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PRJNA438478: RNAseq of wild type zebrafish germline
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Results for ikzf2
Z-value: 1.11
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Transcription factors associated with ikzf2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IKZF2 | dr11_v1_chr9_-_40073255_40073255 | 0.41 | 9.4e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_38626926 Show fit | 2.46 |
ENSDART00000190339
|
ATPase phospholipid transporting 10A |
|
| chr6_+_38626684 Show fit | 2.25 |
ENSDART00000086533
|
ATPase phospholipid transporting 10A |
|
| chr19_+_41479990 Show fit | 2.15 |
ENSDART00000087187
|
argonaute RISC catalytic component 2 |
|
| chr14_-_21618005 Show fit | 2.00 |
ENSDART00000043162
|
receptor accessory protein 2 |
|
| chr14_-_34605607 Show fit | 1.96 |
ENSDART00000191608
|
actin filament associated protein 1-like 1a |
|
| chr17_+_32531854 Show fit | 1.95 |
ENSDART00000123399
|
GC-rich sequence DNA-binding factor 2 |
|
| chr16_-_38333976 Show fit | 1.81 |
ENSDART00000031895
|
CDC42 small effector 1 |
|
| chr3_-_15470944 Show fit | 1.79 |
ENSDART00000185302
|
spinster homolog 1 (Drosophila) |
|
| chr14_-_46198373 Show fit | 1.78 |
ENSDART00000031640
ENSDART00000132966 |
zgc:113425 |
|
| chr4_+_9279784 Show fit | 1.73 |
ENSDART00000014897
|
SLIT-ROBO Rho GTPase activating protein 1b |
Network of associatons between targets according to the STRING database.
First level regulatory network of ikzf2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.7 | GO:0045332 | phospholipid translocation(GO:0045332) |
| 0.1 | 4.6 | GO:0030336 | negative regulation of cell migration(GO:0030336) |
| 0.0 | 2.7 | GO:0061640 | cytoskeleton-dependent cytokinesis(GO:0061640) |
| 0.2 | 2.6 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.0 | 2.4 | GO:0016573 | histone acetylation(GO:0016573) |
| 0.2 | 2.3 | GO:0035278 | miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974) |
| 0.4 | 2.1 | GO:0035279 | mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795) |
| 0.0 | 2.0 | GO:0090504 | epiboly(GO:0090504) |
| 0.0 | 2.0 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.1 | 1.8 | GO:0090398 | cellular senescence(GO:0090398) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.4 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.3 | 3.7 | GO:0002102 | podosome(GO:0002102) |
| 0.4 | 3.3 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.1 | 3.1 | GO:0032156 | septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.2 | 2.0 | GO:0005688 | U6 snRNP(GO:0005688) |
| 0.2 | 2.0 | GO:0098827 | endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827) |
| 0.0 | 1.7 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.1 | 1.6 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 1.6 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.4 | 1.5 | GO:0098890 | extrinsic component of postsynaptic membrane(GO:0098890) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 3.9 | GO:0060090 | binding, bridging(GO:0060090) |
| 0.1 | 3.5 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.7 | 3.4 | GO:0035197 | siRNA binding(GO:0035197) |
| 0.0 | 3.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 2.0 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.1 | 1.9 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.2 | 1.7 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.1 | 1.7 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.3 | 1.6 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 2.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 1.5 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.0 | 1.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 1.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 1.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 0.9 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 0.9 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.0 | 0.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 2.1 | REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON | Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon |
| 0.1 | 2.0 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 2.0 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 1.6 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 1.5 | REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.1 | 1.4 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.1 | 1.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 1.2 | REACTOME REGULATORY RNA PATHWAYS | Genes involved in Regulatory RNA pathways |
| 0.1 | 1.1 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |