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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for meis3

Z-value: 0.39

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Transcription factors associated with meis3

Gene Symbol Gene ID Gene Info
meis3
ENSDARG00000002795 myeloid ecotropic viral integration site 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
meis3dr11_v1_chr15_-_6863317_68633170.962.5e-10Click!

Activity profile of meis3 motif

Sorted Z-values of meis3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_25569903 1.56 ENSDART00000062375
si:dkey-48j7.3
si:dkey-48j7.3
chr6_+_48041759 1.53 ENSDART00000140086
si:dkey-92f12.2
si:dkey-92f12.2
chr10_+_26667475 1.20 ENSDART00000133281
ENSDART00000147013
si:ch73-52f15.5
si:ch73-52f15.5
chr20_-_22798794 1.09 ENSDART00000148084
fip1l1a
FIP1 like 1a (S. cerevisiae)
chr23_+_23658474 1.02 ENSDART00000162838
agrn
agrin
chr15_-_34056733 1.01 ENSDART00000170130
ENSDART00000188272
VWDE
si:dkey-30e9.7
chr2_-_44183613 0.98 ENSDART00000079596
cadm3
cell adhesion molecule 3
chr18_+_36769758 0.95 ENSDART00000180375
ENSDART00000136463
ENSDART00000133487
ENSDART00000130206
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr2_-_44183451 0.90 ENSDART00000111246
cadm3
cell adhesion molecule 3
chr3_+_26734162 0.87 ENSDART00000114552
si:dkey-202l16.5
si:dkey-202l16.5
chr25_-_28600433 0.80 ENSDART00000138980
agbl2
ATP/GTP binding protein-like 2
chr25_-_7753207 0.78 ENSDART00000126499
phf21ab
PHD finger protein 21Ab
chr6_+_15762647 0.71 ENSDART00000127133
ENSDART00000128939
iqca1
IQ motif containing with AAA domain 1
chr13_+_22295905 0.65 ENSDART00000180133
ENSDART00000181125
usp54a
ubiquitin specific peptidase 54a
chr8_+_8291492 0.64 ENSDART00000151314
srpk3
SRSF protein kinase 3
chr11_+_12879635 0.64 ENSDART00000182515
ENSDART00000081296
si:dkey-11m19.5
si:dkey-11m19.5
chr24_+_12989727 0.61 ENSDART00000126842
ENSDART00000129309
flj11011l
hypothetical protein FLJ11011-like (H. sapiens)
chr14_-_26436951 0.60 ENSDART00000140173
si:dkeyp-110e4.6
si:dkeyp-110e4.6
chr20_+_51104367 0.60 ENSDART00000073981
eif2s1b
eukaryotic translation initiation factor 2, subunit 1 alpha b
chr7_+_65673885 0.58 ENSDART00000169182
parvab
parvin, alpha b
chr25_+_32525131 0.57 ENSDART00000156145
scaper
S-phase cyclin A-associated protein in the ER
chr18_+_36770166 0.57 ENSDART00000078151
fosb
FBJ murine osteosarcoma viral oncogene homolog B
chr5_+_37091626 0.57 ENSDART00000161054
tagln2
transgelin 2
chr2_+_6127593 0.57 ENSDART00000184007
fzr1b
fizzy/cell division cycle 20 related 1b
chr20_-_23171430 0.53 ENSDART00000109234
spata18
spermatogenesis associated 18
chr21_+_45733871 0.45 ENSDART00000187285
ENSDART00000193018
zgc:77058
zgc:77058
chr23_+_21663631 0.42 ENSDART00000066125
dhrs3a
dehydrogenase/reductase (SDR family) member 3a
chr17_+_35362851 0.39 ENSDART00000137659
cmpk2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
chr20_-_26420939 0.38 ENSDART00000110883
akap12b
A kinase (PRKA) anchor protein 12b
chr3_-_45308394 0.36 ENSDART00000155324
pdpk1a
3-phosphoinositide dependent protein kinase 1a
chr21_+_30194904 0.36 ENSDART00000137023
ENSDART00000078403
BRD8
si:ch211-59d17.3
chr25_-_3192405 0.36 ENSDART00000104835
hps5
Hermansky-Pudlak syndrome 5
chr20_-_26421112 0.35 ENSDART00000183767
ENSDART00000182330
akap12b
A kinase (PRKA) anchor protein 12b
chr8_-_18225968 0.34 ENSDART00000135504
si:ch211-241d21.5
si:ch211-241d21.5
chr8_-_7444390 0.33 ENSDART00000149671
hdac6
histone deacetylase 6
chr12_+_36413886 0.31 ENSDART00000126325
si:ch211-250n8.1
si:ch211-250n8.1
chr24_-_26369185 0.31 ENSDART00000080039
lrrc31
leucine rich repeat containing 31
chr11_-_17981421 0.31 ENSDART00000005999
ENSDART00000104046
twf2b
twinfilin actin-binding protein 2b
chr8_-_7444155 0.30 ENSDART00000148993
hdac6
histone deacetylase 6
chr11_-_41966854 0.28 ENSDART00000055709
her2
hairy-related 2
chr19_+_34742706 0.28 ENSDART00000103276
fam206a
family with sequence similarity 206, member A
chr6_-_30210378 0.27 ENSDART00000157359
ENSDART00000113924
lrrc7
leucine rich repeat containing 7
chr20_-_26467307 0.27 ENSDART00000078072
ENSDART00000158213
akap12b
A kinase (PRKA) anchor protein 12b
chr22_-_34872533 0.27 ENSDART00000167176
slit1b
slit homolog 1b (Drosophila)
chr18_-_7810214 0.26 ENSDART00000139505
ENSDART00000139188
shank3a
SH3 and multiple ankyrin repeat domains 3a
chr5_+_24245682 0.26 ENSDART00000049003
atp6v1aa
ATPase H+ transporting V1 subunit Aa
chr11_-_18799827 0.26 ENSDART00000185438
ENSDART00000189116
ENSDART00000180504
pfkfb2b
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2b
chr1_-_44084071 0.26 ENSDART00000166912
vwa11
von Willebrand factor A domain containing 11
chr7_-_67214972 0.25 ENSDART00000156861
swap70a
switching B cell complex subunit SWAP70a
chr10_-_33379850 0.25 ENSDART00000186924
ska2
spindle and kinetochore associated complex subunit 2
chr7_-_26306546 0.25 ENSDART00000140817
zgc:77439
zgc:77439
chr6_-_14146979 0.24 ENSDART00000089564
cacnb4b
calcium channel, voltage-dependent, beta 4b subunit
chr25_-_3139805 0.23 ENSDART00000166625
epx
eosinophil peroxidase
chr21_+_30351256 0.22 ENSDART00000078341
foxi3a
forkhead box I3a
chr6_+_3827751 0.22 ENSDART00000003008
ENSDART00000122348
gad1b
glutamate decarboxylase 1b
chr2_-_32558795 0.20 ENSDART00000140026
smarcd3a
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3a
chr8_-_26609259 0.19 ENSDART00000027301
sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
chr19_-_35596207 0.19 ENSDART00000136811
col8a2
collagen, type VIII, alpha 2
chr2_+_9918935 0.18 ENSDART00000140434
acbd5b
acyl-CoA binding domain containing 5b
chr23_-_764135 0.17 ENSDART00000010248
ENSDART00000183978
mitfb
microphthalmia-associated transcription factor b
chr8_-_19280856 0.16 ENSDART00000100473
zgc:77486
zgc:77486
chr2_+_9918678 0.16 ENSDART00000081253
acbd5b
acyl-CoA binding domain containing 5b
chr18_+_660578 0.15 ENSDART00000161203
CELF6
si:dkey-205h23.2
chr1_-_40911332 0.15 ENSDART00000027463
hmx4
H6 family homeobox 4
chr6_+_9952678 0.14 ENSDART00000019325
cyp20a1
cytochrome P450, family 20, subfamily A, polypeptide 1
chr11_-_20987378 0.14 ENSDART00000110140
taf4a
TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor
chr1_+_34496855 0.14 ENSDART00000012873
klf12a
Kruppel-like factor 12a
chr1_-_10347198 0.13 ENSDART00000109141
ENSDART00000152565
si:ch211-243g6.3
si:ch211-243g6.3
chr16_-_41762983 0.13 ENSDART00000192936
si:dkey-199f5.8
si:dkey-199f5.8
chr5_-_46980651 0.13 ENSDART00000181022
ENSDART00000168038
edil3a
EGF-like repeats and discoidin I-like domains 3a
chr5_+_36752943 0.13 ENSDART00000017138
exoc3l2a
exocyst complex component 3-like 2a
chr16_-_26537103 0.12 ENSDART00000134908
ENSDART00000008152
sgk2b
serum/glucocorticoid regulated kinase 2b
chr23_-_15216654 0.11 ENSDART00000131649
sulf2b
sulfatase 2b
chr3_+_22443313 0.10 ENSDART00000156450
wnk4b
WNK lysine deficient protein kinase 4b
chr10_+_406146 0.10 ENSDART00000145124
dact3a
dishevelled-binding antagonist of beta-catenin 3a
chr8_-_11229523 0.09 ENSDART00000002164
unc45b
unc-45 myosin chaperone B
chr20_+_32406011 0.09 ENSDART00000018640
ENSDART00000137910
snx3
sorting nexin 3
chr16_-_1502699 0.08 ENSDART00000187189
sim1a
single-minded family bHLH transcription factor 1a
chr13_+_30169681 0.07 ENSDART00000138326
pald1b
phosphatase domain containing, paladin 1b
chr15_-_23442891 0.07 ENSDART00000059376
ube4a
ubiquitination factor E4A (UFD2 homolog, yeast)
chr1_-_26026956 0.07 ENSDART00000102346
si:ch211-145b13.6
si:ch211-145b13.6
chr7_+_6879534 0.07 ENSDART00000157731
zgc:175248
zgc:175248
chr24_-_30091937 0.06 ENSDART00000148249
plppr4b
phospholipid phosphatase related 4b
chr15_-_23443588 0.05 ENSDART00000170427
ube4a
ubiquitination factor E4A (UFD2 homolog, yeast)
chr17_-_30839338 0.05 ENSDART00000139707
gdf7
growth differentiation factor 7
chr22_+_30335936 0.05 ENSDART00000059923
mxi1
max interactor 1, dimerization protein
chr16_+_24971717 0.05 ENSDART00000156958
fpr1
formyl peptide receptor 1
chr10_-_39011514 0.05 ENSDART00000075123
pcp4a
Purkinje cell protein 4a
chr17_-_43552894 0.05 ENSDART00000181226
ENSDART00000188125
nt5c1ab
5'-nucleotidase, cytosolic IAb
chr4_+_20812900 0.04 ENSDART00000005847
nav3
neuron navigator 3
chr12_-_45876387 0.04 ENSDART00000043210
ENSDART00000149044
pax2b
paired box 2b
chr2_+_47623202 0.04 ENSDART00000154465
si:ch211-165b10.3
si:ch211-165b10.3
chr19_+_24872159 0.04 ENSDART00000158490
si:ch211-195b13.1
si:ch211-195b13.1
chr22_-_5006119 0.04 ENSDART00000187998
rx1
retinal homeobox gene 1
chr8_-_8698607 0.03 ENSDART00000046712
zgc:86609
zgc:86609
chr8_-_25569920 0.03 ENSDART00000136869
prex1
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
chr17_+_7595356 0.03 ENSDART00000130625
si:dkeyp-110a12.4
si:dkeyp-110a12.4
chr14_-_9355177 0.03 ENSDART00000138535
fam46d
family with sequence similarity 46, member D
chr11_-_38513978 0.03 ENSDART00000123381
si:ch211-117k10.3
si:ch211-117k10.3
chr17_-_5583345 0.02 ENSDART00000035944
clic5a
chloride intracellular channel 5a
chr5_-_34964830 0.02 ENSDART00000133170
arhgef28
Rho guanine nucleotide exchange factor (GEF) 28
chr13_+_45524475 0.02 ENSDART00000074567
ENSDART00000019113
maco1b
macoilin 1b
chr2_+_45081489 0.02 ENSDART00000123966
chrng
cholinergic receptor, nicotinic, gamma
chr5_+_23118470 0.02 ENSDART00000149893
nexmifa
neurite extension and migration factor a
chr5_+_38913621 0.01 ENSDART00000137112
fras1
Fraser extracellular matrix complex subunit 1
chr20_-_26001288 0.01 ENSDART00000136518
ENSDART00000063177
capn3b
calpain 3b
chr19_+_42693855 0.01 ENSDART00000136873
clasp2
cytoplasmic linker associated protein 2
chr3_+_58656312 0.01 ENSDART00000148094
FP016018.1

chr12_+_47122104 0.00 ENSDART00000184248
CABZ01088982.1

chr25_-_10610961 0.00 ENSDART00000153474
ppp6r3
protein phosphatase 6, regulatory subunit 3
chr9_-_25181137 0.00 ENSDART00000192624
esd
esterase D/formylglutathione hydrolase
chr19_-_30565122 0.00 ENSDART00000185650
hpcal4
hippocalcin like 4

Network of associatons between targets according to the STRING database.

First level regulatory network of meis3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1902571 regulation of serine-type peptidase activity(GO:1902571)
0.3 1.0 GO:1904969 bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.2 0.8 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.1 0.4 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.1 1.1 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1 0.6 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.1 0.2 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 0.3 GO:0010591 regulation of lamellipodium assembly(GO:0010591)
0.1 0.2 GO:0009957 epidermal cell fate specification(GO:0009957)
0.1 0.4 GO:0048069 eye pigmentation(GO:0048069)
0.0 0.3 GO:0007405 neuroblast proliferation(GO:0007405)
0.0 1.5 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.3 GO:2000463 postsynaptic density assembly(GO:0097107) modulation of excitatory postsynaptic potential(GO:0098815) positive regulation of excitatory postsynaptic potential(GO:2000463)
0.0 0.8 GO:0060324 face development(GO:0060324)
0.0 0.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0072020 proximal straight tubule development(GO:0072020)
0.0 0.2 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.0 0.1 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.0 0.3 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.3 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:0019747 retinoic acid biosynthetic process(GO:0002138) regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 0.6 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.6 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 0.5 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0043614 multi-eIF complex(GO:0043614)
0.1 0.6 GO:0036156 inner dynein arm(GO:0036156)
0.1 1.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.1 1.1 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0031082 BLOC complex(GO:0031082)
0.0 0.2 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0005811 lipid particle(GO:0005811)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0047611 tubulin deacetylase activity(GO:0042903) acetylspermidine deacetylase activity(GO:0047611)
0.1 0.4 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 1.5 GO:0043495 protein anchor(GO:0043495)
0.1 0.6 GO:1990757 anaphase-promoting complex binding(GO:0010997) ubiquitin ligase activator activity(GO:1990757)
0.1 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 0.4 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 1.0 GO:0043236 laminin binding(GO:0043236)
0.0 0.3 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 1.0 GO:0051018 protein kinase A binding(GO:0051018)
0.0 0.8 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.6 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.3 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.0 0.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.6 GO:0043022 ribosome binding(GO:0043022)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.6 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription