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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for mafb+mafba+nrl
Z-value: 0.85
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Transcription factors associated with mafb+mafba+nrl
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSDARG00000017121 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ba | |
| ENSDARG00000076520 | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog b (paralog b) | |
| ENSDARG00000100466 | neural retina leucine zipper |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| mafb | dr11_v1_chr25_+_36674715_36674715 | 0.63 | 4.9e-03 | Click! |
| nrl | dr11_v1_chr20_+_661037_661037 | -0.27 | 2.8e-01 | Click! |
| mafba | dr11_v1_chr23_-_3408777_3408777 | -0.10 | 7.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr25_-_4482449 Show fit | 1.72 |
ENSDART00000056278
ENSDART00000149425 |
solute carrier family 25 member 22a |
|
| chr24_+_13277573 Show fit | 1.60 |
ENSDART00000137886
|
si:ch211-171b20.3 |
|
| chr5_-_71722257 Show fit | 1.42 |
ENSDART00000013404
|
adenylate kinase 1 |
|
| chr16_-_54465271 Show fit | 1.16 |
ENSDART00000185978
|
cytochrome P450, family 11, subfamily C, polypeptide 1 |
|
| chr5_+_62723233 Show fit | 1.08 |
ENSDART00000183718
|
nanos homolog 2 |
|
| chr14_-_24397718 Show fit | 1.04 |
ENSDART00000110164
|
si:ch211-163m17.4 |
|
| chr19_+_233143 Show fit | 1.01 |
ENSDART00000175273
|
synaptic Ras GTPase activating protein 1a |
|
| chr13_+_50375800 Show fit | 1.01 |
ENSDART00000099537
|
cytochrome c oxidase subunit Vb 2 |
|
| chr25_-_19584735 Show fit | 0.91 |
ENSDART00000137930
|
synaptonemal complex protein 3 |
|
| chr1_-_59287410 Show fit | 0.90 |
ENSDART00000158011
ENSDART00000170580 |
collagen, type V, alpha 3b |
Network of associatons between targets according to the STRING database.
First level regulatory network of mafb+mafba+nrl
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.7 | GO:0043490 | acidic amino acid transport(GO:0015800) aspartate transport(GO:0015810) L-glutamate transport(GO:0015813) malate-aspartate shuttle(GO:0043490) |
| 0.2 | 1.4 | GO:0006172 | ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) |
| 0.2 | 1.2 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.1 | 1.1 | GO:0034122 | negative regulation of toll-like receptor signaling pathway(GO:0034122) |
| 0.0 | 1.0 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.2 | 0.9 | GO:0010873 | regulation of cholesterol esterification(GO:0010872) positive regulation of cholesterol esterification(GO:0010873) |
| 0.1 | 0.9 | GO:0034755 | iron ion transmembrane transport(GO:0034755) |
| 0.1 | 0.9 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.9 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.1 | 0.8 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.2 | GO:0031514 | motile cilium(GO:0031514) |
| 0.2 | 1.1 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 1.1 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 1.0 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.9 | GO:0000795 | synaptonemal complex(GO:0000795) |
| 0.0 | 0.9 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 0.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.8 | GO:0030496 | midbody(GO:0030496) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.4 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 1.2 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.0 | 1.1 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 1.0 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.2 | 0.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.2 | 0.9 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.0 | 0.9 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 0.7 | GO:0031720 | haptoglobin binding(GO:0031720) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.0 | 0.8 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 0.7 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 0.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.6 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.4 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.0 | 0.4 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.2 | 1.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.0 | 1.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 0.8 | REACTOME CD28 DEPENDENT VAV1 PATHWAY | Genes involved in CD28 dependent Vav1 pathway |
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.7 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 0.6 | REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.0 | 0.6 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 0.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |