ISMARA results: mybl2b

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for mybl2b

Z-value: 1.08

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Transcription factors associated with mybl2b

Gene Symbol	Gene ID	Gene Info
mybl2b NCBI UniProt	ENSDARG00000032264	v-myb avian myeloblastosis viral oncogene homolog-like 2b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
mybl2b	dr11_v1_chr11_+_1565806_1565806	-0.84	1.1e-05	Click!

Activity profile of mybl2b motif

Sorted Z-values of mybl2b motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_+_6795531 Show fit	4.17	ENSDART00000092131	si:ch211-117c9.5 NCBI UniProt Show fit	si:ch211-117c9.5
chr21_-_40799404 Show fit	3.53	ENSDART00000147405 ENSDART00000157512	zgc:162239 NCBI UniProt Show fit	zgc:162239
chr12_-_27242498 Show fit	3.48	ENSDART00000152609 ENSDART00000152170	si:dkey-11c5.11 NCBI UniProt Show fit	si:dkey-11c5.11
chr10_-_17083180 Show fit	3.36	ENSDART00000170083	fam166b NCBI UniProt Show fit	family with sequence similarity 166, member B
chr18_+_46382484 Show fit	3.10	ENSDART00000024202 ENSDART00000142790	daw1 NCBI UniProt Show fit	dynein assembly factor with WDR repeat domains 1
chr8_-_51349429 Show fit	3.05	ENSDART00000134043 ENSDART00000098282	si:ch211-198o12.4 NCBI UniProt Show fit	si:ch211-198o12.4
chr23_+_6795709 Show fit	2.86	ENSDART00000149136	si:ch211-117c9.5 NCBI UniProt Show fit	si:ch211-117c9.5
chr12_+_20149305 Show fit	2.75	ENSDART00000126676 ENSDART00000153327	foxj1b NCBI UniProt Show fit	forkhead box J1b
chr3_+_13929860 Show fit	2.64	ENSDART00000164179	syce2 NCBI UniProt Show fit	synaptonemal complex central element protein 2
chr21_-_5799122 Show fit	2.61	ENSDART00000129351 ENSDART00000151202	ccni NCBI UniProt Show fit	cyclin I

Showing 1 to 10 of 177 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of mybl2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	7.0	GO:0035725	sodium ion transmembrane transport(GO:0035725)
0.3	5.0	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.0	4.0	GO:0061640	cytoskeleton-dependent cytokinesis(GO:0061640)
0.2	3.1	GO:0001539	cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.7	2.6	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.1	2.6	GO:0007130	synaptonemal complex assembly(GO:0007130) synaptonemal complex organization(GO:0070193)
0.1	2.6	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.1	2.5	GO:0006383	transcription from RNA polymerase III promoter(GO:0006383)
0.2	2.1	GO:0061718	glucose catabolic process(GO:0006007) NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0	1.9	GO:0043044	ATP-dependent chromatin remodeling(GO:0043044)

Showing 1 to 10 of 61 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.0	GO:0005940	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	3.6	GO:0005882	intermediate filament(GO:0005882)
0.4	2.6	GO:0000801	central element(GO:0000801)
0.1	2.6	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1	2.5	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.2	2.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.2	1.9	GO:0016586	RSC complex(GO:0016586)
0.2	1.5	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	1.5	GO:0016323	basolateral plasma membrane(GO:0016323)
0.1	1.4	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	6.4	GO:0015293	symporter activity(GO:0015293)
0.0	3.4	GO:0019902	phosphatase binding(GO:0019902)
0.0	3.3	GO:0060090	binding, bridging(GO:0060090)
0.0	2.6	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2	2.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	2.0	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	1.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.3	1.8	GO:0019808	polyamine binding(GO:0019808) spermidine binding(GO:0019809)
0.2	1.5	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.1	1.5	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)

Showing 1 to 10 of 39 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	1.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	1.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	1.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	0.8	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.8	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	0.7	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	0.6	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Showing 1 to 9 of 9 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	1.0	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.9	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.1	0.8	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	0.8	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.8	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.1	0.7	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.7	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.7	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.6	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling

Showing 1 to 10 of 11 entries

Results for mybl2b

Z-value: 1.08

Motif logo

Transcription factors associated with mybl2b

Activity-expression correlation:

Activity profile of mybl2b motif

Sorted Z-values of mybl2b motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of mybl2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: