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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for nfatc2a
Z-value: 1.24
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Transcription factors associated with nfatc2a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| nfatc2a | dr11_v1_chr23_+_39089574_39089574 | -0.55 | 1.7e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_46040666 Show fit | 1.41 |
ENSDART00000060744
|
si:dkey-7c18.24 |
|
| chr19_+_41479990 Show fit | 1.27 |
ENSDART00000087187
|
argonaute RISC catalytic component 2 |
|
| chr24_-_17029374 Show fit | 1.20 |
ENSDART00000039267
|
prostaglandin D2 synthase b, tandem duplicate 1 |
|
| chr12_-_25887864 Show fit | 1.15 |
ENSDART00000152983
|
si:dkey-193p11.2 |
|
| chr5_-_3991655 Show fit | 1.11 |
ENSDART00000159368
|
myosin XIX |
|
| chr17_-_30521043 Show fit | 1.11 |
ENSDART00000087111
|
intersectin 2b |
|
| chr8_+_13106760 Show fit | 1.08 |
ENSDART00000029308
|
integrin, beta 4 |
|
| chr10_+_5954787 Show fit | 1.06 |
ENSDART00000161887
ENSDART00000160345 ENSDART00000190046 |
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase |
|
| chr7_+_33424044 Show fit | 1.04 |
ENSDART00000180260
|
glucuronic acid epimerase b |
|
| chr18_-_39696853 Show fit | 1.01 |
ENSDART00000148383
|
Dmx-like 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of nfatc2a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.0 | 1.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 1.6 | GO:0061640 | cytoskeleton-dependent cytokinesis(GO:0061640) |
| 0.0 | 1.5 | GO:0048920 | posterior lateral line neuromast primordium migration(GO:0048920) |
| 0.3 | 1.4 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.2 | 1.4 | GO:0003422 | growth plate cartilage morphogenesis(GO:0003422) chondrocyte intercalation involved in growth plate cartilage morphogenesis(GO:0003428) |
| 0.1 | 1.4 | GO:0046660 | female sex differentiation(GO:0046660) |
| 0.3 | 1.3 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.0 | 1.3 | GO:0006303 | double-strand break repair via nonhomologous end joining(GO:0006303) |
| 0.0 | 1.3 | GO:0099515 | vesicle transport along actin filament(GO:0030050) actin filament-based transport(GO:0099515) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.3 | GO:0005912 | adherens junction(GO:0005912) |
| 0.1 | 2.2 | GO:0031105 | septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.0 | 1.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.8 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.0 | 1.8 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
| 0.3 | 1.7 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.0 | 1.7 | GO:0008305 | integrin complex(GO:0008305) |
| 0.1 | 1.6 | GO:0044666 | MLL3/4 complex(GO:0044666) |
| 0.1 | 1.5 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.2 | 1.4 | GO:0089701 | U2AF(GO:0089701) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.9 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.0 | 2.6 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 2.4 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 2.0 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.1 | 1.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.2 | 1.8 | GO:0001217 | bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217) |
| 0.0 | 1.8 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.3 | 1.7 | GO:0035197 | siRNA binding(GO:0035197) |
| 0.1 | 1.6 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.0 | 1.6 | GO:0060090 | binding, bridging(GO:0060090) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.8 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 2.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.1 | 1.2 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 1.1 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 1.1 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.0 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.9 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 0.7 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 2.3 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 1.5 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.0 | 1.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 1.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 1.0 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.1 | 1.0 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.1 | 0.8 | REACTOME SEMA3A PAK DEPENDENT AXON REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
| 0.0 | 0.8 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.2 | 0.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |