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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for lhx6-1

Z-value: 0.59

Motif logo

Transcription factors associated with lhx6-1

Gene Symbol Gene ID Gene Info
ENSDARG00000052165 si_ch211-236k19.2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
si:ch211-236k19.2dr11_v1_chr5_-_64900552_64900552-0.493.9e-02Click!

Activity profile of lhx6-1 motif

Sorted Z-values of lhx6-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_28208973 2.17 ENSDART00000171216
ENSDART00000171377
ENSDART00000167389
ENSDART00000166988
si:ch73-14h10.2
chr12_-_33354409 1.75 ENSDART00000178515
solute carrier family 16 (monocarboxylate transporter), member 3
chr2_-_38284648 1.72 ENSDART00000148281
ENSDART00000132621
si:ch211-14a17.7
chr9_+_44994214 1.49 ENSDART00000141434
retinol saturase (all-trans-retinol 13,14-reductase) like
chr12_-_33357655 1.48 ENSDART00000066233
ENSDART00000148165
solute carrier family 16 (monocarboxylate transporter), member 3
chr6_-_8360918 1.39 ENSDART00000004716
acid phosphatase 5a, tartrate resistant
chr24_-_9979342 1.32 ENSDART00000138576
ENSDART00000191206
zgc:171977
chr2_+_6255434 1.25 ENSDART00000139429
zona pellucida glycoprotein 3b
chr7_+_51795667 1.23 ENSDART00000174201
ENSDART00000073839
solute carrier family 38, member 7
chr8_-_23780334 1.18 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr5_+_37903790 1.18 ENSDART00000162470
transmembrane protease, serine 4b
chr24_-_24724233 1.17 ENSDART00000127044
ENSDART00000012399
armadillo repeat containing 1
chr11_-_16021424 1.11 ENSDART00000193291
ENSDART00000170731
ENSDART00000104107
zgc:173544
chr4_+_9467049 1.08 ENSDART00000012659
zgc:55888
chr10_-_34915886 1.05 ENSDART00000141201
ENSDART00000002166
cyclin A1
chr8_-_16464453 1.01 ENSDART00000098691
ring finger protein 11b
chr25_+_3759553 0.98 ENSDART00000180601
ENSDART00000055845
ENSDART00000157050
ENSDART00000153905
THO complex 5
chr10_+_16036246 0.97 ENSDART00000141586
ENSDART00000135868
ENSDART00000065037
ENSDART00000124502
lamin B1
chr10_-_34916208 0.95 ENSDART00000187371
cyclin A1
chr1_+_30723380 0.94 ENSDART00000127943
ENSDART00000062628
ENSDART00000127670
bora, aurora kinase A activator
chr19_-_4793263 0.92 ENSDART00000147510
ENSDART00000141336
ENSDART00000110551
ENSDART00000146684
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr16_+_47207691 0.91 ENSDART00000062507
islet cell autoantigen 1
chr1_+_30723677 0.87 ENSDART00000177900
bora, aurora kinase A activator
chr24_-_33366188 0.87 ENSDART00000074161
solute carrier family 4 (anion exchanger), member 2b
chr16_+_39159752 0.86 ENSDART00000122081
syntabulin (syntaxin-interacting)
chr5_+_25733774 0.84 ENSDART00000137088
ENSDART00000098467
abhydrolase domain containing 17B
chr7_+_22313533 0.80 ENSDART00000123457
si:dkey-11f12.2
chr13_-_35808904 0.80 ENSDART00000171667
mitogen-activated protein kinase kinase kinase 4
chr5_-_67241633 0.80 ENSDART00000114783
CAP-GLY domain containing linker protein 1a
chr3_+_26813058 0.75 ENSDART00000055537
suppressor of cytokine signaling 1a
chr21_+_15592426 0.73 ENSDART00000138207
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr8_-_15129573 0.73 ENSDART00000142358
BCAR3, NSP family adaptor protein
chr6_-_40778294 0.72 ENSDART00000019845
actin related protein 2/3 complex, subunit 4
chr2_+_6253246 0.72 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr10_+_7709724 0.68 ENSDART00000097670
gamma-glutamyl carboxylase
chr21_-_39177564 0.67 ENSDART00000065143
unc-119 homolog b (C. elegans)
chr19_-_4785734 0.66 ENSDART00000113088
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr22_-_26274177 0.66 ENSDART00000060978
WD repeat domain containing 83
chr5_-_40292299 0.66 ENSDART00000097525
sorting nexin 18a
chr21_-_2042037 0.66 ENSDART00000171131
ENSDART00000160144
adducin 1 (alpha)
chr25_-_6049339 0.65 ENSDART00000075184
sorting nexin 1a
chr6_+_40922572 0.64 ENSDART00000133599
ENSDART00000002728
ENSDART00000145153
eukaryotic translation initiation factor 4E nuclear import factor 1
chr8_+_11325310 0.64 ENSDART00000142577
frataxin
chr20_+_23947004 0.64 ENSDART00000144195
caspase 8 associated protein 2
chr4_-_9191220 0.64 ENSDART00000156919
host cell factor C2
chr2_+_24936766 0.64 ENSDART00000025962
glycogenin 1a
chr20_+_19006703 0.63 ENSDART00000128435
PIN2/TERF1 interacting, telomerase inhibitor 1
chr5_+_13394543 0.63 ENSDART00000051669
ENSDART00000135921
tectonic family member 2
chr20_-_51831816 0.62 ENSDART00000060505
melanoma inhibitory activity family, member 3
chr13_-_9213207 0.62 ENSDART00000139861
ENSDART00000140524
si:dkey-33c12.11
chr25_-_2723682 0.62 ENSDART00000113382
ADP-dependent glucokinase
chr22_-_21897203 0.61 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr5_-_30074332 0.60 ENSDART00000147963
beta-carotene oxygenase 2a
chr16_-_54498109 0.60 ENSDART00000083713
CDC-like kinase 2b
chr3_-_30885250 0.59 ENSDART00000109104
lysine methyltransferase 5C
chr25_-_2723902 0.59 ENSDART00000143721
ENSDART00000175224
ADP-dependent glucokinase
chr6_-_40922971 0.58 ENSDART00000155363
SFI1 centrin binding protein
chr12_+_22580579 0.57 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr4_+_2637947 0.57 ENSDART00000130623
dihydrouridine synthase 4-like (S. cerevisiae)
chr4_-_837768 0.57 ENSDART00000185280
ENSDART00000135618
sine oculis binding protein homolog (Drosophila) b
chr13_-_25198025 0.57 ENSDART00000159585
ENSDART00000144227
adenosine kinase a
chr10_+_34001444 0.56 ENSDART00000149934
klotho
chr13_+_38817871 0.55 ENSDART00000187708
collagen, type XIX, alpha 1
chr24_+_11908833 0.55 ENSDART00000178622
flap structure-specific endonuclease 1
chr7_-_33868903 0.54 ENSDART00000173500
ENSDART00000178746
uveal autoantigen with coiled-coil domains and ankyrin repeats b
chr11_+_5588122 0.54 ENSDART00000113281
zgc:172302
chr13_-_9236905 0.53 ENSDART00000142597
ENSDART00000147176
ENSDART00000181670
si:dkey-33c12.12
si:dkey-112g5.12
chr22_-_4439311 0.53 ENSDART00000169317
ubiquitin-like with PHD and ring finger domains 1
chr24_+_19415124 0.52 ENSDART00000186931
sulfatase 1
chr19_-_12648122 0.52 ENSDART00000151184
family with sequence similarity 210, member Aa
chr19_+_9231766 0.52 ENSDART00000190617
lysine (K)-specific methyltransferase 2Ba
chr2_-_40890004 0.51 ENSDART00000191746
UDP-glucose glycoprotein glucosyltransferase 1
chr12_+_36428052 0.51 ENSDART00000131300
unkempt family zinc finger
chr3_-_40836081 0.50 ENSDART00000143135
WD repeat domain, phosphoinositide interacting 2
chr2_+_2957515 0.50 ENSDART00000160715
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)
chr4_-_2637689 0.49 ENSDART00000192550
ENSDART00000021953
ENSDART00000150344
component of oligomeric golgi complex 5
chr9_-_12886108 0.49 ENSDART00000177283
ankyrin repeat and zinc finger domain containing 1
chr21_+_4410733 0.48 ENSDART00000136831
ENSDART00000131612
si:dkey-84o3.7
chr7_+_56703254 0.47 ENSDART00000184547
ENSDART00000004964
ENSDART00000147259
ENSDART00000134173
NAD(P)H dehydrogenase, quinone 1
chr11_-_11791718 0.47 ENSDART00000180476
cell division cycle 6 homolog (S. cerevisiae)
chr5_-_22052852 0.47 ENSDART00000002938
myotubularin related protein 8
chr22_-_37738203 0.46 ENSDART00000143190
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr24_-_25004553 0.46 ENSDART00000080997
ENSDART00000136860
zinc finger, DHHC-type containing 20b
chr2_-_1622641 0.46 ENSDART00000082143
protein kinase, cAMP-dependent, catalytic, beta b
chr12_+_47446158 0.45 ENSDART00000152857
formin 2b
chr13_-_24825691 0.45 ENSDART00000142745
STE20-like kinase a
chr20_-_37813863 0.44 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr24_+_11908480 0.44 ENSDART00000024224
flap structure-specific endonuclease 1
chr12_+_3571770 0.44 ENSDART00000164707
ENSDART00000189819
cytochrome C oxidase assembly factor 3a
chr14_+_21820034 0.44 ENSDART00000122739
C-terminal binding protein 1
chr22_-_20403194 0.44 ENSDART00000010048
mitogen-activated protein kinase kinase 2a
chr1_+_13930625 0.43 ENSDART00000111026
nocturnin b
chr14_-_14659023 0.43 ENSDART00000170355
ENSDART00000159888
ENSDART00000172241
NAD(P) dependent steroid dehydrogenase-like
chr12_+_1469090 0.43 ENSDART00000183637
ubiquitin specific peptidase 22
chr12_+_5048044 0.42 ENSDART00000161548
ENSDART00000172607
kinesin family member 22
chr13_-_9257728 0.42 ENSDART00000145985
ENSDART00000169991
ENSDART00000132764
zgc:173425
chr2_-_37462462 0.42 ENSDART00000145896
si:dkey-57k2.7
chr23_-_14766902 0.41 ENSDART00000168113
glutathione synthetase
chr13_+_9521629 0.41 ENSDART00000149870
ENSDART00000137666
si:dkey-19p15.4
chr6_+_7414215 0.41 ENSDART00000049339
SRY (sex determining region Y)-box 21a
chr7_+_38680034 0.41 ENSDART00000171691
ENSDART00000007913
proteasome 26S subunit, ATPase 3
chr19_-_3724605 0.41 ENSDART00000123757
small integral membrane protein 13
chr4_-_77260727 0.40 ENSDART00000075770
zgc:162948
chr3_-_3366590 0.40 ENSDART00000109428
ENSDART00000175329
si:dkey-46g23.1
chr6_+_40951227 0.40 ENSDART00000156660
POZ (BTB) and AT hook containing zinc finger 1
chr20_-_29532939 0.40 ENSDART00000049224
ENSDART00000062377
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
chr21_+_4328348 0.39 ENSDART00000131658
ENSDART00000143799
si:dkey-84o3.7
chr9_+_16241656 0.39 ENSDART00000154326
si:ch211-261p9.4
chr5_-_9625459 0.39 ENSDART00000143347
SH2B adaptor protein 3
chr4_-_73756673 0.39 ENSDART00000174274
ENSDART00000192913
ENSDART00000113546

si:dkey-262g12.14
zgc:171551
chr11_+_42600731 0.38 ENSDART00000182753
ENSDART00000192028
ENSDART00000085868
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr19_+_12406583 0.38 ENSDART00000013865
ENSDART00000151535
SEH1-like (S. cerevisiae)
chr9_+_43799829 0.37 ENSDART00000186240
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
chr8_-_50888806 0.37 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr13_-_9111927 0.37 ENSDART00000133815
ENSDART00000109783
ENSDART00000142540
ENSDART00000192613
si:dkey-19p15.4
si:dkey-112g5.12
chr9_+_18829360 0.37 ENSDART00000006514
general transcription factor IIF, polypeptide 2b
chr19_-_12648408 0.37 ENSDART00000103692
family with sequence similarity 210, member Aa
chr9_-_12595003 0.37 ENSDART00000184900
transformer 2 beta homolog
chr7_+_69459759 0.36 ENSDART00000160500
CTD nuclear envelope phosphatase 1b
chr19_-_20430892 0.36 ENSDART00000111409
TBC1 domain family, member 5
chr16_-_28658341 0.35 ENSDART00000148456
ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr5_-_25733745 0.35 ENSDART00000051566
zgc:101016
chr19_-_46088429 0.35 ENSDART00000161385
phosphatidylserine synthase 1b
chr19_-_5805923 0.35 ENSDART00000134340
si:ch211-264f5.8
chr16_+_33144306 0.35 ENSDART00000101953
rhomboid, veinlet-like 2 (Drosophila)
chr17_+_38030327 0.35 ENSDART00000085481
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
chr13_-_9159852 0.34 ENSDART00000170185
ENSDART00000158697
ENSDART00000143393
ENSDART00000164973
ENSDART00000159910
si:dkey-112g5.16
chr3_+_13848226 0.34 ENSDART00000184342
interleukin enhancer binding factor 3b
chr5_+_61508418 0.34 ENSDART00000023676
branched chain ketoacid dehydrogenase kinase
chr13_+_9468535 0.33 ENSDART00000135088
ENSDART00000164270
ENSDART00000099619
ENSDART00000164656
si:dkey-265c15.6
chr24_-_18809433 0.32 ENSDART00000152009
ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
chr3_+_46559639 0.32 ENSDART00000146189
ENSDART00000127832
ENSDART00000151035
ribonucleoprotein, PTB-binding 1
chr10_-_105100 0.32 ENSDART00000145716
tetratricopeptide repeat domain 3
chr5_+_29715040 0.31 ENSDART00000192563
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr19_+_1673599 0.31 ENSDART00000163127
kelch-like family member 7
chr11_+_2855430 0.31 ENSDART00000172837
kinesin family member 21B
chr9_-_12594759 0.31 ENSDART00000021266
transformer 2 beta homolog
chr5_+_29714786 0.30 ENSDART00000148314
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
chr12_-_4408828 0.30 ENSDART00000152447
si:ch211-173d10.1
chr13_-_9184132 0.30 ENSDART00000135289
ENSDART00000136309
ENSDART00000132630
si:dkey-33c12.10
chr5_+_20257225 0.30 ENSDART00000127919
slingshot protein phosphatase 1a
chr23_+_38952529 0.30 ENSDART00000190076
ATPase phospholipid transporting 9A (putative)
chr4_+_77957611 0.29 ENSDART00000156692
ADP-ribosylation factor GTPase activating protein 3
chr14_+_7902374 0.29 ENSDART00000113299
zgc:110843
chr21_+_4429001 0.29 ENSDART00000134520
si:dkey-84o3.6
chr22_-_29083070 0.29 ENSDART00000104812
ENSDART00000172576
chromobox homolog 6a
chr8_-_39822917 0.29 ENSDART00000067843
zgc:162025
chr15_-_9593532 0.29 ENSDART00000169912
GRB2-associated binding protein 2
chr3_-_5067585 0.29 ENSDART00000169609
thyrotrophic embryonic factor b
chr13_-_9070754 0.28 ENSDART00000143783
ENSDART00000102121
ENSDART00000140820
ENSDART00000184210
si:dkey-112g5.12
chr10_-_32494499 0.28 ENSDART00000129395
UV radiation resistance associated gene
chr21_-_13662237 0.28 ENSDART00000091647
ENSDART00000151547
patatin-like phospholipase domain containing 7a
chr10_+_34175476 0.27 ENSDART00000102123
zgc:174193
chr10_-_3138859 0.27 ENSDART00000190606
ubiquitin-conjugating enzyme E2L 3a
chr22_-_7050 0.27 ENSDART00000127829
ATPase family, AAA domain containing 3
chr20_-_9123296 0.27 ENSDART00000188495
Myb-like, SWIRM and MPN domains 1
chr7_+_9308625 0.26 ENSDART00000084598
selenoprotein S
chr13_-_9045879 0.26 ENSDART00000155463
ENSDART00000140041
ENSDART00000137454
si:dkey-112g5.11
chr3_+_33345348 0.26 ENSDART00000059262
membrane protein, palmitoylated 2a (MAGUK p55 subfamily member 2)
chr1_+_47335038 0.26 ENSDART00000188153
B cell CLL/lymphoma 9
chr5_-_62925282 0.25 ENSDART00000188048
sperm antigen with calponin homology and coiled-coil domains 1
chr7_+_36898850 0.25 ENSDART00000113342
TOX high mobility group box family member 3
chr21_+_4348600 0.25 ENSDART00000138463
si:dkey-84o3.2
chr9_-_3934963 0.24 ENSDART00000062336
ubiquitin protein ligase E3 component n-recognin 3
chr16_+_33144112 0.24 ENSDART00000183149
rhomboid, veinlet-like 2 (Drosophila)
chr10_-_3138403 0.24 ENSDART00000183365
ubiquitin-conjugating enzyme E2L 3a
chr6_+_3334710 0.24 ENSDART00000132848
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr2_-_30721502 0.23 ENSDART00000132389
si:dkey-94e7.1
chr4_+_62431132 0.23 ENSDART00000160226
si:ch211-79g12.1
chr12_+_1469327 0.23 ENSDART00000059143
ubiquitin specific peptidase 22
chr13_+_2442841 0.23 ENSDART00000114456
ENSDART00000137124
ENSDART00000193737
ENSDART00000189722
ENSDART00000187485
ARFGEF family member 3
chr25_-_10791437 0.23 ENSDART00000127054

chr12_-_42214 0.22 ENSDART00000045071
forkhead box K2
chr8_+_49975160 0.22 ENSDART00000156403
ENSDART00000080135
glutamine--fructose-6-phosphate transaminase 1
chr20_+_46040666 0.22 ENSDART00000060744
si:dkey-7c18.24
chr10_-_32494304 0.22 ENSDART00000028161
UV radiation resistance associated gene
chr13_-_9091354 0.22 ENSDART00000140319
ENSDART00000142697
si:dkey-112g5.13
chr22_-_22259175 0.22 ENSDART00000113824
HDGF like 2
chr21_-_40398932 0.22 ENSDART00000162500
nucleoporin 98
chr1_+_19708508 0.22 ENSDART00000054581
ENSDART00000131206
membrane-associated ring finger (C3HC4) 1
chr3_-_27915270 0.22 ENSDART00000115370
methyltransferase like 22
chr24_-_32582378 0.21 ENSDART00000066590
retinol dehydrogenase 12, like
chr12_-_22238004 0.21 ENSDART00000038310
ORMDL sphingolipid biosynthesis regulator 3
chr21_+_4313039 0.21 ENSDART00000141146
si:dkey-84o3.4
chr19_-_1871415 0.21 ENSDART00000004585
CLPTM1-like
chr5_-_27993972 0.20 ENSDART00000175819
protein phosphatase 3, catalytic subunit, gamma isozyme, a
chr9_+_33145522 0.19 ENSDART00000005879
ATP synthase peripheral stalk subunit OSCP
chr7_+_15308219 0.19 ENSDART00000165683
mesoderm posterior ba
chr8_-_45867358 0.19 ENSDART00000132810
ADAM metallopeptidase domain 9
chr19_-_2861444 0.18 ENSDART00000169053
C-type lectin domain family 3, member Bb
chr3_+_45364849 0.18 ENSDART00000153974
ubiquitin-conjugating enzyme E2Ia
chr7_+_69528850 0.17 ENSDART00000109507
Rap1 GTPase-GDP dissociation stimulator 1
chr12_+_6098713 0.17 ENSDART00000139054
sphingomyelin synthase 1
chr14_-_47815467 0.17 ENSDART00000166827
Rap guanine nucleotide exchange factor (GEF) 2
chr7_+_65398161 0.17 ENSDART00000166109
ENSDART00000157399
ubiquitin specific peptidase 47
chr25_+_459901 0.17 ENSDART00000154895
protogenin homolog b (Gallus gallus)
chr7_-_40630698 0.17 ENSDART00000134547
ubiquitin protein ligase E3C
chr25_+_13498188 0.16 ENSDART00000015710
SNF related kinase b
chr3_-_11008532 0.16 ENSDART00000165086

chr14_-_12020653 0.16 ENSDART00000106654
zinc finger protein 711

Network of associatons between targets according to the STRING database.

First level regulatory network of lhx6-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0045601 regulation of endothelial cell differentiation(GO:0045601)
0.2 3.7 GO:0035803 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 0.9 GO:0060074 synapse maturation(GO:0060074)
0.2 0.6 GO:0034770 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.2 0.5 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.2 1.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.8 GO:0060330 regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 0.8 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.1 1.8 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.1 1.4 GO:0045453 bone resorption(GO:0045453)
0.1 0.7 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.1 0.4 GO:0070129 regulation of mitochondrial translation(GO:0070129) positive regulation of mitochondrial translation(GO:0070131)
0.1 0.7 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 0.4 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 0.3 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1 0.6 GO:0044209 AMP salvage(GO:0044209)
0.1 0.7 GO:1900186 caveolin-mediated endocytosis(GO:0072584) negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of caveolin-mediated endocytosis(GO:2001286) negative regulation of caveolin-mediated endocytosis(GO:2001287)
0.1 0.4 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 0.4 GO:0010867 regulation of triglyceride biosynthetic process(GO:0010866) positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1 0.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.4 GO:0045899 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 0.6 GO:0016121 carotene metabolic process(GO:0016119) carotene catabolic process(GO:0016121) terpene metabolic process(GO:0042214) terpene catabolic process(GO:0046247)
0.1 0.3 GO:0035522 monoubiquitinated protein deubiquitination(GO:0035520) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.1 0.5 GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 0.8 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.5 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.1 0.6 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 0.2 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.5 GO:0033700 phospholipid efflux(GO:0033700)
0.1 0.4 GO:0051315 attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.1 0.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.5 GO:0044030 regulation of DNA methylation(GO:0044030)
0.1 0.2 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.0 0.2 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.3 GO:0097065 anterior head development(GO:0097065)
0.0 0.2 GO:0036306 embryonic heart tube elongation(GO:0036306)
0.0 0.2 GO:0097101 blood vessel endothelial cell fate specification(GO:0097101)
0.0 0.5 GO:0043550 regulation of lipid kinase activity(GO:0043550) regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.0 0.9 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.0 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0 1.9 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.8 GO:0050796 regulation of insulin secretion(GO:0050796)
0.0 0.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.5 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 3.2 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 0.5 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.6 GO:0035459 cargo loading into vesicle(GO:0035459)
0.0 0.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.0 0.7 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.3 GO:1905066 regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.6 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.2 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.4 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 1.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.5 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.6 GO:0051014 actin filament severing(GO:0051014)
0.0 0.2 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.0 0.5 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 0.3 GO:0001966 thigmotaxis(GO:0001966)
0.0 0.6 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.3 GO:0010906 regulation of glucose metabolic process(GO:0010906)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.8 GO:0045010 actin nucleation(GO:0045010)
0.0 0.5 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0001508 action potential(GO:0001508)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
0.1 1.0 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 0.4 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.7 GO:0035060 brahma complex(GO:0035060)
0.1 0.4 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
0.1 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.7 GO:0030904 retromer complex(GO:0030904)
0.1 0.4 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 1.0 GO:0030667 secretory granule membrane(GO:0030667)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:0000792 heterochromatin(GO:0000792)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.6 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.2 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 1.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.1 GO:0035517 PR-DUB complex(GO:0035517)
0.0 0.1 GO:0071818 BAT3 complex(GO:0071818)
0.0 0.4 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.6 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0030914 STAGA complex(GO:0030914)
0.0 0.3 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.3 3.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 3.7 GO:0032190 acrosin binding(GO:0032190)
0.2 0.6 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.2 1.6 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2 1.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 0.5 GO:1990715 mRNA CDS binding(GO:1990715)
0.2 0.7 GO:0008488 gamma-glutamyl carboxylase activity(GO:0008488)
0.2 0.6 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 1.0 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.1 0.4 GO:0001163 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.1 0.4 GO:0015462 protein-transmembrane transporting ATPase activity(GO:0015462) efflux transmembrane transporter activity(GO:0015562)
0.1 0.6 GO:0004001 adenosine kinase activity(GO:0004001)
0.1 0.5 GO:0090554 phospholipid-translocating ATPase activity(GO:0004012) phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.1 0.5 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.1 0.6 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 0.6 GO:0016530 metallochaperone activity(GO:0016530)
0.1 0.6 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.1 0.6 GO:0010436 beta-carotene 15,15'-monooxygenase activity(GO:0003834) carotenoid dioxygenase activity(GO:0010436)
0.1 0.4 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.6 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.2 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.0 0.2 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 1.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.9 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.3 GO:0017091 AU-rich element binding(GO:0017091) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.8 GO:0019894 kinesin binding(GO:0019894)
0.0 0.4 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.0 0.2 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.0 2.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.2 GO:0004408 holocytochrome-c synthase activity(GO:0004408)
0.0 0.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.4 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 0.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.7 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 0.5 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.5 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.9 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:0043295 glutathione binding(GO:0043295)
0.0 0.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.3 GO:0070122 isopeptidase activity(GO:0070122)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.0 GO:0050333 thiamin-triphosphatase activity(GO:0050333)
0.0 0.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.8 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID EPO PATHWAY EPO signaling pathway
0.0 0.7 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.4 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.2 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 0.5 PID ATR PATHWAY ATR signaling pathway
0.0 0.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.2 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 1.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.0 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.0 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.1 0.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.7 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.6 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.4 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.5 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.9 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.3 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import