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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for isl2a+isl2b
Z-value: 0.54
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Transcription factors associated with isl2a+isl2b
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| isl2a | dr11_v1_chr25_-_32751982_32751982 | 0.92 | 8.9e-08 | Click! |
| isl2b | dr11_v1_chr7_+_29992889_29992889 | 0.84 | 1.5e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_+_15433518 Show fit | 2.60 |
ENSDART00000026180
|
fatty acid binding protein 7, brain, a |
|
| chr17_+_15433671 Show fit | 2.33 |
ENSDART00000149568
|
fatty acid binding protein 7, brain, a |
|
| chr15_+_34988148 Show fit | 2.07 |
ENSDART00000076269
|
coiled-coil domain containing 105 |
|
| chr10_-_17083180 Show fit | 1.63 |
ENSDART00000170083
|
family with sequence similarity 166, member B |
|
| chr24_+_33622769 Show fit | 1.61 |
ENSDART00000079342
|
dynein, axonemal, heavy chain 5 like |
|
| chr5_-_41494831 Show fit | 1.51 |
ENSDART00000051081
|
eukaryotic translation elongation factor 2, like 2 |
|
| chr5_+_69747417 Show fit | 1.37 |
ENSDART00000153717
|
si:ch211-275j6.5 |
|
| chr3_-_19200571 Show fit | 1.36 |
ENSDART00000131503
ENSDART00000012335 |
regulatory factor X, 1a (influences HLA class II expression) |
|
| chr8_+_24747865 Show fit | 1.33 |
ENSDART00000078656
|
solute carrier family 16, member 4 |
|
| chr3_-_39180048 Show fit | 1.25 |
ENSDART00000049720
|
cyclin-dependent kinase 21 |
Network of associatons between targets according to the STRING database.
First level regulatory network of isl2a+isl2b
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.9 | GO:0046777 | protein autophosphorylation(GO:0046777) |
| 0.0 | 2.0 | GO:0006414 | translational elongation(GO:0006414) |
| 0.1 | 1.6 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.1 | 1.4 | GO:0006415 | translational termination(GO:0006415) |
| 0.0 | 1.1 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.0 | 1.1 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.3 | 1.0 | GO:1904158 | axonemal central apparatus assembly(GO:1904158) |
| 0.0 | 1.0 | GO:0042738 | drug metabolic process(GO:0017144) drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) |
| 0.1 | 0.8 | GO:0097104 | presynaptic membrane organization(GO:0097090) postsynaptic membrane assembly(GO:0097104) presynaptic membrane assembly(GO:0097105) |
| 0.0 | 0.8 | GO:1990399 | sensory epithelium regeneration(GO:0070654) epithelium regeneration(GO:1990399) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 1.4 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.3 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.0 | GO:0044447 | axoneme part(GO:0044447) |
| 0.1 | 0.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.5 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 0.4 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 0.3 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.3 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.0 | 0.2 | GO:0042788 | polysomal ribosome(GO:0042788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.9 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.1 | 1.6 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 1.5 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.1 | 1.4 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.1 | 1.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.1 | 1.1 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.0 | 1.1 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 1.0 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.3 | 0.8 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.2 | 0.7 | GO:0015220 | choline transmembrane transporter activity(GO:0015220) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.0 | 0.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.5 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.1 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.6 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.0 | 0.5 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.0 | 0.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.0 | 0.3 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 0.3 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.2 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.0 | 0.2 | REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 | Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| 0.0 | 0.1 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |