ISMARA results: hoxb3a

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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hoxb3a

Z-value: 1.06

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Transcription factors associated with hoxb3a

Gene Symbol	Gene ID	Gene Info
hoxb3a NCBI UniProt	ENSDARG00000029263	homeobox B3a

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
hoxb3a	dr11_v1_chr3_+_23726148_23726148	-0.97	3.0e-11	Click!

Activity profile of hoxb3a motif

Sorted Z-values of hoxb3a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_8362419 Show fit	4.89	ENSDART00000142752 ENSDART00000135810	acp5a NCBI UniProt Show fit	acid phosphatase 5a, tartrate resistant
chr8_-_23780334 Show fit	4.74	ENSDART00000145179 ENSDART00000145894	zgc:195245 NCBI UniProt Show fit	zgc:195245
chr10_-_21545091 Show fit	3.29	ENSDART00000029122 ENSDART00000132207	zgc:165539 NCBI UniProt Show fit	zgc:165539
chr5_+_37903790 Show fit	3.27	ENSDART00000162470	tmprss4b NCBI UniProt Show fit	transmembrane protease, serine 4b
chr25_+_36292057 Show fit	3.13	ENSDART00000152329	bmb NCBI UniProt Show fit	brambleberry
chr11_+_12811906 Show fit	3.05	ENSDART00000123445	rtel1 NCBI UniProt Show fit	regulator of telomere elongation helicase 1
chr6_+_21001264 Show fit	3.03	ENSDART00000044519 ENSDART00000151278	cx44.2 NCBI UniProt Show fit	connexin 44.2
chr25_+_5972690 Show fit	3.01	ENSDART00000067517	si:ch211-11i22.4 NCBI UniProt Show fit	si:ch211-11i22.4
chr5_+_25733774 Show fit	2.53	ENSDART00000137088 ENSDART00000098467	abhd17b NCBI UniProt Show fit	abhydrolase domain containing 17B
chr24_-_9979342 Show fit	2.46	ENSDART00000138576 ENSDART00000191206	zgc:171977 NCBI UniProt Show fit	zgc:171977

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb3a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.9	GO:0045453	bone resorption(GO:0045453)
0.8	4.2	GO:0070986	left/right axis specification(GO:0070986)
0.2	3.2	GO:0060046	binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.6	3.1	GO:0000741	karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.3	3.1	GO:0032205	negative regulation of telomere maintenance(GO:0032205)
0.2	2.4	GO:0046037	GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.1	2.4	GO:0015693	magnesium ion transport(GO:0015693)
0.2	2.3	GO:0006622	protein targeting to lysosome(GO:0006622)
0.1	2.3	GO:1902807	negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.4	2.1	GO:0038107	nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)

Showing 1 to 10 of 85 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	9.1	GO:0005730	nucleolus(GO:0005730)
0.0	5.3	GO:0010008	endosome membrane(GO:0010008)
0.8	2.3	GO:0031310	integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3	2.2	GO:0035060	brahma complex(GO:0035060)
0.2	2.2	GO:0097651	phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0	2.1	GO:0001726	ruffle(GO:0001726)
0.1	1.8	GO:0005685	U1 snRNP(GO:0005685)
0.1	1.8	GO:0043596	nuclear replication fork(GO:0043596)
0.0	1.6	GO:0031965	nuclear membrane(GO:0031965)
0.0	1.4	GO:0035097	histone methyltransferase complex(GO:0035097)

Showing 1 to 10 of 41 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	4.9	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	4.6	GO:0035091	phosphatidylinositol binding(GO:0035091)
0.2	3.6	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	3.3	GO:0005044	scavenger receptor activity(GO:0005044)
0.2	3.2	GO:0032190	acrosin binding(GO:0032190)
0.8	3.1	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	2.4	GO:0003678	DNA helicase activity(GO:0003678)
0.0	2.3	GO:0019902	phosphatase binding(GO:0019902)
0.1	2.2	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	2.1	GO:0008083	growth factor activity(GO:0008083)

Showing 1 to 10 of 70 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.1	2.2	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	2.2	PID ATM PATHWAY	ATM pathway
0.0	2.0	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	1.8	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	1.8	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	1.6	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.3	PID LKB1 PATHWAY	LKB1 signaling events
0.1	1.1	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	1.0	PID HIF2PATHWAY	HIF-2-alpha transcription factor network

Showing 1 to 10 of 14 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	2.2	REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	Genes involved in G beta:gamma signalling through PI3Kgamma
0.2	1.9	REACTOME EARLY PHASE OF HIV LIFE CYCLE	Genes involved in Early Phase of HIV Life Cycle
0.1	1.9	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.2	1.7	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	1.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	1.4	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.1	1.2	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	1.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.1	1.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle

Showing 1 to 10 of 23 entries

Results for hoxb3a

Z-value: 1.06

Motif logo

Transcription factors associated with hoxb3a

Activity-expression correlation:

Activity profile of hoxb3a motif

Sorted Z-values of hoxb3a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb3a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: