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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for myca+mych
Z-value: 0.92
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Transcription factors associated with myca+mych
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| myca | dr11_v1_chr24_+_10414028_10414028 | -0.66 | 3.0e-03 | Click! |
| mych | dr11_v1_chr6_+_50452699_50452699 | -0.53 | 2.5e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of myca+mych
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | GO:0006486 | protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413) |
| 0.0 | 3.3 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.1 | 2.6 | GO:0071456 | cellular response to hypoxia(GO:0071456) |
| 0.0 | 2.4 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.1 | 2.3 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.3 | 2.2 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.2 | 2.1 | GO:0000491 | small nucleolar ribonucleoprotein complex assembly(GO:0000491) |
| 0.2 | 2.1 | GO:0006189 | 'de novo' IMP biosynthetic process(GO:0006189) |
| 0.0 | 2.0 | GO:0051298 | centrosome duplication(GO:0051298) |
| 0.6 | 1.8 | GO:1902102 | meiotic cell cycle phase transition(GO:0044771) metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.9 | 2.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 2.1 | GO:0030496 | midbody(GO:0030496) |
| 0.1 | 1.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.1 | 1.7 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.1 | 1.7 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.2 | 1.4 | GO:0035517 | PR-DUB complex(GO:0035517) |
| 0.2 | 1.4 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 1.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.3 | GO:0000177 | nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.6 | GO:0015129 | lactate transmembrane transporter activity(GO:0015129) |
| 0.1 | 5.5 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.1 | 3.0 | GO:0034062 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.0 | 2.5 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 2.5 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 2.4 | GO:0008175 | tRNA methyltransferase activity(GO:0008175) |
| 0.2 | 2.3 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.0 | 2.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.2 | 1.7 | GO:0050262 | ribosylnicotinamide kinase activity(GO:0050262) |
| 0.1 | 1.5 | GO:0035925 | AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.7 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.1 | 2.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 1.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 1.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 0.7 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.6 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.1 | 3.2 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 0.1 | 3.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.2 | 2.8 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 2.5 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 2.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.2 | 1.5 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 1.4 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.1 | 1.4 | REACTOME RNA POL I TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 1.4 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |