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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for klf3+klf8

Z-value: 0.46

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Transcription factors associated with klf3+klf8

Gene Symbol Gene ID Gene Info
ENSDARG00000015495 Kruppel-like factor 3 (basic)
ENSDARG00000060661 Kruppel-like factor 8
ENSDARG00000114143 Kruppel-like factor 3 (basic)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
klf8dr11_v1_chr21_+_38073210_38073216-0.945.2e-09Click!
klf3dr11_v1_chr1_-_18615063_18615063-0.371.3e-01Click!

Activity profile of klf3+klf8 motif

Sorted Z-values of klf3+klf8 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_120181 1.18 ENSDART00000151209
ENSDART00000185930
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr23_-_45049044 1.15 ENSDART00000067630
SH3 domain containing GRB2 like 2, endophilin A1
chr4_-_193762 1.10 ENSDART00000169667
protein tyrosine phosphatase, receptor type, O
chr16_+_23978978 1.03 ENSDART00000058964
ENSDART00000135084
apolipoprotein A-II
chr20_+_54356272 1.02 ENSDART00000145735
zinc finger protein 410
chr4_-_191736 0.86 ENSDART00000169187
ENSDART00000192054
protein tyrosine phosphatase, receptor type, O
chr3_+_55093581 0.84 ENSDART00000101709
hemoglobin, alpha adult 2
chr5_-_24174956 0.77 ENSDART00000137631
si:ch211-137i24.10
chr21_-_280769 0.76 ENSDART00000157753
plasminogen receptor, C-terminal lysine transmembrane protein
chr18_+_5549672 0.72 ENSDART00000184970
nicotinamide nucleotide transhydrogenase 2
chr19_+_233143 0.69 ENSDART00000175273
synaptic Ras GTPase activating protein 1a
chr3_-_1190132 0.64 ENSDART00000149709
single-pass membrane protein with aspartate-rich tail 1a
chr4_+_37992753 0.64 ENSDART00000193890

chr16_-_23471387 0.63 ENSDART00000180899

chr23_-_45439903 0.63 ENSDART00000170729
nephronectin
chr1_-_49434798 0.56 ENSDART00000150842
ENSDART00000150789
si:dkeyp-80c12.10
chr19_+_19786117 0.49 ENSDART00000167757
ENSDART00000163546
homeobox A1a
chr7_-_19600181 0.48 ENSDART00000100757
oxidase (cytochrome c) assembly 1-like
chr1_-_44940830 0.48 ENSDART00000097500
ENSDART00000134464
ENSDART00000137216
transmembrane protein 176
chr9_-_56459660 0.46 ENSDART00000162771
UBX domain protein 4
chr15_-_47822597 0.44 ENSDART00000193236
ENSDART00000161391

chr11_+_37278457 0.43 ENSDART00000188946
cysteine-rich with EGF-like domains 1a
chr3_-_32927516 0.42 ENSDART00000140117
amine oxidase, copper containing 2
chr8_-_34762163 0.42 ENSDART00000114080
SET domain containing 1B, b
chr18_+_54354 0.41 ENSDART00000097163
zgc:158482
chr2_-_30135446 0.40 ENSDART00000141906
transient receptor potential cation channel, subfamily A, member 1a
chr25_+_37348730 0.40 ENSDART00000156639
peptidase domain containing associated with muscle regeneration 1
chr13_+_681628 0.38 ENSDART00000016604
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr6_+_46258866 0.38 ENSDART00000134584
zgc:162324
chr20_+_50052627 0.38 ENSDART00000188799
cleavage and polyadenylation specific factor 2
chr21_-_29197700 0.37 ENSDART00000172614
si:ch211-57b15.2
chr18_-_45617146 0.37 ENSDART00000146543
wilms tumor 1b
chr18_-_5103931 0.36 ENSDART00000188091
programmed cell death 10a
chr14_-_48260744 0.34 ENSDART00000183955
relaxin/insulin-like family peptide receptor 1
chr11_-_8269227 0.31 ENSDART00000127202
ENSDART00000158079
ENSDART00000158748
si:cabz01021067.1
Pim proto-oncogene, serine/threonine kinase, related 202
chr12_+_48851381 0.31 ENSDART00000187241
ENSDART00000187796
discs, large homolog 5b (Drosophila), tandem duplicate 1
chr7_-_6351021 0.30 ENSDART00000159542
zgc:112234
chr20_-_54377933 0.29 ENSDART00000182664
ectonucleoside triphosphate diphosphohydrolase 5b
chr7_-_67317119 0.29 ENSDART00000183915
proteasome 26S subunit, non-ATPase 7
chr18_+_5618368 0.28 ENSDART00000159945
unc-51 like kinase 3
chr21_+_27448856 0.28 ENSDART00000100784
complement factor b-like
chr22_-_30948457 0.28 ENSDART00000139887
ssu-2 homolog, tandem duplicate 1
chr12_+_34763795 0.28 ENSDART00000153097
solute carrier family 38, member 10
chr19_+_56351 0.28 ENSDART00000168334
collagen, type XIV, alpha 1b
chr11_+_45461419 0.27 ENSDART00000173424
son of sevenless homolog 1 (Drosophila)
chr3_-_15444396 0.24 ENSDART00000104361
si:dkey-56d12.4
chr14_-_21218891 0.24 ENSDART00000158294
protein phosphatase 2, regulatory subunit B, gamma b
chr7_-_67316903 0.24 ENSDART00000159408
proteasome 26S subunit, non-ATPase 7
chr10_+_466926 0.22 ENSDART00000145220
ARVCF, delta catenin family member a
chr19_+_164013 0.22 ENSDART00000167379
capping protein regulator and myosin 1 linker 1
chr1_-_59571758 0.22 ENSDART00000193546
ENSDART00000167087
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
chr1_-_625875 0.22 ENSDART00000167331
amyloid beta (A4) precursor protein a
chr1_+_36194761 0.21 ENSDART00000053773
ENSDART00000147458
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
chr4_+_53976731 0.21 ENSDART00000165813
si:ch211-249c2.1
chr24_-_40668208 0.21 ENSDART00000171543
slow myosin heavy chain 1
chr2_+_10007113 0.20 ENSDART00000155213
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3b
chr2_-_16217344 0.20 ENSDART00000152031
Rho guanine nucleotide exchange factor (GEF) 4
chr22_+_1440702 0.19 ENSDART00000165677
si:dkeyp-53d3.3
chr25_+_23489979 0.19 ENSDART00000158200

chr1_+_44941031 0.19 ENSDART00000141145
si:dkey-9i23.16
chr25_-_28587896 0.19 ENSDART00000111908
si:dkeyp-67e1.6
chr22_+_1006573 0.17 ENSDART00000123458
peroxisome proliferator-activated receptor delta a
chr20_-_39391833 0.16 ENSDART00000135149
si:dkey-217m5.8
chr24_-_40667800 0.15 ENSDART00000169315
slow myosin heavy chain 1
chr6_+_4084739 0.14 ENSDART00000087661
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5Bb
chr5_-_29587351 0.13 ENSDART00000136446
ENSDART00000051434
ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 1
chr12_+_19030391 0.13 ENSDART00000153927
si:ch73-139e5.2
chr9_-_56420087 0.13 ENSDART00000112016
ARP3 actin related protein 3 homolog
chr8_-_1973220 0.12 ENSDART00000184435
si:dkey-178e17.1
chr10_+_4875262 0.12 ENSDART00000165942
paralemmin 2
chr8_-_30204650 0.12 ENSDART00000133209
zgc:162939
chr20_-_39391492 0.12 ENSDART00000184886
si:dkey-217m5.8
chr14_+_13453130 0.11 ENSDART00000054849
plastin 3 (T isoform)
chr15_+_29085955 0.11 ENSDART00000156799
si:ch211-137a8.4
chr7_+_35229645 0.11 ENSDART00000144327
tubulin polymerization-promoting protein family member 3
chr18_+_7309150 0.10 ENSDART00000052792
ceramide synthase 3b
chr19_-_677713 0.09 ENSDART00000025146
solute carrier family 6 (neutral amino acid transporter), member 19a, tandem duplicate 1
chr8_+_28065803 0.09 ENSDART00000178481
potassium voltage-gated channel, Shal-related subfamily, member 3
chr16_-_20492799 0.09 ENSDART00000014769
chimerin 2
chr17_-_24353462 0.08 ENSDART00000191021
WD repeat containing planar cell polarity effector
chr6_-_39344259 0.08 ENSDART00000104074
zgc:158846
chr18_+_814328 0.08 ENSDART00000157801
ENSDART00000188492
ENSDART00000184489
family with sequence similarity 219, member B
chr23_-_44233408 0.08 ENSDART00000149318
ENSDART00000085528
zgc:158659
chr7_-_2039060 0.08 ENSDART00000173879
si:cabz01007794.1
chr18_-_24988645 0.06 ENSDART00000136434
ENSDART00000085735
chromodomain helicase DNA binding protein 2
chr19_-_24218942 0.05 ENSDART00000189198

chr16_-_50918908 0.05 ENSDART00000108744

chr7_-_32599669 0.05 ENSDART00000173752
potassium voltage-gated channel, shaker-related subfamily, member 4
chr6_+_41181869 0.05 ENSDART00000002046
opsin 1 (cone pigments), medium-wave-sensitive, 1
chr16_-_35329803 0.05 ENSDART00000161729
ENSDART00000157700
ENSDART00000184584
ENSDART00000174713
ENSDART00000162518
protein tyrosine phosphatase, receptor type, U, b
chr25_+_126174 0.05 ENSDART00000168913
contactin 1a
chr4_+_69577362 0.05 ENSDART00000160913
zinc finger protein 1030
chr24_-_38644937 0.04 ENSDART00000170194
solute carrier family 6, member 16b
chr6_+_41186320 0.04 ENSDART00000025241
opsin 1 (cone pigments), medium-wave-sensitive, 2
chr6_-_52757276 0.03 ENSDART00000159154

chr8_+_54013199 0.03 ENSDART00000158497

chr8_-_3413139 0.03 ENSDART00000182673
ENSDART00000166741
ENSDART00000169430
ENSDART00000170478
zgc:103510
zgc:165519
fucosyltransferase 9b
chr18_-_40508528 0.03 ENSDART00000185249
cholinergic receptor, nicotinic, alpha 5
chr7_-_1163829 0.02 ENSDART00000181937

chr19_+_7847920 0.02 ENSDART00000132454
si:dkeyp-85e10.1
chr10_+_4874542 0.02 ENSDART00000101431
paralemmin 2
chr5_-_35953472 0.02 ENSDART00000143448
relaxin/insulin-like family peptide receptor 2, like
chr2_-_54639964 0.02 ENSDART00000100103
acyl-CoA synthetase short chain family member 2 like
chr22_-_10019768 0.01 ENSDART00000162077

chr24_+_37461457 0.01 ENSDART00000165775
NLR family, CARD domain containing 3
chr22_-_16412496 0.01 ENSDART00000137497
cathepsin 12
chr13_-_40238813 0.01 ENSDART00000044963
lysyl oxidase-like 4
chr20_+_48129759 0.01 ENSDART00000148494
translocation associated membrane protein 2
chr9_-_11551608 0.00 ENSDART00000128629
FEV (ETS oncogene family)
chr4_+_64562090 0.00 ENSDART00000188810
si:ch211-223a21.3
chr21_+_21811867 0.00 ENSDART00000185752
sialidase 3 (membrane sialidase), tandem duplicate 4

Network of associatons between targets according to the STRING database.

First level regulatory network of klf3+klf8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0010755 regulation of plasminogen activation(GO:0010755)
0.2 0.7 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.4 GO:1903358 regulation of Golgi organization(GO:1903358)
0.1 0.4 GO:0050955 thermoception(GO:0050955) detection of temperature stimulus involved in thermoception(GO:0050960) detection of temperature stimulus involved in sensory perception(GO:0050961)
0.1 0.5 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.1 0.2 GO:2000812 regulation of barbed-end actin filament capping(GO:2000812)
0.1 0.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.4 GO:0031444 slow-twitch skeletal muscle fiber contraction(GO:0031444)
0.0 2.0 GO:0021587 cerebellum morphogenesis(GO:0021587)
0.0 0.8 GO:0015671 oxygen transport(GO:0015671)
0.0 0.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:0006843 mitochondrial citrate transport(GO:0006843)
0.0 0.1 GO:0097623 potassium ion export(GO:0071435) potassium ion export across plasma membrane(GO:0097623)
0.0 0.4 GO:0045762 activation of adenylate cyclase activity(GO:0007190) positive regulation of cAMP metabolic process(GO:0030816) positive regulation of cAMP biosynthetic process(GO:0030819) positive regulation of adenylate cyclase activity(GO:0045762)
0.0 0.4 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.5 GO:0021551 central nervous system morphogenesis(GO:0021551)
0.0 0.2 GO:0010887 negative regulation of cholesterol storage(GO:0010887)
0.0 0.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.4 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 0.2 GO:0015781 pyrimidine nucleotide-sugar transport(GO:0015781) pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 1.0 GO:0055113 epiboly involved in gastrulation with mouth forming second(GO:0055113)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0090443 FAR/SIN/STRIPAK complex(GO:0090443)
0.1 0.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 0.6 GO:1990246 uniplex complex(GO:1990246)
0.0 0.1 GO:0097541 axonemal basal plate(GO:0097541)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.4 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.5 GO:0005838 proteasome regulatory particle(GO:0005838)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0008746 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.1 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.8 GO:0031720 haptoglobin binding(GO:0031720)
0.1 0.5 GO:0032977 membrane insertase activity(GO:0032977)
0.0 0.5 GO:0070122 isopeptidase activity(GO:0070122)
0.0 0.4 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.4 GO:0045134 guanosine-diphosphatase activity(GO:0004382) uridine-diphosphatase activity(GO:0045134)
0.0 0.2 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.4 GO:0015278 calcium-release channel activity(GO:0015278)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.2 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.0 0.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.4 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease