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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for irf5
Z-value: 1.27
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Transcription factors associated with irf5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| irf5 | dr11_v1_chr4_-_13613148_13613148 | 0.67 | 2.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_69187585 Show fit | 3.53 |
ENSDART00000160499
ENSDART00000166258 |
MARVEL domain containing 3 |
|
| chr18_+_44532668 Show fit | 2.73 |
ENSDART00000140672
|
suppression of tumorigenicity 14 (colon carcinoma) a |
|
| chr18_+_44532370 Show fit | 2.58 |
ENSDART00000086952
|
suppression of tumorigenicity 14 (colon carcinoma) a |
|
| chr18_+_44532199 Show fit | 2.53 |
ENSDART00000135386
|
suppression of tumorigenicity 14 (colon carcinoma) a |
|
| chr10_-_22150419 Show fit | 2.42 |
ENSDART00000006173
|
claudin 7b |
|
| chr23_+_2666944 Show fit | 2.36 |
ENSDART00000192861
|
|
|
| chr17_-_2039511 Show fit | 2.33 |
ENSDART00000160223
|
serine peptidase inhibitor, Kunitz type 1 a |
|
| chr15_-_33964897 Show fit | 2.29 |
ENSDART00000172075
ENSDART00000158126 ENSDART00000160456 |
lipolysis stimulated lipoprotein receptor |
|
| chr10_-_15879569 Show fit | 2.22 |
ENSDART00000136789
|
tight junction protein 2a (zona occludens 2) |
|
| chr15_+_44201056 Show fit | 2.21 |
ENSDART00000162433
ENSDART00000148336 |
|
Network of associatons between targets according to the STRING database.
First level regulatory network of irf5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.1 | GO:0008544 | epidermis development(GO:0008544) |
| 0.0 | 3.7 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 1.2 | 3.5 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
| 0.1 | 3.4 | GO:0090557 | establishment of endothelial intestinal barrier(GO:0090557) |
| 0.2 | 3.0 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
| 0.1 | 2.8 | GO:0046890 | regulation of lipid biosynthetic process(GO:0046890) |
| 0.4 | 2.4 | GO:0060876 | semicircular canal formation(GO:0060876) |
| 0.0 | 2.4 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.0 | 2.2 | GO:0031016 | pancreas development(GO:0031016) |
| 0.0 | 2.1 | GO:0048015 | phosphatidylinositol-mediated signaling(GO:0048015) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.7 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 6.2 | GO:0005764 | lysosome(GO:0005764) |
| 0.1 | 3.1 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 2.8 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.2 | 2.1 | GO:1990589 | ATF4-CREB1 transcription factor complex(GO:1990589) |
| 0.5 | 2.0 | GO:0097134 | cyclin E1-CDK2 complex(GO:0097134) |
| 0.1 | 2.0 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 1.9 | GO:0005845 | mRNA cap binding complex(GO:0005845) |
| 0.2 | 1.9 | GO:0032783 | ELL-EAF complex(GO:0032783) |
| 0.2 | 1.9 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 6.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 3.7 | GO:0050839 | cell adhesion molecule binding(GO:0050839) |
| 0.2 | 3.0 | GO:0035612 | AP-2 adaptor complex binding(GO:0035612) |
| 0.0 | 2.3 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.1 | 2.1 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629) |
| 0.1 | 2.0 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.0 | 2.0 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 2.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.3 | 1.9 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 2.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 2.0 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 1.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 1.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 0.9 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.0 | 0.8 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.0 | 0.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.0 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 2.0 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.0 | 1.8 | REACTOME PI METABOLISM | Genes involved in PI Metabolism |
| 0.1 | 1.7 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 0.0 | 1.7 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 1.4 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 1.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 1.3 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 1.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |