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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for mbd2

Z-value: 0.43

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Transcription factors associated with mbd2

Gene Symbol Gene ID Gene Info
mbd2
ENSDARG00000075952 methyl-CpG binding domain protein 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
mbd2dr11_v1_chr5_-_1047222_1047222-0.351.6e-01Click!

Activity profile of mbd2 motif

Sorted Z-values of mbd2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_127558 1.06 ENSDART00000149556
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr19_-_42045372 0.88 ENSDART00000144275
trioa
trio Rho guanine nucleotide exchange factor a
chr10_+_16225870 0.82 ENSDART00000164647
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr18_-_127873 0.69 ENSDART00000148490
trpm7
transient receptor potential cation channel, subfamily M, member 7
chr19_+_14352332 0.59 ENSDART00000164386
arid1ab
AT rich interactive domain 1Ab (SWI-like)
chr10_+_16036573 0.59 ENSDART00000188757
lmnb1
lamin B1
chr22_-_36829006 0.58 ENSDART00000170256
ENSDART00000086064
map1sa
microtubule-associated protein 1Sa
chr2_-_56635744 0.57 ENSDART00000167790
ENSDART00000168160
pip5k1cb
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b
chr10_+_16036246 0.57 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lmnb1
lamin B1
chr2_-_32738535 0.55 ENSDART00000135293
nrbp2a
nuclear receptor binding protein 2a
chr3_+_16664212 0.53 ENSDART00000013816
zgc:55558
zgc:55558
chr7_-_9556354 0.53 ENSDART00000127974
lrrk1
leucine-rich repeat kinase 1
chr14_+_44860335 0.53 ENSDART00000091620
ENSDART00000173043
ENSDART00000091625
atp8a1
ATPase phospholipid transporting 8A1
chr15_-_41677689 0.52 ENSDART00000187063
spsb4b
splA/ryanodine receptor domain and SOCS box containing 4b
chr8_-_20230802 0.51 ENSDART00000063400
mllt1a
MLLT1, super elongation complex subunit a
chr8_-_20230559 0.50 ENSDART00000193677
mllt1a
MLLT1, super elongation complex subunit a
chr18_+_3579829 0.50 ENSDART00000158763
ENSDART00000182850
ENSDART00000162754
ENSDART00000178789
ENSDART00000172656
lrch3
leucine-rich repeats and calponin homology (CH) domain containing 3
chr23_-_9807546 0.50 ENSDART00000136740
ENSDART00000004474
mapre1b
microtubule-associated protein, RP/EB family, member 1b
chr22_-_506522 0.47 ENSDART00000106645
ENSDART00000067637
dstyk
dual serine/threonine and tyrosine protein kinase
chr8_+_8643901 0.46 ENSDART00000142076
ENSDART00000075624
usp11
ubiquitin specific peptidase 11
chr24_-_35699595 0.44 ENSDART00000167990
mapre2
microtubule-associated protein, RP/EB family, member 2
chr14_+_6962271 0.44 ENSDART00000148447
ENSDART00000149114
ENSDART00000149492
ENSDART00000148394
hnrnpaba
heterogeneous nuclear ribonucleoprotein A/Ba
chr4_-_25796848 0.43 ENSDART00000122881
tmcc3
transmembrane and coiled-coil domain family 3
chr22_-_3564563 0.42 ENSDART00000145114
ptprsa
protein tyrosine phosphatase, receptor type, s, a
chr8_+_23861461 0.40 ENSDART00000037109
srpk1a
SRSF protein kinase 1a
chr24_-_35699444 0.38 ENSDART00000166567
mapre2
microtubule-associated protein, RP/EB family, member 2
chr9_+_2452672 0.36 ENSDART00000193993
chn1
chimerin 1
chr5_+_393738 0.35 ENSDART00000161456
june
JunE proto-oncogene, AP-1 transcription factor subunit
chr12_-_3773869 0.35 ENSDART00000092983
si:ch211-166g5.4
si:ch211-166g5.4
chr14_-_30983011 0.34 ENSDART00000014095
rap2c
RAP2C, member of RAS oncogene family
chr15_+_11693624 0.34 ENSDART00000193630
ENSDART00000161930
strn4
striatin, calmodulin binding protein 4
chr20_+_46699021 0.33 ENSDART00000167398
ENSDART00000029894
wdr26b
WD repeat domain 26b
chr22_+_10606863 0.32 ENSDART00000147975
rad54l2
RAD54 like 2
chr1_+_52792439 0.32 ENSDART00000123972
smarca5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr10_+_16225553 0.31 ENSDART00000129844
slc12a2
solute carrier family 12 (sodium/potassium/chloride transporter), member 2
chr22_-_5099824 0.31 ENSDART00000122341
ENSDART00000161345
zfr2
zinc finger RNA binding protein 2
chr20_+_34502606 0.30 ENSDART00000139739
gorab
golgin, rab6-interacting
chr3_-_5228137 0.30 ENSDART00000137105
myh9b
myosin, heavy chain 9b, non-muscle
chr22_+_10606573 0.30 ENSDART00000192638
rad54l2
RAD54 like 2
chr18_-_44847855 0.29 ENSDART00000086823
srpr
signal recognition particle receptor (docking protein)
chr18_+_18879733 0.28 ENSDART00000019581
arih1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)
chr12_+_5708400 0.28 ENSDART00000017191
dlx3b
distal-less homeobox 3b
chr20_+_40457599 0.27 ENSDART00000017553
serinc1
serine incorporator 1
chr4_+_279669 0.27 ENSDART00000184884
CABZ01085275.1

chr1_-_69444 0.27 ENSDART00000166954
si:zfos-1011f11.1
si:zfos-1011f11.1
chr6_-_21726758 0.26 ENSDART00000083085
mtmr14
myotubularin related protein 14
chr20_-_44055095 0.25 ENSDART00000125898
ENSDART00000082265
runx2b
runt-related transcription factor 2b
chr13_-_51922290 0.24 ENSDART00000168648
srfb
serum response factor b
chr23_-_17450746 0.23 ENSDART00000145399
ENSDART00000136457
ENSDART00000133125
ENSDART00000145719
ENSDART00000147524
ENSDART00000005366
ENSDART00000104680
tpd52l2b
tumor protein D52-like 2b
chr16_+_38940758 0.23 ENSDART00000102482
ENSDART00000136215
eny2
enhancer of yellow 2 homolog (Drosophila)
chr20_+_18943406 0.23 ENSDART00000193590
mtmr9
myotubularin related protein 9
chr25_+_20272145 0.23 ENSDART00000109605
si:dkey-219c3.2
si:dkey-219c3.2
chr2_+_50062165 0.22 ENSDART00000097939
ENSDART00000138214
zcchc2
zinc finger, CCHC domain containing 2
chr17_-_10738001 0.21 ENSDART00000051526
jmjd7
jumonji domain containing 7
chr22_-_12862415 0.21 ENSDART00000145156
ENSDART00000137280
glsa
glutaminase a
chr10_+_6013076 0.21 ENSDART00000167613
ENSDART00000159216
hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr2_+_56139941 0.20 ENSDART00000164741
pgpep1
pyroglutamyl-peptidase I
chr21_-_45685063 0.20 ENSDART00000162422
sar1b
secretion associated, Ras related GTPase 1B
chr13_+_51710725 0.20 ENSDART00000163741
pwwp2b
PWWP domain containing 2B
chr10_-_28193642 0.18 ENSDART00000019050
rps6kb1a
ribosomal protein S6 kinase b, polypeptide 1a
chr16_+_27564270 0.18 ENSDART00000140460
tmem67
transmembrane protein 67
chr13_-_45155284 0.18 ENSDART00000161144
runx3
runt-related transcription factor 3
chr23_-_7052362 0.17 ENSDART00000127702
ENSDART00000192468
prpf6
PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)
chr9_+_711822 0.17 ENSDART00000136627
ybey
ybeY metallopeptidase
chr13_-_27620815 0.17 ENSDART00000139904
kcnq5a
potassium voltage-gated channel, KQT-like subfamily, member 5a
chr9_+_711638 0.16 ENSDART00000191964
ybey
ybeY metallopeptidase
chr12_-_287633 0.16 ENSDART00000113335
map2k4b
mitogen-activated protein kinase kinase 4b
chr7_-_7797654 0.15 ENSDART00000084503
ENSDART00000192779
ENSDART00000173079
trmt10b
tRNA methyltransferase 10B
chr5_-_23485161 0.15 ENSDART00000170293
ENSDART00000134069
si:dkeyp-20g2.1
si:dkeyp-20g2.3
si:dkeyp-20g2.1
si:dkeyp-20g2.3
chr17_-_8673278 0.14 ENSDART00000171850
ENSDART00000017337
ENSDART00000148504
ENSDART00000148808
ctbp2a
C-terminal binding protein 2a
chr8_-_41519234 0.14 ENSDART00000167283
ENSDART00000180666
golga1
golgin A1
chr13_+_4888351 0.13 ENSDART00000145940
micu1
mitochondrial calcium uptake 1
chr17_+_10738126 0.13 ENSDART00000051527
tbpl2
TATA box binding protein like 2
chr19_-_45534392 0.13 ENSDART00000163920
trps1
trichorhinophalangeal syndrome I
chr6_-_31336317 0.11 ENSDART00000193927
dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6
chr13_-_44782462 0.11 ENSDART00000141298
ENSDART00000099990
btbd9
BTB (POZ) domain containing 9
chr14_-_45967712 0.11 ENSDART00000043751
ENSDART00000141357
macrod1
MACRO domain containing 1
chr9_-_21936841 0.09 ENSDART00000144843
lmo7a
LIM domain 7a
chr17_-_26604549 0.09 ENSDART00000174773
fam149b1
family with sequence similarity 149, member B1
chr16_-_27161410 0.09 ENSDART00000177503
LO017771.1

chr15_-_3078600 0.08 ENSDART00000172842
fndc3a
fibronectin type III domain containing 3A
chr25_+_34407740 0.07 ENSDART00000012677
OTUD7A
si:dkey-37f18.2
chr15_+_30158652 0.07 ENSDART00000190682
nlk2
nemo-like kinase, type 2
chr22_-_2929127 0.07 ENSDART00000123730
ENSDART00000046678
pak2b
p21 protein (Cdc42/Rac)-activated kinase 2b
chr19_-_18313303 0.07 ENSDART00000164644
ENSDART00000167480
ENSDART00000163104
si:dkey-208k4.2
si:dkey-208k4.2
chr25_+_34407529 0.07 ENSDART00000156751
OTUD7A
si:dkey-37f18.2
chr22_+_1853999 0.07 ENSDART00000163288
znf1174
zinc finger protein 1174
chr7_-_35314347 0.07 ENSDART00000005053
slc12a4
solute carrier family 12 (potassium/chloride transporter), member 4
chr4_+_68562464 0.06 ENSDART00000192954
BX548011.4

chr17_+_6382275 0.06 ENSDART00000056324
CR628323.2

chr1_-_22803147 0.06 ENSDART00000086867
tapt1b
transmembrane anterior posterior transformation 1b
chr23_+_39331216 0.05 ENSDART00000160957
kcng1
potassium voltage-gated channel, subfamily G, member 1
chr4_-_77557279 0.04 ENSDART00000180113
AL935186.10

chr7_+_53755054 0.04 ENSDART00000181629
neo1a
neogenin 1a
chr7_+_53754653 0.04 ENSDART00000163261
ENSDART00000158160
neo1a
neogenin 1a
chr14_+_94603 0.04 ENSDART00000162480
mcm7
minichromosome maintenance complex component 7
chr19_+_56351 0.04 ENSDART00000168334
col14a1b
collagen, type XIV, alpha 1b
chr21_-_12272543 0.03 ENSDART00000081510
ENSDART00000151297
celf4
CUGBP, Elav-like family member 4
chr2_+_35854242 0.03 ENSDART00000134918
dhx9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr9_+_24159725 0.03 ENSDART00000137756
hecw2a
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
chr6_-_1874664 0.02 ENSDART00000007972
dlgap4b
discs, large (Drosophila) homolog-associated protein 4b
chr13_-_133520 0.02 ENSDART00000180874
FO904997.1

chr6_+_49771626 0.02 ENSDART00000134207
ctsz
cathepsin Z
chr14_+_743346 0.02 ENSDART00000110511
klb
klotho beta
chr18_-_46763170 0.02 ENSDART00000171880
dner
delta/notch-like EGF repeat containing
chr19_+_770300 0.02 ENSDART00000062518
gstr
glutathione S-transferase rho
chr6_-_19664848 0.02 ENSDART00000159749
usp43a
ubiquitin specific peptidase 43a
chr17_-_50010121 0.02 ENSDART00000122747
tmem30aa
transmembrane protein 30Aa
chr6_-_19665114 0.01 ENSDART00000168985
usp43a
ubiquitin specific peptidase 43a
chr5_-_8817458 0.01 ENSDART00000191098
fgf10b
fibroblast growth factor 10b
chr11_-_27738489 0.01 ENSDART00000181612
fam120a
family with sequence similarity 120A
chr22_+_35275206 0.01 ENSDART00000112234
rubcn
RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
chr3_-_17716322 0.01 ENSDART00000192664
CABZ01018956.1

chr17_-_52636937 0.01 ENSDART00000084268
fam98b
family with sequence similarity 98, member B
chr13_-_40120252 0.01 ENSDART00000157852
crtac1b
cartilage acidic protein 1b
chr20_+_812012 0.00 ENSDART00000179299
ENSDART00000137135
mei4
meiosis-specific, MEI4 homolog (S. cerevisiae)

Network of associatons between targets according to the STRING database.

First level regulatory network of mbd2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 1.3 GO:0035372 protein localization to microtubule(GO:0035372) protein localization to microtubule plus-end(GO:1904825)
0.1 0.3 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.1 0.4 GO:0021557 oculomotor nerve development(GO:0021557)
0.1 1.1 GO:0048796 swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 0.2 GO:1902767 farnesyl diphosphate biosynthetic process, mevalonate pathway(GO:0010142) isoprenoid biosynthetic process via mevalonate(GO:1902767)
0.1 0.2 GO:0030299 intestinal cholesterol absorption(GO:0030299)
0.1 0.5 GO:0060036 notochord cell vacuolation(GO:0060036)
0.1 0.3 GO:0070650 actin filament bundle distribution(GO:0070650)
0.0 0.3 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 0.1 GO:0008344 adult locomotory behavior(GO:0008344)
0.0 0.2 GO:0090646 mitochondrial tRNA processing(GO:0090646)
0.0 0.4 GO:0099560 synaptic membrane adhesion(GO:0099560)
0.0 0.3 GO:0046716 muscle cell cellular homeostasis(GO:0046716)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.2 GO:0006543 glutamate biosynthetic process(GO:0006537) glutamine catabolic process(GO:0006543)
0.0 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.6 GO:0031114 regulation of microtubule depolymerization(GO:0031114)
0.0 0.1 GO:0070073 clustering of voltage-gated calcium channels(GO:0070073)
0.0 0.1 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0035060 brahma complex(GO:0035060)
0.1 0.3 GO:0016589 NURF complex(GO:0016589)
0.1 1.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0070390 transcription export complex 2(GO:0070390)
0.0 0.3 GO:0016234 inclusion body(GO:0016234) Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 1.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 1.2 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.1 1.7 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.1 0.2 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.1 0.2 GO:0016920 pyroglutamyl-peptidase activity(GO:0016920)
0.1 0.3 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 0.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.2 GO:0052905 tRNA (guanine(9)-N(1))-methyltransferase activity(GO:0052905)
0.0 1.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.4 GO:0016251 obsolete general RNA polymerase II transcription factor activity(GO:0016251)
0.0 0.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.5 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.6 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.5 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.2 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis