ISMARA results: maza+mazb

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for maza+mazb

Z-value: 1.18

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Transcription factors associated with maza+mazb

Gene Symbol	Gene ID	Gene Info
mazb NCBI UniProt	ENSDARG00000063555	si_ch211-166g5.4
maza NCBI UniProt	ENSDARG00000087330	MYC-associated zinc finger protein a (purine-binding transcription factor)

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
maza	dr11_v1_chr3_-_21118969_21118969	-0.98	4.9e-13	Click!
si:ch211-166g5.4	dr11_v1_chr12_-_3778848_3778848	0.48	4.2e-02	Click!

Activity profile of maza+mazb motif

Sorted Z-values of maza+mazb motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_44183613 Show fit	7.00	ENSDART00000079596	cadm3 NCBI UniProt Show fit	cell adhesion molecule 3
chr2_-_44183451 Show fit	6.45	ENSDART00000111246	cadm3 NCBI UniProt Show fit	cell adhesion molecule 3
chr24_+_31361407 Show fit	4.11	ENSDART00000162668	cremb NCBI UniProt Show fit	cAMP responsive element modulator b
chr10_-_641609 Show fit	3.61	ENSDART00000041236	rfx3 NCBI UniProt Show fit	regulatory factor X, 3 (influences HLA class II expression)
chr20_-_7080427 Show fit	2.63	ENSDART00000140166 ENSDART00000023677	si:ch211-121a2.2 NCBI UniProt Show fit	si:ch211-121a2.2
chr3_+_32425202 Show fit	2.57	ENSDART00000156464	prr12b NCBI UniProt Show fit	proline rich 12b
chr6_+_59029485 Show fit	1.90	ENSDART00000050140	CABZ01088367.1 NCBI UniProt Show fit
chr17_-_4395373 Show fit	1.90	ENSDART00000015923	klhl10a NCBI UniProt Show fit	kelch-like family member 10a
chr25_+_1732838 Show fit	1.87	ENSDART00000159555 ENSDART00000168161	FBLN1 NCBI UniProt Show fit	fibulin 1
chr21_+_13577227 Show fit	1.83	ENSDART00000146283	si:dkey-248f6.3 NCBI UniProt Show fit	si:dkey-248f6.3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of maza+mazb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	8.7	GO:0046777	protein autophosphorylation(GO:0046777)
0.3	3.6	GO:0001539	cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0	3.5	GO:0006470	protein dephosphorylation(GO:0006470)
0.1	2.9	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.2	2.8	GO:1903286	positive regulation of sodium ion transport(GO:0010765) positive regulation of sodium ion transmembrane transport(GO:1902307) regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.1	2.6	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	2.1	GO:0045732	positive regulation of protein catabolic process(GO:0045732)
0.1	1.8	GO:0021884	forebrain neuron development(GO:0021884)
0.6	1.7	GO:0032060	bleb assembly(GO:0032060) slow muscle cell migration(GO:1904969)
0.3	1.7	GO:0031649	heat generation(GO:0031649) regulation of heat generation(GO:0031650) positive regulation of heat generation(GO:0031652) regulation of phospholipid biosynthetic process(GO:0071071) negative regulation of phospholipid biosynthetic process(GO:0071072)

Showing 1 to 10 of 138 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	5.7	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
0.0	2.6	GO:0005882	intermediate filament(GO:0005882)
0.0	1.6	GO:0005871	kinesin complex(GO:0005871)
0.1	1.4	GO:0000795	synaptonemal complex(GO:0000795)
0.1	1.3	GO:0044295	axonal growth cone(GO:0044295)
0.0	1.3	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.1	1.2	GO:0031209	SCAR complex(GO:0031209)
0.1	1.2	GO:0098844	postsynaptic endocytic zone membrane(GO:0098844)
0.0	1.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.1	1.1	GO:0005964	phosphorylase kinase complex(GO:0005964)

Showing 1 to 10 of 44 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.3	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2	2.8	GO:0019870	chloride channel inhibitor activity(GO:0019869) potassium channel inhibitor activity(GO:0019870)
0.0	2.2	GO:0015179	L-amino acid transmembrane transporter activity(GO:0015179)
0.1	1.9	GO:0051018	protein kinase A binding(GO:0051018)
0.3	1.7	GO:1903924	estradiol binding(GO:1903924)
0.2	1.7	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2	1.6	GO:0070700	BMP receptor binding(GO:0070700)
0.0	1.6	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	1.6	GO:0005518	collagen binding(GO:0005518)
0.0	1.6	GO:0005212	structural constituent of eye lens(GO:0005212)

Showing 1 to 10 of 96 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	2.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	2.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	1.0	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.4	PID FGF PATHWAY	FGF signaling pathway
0.0	0.3	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0	0.3	PID RAS PATHWAY	Regulation of Ras family activation
0.1	0.2	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Showing 1 to 10 of 13 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.8	REACTOME SIGNALING BY ERBB4	Genes involved in Signaling by ERBB4
0.1	1.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	1.4	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0	1.4	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.1	1.3	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	1.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	1.0	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0	0.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.6	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.6	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 25 entries

Results for maza+mazb

Z-value: 1.18

Motif logo

Transcription factors associated with maza+mazb

Activity-expression correlation:

Activity profile of maza+mazb motif

Sorted Z-values of maza+mazb motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of maza+mazb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: