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PRJNA438478: RNAseq of wild type zebrafish germline

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Results for hoxb3a

Z-value: 1.06

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Transcription factors associated with hoxb3a

Gene Symbol Gene ID Gene Info
ENSDARG00000029263 homeobox B3a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
hoxb3adr11_v1_chr3_+_23726148_23726148-0.973.0e-11Click!

Activity profile of hoxb3a motif

Sorted Z-values of hoxb3a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_8362419 4.89 ENSDART00000142752
ENSDART00000135810
acid phosphatase 5a, tartrate resistant
chr8_-_23780334 4.74 ENSDART00000145179
ENSDART00000145894
zgc:195245
chr10_-_21545091 3.29 ENSDART00000029122
ENSDART00000132207
zgc:165539
chr5_+_37903790 3.27 ENSDART00000162470
transmembrane protease, serine 4b
chr25_+_36292057 3.13 ENSDART00000152329
brambleberry
chr11_+_12811906 3.05 ENSDART00000123445
regulator of telomere elongation helicase 1
chr6_+_21001264 3.03 ENSDART00000044519
ENSDART00000151278
connexin 44.2
chr25_+_5972690 3.01 ENSDART00000067517
si:ch211-11i22.4
chr5_+_25733774 2.53 ENSDART00000137088
ENSDART00000098467
abhydrolase domain containing 17B
chr24_-_9979342 2.46 ENSDART00000138576
ENSDART00000191206
zgc:171977
chr3_+_3469600 2.36 ENSDART00000113616
zgc:171426
chr14_-_33481428 2.27 ENSDART00000147059
ENSDART00000140001
ENSDART00000124242
ENSDART00000164836
ENSDART00000190104
ENSDART00000186833
ENSDART00000180873
lysosomal-associated membrane protein 2
chr19_-_18127808 2.25 ENSDART00000108627
sorting nexin 10a
chr6_+_19948043 2.23 ENSDART00000182636
phosphoinositide-3-kinase, regulatory subunit 5
chr3_-_60856157 2.20 ENSDART00000053502

chr17_-_4245902 2.12 ENSDART00000151851
growth differentiation factor 3
chr12_-_48188928 2.06 ENSDART00000184384
phosphatase domain containing, paladin 1a
chr20_+_27087539 2.03 ENSDART00000062094
transmembrane protein 251
chr19_-_18127629 1.99 ENSDART00000187722
sorting nexin 10a
chr2_-_38287987 1.97 ENSDART00000185329
ENSDART00000061677
si:ch211-14a17.6
chr20_+_19006703 1.96 ENSDART00000128435
PIN2/TERF1 interacting, telomerase inhibitor 1
chr21_-_32060993 1.96 ENSDART00000131651
si:ch211-160j14.2
chr2_-_21819421 1.82 ENSDART00000121586
chromodomain helicase DNA binding protein 7
chr17_-_15189397 1.77 ENSDART00000133710
ENSDART00000110507
WD repeat and HMG-box DNA binding protein 1
chr20_-_14114078 1.76 ENSDART00000168434
ENSDART00000104032
si:ch211-223m11.2
chr1_-_51710225 1.75 ENSDART00000057601
ENSDART00000152745
small nuclear ribonucleoprotein polypeptide B2
chr6_+_37655078 1.74 ENSDART00000122199
ENSDART00000065127
cytoplasmic FMR1 interacting protein 1
chr12_-_4249000 1.71 ENSDART00000059298
zgc:92313
chr22_-_21897203 1.70 ENSDART00000158501
ENSDART00000105566
ENSDART00000136795
guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
chr5_+_65970235 1.66 ENSDART00000166432
solute carrier family 2 (facilitated glucose transporter), member 8
chr20_+_29209767 1.64 ENSDART00000141252
katanin p80 subunit B-like 1
chr7_-_58251527 1.62 ENSDART00000114008
ENSDART00000185189
un-named hu7910
chr8_-_15129573 1.61 ENSDART00000142358
BCAR3, NSP family adaptor protein
chr6_+_36839509 1.57 ENSDART00000190605
ENSDART00000104160
zgc:110788
chr18_+_34181655 1.55 ENSDART00000130831
ENSDART00000109535
guanine monophosphate synthase
chr20_+_29209926 1.53 ENSDART00000152949
ENSDART00000153016
katanin p80 subunit B-like 1
chr17_+_16429826 1.53 ENSDART00000136078
EF-hand calcium binding domain 11
chr20_+_29209615 1.43 ENSDART00000062350
katanin p80 subunit B-like 1
chr9_-_11676491 1.41 ENSDART00000022358
zinc finger CCCH-type containing 15
chr6_-_42949184 1.41 ENSDART00000147208
ER degradation enhancer, mannosidase alpha-like 1
chr17_+_38602602 1.40 ENSDART00000187996
coiled-coil domain containing 88C
chr19_+_9231766 1.39 ENSDART00000190617
lysine (K)-specific methyltransferase 2Ba
chr19_-_425145 1.35 ENSDART00000164905
dihydrouridine synthase 3-like (S. cerevisiae)
chr2_-_58075414 1.32 ENSDART00000161920
nectin cell adhesion molecule 4
chr19_+_14351560 1.32 ENSDART00000182732
AT rich interactive domain 1Ab (SWI-like)
chr20_+_14114258 1.31 ENSDART00000044937
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3b
chr2_+_41524238 1.31 ENSDART00000122860
ENSDART00000017977
activin A receptor, type 1 like
chr24_+_19415124 1.31 ENSDART00000186931
sulfatase 1
chr15_+_17345609 1.30 ENSDART00000111753
vacuole membrane protein 1
chr9_+_38888025 1.29 ENSDART00000148306
microtubule-associated protein 2
chr25_+_17860798 1.29 ENSDART00000146845
parathyroid hormone 1a
chr23_+_33947874 1.27 ENSDART00000136104
si:ch211-148l7.4
chr7_-_64589920 1.26 ENSDART00000172619
ENSDART00000184113

chr2_-_1622641 1.25 ENSDART00000082143
protein kinase, cAMP-dependent, catalytic, beta b
chr9_+_16241656 1.25 ENSDART00000154326
si:ch211-261p9.4
chr2_+_30182431 1.24 ENSDART00000004903
retinol dehydrogenase 10b
chr3_+_22035863 1.23 ENSDART00000177169
cell division cycle 27
chr6_+_29861288 1.21 ENSDART00000166782
discs, large homolog 1 (Drosophila)
chr5_+_13472234 1.21 ENSDART00000114069
ENSDART00000132406
cyclin and CBS domain divalent metal cation transport mediator 4b
chr16_-_19568795 1.21 ENSDART00000185141
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr4_+_2482046 1.19 ENSDART00000103371
zinc finger, DHHC-type containing 17
chr2_+_6253246 1.18 ENSDART00000058256
ENSDART00000076700
zona pellucida glycoprotein 3b
chr6_-_37744430 1.18 ENSDART00000150177
ENSDART00000149722
non imprinted in Prader-Willi/Angelman syndrome 2 (human)
chr22_-_26274177 1.17 ENSDART00000060978
WD repeat domain containing 83
chr21_+_11834880 1.17 ENSDART00000081661
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr8_-_537716 1.17 ENSDART00000051777
zgc:101664
chr8_-_50888806 1.16 ENSDART00000053750
acyl-CoA synthetase long chain family member 2
chr18_+_27571448 1.14 ENSDART00000147886
CD82 molecule b
chr23_-_32194397 1.12 ENSDART00000184206
ENSDART00000166682
nuclear receptor subfamily 4, group A, member 1
chr14_-_30905288 1.11 ENSDART00000173449
ENSDART00000173451
si:ch211-126c2.4
chr2_+_1988036 1.10 ENSDART00000155956
synovial sarcoma, X breakpoint 2 interacting protein a
chr11_-_44979281 1.08 ENSDART00000190972
LIM-domain binding 1b
chr6_+_29860776 1.07 ENSDART00000028406
discs, large homolog 1 (Drosophila)
chr13_+_27770424 1.06 ENSDART00000159281
asparaginase like 1
chr11_+_31864921 1.04 ENSDART00000180252
diaphanous-related formin 3
chr20_+_46040666 1.04 ENSDART00000060744
si:dkey-7c18.24
chr23_-_20051369 1.04 ENSDART00000049836
biglycan b
chr21_-_41065369 1.04 ENSDART00000143749
leucyl-tRNA synthetase b
chr11_+_11303458 1.03 ENSDART00000162486
ENSDART00000160703
si:dkey-23f9.4
chr24_-_25004553 1.03 ENSDART00000080997
ENSDART00000136860
zinc finger, DHHC-type containing 20b
chr18_+_50650713 1.01 ENSDART00000159095
si:dkey-151j17.4
chr24_+_11908833 1.01 ENSDART00000178622
flap structure-specific endonuclease 1
chr15_+_24795473 1.01 ENSDART00000139689
ENSDART00000141033
ENSDART00000100746
ENSDART00000135677
golgi SNAP receptor complex member 1
chr4_+_25917915 0.99 ENSDART00000138603
vezatin, adherens junctions transmembrane protein
chr8_+_11325310 0.97 ENSDART00000142577
frataxin
chr3_-_31086770 0.95 ENSDART00000103421
zgc:153292
chr7_+_13609457 0.94 ENSDART00000172857
ankyrin repeat and death domain containing 1A
chr3_-_60886984 0.94 ENSDART00000170974
phosphatidylinositol transfer protein, cytoplasmic 1
chr7_-_8712148 0.94 ENSDART00000065488
testis expressed 261
chr14_+_14841685 0.94 ENSDART00000158291
ENSDART00000162039
stem-loop binding protein
chr22_+_737211 0.93 ENSDART00000017305
zinc finger protein 76
chr24_+_11908480 0.92 ENSDART00000024224
flap structure-specific endonuclease 1
chr21_+_15592426 0.91 ENSDART00000138207
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b
chr24_+_36204028 0.89 ENSDART00000063832
ENSDART00000155260
retinoblastoma binding protein 8
chr20_+_47491247 0.89 ENSDART00000113412
lin-28 homolog B (C. elegans)
chr8_-_39822917 0.88 ENSDART00000067843
zgc:162025
chr25_+_15273370 0.87 ENSDART00000045659
t-complex 11, testis-specific-like 1
chr18_+_7553950 0.87 ENSDART00000193420
ENSDART00000062143
zgc:77650
chr7_-_14446512 0.87 ENSDART00000041577
kinesin family member 7
chr25_-_19608382 0.86 ENSDART00000022279
ENSDART00000135201
ENSDART00000147223
ENSDART00000190220
ENSDART00000184242
ENSDART00000166824
G-2 and S-phase expressed 1
chr2_-_17393216 0.83 ENSDART00000123137
ST3 beta-galactoside alpha-2,3-sialyltransferase 3b
chr5_+_61467618 0.83 ENSDART00000074073
ENSDART00000182094
alkB homolog 4, lysine demthylase
chr5_-_24542726 0.82 ENSDART00000182975
tRNA methyltransferase 2 homolog A
chr20_-_37813863 0.81 ENSDART00000147529
basic leucine zipper transcription factor, ATF-like 3
chr4_-_77260727 0.81 ENSDART00000075770
zgc:162948
chr16_-_27677930 0.80 ENSDART00000145991
transforming growth factor beta regulator 4
chr18_+_50650512 0.80 ENSDART00000161022
si:dkey-151j17.4
chr14_+_21820034 0.80 ENSDART00000122739
C-terminal binding protein 1
chr14_-_48961056 0.80 ENSDART00000124192
si:dkeyp-121d2.7
chr6_-_11792152 0.79 ENSDART00000183403
membrane-associated ring finger (C3HC4) 7
chr12_-_19119176 0.79 ENSDART00000149180
aconitase 2, mitochondrial
chr13_+_28785814 0.79 ENSDART00000039028
NSE4 homolog A, SMC5-SMC6 complex component
chr25_-_37338048 0.78 ENSDART00000073439
tripartite motif containing 44
chr12_+_22580579 0.78 ENSDART00000171725
ENSDART00000192290
capping protein (actin filament), gelsolin-like b
chr12_+_1139690 0.77 ENSDART00000160442

chr8_-_53044300 0.75 ENSDART00000191653
nuclear receptor subfamily 6, group A, member 1a
chr23_-_14766902 0.74 ENSDART00000168113
glutathione synthetase
chr6_+_40832635 0.73 ENSDART00000011931
RuvB-like AAA ATPase 1
chr2_+_54086436 0.73 ENSDART00000174581

chr23_+_4741543 0.71 ENSDART00000144761
Raf-1 proto-oncogene, serine/threonine kinase a
chr7_-_22632518 0.70 ENSDART00000161046
si:dkey-112a7.4
chr15_-_5720583 0.69 ENSDART00000158034
ENSDART00000190332
ENSDART00000109599
URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
chr5_+_66044128 0.67 ENSDART00000165573
Janus kinase 2b
chr25_+_35891342 0.67 ENSDART00000147093
LSM14A mRNA processing body assembly factor a
chr13_-_9213207 0.66 ENSDART00000139861
ENSDART00000140524
si:dkey-33c12.11
chr20_+_38458084 0.66 ENSDART00000020153
ENSDART00000135912
coenzyme Q8A
chr7_+_26466826 0.65 ENSDART00000058908
mannose-P-dolichol utilization defect 1b
chr9_-_36924388 0.65 ENSDART00000059756
v-ral simian leukemia viral oncogene homolog Ba (ras related)
chr2_+_25315591 0.64 ENSDART00000161386
fibronectin type III domain containing 3Ba
chr5_+_66043820 0.63 ENSDART00000016019
Janus kinase 2b
chr7_-_22632690 0.63 ENSDART00000165245
si:dkey-112a7.4
chr11_-_486532 0.62 ENSDART00000093148
ISY1 splicing factor homolog
chr14_+_2487672 0.61 ENSDART00000170629
ENSDART00000123063
fibroblast growth factor 18a
chr10_+_35347993 0.60 ENSDART00000131350
si:dkey-259j3.5
chr3_+_19685873 0.60 ENSDART00000006490
tousled-like kinase 2
chr21_-_13662237 0.60 ENSDART00000091647
ENSDART00000151547
patatin-like phospholipase domain containing 7a
chr5_-_37881345 0.59 ENSDART00000084819
Rho GTPase activating protein 35b
chr9_+_18829360 0.58 ENSDART00000006514
general transcription factor IIF, polypeptide 2b
chr8_-_21091961 0.58 ENSDART00000100281
aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 2
chr3_+_16724614 0.57 ENSDART00000182135
glycogen synthase 1 (muscle)
chr7_+_21787507 0.56 ENSDART00000100936
transmembrane protein 88 b
chr6_+_3334710 0.56 ENSDART00000132848
ST3 beta-galactoside alpha-2,3-sialyltransferase 3a
chr23_+_4709607 0.56 ENSDART00000166503
ENSDART00000158752
ENSDART00000163860
ENSDART00000172739
Raf-1 proto-oncogene, serine/threonine kinase a
Raf-1 proto-oncogene, serine/threonine kinase a
chr17_+_38030327 0.55 ENSDART00000085481
solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
chr8_+_52314542 0.55 ENSDART00000013059
ENSDART00000125241
drebrin-like b
chr1_+_44523516 0.55 ENSDART00000147702
zinc finger, DHHC-type containing 5a
chr5_+_1493767 0.55 ENSDART00000022132
HAUS augmin-like complex, subunit 4
chr9_+_18576047 0.55 ENSDART00000145174
laccase (multicopper oxidoreductase) domain containing 1
chr19_+_46222428 0.54 ENSDART00000183984
vacuolar protein sorting 28 (yeast)
chr5_-_25733745 0.53 ENSDART00000051566
zgc:101016
chr8_-_4596662 0.53 ENSDART00000138199
septin 5a
chr1_-_15797663 0.53 ENSDART00000177122
sarcoglycan zeta
chr22_+_8979955 0.53 ENSDART00000144005
si:ch211-213a13.1
chr8_-_49764156 0.52 ENSDART00000177589
ENSDART00000189142
heterogeneous nuclear ribonucleoprotein K
chr23_-_17450746 0.52 ENSDART00000145399
ENSDART00000136457
ENSDART00000133125
ENSDART00000145719
ENSDART00000147524
ENSDART00000005366
ENSDART00000104680
tumor protein D52-like 2b
chr15_+_2857556 0.52 ENSDART00000157758
MRE11 homolog A, double strand break repair nuclease
chr19_+_19976990 0.52 ENSDART00000052627
neuropeptide VF precursor
chr9_-_32158288 0.48 ENSDART00000037182
ankyrin repeat domain 44
chr13_-_31025505 0.48 ENSDART00000137709
WDFY family member 4
chr4_-_72295710 0.48 ENSDART00000182983
si:cabz01071911.3
chr18_+_8833251 0.48 ENSDART00000143519
IMP (inosine 5'-monophosphate) dehydrogenase 1a
chr18_+_41768357 0.47 ENSDART00000192658
transient receptor potential cation channel, subfamily C, member 6b
chr15_-_1651766 0.46 ENSDART00000127396
protein phosphatase, Mg2+/Mn2+ dependent, 1Lb
chr6_+_2457455 0.44 ENSDART00000157456

chr23_+_45910033 0.43 ENSDART00000165025
ATP-binding cassette, sub-family G (WHITE), member 2a
chr23_-_900795 0.43 ENSDART00000190517
ENSDART00000182849
ENSDART00000111456
ENSDART00000185430
RNA binding motif protein 10
chr6_+_7414215 0.43 ENSDART00000049339
SRY (sex determining region Y)-box 21a
chr12_-_28349026 0.43 ENSDART00000183768
ENSDART00000152998
zgc:195081
chr11_-_44498975 0.42 ENSDART00000173066
ENSDART00000189976
si:ch1073-365p7.2
chr4_-_73756673 0.42 ENSDART00000174274
ENSDART00000192913
ENSDART00000113546

si:dkey-262g12.14
zgc:171551
chr21_-_28340977 0.40 ENSDART00000141629
neurexin 2a
chr3_+_33300522 0.40 ENSDART00000114023
heat shock protein, alpha-crystallin-related, 9
chr6_+_59642695 0.40 ENSDART00000166373
ENSDART00000161030
R3H domain containing 2
chr8_+_26059677 0.39 ENSDART00000009178
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr5_-_35161877 0.39 ENSDART00000139673
FCH domain only 2
chr8_-_18010097 0.38 ENSDART00000122730
ENSDART00000133666
acyl-CoA thioesterase 11b
chr9_-_35334642 0.38 ENSDART00000157195
neural cell adhesion molecule 2
chr17_-_14523722 0.37 ENSDART00000024726
dishevelled associated activator of morphogenesis 1a
chr1_-_18585046 0.37 ENSDART00000147228
family with sequence similarity 114, member A1
chr17_+_44697604 0.37 ENSDART00000156625
placental growth factor b
chr9_-_12034444 0.36 ENSDART00000038651
zinc finger protein 804A
chr17_+_24222190 0.35 ENSDART00000181698
ENSDART00000189411
EH domain binding protein 1
chr12_+_1492641 0.35 ENSDART00000152411
ubiquitin specific peptidase 22
chr7_+_38267136 0.35 ENSDART00000173613
G patch domain containing 1
chr3_+_31087509 0.34 ENSDART00000129564
si:dkey-66i24.8
chr1_-_23157583 0.33 ENSDART00000144208
adhesion G protein-coupled receptor L3.1
chr17_-_37195354 0.33 ENSDART00000190963
additional sex combs like transcriptional regulator 2
chr7_-_7692992 0.33 ENSDART00000192619
aminoadipate aminotransferase
chr17_-_200316 0.32 ENSDART00000190561

chr17_-_37195163 0.31 ENSDART00000108514
additional sex combs like transcriptional regulator 2
chr25_-_27722614 0.31 ENSDART00000190154
zgc:153935
chr13_-_30142087 0.30 ENSDART00000110157
trypsin domain containing 1
chr13_-_8692860 0.30 ENSDART00000058107
multiple coagulation factor deficiency 2
chr15_+_34592215 0.30 ENSDART00000099776
tetraspanin 13a
chr23_-_31969786 0.30 ENSDART00000134550
ORMDL sphingolipid biosynthesis regulator 2
chr21_-_13661631 0.29 ENSDART00000184408
patatin-like phospholipase domain containing 7a
chr7_+_24729558 0.29 ENSDART00000111542
ENSDART00000170100
shroom family member 4
chr21_+_4429001 0.29 ENSDART00000134520
si:dkey-84o3.6
chr25_-_19648154 0.28 ENSDART00000148570
ATPase plasma membrane Ca2+ transporting 1b
chr9_-_394088 0.28 ENSDART00000169014
si:dkey-11f4.7

Network of associatons between targets according to the STRING database.

First level regulatory network of hoxb3a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.2 GO:0070986 left/right axis specification(GO:0070986)
0.6 3.1 GO:0000741 karyogamy(GO:0000741) pronuclear fusion(GO:0007344)
0.4 4.9 GO:0045453 bone resorption(GO:0045453)
0.4 1.7 GO:0099563 modification of synaptic structure(GO:0099563)
0.4 2.1 GO:0038107 nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145)
0.4 1.2 GO:0050787 response to mercury ion(GO:0046689) detoxification of mercury ion(GO:0050787)
0.4 1.2 GO:0045830 regulation of isotype switching(GO:0045191) positive regulation of isotype switching(GO:0045830)
0.3 3.1 GO:0032205 negative regulation of telomere maintenance(GO:0032205)
0.3 1.3 GO:0035124 embryonic caudal fin morphogenesis(GO:0035124)
0.3 1.6 GO:0042264 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.3 1.9 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 0.9 GO:0045002 double-strand break repair via single-strand annealing(GO:0045002)
0.3 1.1 GO:0033345 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.2 2.4 GO:0046037 GMP biosynthetic process(GO:0006177) GMP metabolic process(GO:0046037)
0.2 0.7 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
0.2 2.3 GO:0006622 protein targeting to lysosome(GO:0006622)
0.2 0.6 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.2 1.0 GO:0048209 regulation of vesicle targeting, to, from or within Golgi(GO:0048209)
0.2 1.2 GO:0048011 neurotrophin TRK receptor signaling pathway(GO:0048011)
0.2 3.2 GO:0060046 binding of sperm to zona pellucida(GO:0007339) egg coat formation(GO:0035803) regulation of acrosome reaction(GO:0060046) positive regulation of acrosome reaction(GO:2000344)
0.2 0.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 1.3 GO:2000290 smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021910) regulation of myotome development(GO:2000290)
0.1 1.9 GO:0098734 protein depalmitoylation(GO:0002084) macromolecule depalmitoylation(GO:0098734)
0.1 0.9 GO:0097065 anterior head development(GO:0097065)
0.1 2.4 GO:0015693 magnesium ion transport(GO:0015693)
0.1 1.8 GO:0009303 rRNA transcription(GO:0009303) swim bladder maturation(GO:0048796) swim bladder inflation(GO:0048798)
0.1 0.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 1.2 GO:0006167 AMP biosynthetic process(GO:0006167)
0.1 0.5 GO:0045938 regulation of endocrine process(GO:0044060) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) endocrine hormone secretion(GO:0060986)
0.1 1.1 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.6 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 1.4 GO:0070252 actin-mediated cell contraction(GO:0070252)
0.1 0.7 GO:0000492 box C/D snoRNP assembly(GO:0000492) regulation of heart growth(GO:0060420)
0.1 2.3 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.1 1.2 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of chromosome segregation(GO:0051984) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.1 0.8 GO:0044528 regulation of mitochondrial mRNA stability(GO:0044528)
0.1 1.2 GO:0042572 retinol metabolic process(GO:0042572)
0.1 0.7 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 0.3 GO:1903173 fatty alcohol metabolic process(GO:1903173)
0.1 0.7 GO:0034063 stress granule assembly(GO:0034063)
0.1 1.7 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 0.6 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.1 0.3 GO:2000303 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.1 1.6 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 0.5 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.1 1.0 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 1.2 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 0.5 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 1.3 GO:0010737 protein kinase A signaling(GO:0010737)
0.1 1.4 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 1.1 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.8 GO:0070989 oxidative demethylation(GO:0070989)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 1.2 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.1 GO:0032640 tumor necrosis factor production(GO:0032640) tumor necrosis factor superfamily cytokine production(GO:0071706)
0.0 0.4 GO:0097531 mast cell chemotaxis(GO:0002551) regulation of mast cell chemotaxis(GO:0060753) positive regulation of mast cell chemotaxis(GO:0060754) mast cell migration(GO:0097531)
0.0 1.4 GO:0008643 carbohydrate transport(GO:0008643)
0.0 0.3 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.3 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998)
0.0 1.0 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.3 GO:0032264 purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.0 0.8 GO:0051014 actin filament severing(GO:0051014)
0.0 1.3 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.0 0.2 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 0.3 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 0.7 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.4 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.2 GO:0070309 lens fiber cell development(GO:0070307) lens fiber cell morphogenesis(GO:0070309)
0.0 0.5 GO:0006828 manganese ion transport(GO:0006828)
0.0 1.3 GO:0021954 central nervous system neuron development(GO:0021954)
0.0 0.5 GO:0045879 negative regulation of smoothened signaling pathway(GO:0045879)
0.0 0.8 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.2 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.1 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.0 0.4 GO:0021986 habenula development(GO:0021986)
0.0 0.2 GO:0051382 kinetochore assembly(GO:0051382)
0.0 1.0 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.0 1.5 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.0 0.7 GO:0030917 midbrain-hindbrain boundary development(GO:0030917)
0.0 0.6 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.6 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 1.3 GO:0051260 protein homooligomerization(GO:0051260)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0031310 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310)
0.3 2.2 GO:0035060 brahma complex(GO:0035060)
0.3 1.3 GO:0070724 BMP receptor complex(GO:0070724)
0.2 0.9 GO:0035301 Hedgehog signaling complex(GO:0035301)
0.2 1.0 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 0.7 GO:0097255 R2TP complex(GO:0097255)
0.2 2.2 GO:0097651 phosphatidylinositol 3-kinase complex, class IB(GO:0005944) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.1 0.4 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 0.8 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.4 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1 0.6 GO:0035517 PR-DUB complex(GO:0035517)
0.1 0.8 GO:0070938 contractile ring(GO:0070938)
0.1 0.5 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.6 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 1.8 GO:0005685 U1 snRNP(GO:0005685)
0.1 0.3 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.6 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.5 GO:0070652 HAUS complex(GO:0070652)
0.1 1.8 GO:0043596 nuclear replication fork(GO:0043596)
0.0 1.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 1.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.0 0.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.5 GO:0000813 ESCRT I complex(GO:0000813)
0.0 9.1 GO:0005730 nucleolus(GO:0005730)
0.0 0.2 GO:0030914 STAGA complex(GO:0030914)
0.0 2.1 GO:0001726 ruffle(GO:0001726)
0.0 0.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 5.3 GO:0010008 endosome membrane(GO:0010008)
0.0 1.2 GO:0005811 lipid particle(GO:0005811)
0.0 0.9 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 1.4 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.2 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.3 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 1.6 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.5 GO:0031105 septin ring(GO:0005940) septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 1.0 GO:0005795 Golgi stack(GO:0005795)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.6 4.9 GO:0003993 acid phosphatase activity(GO:0003993)
0.5 2.0 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.4 1.6 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.3 0.9 GO:0070336 flap-structured DNA binding(GO:0070336)
0.3 1.9 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 0.8 GO:0003994 aconitate hydratase activity(GO:0003994)
0.3 1.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 1.3 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.2 1.3 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427) calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 1.8 GO:0030619 U1 snRNA binding(GO:0030619)
0.2 1.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.2 1.4 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity(GO:0008118)
0.2 1.7 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.2 3.2 GO:0032190 acrosin binding(GO:0032190)
0.2 3.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.2 1.1 GO:0030274 LIM domain binding(GO:0030274)
0.1 0.7 GO:0043295 glutathione binding(GO:0043295)
0.1 0.7 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.1 0.6 GO:0019145 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.1 0.9 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.6 GO:0004373 glycogen (starch) synthase activity(GO:0004373)
0.1 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.0 GO:0016530 metallochaperone activity(GO:0016530)
0.1 1.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 1.7 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 1.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.4 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.1 1.1 GO:0015924 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 1.2 GO:0047676 arachidonate-CoA ligase activity(GO:0047676)
0.1 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 1.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.9 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 1.2 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.2 GO:0048030 disaccharide binding(GO:0048030)
0.1 2.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.1 1.4 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 1.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.1 0.3 GO:0051903 alcohol dehydrogenase activity, zinc-dependent(GO:0004024) S-(hydroxymethyl)glutathione dehydrogenase activity(GO:0051903)
0.0 3.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.3 GO:0016212 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 1.0 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.9 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 0.1 GO:1904121 phosphatidylethanolamine transporter activity(GO:1904121)
0.0 2.4 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.5 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.8 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.3 GO:0019902 phosphatase binding(GO:0019902)
0.0 1.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 1.3 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 1.0 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 4.6 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.6 GO:0019003 GDP binding(GO:0019003)
0.0 0.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 2.1 GO:0008083 growth factor activity(GO:0008083)
0.0 0.7 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.5 GO:0005507 copper ion binding(GO:0005507)
0.0 0.8 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.0 0.1 GO:0038187 pattern recognition receptor activity(GO:0038187)
0.0 0.0 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 2.2 PID ATM PATHWAY ATM pathway
0.1 1.8 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 0.8 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 1.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 1.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 2.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.0 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.2 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 1.9 REACTOME EARLY PHASE OF HIV LIFE CYCLE Genes involved in Early Phase of HIV Life Cycle
0.2 2.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 1.9 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 2.2 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 0.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.2 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 0.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 1.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.5 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 0.8 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.1 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 1.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 1.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 1.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.6 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.1 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse