ISMARA results: irf1b+irf2+irf2a

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for irf1b+irf2+irf2a

Z-value: 0.81

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Transcription factors associated with irf1b+irf2+irf2a

Gene Symbol	Gene ID	Gene Info
irf2a NCBI UniProt	ENSDARG00000007387	interferon regulatory factor 2a
irf2 NCBI UniProt	ENSDARG00000040465	interferon regulatory factor 2
irf1b NCBI UniProt	ENSDARG00000043249	interferon regulatory factor 1b

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
irf2a	dr11_v1_chr1_+_39865748_39865753	0.85	6.8e-06	Click!
irf2	dr11_v1_chr14_-_4121052_4121052	-0.75	3.2e-04	Click!
irf1b	dr11_v1_chr21_+_45626136_45626136	-0.47	5.0e-02	Click!

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr23_+_43668756 Show fit	1.97	ENSDART00000112598	otud4 NCBI UniProt Show fit	OTU deubiquitinase 4
chr9_-_20853439 Show fit	1.95	ENSDART00000028247 ENSDART00000133321	gdap2 NCBI UniProt Show fit	ganglioside induced differentiation associated protein 2
chr15_+_25489406 Show fit	1.94	ENSDART00000162482	zgc:152863 NCBI UniProt Show fit	zgc:152863
chr14_+_36414856 Show fit	1.72	ENSDART00000123343 ENSDART00000015761	neil3 NCBI UniProt Show fit	nei-like DNA glycosylase 3
chr6_+_38896158 Show fit	1.72	ENSDART00000029930 ENSDART00000131347	slc48a1b NCBI UniProt Show fit	solute carrier family 48 (heme transporter), member 1b
chr2_+_35603637 Show fit	1.71	ENSDART00000147278	plk3 NCBI UniProt Show fit	polo-like kinase 3 (Drosophila)
chr11_+_37638873 Show fit	1.67	ENSDART00000186384 ENSDART00000184291 ENSDART00000131782 ENSDART00000140502	sh2d5 NCBI UniProt Show fit	SH2 domain containing 5
chr2_-_42552666 Show fit	1.61	ENSDART00000141399	dip2cb NCBI UniProt Show fit	disco-interacting protein 2 homolog Cb
chr16_+_23487051 Show fit	1.58	ENSDART00000145496	icn2 NCBI UniProt Show fit	ictacalcin 2
chr3_-_34586403 Show fit	1.50	ENSDART00000151515	sept9a NCBI UniProt Show fit	septin 9a

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	3.0	GO:0017148	negative regulation of translation(GO:0017148)
0.3	2.8	GO:1901678	heme transport(GO:0015886) iron coordination entity transport(GO:1901678)
0.6	2.4	GO:0048308	organelle inheritance(GO:0048308) Golgi inheritance(GO:0048313)
0.0	2.2	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
0.5	2.0	GO:2000660	regulation of interleukin-1-mediated signaling pathway(GO:2000659) negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3	1.9	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	1.9	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1	1.7	GO:0000076	DNA replication checkpoint(GO:0000076)
0.0	1.7	GO:0006289	nucleotide-excision repair(GO:0006289)
0.0	1.7	GO:0090630	activation of GTPase activity(GO:0090630)

Showing 1 to 10 of 127 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.2	GO:0005764	lysosome(GO:0005764)
0.0	3.2	GO:0000922	spindle pole(GO:0000922)
0.0	2.7	GO:0001726	ruffle(GO:0001726)
0.1	2.6	GO:0005940	septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0	1.9	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	1.6	GO:0043296	apical junction complex(GO:0043296)
0.1	1.3	GO:0000815	ESCRT III complex(GO:0000815)
0.1	1.3	GO:0015030	Cajal body(GO:0015030)
0.0	1.3	GO:0005795	Golgi stack(GO:0005795)
0.3	1.2	GO:0044326	dendritic spine neck(GO:0044326) dendritic filopodium(GO:1902737)

Showing 1 to 10 of 46 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	4.2	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.3	2.8	GO:0015232	heme transporter activity(GO:0015232)
0.0	2.4	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.1	2.0	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.1	1.9	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	1.9	GO:0060090	binding, bridging(GO:0060090)
0.0	1.8	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	1.8	GO:0019208	phosphatase regulator activity(GO:0019208)
0.1	1.7	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	1.6	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435) phospholipase C activity(GO:0004629)

Showing 1 to 10 of 86 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	1.5	PID P73PATHWAY	p73 transcription factor network
0.1	1.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.1	PID BARD1 PATHWAY	BARD1 signaling events
0.0	1.1	PID ATR PATHWAY	ATR signaling pathway
0.0	0.9	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	0.8	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.8	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.8	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	0.7	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.

Showing 1 to 10 of 16 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.1	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.1	2.0	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	2.0	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1	1.5	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	1.5	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	1.5	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	1.3	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1	1.2	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	1.0	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	0.9	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus

Showing 1 to 10 of 33 entries

Results for irf1b+irf2+irf2a

Z-value: 0.81

Motif logo

Transcription factors associated with irf1b+irf2+irf2a

Activity-expression correlation:

Activity profile of irf1b+irf2+irf2a motif

Sorted Z-values of irf1b+irf2+irf2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of irf1b+irf2+irf2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: