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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for mafk
Z-value: 1.28
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Transcription factors associated with mafk
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mafk | dr11_v1_chr3_-_42981739_42981739 | -0.53 | 2.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_30960470 Show fit | 4.61 |
ENSDART00000129989
|
si:ch211-191o15.6 |
|
| chr18_+_7611298 Show fit | 4.04 |
ENSDART00000062156
|
outer dense fiber of sperm tails 3B |
|
| chr5_+_66355153 Show fit | 3.94 |
ENSDART00000082745
|
si:ch211-261c8.5 |
|
| chr18_+_7456597 Show fit | 3.90 |
ENSDART00000142270
|
telomere repeat binding bouquet formation protein 1 |
|
| chr24_+_24923166 Show fit | 3.76 |
ENSDART00000065288
|
phosphate cytidylyltransferase 1, choline, beta a |
|
| chr13_+_2908764 Show fit | 3.13 |
ENSDART00000162362
|
wu:fj16a03 |
|
| chr3_-_26017592 Show fit | 3.00 |
ENSDART00000030890
|
heme oxygenase 1a |
|
| chr11_+_26609110 Show fit | 2.90 |
ENSDART00000042322
|
microtubule-associated protein 1 light chain 3 alpha |
|
| chr6_+_48348415 Show fit | 2.85 |
ENSDART00000064826
|
Mov10 RISC complex RNA helicase a |
|
| chr12_+_1455147 Show fit | 2.80 |
ENSDART00000018752
|
COP9 signalosome subunit 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of mafk
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.6 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.7 | 10.2 | GO:0043248 | proteasome assembly(GO:0043248) |
| 1.8 | 5.5 | GO:0007585 | respiratory gaseous exchange(GO:0007585) regulation of respiratory gaseous exchange(GO:0043576) |
| 0.0 | 4.9 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 1.3 | 3.9 | GO:0045141 | telomere localization(GO:0034397) telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic telomere clustering(GO:0045141) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220) chromosome attachment to the nuclear envelope(GO:0097240) |
| 0.0 | 3.5 | GO:0007596 | blood coagulation(GO:0007596) |
| 0.2 | 2.9 | GO:0006995 | cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562) |
| 0.1 | 2.9 | GO:0035194 | posttranscriptional gene silencing(GO:0016441) posttranscriptional gene silencing by RNA(GO:0035194) |
| 0.3 | 2.6 | GO:0071379 | cellular response to prostaglandin stimulus(GO:0071379) |
| 0.1 | 2.4 | GO:0036376 | cellular potassium ion homeostasis(GO:0030007) sodium ion export from cell(GO:0036376) sodium ion export(GO:0071436) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 5.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.4 | 4.4 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.3 | 4.4 | GO:0070187 | telosome(GO:0070187) |
| 0.0 | 3.5 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 3.2 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.1 | 2.9 | GO:0043186 | P granule(GO:0043186) |
| 0.1 | 2.9 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.3 | 2.8 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.4 | 2.6 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 2.0 | GO:0005882 | intermediate filament(GO:0005882) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.5 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.0 | 5.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 5.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.4 | 4.6 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.1 | 3.7 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 3.3 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.6 | 3.0 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 1.0 | 2.9 | GO:0032574 | 5'-3' RNA helicase activity(GO:0032574) |
| 0.5 | 2.8 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.4 | 2.8 | GO:0001130 | bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding(GO:0001130) bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding(GO:0001217) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 2.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 1.9 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 1.8 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 1.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 1.5 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 1.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 0.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.5 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 0.3 | ST JAK STAT PATHWAY | Jak-STAT Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.2 | 2.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.2 | 1.9 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 1.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 1.4 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |
| 0.0 | 1.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.1 | 1.3 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 1.2 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.0 | 1.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 1.1 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |