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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for myb+mybl1
Z-value: 1.57
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Transcription factors associated with myb+mybl1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mybl1 | dr11_v1_chr24_+_23791758_23791839 | 0.92 | 9.4e-08 | Click! |
| myb | dr11_v1_chr23_+_31815423_31815492 | 0.69 | 1.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_21672281 Show fit | 3.27 |
ENSDART00000153923
|
si:dkey-40g16.5 |
|
| chr24_-_37568359 Show fit | 3.02 |
ENSDART00000056286
|
H1 histone family, member 0 |
|
| chr15_+_21672700 Show fit | 2.75 |
ENSDART00000187043
|
si:dkey-40g16.5 |
|
| chr16_-_29557338 Show fit | 2.58 |
ENSDART00000058888
|
HORMA domain containing 1 |
|
| chr20_-_53981626 Show fit | 2.52 |
ENSDART00000023550
|
heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 |
|
| chr17_+_10593398 Show fit | 1.99 |
ENSDART00000168897
ENSDART00000193989 ENSDART00000191664 ENSDART00000167188 |
mitogen-activated protein kinase binding protein 1 |
|
| chr11_+_2642013 Show fit | 1.86 |
ENSDART00000111324
|
zgc:193807 |
|
| chr17_-_33716688 Show fit | 1.86 |
ENSDART00000043651
|
dynein, axonemal, light chain 1 |
|
| chr11_-_4286010 Show fit | 1.84 |
ENSDART00000171558
|
|
|
| chr20_-_13640598 Show fit | 1.80 |
ENSDART00000128823
ENSDART00000103394 |
radial spoke 3 homolog |
Network of associatons between targets according to the STRING database.
First level regulatory network of myb+mybl1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0060631 | regulation of meiosis I(GO:0060631) |
| 0.0 | 2.4 | GO:0032869 | cellular response to insulin stimulus(GO:0032869) |
| 0.5 | 2.3 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 2.2 | GO:0060079 | excitatory postsynaptic potential(GO:0060079) |
| 0.1 | 2.0 | GO:0060287 | epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.0 | 2.0 | GO:0032922 | circadian regulation of gene expression(GO:0032922) |
| 0.1 | 1.9 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 1.8 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.2 | 1.7 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.0 | 1.7 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.2 | GO:0030286 | dynein complex(GO:0030286) |
| 0.1 | 2.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 2.2 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 1.8 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 1.6 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 1.5 | GO:0044545 | NSL complex(GO:0044545) |
| 0.0 | 1.5 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 1.4 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 1.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.2 | 1.3 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.0 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 2.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 2.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.2 | 1.9 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.1 | 1.8 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 1.8 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 1.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 1.6 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.0 | 1.5 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.2 | 1.4 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 1.3 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.2 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.1 | PID IL2 PI3K PATHWAY | IL2 signaling events mediated by PI3K |
| 0.0 | 1.1 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.0 | 1.0 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.9 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.9 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.0 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 1.8 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.6 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.2 | 1.5 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 1.2 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.1 | 1.1 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |
| 0.0 | 1.1 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 1.1 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 1.0 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 1.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |