| chr4_-_8030583 Show fit | 1.21 |
ENSDART00000113628
|
si:ch211-240l19.8 |
|
| chr7_-_25049377 Show fit | 1.15 |
ENSDART00000077191
|
ADP-ribosylation factor-like 2 |
|
| chr14_+_6954579 Show fit | 1.09 |
ENSDART00000060998
|
NME/NM23 family member 5 |
|
| chr2_-_24898226 Show fit | 1.07 |
ENSDART00000134936
|
si:dkey-149i17.9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nfixa+nfixb
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0070646 | protein modification by small protein removal(GO:0070646) |
| 0.1 | 1.4 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 1.4 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.4 | 1.2 | GO:1902175 | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902175) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) |
| 0.2 | 1.1 | GO:0031116 | positive regulation of microtubule polymerization(GO:0031116) |
| 0.2 | 1.0 | GO:0009098 | leucine biosynthetic process(GO:0009098) |
| 0.0 | 1.0 | GO:0055003 | cardiac myofibril assembly(GO:0055003) |
| 0.1 | 0.9 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.3 | 0.8 | GO:2000471 | regulation of hematopoietic stem cell migration(GO:2000471) |
| 0.2 | 0.7 | GO:0034382 | chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) intermediate-density lipoprotein particle clearance(GO:0071831) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.1 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.2 | 0.7 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.0 | 0.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 0.5 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.4 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.0 | 0.4 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.4 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.4 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.3 | GO:0005883 | neurofilament(GO:0005883) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0101005 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 1.5 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 1.4 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 1.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 1.0 | GO:0004084 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
| 0.2 | 0.8 | GO:0015355 | secondary active monocarboxylate transmembrane transporter activity(GO:0015355) |
| 0.0 | 0.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 0.7 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.7 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
| 0.0 | 0.7 | GO:0019957 | C-C chemokine binding(GO:0019957) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 0.4 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.8 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 1.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 1.4 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.0 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |
| 0.0 | 0.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.3 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 0.3 | REACTOME PLATELET SENSITIZATION BY LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 0.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.3 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.2 | REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS | Genes involved in Tandem pore domain potassium channels |