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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for mecp2
Z-value: 1.21
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Transcription factors associated with mecp2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mecp2 | dr11_v1_chr8_-_7637626_7637640 | 0.18 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_68789 Show fit | 3.53 |
ENSDART00000058569
|
claudin 1 |
|
| chr1_-_55248496 Show fit | 2.90 |
ENSDART00000098615
|
nanos homolog 3 |
|
| chr2_-_38287987 Show fit | 2.82 |
ENSDART00000185329
ENSDART00000061677 |
si:ch211-14a17.6 |
|
| chr4_-_77561679 Show fit | 2.72 |
ENSDART00000180809
|
|
|
| chr4_-_12930086 Show fit | 2.62 |
ENSDART00000013604
|
LEM domain containing 3 |
|
| chr18_+_18000695 Show fit | 2.59 |
ENSDART00000146898
|
si:ch211-212o1.2 |
|
| chr19_-_27830818 Show fit | 2.54 |
ENSDART00000131767
|
PAP associated domain containing 7 |
|
| chr4_-_77557279 Show fit | 2.54 |
ENSDART00000180113
|
|
|
| chr12_-_13730501 Show fit | 2.51 |
ENSDART00000152370
|
forkhead box H1 |
|
| chr19_+_14454306 Show fit | 2.46 |
ENSDART00000161965
|
zinc finger, DHHC-type containing 18b |
Network of associatons between targets according to the STRING database.
First level regulatory network of mecp2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.8 | GO:0006457 | protein folding(GO:0006457) |
| 0.3 | 4.3 | GO:0007339 | binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344) |
| 0.2 | 4.1 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.1 | 3.5 | GO:0070830 | apical junction assembly(GO:0043297) bicellular tight junction assembly(GO:0070830) |
| 0.1 | 3.5 | GO:0000086 | G2/M transition of mitotic cell cycle(GO:0000086) |
| 0.1 | 3.2 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 3.0 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 0.7 | 2.9 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.1 | 2.7 | GO:0043113 | receptor clustering(GO:0043113) |
| 0.2 | 2.6 | GO:0061300 | cerebellum vasculature development(GO:0061300) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 4.5 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 4.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 3.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 3.5 | GO:0005923 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.1 | 3.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.1 | 3.1 | GO:0043186 | P granule(GO:0043186) |
| 0.0 | 3.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 2.6 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.0 | 2.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.3 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.3 | 4.1 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.1 | 3.3 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 3.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 3.0 | GO:0042393 | histone binding(GO:0042393) |
| 0.3 | 2.9 | GO:0017091 | AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 2.3 | GO:0015379 | cation:chloride symporter activity(GO:0015377) potassium:chloride symporter activity(GO:0015379) |
| 0.6 | 2.2 | GO:0004534 | 5'-3' exoribonuclease activity(GO:0004534) |
| 0.2 | 2.2 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 2.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 3.5 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.2 | 2.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 1.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 1.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.0 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 1.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.0 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 0.8 | ST G ALPHA S PATHWAY | G alpha s Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.5 | 4.1 | REACTOME ARMS MEDIATED ACTIVATION | Genes involved in ARMS-mediated activation |
| 0.1 | 2.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.2 | 2.7 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 2.6 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.3 | 2.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 2.2 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 2.0 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 0.0 | 1.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.1 | 1.7 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |