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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for lhx8a+lhx8b

Z-value: 0.66

Motif logo

Transcription factors associated with lhx8a+lhx8b

Gene Symbol Gene ID Gene Info
ENSDARG00000002330 LIM homeobox 8a
ENSDARG00000042145 LIM homeobox 8b

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
lhx8adr11_v1_chr2_+_11205795_11205795-0.644.1e-03Click!
lhx8bdr11_v1_chr8_-_17926620_179266200.233.6e-01Click!

Activity profile of lhx8a+lhx8b motif

Sorted Z-values of lhx8a+lhx8b motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_32384683 0.95 ENSDART00000182942
ENSDART00000141757
upstream binding transcription factor, like
chr11_+_13424116 0.86 ENSDART00000125563
homer scaffolding protein 3b
chr11_+_13423776 0.66 ENSDART00000102553
homer scaffolding protein 3b
chr8_+_29635968 0.61 ENSDART00000139029
ENSDART00000091409
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr11_-_43200994 0.59 ENSDART00000164700
spectrin, beta, non-erythrocytic 1
chr17_+_10570906 0.57 ENSDART00000182371
ENSDART00000176097
ENSDART00000110593
ENSDART00000169356
MGA, MAX dimerization protein a
chr21_-_36571804 0.57 ENSDART00000138129
WW and C2 domain containing 1
chr10_+_20364009 0.57 ENSDART00000186139
ENSDART00000080395
golgin A7
chr8_+_29636431 0.56 ENSDART00000133047
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 a
chr4_+_14727018 0.56 ENSDART00000124189
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr18_-_158541 0.55 ENSDART00000188914
ENSDART00000191052
transient receptor potential cation channel, subfamily M, member 7
chr2_+_49644803 0.52 ENSDART00000160342
si:ch211-209f23.7
chr4_+_14727212 0.51 ENSDART00000158094
cytidine monophosphate N-acetylneuraminic acid synthetase a
chr7_+_13609457 0.50 ENSDART00000172857
ankyrin repeat and death domain containing 1A
chr20_-_7080427 0.49 ENSDART00000140166
ENSDART00000023677
si:ch211-121a2.2
chr7_+_41887429 0.49 ENSDART00000115090
glutamic pyruvate transaminase (alanine aminotransferase) 2
chr15_-_34866219 0.49 ENSDART00000099723
SH3-binding domain protein 5-like, a
chr16_-_36979592 0.48 ENSDART00000168443
small nuclear ribonucleoprotein 48 (U11/U12)
chr15_+_11427620 0.47 ENSDART00000168688
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr8_+_10823069 0.46 ENSDART00000081341
mitogen-activated protein kinase 13
chr16_-_21903083 0.45 ENSDART00000165849
SET domain, bifurcated 1b
chr15_-_34865952 0.44 ENSDART00000186868
SH3-binding domain protein 5-like, a
chr21_-_13662237 0.44 ENSDART00000091647
ENSDART00000151547
patatin-like phospholipase domain containing 7a
chr19_+_46222428 0.44 ENSDART00000183984
vacuolar protein sorting 28 (yeast)
chr1_+_45671687 0.44 ENSDART00000146101
mucolipin 1a
chr20_+_6535438 0.44 ENSDART00000145763
si:ch211-191a24.4
chr7_-_39378903 0.42 ENSDART00000173659
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr23_-_29668286 0.42 ENSDART00000129248
calsyntenin 1
chr25_+_19238175 0.42 ENSDART00000110730
ENSDART00000193619
ENSDART00000154420
diphosphoinositol pentakisphosphate kinase 1b
chr24_+_39027481 0.41 ENSDART00000085565
calpain 15
chr9_-_12401871 0.40 ENSDART00000191901
nucleoporin 35
chr5_+_44944778 0.40 ENSDART00000130428
ENSDART00000044361
ENSDART00000128825
ENSDART00000124637
ENSDART00000126066
ENSDART00000177635
doublesex and mab-3 related transcription factor 1
chr5_-_15494164 0.40 ENSDART00000140668
ENSDART00000188076
ENSDART00000085943
TAO kinase 3a
chr13_+_29925397 0.39 ENSDART00000123482
CUE domain containing 2
chr4_-_5775507 0.38 ENSDART00000021753
cyclin C
chr16_-_35329803 0.38 ENSDART00000161729
ENSDART00000157700
ENSDART00000184584
ENSDART00000174713
ENSDART00000162518
protein tyrosine phosphatase, receptor type, U, b
chr17_-_29271359 0.37 ENSDART00000104219
REST corepressor 1
chr25_-_36263115 0.36 ENSDART00000143046
ENSDART00000139002
dihydrouridine synthase 2
chr21_-_34926619 0.36 ENSDART00000065337
ENSDART00000192740
kinesin family member 20A
chr3_-_33935200 0.35 ENSDART00000151211
general transcription factor IIF, polypeptide 1
chr14_-_23801389 0.35 ENSDART00000054264
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr14_+_28518349 0.34 ENSDART00000159961
stromal antigen 2b
chr17_+_15559046 0.34 ENSDART00000187126
BTB and CNC homology 1, basic leucine zipper transcription factor 2a
chr5_+_36654817 0.34 ENSDART00000131339
calpain, small subunit 1 a
chr7_-_32629458 0.34 ENSDART00000001376
ADP-ribosylation factor-like 14 effector protein
chr9_+_42606681 0.34 ENSDART00000191186
GULP, engulfment adaptor PTB domain containing 1a
chr3_-_30488063 0.34 ENSDART00000055393
ENSDART00000151367
mediator complex subunit 25
chr4_+_9536860 0.33 ENSDART00000130083
LSM8 homolog, U6 small nuclear RNA associated
chr25_+_21098675 0.33 ENSDART00000079012
RAD52 homolog, DNA repair protein
chr17_-_33412868 0.33 ENSDART00000187521

chr8_-_16725959 0.32 ENSDART00000183593
DEP domain containing 1a
chr14_-_33945692 0.32 ENSDART00000168546
ENSDART00000189778
zinc finger, DHHC-type containing 24
chr6_+_2195625 0.32 ENSDART00000155659
activin A receptor type 1Bb
chr24_+_12945803 0.32 ENSDART00000005105
proteasome activator subunit 1
chr14_+_8638353 0.32 ENSDART00000163240
si:dkeyp-115e12.6
chr8_-_16725573 0.32 ENSDART00000049676
DEP domain containing 1a
chr24_+_792429 0.31 ENSDART00000082523
inositol(myo)-1(or 4)-monophosphatase 2
chr21_+_27302752 0.31 ENSDART00000012855
SART1, U4/U6.U5 tri-snRNP-associated protein 1
chr13_-_8892514 0.30 ENSDART00000144553
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr1_-_55873178 0.30 ENSDART00000019936
protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b
chr3_-_33934788 0.29 ENSDART00000151411
general transcription factor IIF, polypeptide 1
chr9_+_42607138 0.29 ENSDART00000138133
ENSDART00000002027
GULP, engulfment adaptor PTB domain containing 1a
chr5_+_13326765 0.29 ENSDART00000090851
YdjC chitooligosaccharide deacetylase homolog
chr9_+_25775816 0.28 ENSDART00000127834
ENSDART00000189994
zinc finger E-box binding homeobox 2a
chr24_-_32025637 0.28 ENSDART00000180448
ENSDART00000159034
Ras suppressor protein 1
chr13_+_29292011 0.28 ENSDART00000115023
poly (ADP-ribose) glycohydrolase a
chr5_+_57320113 0.28 ENSDART00000036331
ATPase H+ transporting V1 subunit G1
chr4_+_15605844 0.27 ENSDART00000101619
ENSDART00000021384
exocyst complex component 4
chr17_+_24590177 0.27 ENSDART00000092941
rearranged L-myc fusion
chr19_-_31042570 0.27 ENSDART00000144337
ENSDART00000136213
ENSDART00000133101
ENSDART00000190949
basic leucine zipper and W2 domains 2
chr17_+_41081512 0.27 ENSDART00000056742
BRISC and BRCA1 A complex member 2
chr1_-_7673376 0.27 ENSDART00000013264
arginine and glutamate rich 1b
chr18_+_26899316 0.27 ENSDART00000050230
tetraspanin 3a
chr21_-_44771213 0.26 ENSDART00000188534
kinesin family member 4
chr22_-_910926 0.26 ENSDART00000180075

chr22_-_15562933 0.25 ENSDART00000141528
ankyrin repeat and MYND domain containing 1
chr24_+_33589667 0.25 ENSDART00000152097
dynein, axonemal, heavy chain 5 like
chr20_-_33507458 0.25 ENSDART00000140287
papilin b, proteoglycan-like sulfated glycoprotein
chr10_+_17747880 0.25 ENSDART00000135044
phosphatidylinositol glycan anchor biosynthesis, class O
chr16_-_35427060 0.25 ENSDART00000172294
CTP synthase 1b
chr2_+_50062165 0.24 ENSDART00000097939
ENSDART00000138214
zinc finger, CCHC domain containing 2
chr1_+_10019653 0.24 ENSDART00000190227
tripartite motif containing 2b
chr19_+_366034 0.24 ENSDART00000093383
vacuolar protein sorting 72 homolog (S. cerevisiae)
chr13_-_24260609 0.24 ENSDART00000138747
URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
chr6_-_16456093 0.24 ENSDART00000083305
ENSDART00000181640
solute carrier family 19 (thiamine transporter), member 2
chr17_+_21486047 0.24 ENSDART00000104608
phospholipase A2, group IVF, tandem duplicate 2
chr15_-_25613114 0.23 ENSDART00000182431
ENSDART00000187405
TAO kinase 1a
chr13_+_8892784 0.23 ENSDART00000075054
ENSDART00000143705
thyroid adenoma associated
chr24_+_39137001 0.23 ENSDART00000181086
ENSDART00000183724
ENSDART00000193466
TBC1 domain family, member 24
chr2_-_22659450 0.23 ENSDART00000115025
THAP domain containing 4
chr15_-_45356635 0.23 ENSDART00000192000

chr11_+_36355348 0.23 ENSDART00000145427
synaptophysin-like 2a
chr7_-_51727760 0.23 ENSDART00000174180
histone deacetylase 8
chr15_-_5901514 0.22 ENSDART00000155252
si:ch73-281n10.2
chr6_-_12456077 0.22 ENSDART00000190107
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr7_-_30280934 0.22 ENSDART00000126741
small EDRK-rich factor 2
chr25_+_15938880 0.21 ENSDART00000089035
PTPRF interacting protein, binding protein 2b (liprin beta 2)
chr9_-_16218097 0.21 ENSDART00000190503
myosin IB
chr22_+_1313046 0.21 ENSDART00000170421
si:ch73-138e16.6
chr3_-_45281350 0.20 ENSDART00000020168
potassium channel tetramerization domain containing 5a
chr21_-_25601648 0.20 ENSDART00000042578
EGF containing fibulin extracellular matrix protein 2b
chr21_-_8153165 0.20 ENSDART00000182580

chr7_-_64770456 0.20 ENSDART00000192618
zinc finger, DHHC-type containing 21
chr16_+_25535993 0.19 ENSDART00000077436
myosin regulatory light chain interacting protein b
chr21_+_21201346 0.19 ENSDART00000142961
RPTOR independent companion of MTOR, complex 2b
chr5_-_8614217 0.19 ENSDART00000164844
RPTOR independent companion of MTOR, complex 2 a
chr13_+_43650632 0.19 ENSDART00000141024
zinc finger, FYVE domain containing 21
chr6_+_40661703 0.18 ENSDART00000142492
enolase 1b, (alpha)
chr7_+_72469724 0.18 ENSDART00000187629
HECT domain E3 ubiquitin protein ligase 4
chr11_+_44236183 0.18 ENSDART00000193470
guanine nucleotide binding protein (G protein), beta polypeptide 4b
chr1_+_7414318 0.18 ENSDART00000127426
si:ch73-383l1.1
chr8_+_7737062 0.18 ENSDART00000166712
FYVE, RhoGEF and PH domain containing 1
chr12_-_24812403 0.17 ENSDART00000185517
forkhead box N2b
chr3_+_50201240 0.17 ENSDART00000156347
epsin 3a
chr8_+_3820134 0.16 ENSDART00000122454
citron rho-interacting serine/threonine kinase b
chr7_-_2285499 0.16 ENSDART00000182211
si:dkey-187j14.6
chr9_-_25055722 0.16 ENSDART00000137131
dynein, axonemal, heavy chain 7
chr17_-_30652738 0.16 ENSDART00000154960
SH3 and SYLF domain containing 1
chr2_-_14387335 0.16 ENSDART00000189332
ENSDART00000164786
ENSDART00000188572
SH3-domain GRB2-like (endophilin) interacting protein 1b
chr9_-_41040492 0.16 ENSDART00000163164
adenosine deaminase, tRNA-specific 3
chr16_+_29514473 0.16 ENSDART00000034102
cathepsin S, ortholog 2, tandem duplicate 2
chr16_+_4838808 0.15 ENSDART00000179363
inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr8_-_23612462 0.15 ENSDART00000025024
solute carrier family 38, member 5b
chr17_-_22552678 0.15 ENSDART00000079401
si:ch211-125o16.4
chr19_-_43004356 0.15 ENSDART00000098101
zinc finger, CCHC domain containing 17
chr20_+_492529 0.15 ENSDART00000141709

chr21_+_43400351 0.15 ENSDART00000141098
FERM domain containing 7
chr11_-_12471837 0.15 ENSDART00000113175
ENSDART00000186965
si:dkey-27d5.6
chr20_+_34151670 0.14 ENSDART00000152870
ENSDART00000010329
ENSDART00000145852
actin related protein 2/3 complex, subunit 5B
chr17_+_7513673 0.14 ENSDART00000156674
kelch-like family member 10b, tandem duplicate 1
chr21_-_17016788 0.14 ENSDART00000186703

chr18_+_30370559 0.14 ENSDART00000165450
Gse1 coiled-coil protein
chr15_-_45246911 0.14 ENSDART00000189557
ENSDART00000185291

chr25_+_28893615 0.14 ENSDART00000156994
ENSDART00000075151
antagonist of mitotic exit network 1 homolog (S. cerevisiae)
chr10_-_44482911 0.14 ENSDART00000085556
huntingtin interacting protein 1 related a
chr23_-_19051710 0.14 ENSDART00000111852
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr8_+_8196087 0.14 ENSDART00000026965
plexin B3
chr5_+_27137473 0.14 ENSDART00000181833
unc-5 netrin receptor Db
chr6_+_19948043 0.14 ENSDART00000182636
phosphoinositide-3-kinase, regulatory subunit 5
chr13_+_21677767 0.13 ENSDART00000165166
mitochondrial ribosome-associated GTPase 1
chr15_-_41708657 0.13 ENSDART00000154384
si:ch211-276c2.4
chr11_+_11430725 0.13 ENSDART00000188040
si:dkey-23f9.11
chr4_-_25812329 0.13 ENSDART00000146658
transmembrane and coiled-coil domain family 3
chr4_+_612363 0.13 ENSDART00000049154
parathyroid hormone-like hormone a
chr2_+_42005217 0.13 ENSDART00000143562
guanylate binding protein 2
chr25_+_7591293 0.13 ENSDART00000130416

chr21_-_17016105 0.12 ENSDART00000189120

chr21_-_11970199 0.12 ENSDART00000114524
NOP56 ribonucleoprotein homolog
chr19_-_20162980 0.12 ENSDART00000184605
family with sequence similarity 221, member A
chr7_-_1101694 0.11 ENSDART00000183017
ENSDART00000182681
dynactin 1a
chr4_-_25515154 0.11 ENSDART00000186524
RNA binding motif protein 17
chr5_-_20205075 0.11 ENSDART00000051611
D-amino-acid oxidase, tandem duplicate 3
chr23_-_19051869 0.11 ENSDART00000140866
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
chr10_-_36721726 0.11 ENSDART00000122132
Pim proto-oncogene, serine/threonine kinase, related 137
chr3_-_52674089 0.11 ENSDART00000154260
ENSDART00000125455
si:dkey-210j14.4
chr22_-_817479 0.11 ENSDART00000123487
zgc:153675
chr24_+_26887487 0.11 ENSDART00000189425

chr7_+_16509201 0.10 ENSDART00000173777
zinc finger, DHHC-type containing 13
chr5_+_51026563 0.10 ENSDART00000050988
glucosaminyl (N-acetyl) transferase 4, core 2, a
chr23_+_32101361 0.10 ENSDART00000138849
zgc:56699
chr8_+_20438884 0.10 ENSDART00000016422
ENSDART00000133794
MAP kinase interacting serine/threonine kinase 2b
chr10_+_14210667 0.10 ENSDART00000138854
si:dkey-286h21.1
chr23_+_45282858 0.10 ENSDART00000162353

chr16_-_24819860 0.10 ENSDART00000183874
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr15_+_36966369 0.09 ENSDART00000163622
kirre like nephrin family adhesion molecule 3, like
chr10_-_43568239 0.09 ENSDART00000131731
ENSDART00000097433
ENSDART00000131309
myocyte enhancer factor 2ca
chr6_+_11249706 0.09 ENSDART00000186547
ENSDART00000193287
ATG9 autophagy related 9 homolog A (S. cerevisiae)
chr9_+_25776971 0.09 ENSDART00000146011
zinc finger E-box binding homeobox 2a
chr9_-_16853462 0.09 ENSDART00000160273

chr11_-_12350237 0.09 ENSDART00000191094
si:dkey-27d5.14
chr9_-_2892250 0.09 ENSDART00000140695
cell division cycle associated 7a
chr23_+_21278948 0.08 ENSDART00000156701
ENSDART00000033970
ubiquitin protein ligase E3 component n-recognin 4
chr18_-_48558420 0.08 ENSDART00000058987
potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1
chr6_+_12865137 0.08 ENSDART00000090065
family with sequence similarity 117, member Ba
chr20_+_18551657 0.08 ENSDART00000147001
si:dkeyp-72h1.1
chr20_+_42563618 0.08 ENSDART00000153441
insulin-like growth factor 2 receptor
chr15_+_5132439 0.08 ENSDART00000010350
phosphoglucomutase 2-like 1
chr23_-_43486714 0.08 ENSDART00000169726
E2F transcription factor 1
chr4_+_3455146 0.08 ENSDART00000180124
zinc finger protein 800b
chr24_+_9003998 0.07 ENSDART00000179656
ENSDART00000191314

chr15_+_32268790 0.07 ENSDART00000154457
FH2 domain containing 4
chr9_-_21918963 0.07 ENSDART00000090782
LIM domain 7a
chr20_+_23173710 0.07 ENSDART00000074172
sarcoglycan, beta (dystrophin-associated glycoprotein)
chr23_+_36095260 0.07 ENSDART00000127384
homeobox C9a
chr4_-_22311610 0.07 ENSDART00000137814
hematopoietic cell-specific Lyn substrate 1
chr9_-_2892045 0.07 ENSDART00000137201
cell division cycle associated 7a
chr1_-_2457546 0.07 ENSDART00000103795
gamma-glutamylamine cyclotransferase, tandem duplicate 1
chr11_+_24620742 0.06 ENSDART00000182471
ENSDART00000048365
synaptotagmin VIb
chr15_-_1038193 0.06 ENSDART00000159462
si:dkey-77f5.3
chr16_+_20926673 0.06 ENSDART00000009827
homeobox A2b
chr14_-_25577094 0.06 ENSDART00000163669
complexin 2
chr13_+_10970614 0.06 ENSDART00000058147
dynein, cytoplasmic 2, light intermediate chain 1
chr6_+_20647155 0.06 ENSDART00000193477
solute carrier family 19 (folate transporter), member 1
chr25_-_28768489 0.06 ENSDART00000088315
WASH complex subunit 4
chr22_+_10010292 0.06 ENSDART00000180096

chr10_+_24631976 0.06 ENSDART00000181928
solute carrier family 46, member 3
chr11_+_25276748 0.05 ENSDART00000126211
cylindromatosis (turban tumor syndrome), b
chr7_-_31441420 0.05 ENSDART00000075398
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr7_-_22941472 0.05 ENSDART00000190334
TNF superfamily member 10, like
chr7_+_53152108 0.05 ENSDART00000171350
cadherin 29

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx8a+lhx8b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 0.6 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 0.4 GO:0030238 male sex determination(GO:0030238)
0.1 0.3 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.1 1.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.1 1.2 GO:0000729 DNA double-strand break processing(GO:0000729)
0.1 0.4 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.4 GO:0071387 cellular response to cortisol stimulus(GO:0071387) response to dexamethasone(GO:0071548)
0.1 0.6 GO:0032475 otolith formation(GO:0032475)
0.1 0.9 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 0.2 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
0.1 0.7 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.3 GO:0090243 fibroblast growth factor receptor signaling pathway involved in somitogenesis(GO:0090243)
0.0 0.1 GO:0002076 osteoblast development(GO:0002076)
0.0 0.4 GO:0045117 azole transport(GO:0045117)
0.0 0.4 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.4 GO:0031937 methylation-dependent chromatin silencing(GO:0006346) positive regulation of chromatin silencing(GO:0031937) regulation of methylation-dependent chromatin silencing(GO:0090308) positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.3 GO:0072401 signal transduction involved in DNA integrity checkpoint(GO:0072401) signal transduction involved in DNA damage checkpoint(GO:0072422) signal transduction involved in G2 DNA damage checkpoint(GO:0072425)
0.0 0.6 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607) nuclear pore organization(GO:0006999)
0.0 0.4 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747) regulation of vitamin metabolic process(GO:0030656) regulation of retinoic acid biosynthetic process(GO:1900052)
0.0 0.6 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
0.0 0.1 GO:0036076 ligamentous ossification(GO:0036076)
0.0 0.1 GO:0006524 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080) D-alanine family amino acid metabolic process(GO:0046144) D-alanine metabolic process(GO:0046436) D-alanine catabolic process(GO:0055130)
0.0 0.2 GO:0070933 histone H4 deacetylation(GO:0070933)
0.0 0.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.1 GO:0001712 ectodermal cell fate commitment(GO:0001712) ectodermal cell fate specification(GO:0001715) ectodermal cell differentiation(GO:0010668) regulation of ectodermal cell fate specification(GO:0042665) regulation of ectoderm development(GO:2000383)
0.0 0.2 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889)
0.0 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0015884 folic acid transport(GO:0015884) drug transport(GO:0015893) methotrexate transport(GO:0051958) reduced folate transmembrane transport(GO:0098838)
0.0 0.3 GO:0051310 metaphase plate congression(GO:0051310)
0.0 0.6 GO:0048264 determination of ventral identity(GO:0048264)
0.0 0.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.0 0.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.4 GO:0060021 palate development(GO:0060021)
0.0 0.4 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.0 0.3 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.1 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.4 GO:0001757 somite specification(GO:0001757)
0.0 0.3 GO:0010737 protein kinase A signaling(GO:0010737)
0.0 0.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.4 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.1 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 0.2 GO:0035476 angioblast cell migration(GO:0035476)
0.0 0.2 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 0.4 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0008091 spectrin(GO:0008091)
0.1 0.6 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.3 GO:0008537 proteasome activator complex(GO:0008537)
0.1 0.3 GO:0032584 growth cone membrane(GO:0032584)
0.1 0.2 GO:0097268 cytoophidium(GO:0097268)
0.0 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.6 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.3 GO:0070552 BRISC complex(GO:0070552)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.2 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.8 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.6 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.3 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.3 GO:0097526 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0008278 cohesin complex(GO:0008278)
0.0 0.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0071203 WASH complex(GO:0071203)
0.0 0.2 GO:0005903 brush border(GO:0005903)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.2 0.6 GO:0001096 TFIIF-class transcription factor binding(GO:0001096)
0.1 0.4 GO:0033857 inositol heptakisphosphate kinase activity(GO:0000829) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.1 0.3 GO:0052833 inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1 1.1 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 0.3 GO:0004649 poly(ADP-ribose) glycohydrolase activity(GO:0004649)
0.1 0.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.2 GO:0003883 CTP synthase activity(GO:0003883)
0.1 0.4 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.4 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1 0.3 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.2 GO:0052717 tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0 0.4 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.9 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.0 0.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 0.2 GO:0045118 azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0 0.1 GO:0003884 D-amino-acid oxidase activity(GO:0003884)
0.0 0.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.0 1.1 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.3 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0047631 ADP-ribose diphosphatase activity(GO:0047631)
0.0 0.1 GO:0015350 reduced folate carrier activity(GO:0008518) methotrexate transporter activity(GO:0015350)
0.0 1.2 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.0 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0031682 G-protein gamma-subunit binding(GO:0031682)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.0 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.3 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.0 0.2 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.2 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.4 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.6 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.0 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery